(149 nodes) Cellular macromolecule biosynthetic process network (Giardia lamblia ATCC 50803)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GL50803_104173	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1165 aa)
	GL50803_8462	Ribosomal protein L27. (135 aa)
	GL50803_8454	WD_REPEATS_REGION domain-containing protein. (452 aa)
	GL50803_4343	Zinc finger domain protein. (612 aa)
	UPPS	Di-trans,poly-cis-undecaprenyl-diphosphate synthase; Cis-prenyl transferase involved in the synthesis of dolichol, a long-chain polyprenol that is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Catalyzes the sequential condensation of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to produce a polyprenyl pyrophosphate which contains 11 (major) and 12 (minor) isoprene units. Belongs to the UPP synthase family. (265 aa)
	GL50803_5845	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (174 aa)
	GL50803_4838	Translation initiation factor eIF-2B delta subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (780 aa)
	GL50803_16934	Tetratricopeptide repeat protein. (1375 aa)
	GL50803_17190	Eukaryotic peptide chain release factor subunit 1. (457 aa)
	GL50803_15520	Ribosomal protein L21. (159 aa)
	GL50803_101501	Seryl-tRNA synthetase. (457 aa)
	GL50803_5772	Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family. (409 aa)
	GL50803_6055	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (268 aa)
	GL50803_7990	Translation elongation factor; Belongs to the eukaryotic initiation factor 4E family. (168 aa)
	GL50803_3570	Ribosomal protein S28. (64 aa)
	GL50803_14091	Ribosomal protein L14. (131 aa)
	GL50803_6022	Ribosomal protein S20. (126 aa)
	GL50803_14975	Phosphatidylinositol-glycan biosynthesis, class O protein. (553 aa)
	GL50803_9529	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (313 aa)
	GL50803_15538	Eukaryotic translation initiation factor 5. (337 aa)
	GL50803_11950	Ribosomal protein L18. (179 aa)
	GL50803_9365	Kinase, NEK. (946 aa)
	GL50803_10367	Ribosomal protein S24. (132 aa)
	GL50803_6283	Uncharacterized protein. (476 aa)
	GL50803_14620	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (248 aa)
	GL50803_14622	60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family. (234 aa)
	GL50803_22808	Histidyl-tRNA synthetase. (961 aa)
	GL50803_10255	Translation initiation factor eIF-4A, putative; Belongs to the DEAD box helicase family. (391 aa)
	GL50803_10822	WD-40 repeat protein family. (342 aa)
	GL50803_17502	GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly. (654 aa)
	GL50803_17547	Ribosomal protein L4. (316 aa)
	GL50803_3032	Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (429 aa)
	GL50803_15495	RRM domain-containing protein. (871 aa)
	GL50803_7999	Ribosomal protein S3. (217 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (246 aa)
	GL50803_8001	Ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family. (204 aa)
	GL50803_16598	Mannose-1-phosphate guanyltransferase. (514 aa)
	GL50803_15587	Protein 21.1. (257 aa)
	GL50803_13156	Eukaryotic initiation factor 4A. (428 aa)
	GL50803_10521	Arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (621 aa)
	GL50803_17460	G1 to S phase transition protein 1, putative. (465 aa)
	GL50803_4606	Methionyl-tRNA synthetase. (235 aa)
	GL50803_8708	Eukaryotic translation initiation factor 1A. (160 aa)
	GL50803_16129	Translation initiation factor. (685 aa)
	GL50803_15260	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
	GL50803_3180	Dolichol-phosphate mannosyltransferase, putative. (253 aa)
	GL50803_41701	O-linked GlcNAc transferase. (155 aa)
	GL50803_16588	Uncharacterized protein. (122 aa)
	GL50803_35670	Zinc finger domain protein. (394 aa)
	GL50803_2970	Translation initiation factor 2 gamma subunit. (478 aa)
	GL50803_15267	GPI-anchor transamidase, putative. (250 aa)
	GL50803_13897	MCT-1 protein-like protein. (237 aa)
	GL50803_16652	Ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family. (154 aa)
	GL50803_98056	Ribosomal protein L17; Belongs to the universal ribosomal protein uL22 family. (164 aa)
	GL50803_7766	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (245 aa)
	GL50803_16766	Lysine--tRNA ligase. (576 aa)
	GL50803_137685	Uncharacterized protein. (719 aa)
