(15 nodes) RNA phosphodiester bond hydrolysis, endonucleolytic network (Giardia lamblia ATCC 50803)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	GL50803_6483	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (243 aa)
	GL50803_2400	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (198 aa)
	GL50803_5294	Protein F10G7.1. (826 aa)
	GL50803_103887	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. (754 aa)
	GL50803_4498	Cleavage and polyadenylation specificity factor, 73 kDa subunit. (757 aa)
	GL50803_15487	WD-40 repeat protein. (960 aa)
	GL50803_10569	Kri1_C domain-containing protein. (505 aa)
	GL50803_34141	Nin one binding protein-like protein; Belongs to the NOB1 family. (461 aa)
	GL50803_102722	Ribosome biogenesis protein BMS1. (1293 aa)
	GL50803_7517	CLP1_P domain-containing protein. (607 aa)
	GL50803_11984	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (176 aa)
	Ago	Protein argonaute; Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity). Belongs to the argonaute family. Ago subfamily. (900 aa)
	GL50803_16246	Prostate cancer susceptibility protein-like protein. (702 aa)
	GL50803_6497	Metal-dependent hydrolase. (334 aa)
	GL50803_14089	WD_REPEATS_REGION domain-containing protein. (506 aa)

Your Current Organism:

Giardia lamblia ATCC 50803

NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ago	GL50803_103887	A8BCK6	A8BQJ3	Protein argonaute; Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity). Belongs to the argonaute family. Ago subfamily.	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	0.608
GL50803_102722	GL50803_103887	A8B382	A8BQJ3	Ribosome biogenesis protein BMS1.	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	0.416
GL50803_102722	GL50803_10569	A8B382	A8BK46	Ribosome biogenesis protein BMS1.	Kri1_C domain-containing protein.	0.894
GL50803_102722	GL50803_11984	A8B382	A8BZ40	Ribosome biogenesis protein BMS1.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.874
GL50803_102722	GL50803_14089	A8B382	A8B4G4	Ribosome biogenesis protein BMS1.	WD_REPEATS_REGION domain-containing protein.	0.947
GL50803_102722	GL50803_15487	A8B382	A8BM09	Ribosome biogenesis protein BMS1.	WD-40 repeat protein.	0.974
GL50803_102722	GL50803_34141	A8B382	A8BA51	Ribosome biogenesis protein BMS1.	Nin one binding protein-like protein; Belongs to the NOB1 family.	0.932
GL50803_102722	GL50803_5294	A8B382	A8BRB4	Ribosome biogenesis protein BMS1.	Protein F10G7.1.	0.993
GL50803_103887	Ago	A8BQJ3	A8BCK6	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Protein argonaute; Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity). Belongs to the argonaute family. Ago subfamily.	0.608
GL50803_103887	GL50803_102722	A8BQJ3	A8B382	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Ribosome biogenesis protein BMS1.	0.416
GL50803_103887	GL50803_16246	A8BQJ3	A8BTH9	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Prostate cancer susceptibility protein-like protein.	0.745
GL50803_103887	GL50803_6483	A8BQJ3	A8B5I7	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.808
GL50803_103887	GL50803_6497	A8BQJ3	A8B4A1	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Metal-dependent hydrolase.	0.469
GL50803_10569	GL50803_102722	A8BK46	A8B382	Kri1_C domain-containing protein.	Ribosome biogenesis protein BMS1.	0.894
GL50803_10569	GL50803_11984	A8BK46	A8BZ40	Kri1_C domain-containing protein.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.577
GL50803_10569	GL50803_14089	A8BK46	A8B4G4	Kri1_C domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.542
GL50803_10569	GL50803_15487	A8BK46	A8BM09	Kri1_C domain-containing protein.	WD-40 repeat protein.	0.780
GL50803_10569	GL50803_2400	A8BK46	A8BGJ9	Kri1_C domain-containing protein.	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.	0.806
GL50803_10569	GL50803_34141	A8BK46	A8BA51	Kri1_C domain-containing protein.	Nin one binding protein-like protein; Belongs to the NOB1 family.	0.588
GL50803_10569	GL50803_5294	A8BK46	A8BRB4	Kri1_C domain-containing protein.	Protein F10G7.1.	0.629