	GL50803_86681	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (702 aa)
	GL50803_11359	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family. (268 aa)
	GL50803_12081	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). (1480 aa)
	GL50803_12102	Elongation factor 1-gamma. (402 aa)
	GL50803_15046	Ribosomal protein L26. (135 aa)
	GL50803_16431	Ribosomal protein L19. (196 aa)
	GL50803_102978	Glycosyltransferase family 28. (192 aa)
	GL50803_5593	Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (173 aa)
	GL50803_39587	Translation initiation factor. (1305 aa)
	GL50803_13943	Eukaryotic translation initiation factor 2 alpha subunit. (334 aa)
	GL50803_7110	Ubiquitin. (82 aa)
	GL50803_104031	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (753 aa)
	GL50803_1657	Translation initiation factor. (105 aa)
	GL50803_91911	Translation initiation factor eIF-2B alpha subunit; Belongs to the eIF-2B alpha/beta/delta subunits family. (332 aa)
	GL50803_4652	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (158 aa)
	GL50803_17337	Ribosomal protein P1B; Belongs to the eukaryotic ribosomal protein P1/P2 family. (118 aa)
	GL50803_5947	Ribosomal protein L35a. (123 aa)
	GL50803_4547	Ribosomal protein S9. (189 aa)
	GL50803_113610	GlcNAc-PI synthesis protein. (454 aa)
	GL50803_16928	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (382 aa)
	GL50803_9011	Glycyl-tRNA synthetase. (621 aa)
	GL50803_14171	Ribosomal protein L37; Binds to the 23S rRNA. (89 aa)
	GL50803_17393	Uncharacterized protein. (339 aa)
	GL50803_10428	Ribosomal protein L10. (210 aa)
	GL50803_5871	Developmentally regulated GTP-binding protein 1. (368 aa)
	GL50803_14049	Ribosomal protein L32. (136 aa)
	GL50803_36069	Ribosomal protein L34. (120 aa)
	GL50803_16368	Ribosomal protein L31B. (106 aa)
	GL50803_7870	Ribosomal protein L23A; Belongs to the universal ribosomal protein uL23 family. (141 aa)
	GL50803_8118	Ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family. (242 aa)
	GL50803_96562	Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (445 aa)
	GL50803_5517	Ribosomal protein L37a. (94 aa)
	GL50803_16612	Tyrosyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (387 aa)
	GL50803_17054	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (326 aa)
	GL50803_17056	Ribosomal protein L9. (185 aa)
	GL50803_16298	Ribosomal_S27 domain-containing protein. (137 aa)
	GL50803_10870	Aspartyl-tRNA synthetase. (555 aa)
	GL50803_10885	4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase. (1731 aa)
	GL50803_16200	Developmentally regulated GTP-binding protein 1. (373 aa)
	GL50803_17364	40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (109 aa)
	GL50803_15983	Prolyl-tRNA synthetase. (542 aa)
	GL50803_6135	Ribosomal protein S17. (137 aa)
	GL50803_6133	Ribosomal protein L35. (152 aa)
	GL50803_19003	Ribosomal protein L24A. (102 aa)
	GL50803_13661	Eukaryotic translation initiation factor 3 subunit 2. (350 aa)
	GL50803_16525	Ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family. (379 aa)
	GL50803_10091	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family. (142 aa)
	GL50803_16265	40S ribosomal protein S3a; Belongs to the eukaryotic ribosomal protein eS1 family. (248 aa)
	GL50803_14699	Ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (143 aa)
	GL50803_13998	Threonyl-tRNA synthetase. (695 aa)
	GL50803_16387	60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. (173 aa)
	GL50803_9348	Glutaminyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (763 aa)
	GL50803_14329	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (190 aa)
	GL50803_14375	Asparaginyl-tRNA synthetase. (548 aa)
	GL50803_16957	WD-40 repeat protein family. (362 aa)
	GL50803_15889	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase. (366 aa)
	GL50803_16111	HSP70 subfamily B suppressor 1. (620 aa)
	GL50803_15823	1,4-alpha-glucan branching enzyme. (783 aa)
	GL50803_17570	Elongation factor 2. (898 aa)
	GL50803_11247	Ribosomal protein L13a. (197 aa)
	GL50803_33862	Ribosomal protein S12. (125 aa)
	GL50803_12174	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (381 aa)
	GL50803_115239	Translation initiation factor IF-2, putative. (926 aa)
	GL50803_112304	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (442 aa)
	GL50803_14827	Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (154 aa)
	GL50803_16044	Uncharacterized protein. (171 aa)
	GL50803_96460	Alanyl-tRNA synthetase. (969 aa)
	GL50803_7652	Translation initiation factor; Belongs to the eIF-2B alpha/beta/delta subunits family. (383 aa)
	GL50803_5665	Ubiquitin/ribosomal protein CEP52. (127 aa)
	GL50803_91398	Eukaryotic translation initiation factor 2 beta subunit. (330 aa)
	GL50803_8621	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1173 aa)
	GL50803_22204	Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (582 aa)
	GL50803_16114	Ribosomal protein L36-1. (90 aa)
	GL50803_14457	60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family. (62 aa)
	GL50803_13561	Translation elongation factor. (220 aa)
	GL50803_17395	Ribosomal protein L5. (297 aa)
	GL50803_16760	Phenylalanyl-tRNA synthetase beta chain. (589 aa)
	GL50803_15551	Ribosomal protein S18; Belongs to the universal ribosomal protein uS13 family. (154 aa)
	GL50803_15228	Ribosomal protein S15A. (130 aa)
	GL50803_16310	Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family. (149 aa)
	GL50803_14614	Eukaryotic translation initiation factor 5A. (149 aa)
	GL50803_12981	Ribosomal protein S5. (190 aa)
	GL50803_12162	Phenylalanyl-tRNA synthetase alpha chain. (541 aa)
	GL50803_137724	Uncharacterized protein. (380 aa)
	GL50803_14236	Uncharacterized protein. (189 aa)
	GL50803_86933	Uncharacterized protein. (362 aa)
	GL50803_9899	eIF2A domain-containing protein. (528 aa)
	GL50803_16086	Ribosomal protein L2. (251 aa)
	GL50803_7662	RNase L inhibitor. (674 aa)
	GL50803_5867	Cysteinyl-tRNA synthetase. (645 aa)
	GL50803_35428	Valine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1218 aa)
	GL50803_1345	Ribosomal protein L10a. (221 aa)

Your Current Organism:

Giardia lamblia ATCC 50803

NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF6	GL50803_10091	A8B8Z3	A8BS37	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L23; Belongs to the universal ribosomal protein uL14 family.	0.999
EIF6	GL50803_10255	A8B8Z3	A8B6X3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Translation initiation factor eIF-4A, putative; Belongs to the DEAD box helicase family.	0.623
EIF6	GL50803_10367	A8B8Z3	A8B593	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein S24.	0.722
EIF6	GL50803_10428	A8B8Z3	A8BM86	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L10.	0.999
EIF6	GL50803_112304	A8B8Z3	A8BVR3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.	0.548
EIF6	GL50803_11247	A8B8Z3	A8BU75	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L13a.	0.999
EIF6	GL50803_11359	A8B8Z3	A8BFE3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family.	0.432
EIF6	GL50803_115239	A8B8Z3	A8BUL3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Translation initiation factor IF-2, putative.	0.800
EIF6	GL50803_11950	A8B8Z3	A8B4T7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L18.	0.999
EIF6	GL50803_12102	A8B8Z3	A8BFR0	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Elongation factor 1-gamma.	0.729
EIF6	GL50803_12162	A8B8Z3	A8BZP3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Phenylalanyl-tRNA synthetase alpha chain.	0.725
EIF6	GL50803_12981	A8B8Z3	A8BZD3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein S5.	0.641
EIF6	GL50803_13156	A8B8Z3	A8B9J2	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Eukaryotic initiation factor 4A.	0.623
EIF6	GL50803_1345	A8B8Z3	E2RU33	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L10a.	0.990
EIF6	GL50803_13561	A8B8Z3	A8BZ22	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Translation elongation factor.	0.573
EIF6	GL50803_13661	A8B8Z3	A8BRM0	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Eukaryotic translation initiation factor 3 subunit 2.	0.714
EIF6	GL50803_13943	A8B8Z3	A8BIJ2	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Eukaryotic translation initiation factor 2 alpha subunit.	0.574
EIF6	GL50803_14049	A8B8Z3	A8BMD9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L32.	0.999
EIF6	GL50803_14091	A8B8Z3	A8B4F8	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L14.	0.999
EIF6	GL50803_14171	A8B8Z3	A8BLV7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L37; Binds to the 23S rRNA.	0.999