(10 nodes) Isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway network (Butyrivibrio hungatei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dxr	1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (380 aa)
	ispD	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (235 aa)
	bhn_I0519	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD. (237 aa)
	bhn_I2608	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE. (289 aa)
	bhn_I2550	RNA-binding protein. (302 aa)
	bhn_I2290	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD. (528 aa)
	ispH	4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (284 aa)
	bhn_I1837	Ribosomal protein S1 RpsA. (380 aa)
	ispF	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (181 aa)
	ispG	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (351 aa)

Your Current Organism:

Butyrivibrio hungatei

NCBI taxonomy Id: 185008
Other names: ATCC BAA-456, B. hungatei, Butyrivibrio hungatei Kopecny et al. 2003, DSM 14810, strain JK 615

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bhn_I0519	bhn_I2608	bhn_I0519	bhn_I2608	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	0.757
bhn_I0519	dxr	bhn_I0519	bhn_I0849	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	0.801
bhn_I0519	ispF	bhn_I0519	bhn_I1672	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).	0.994
bhn_I0519	ispG	bhn_I0519	bhn_I0851	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.	0.753
bhn_I0519	ispH	bhn_I0519	bhn_I1838	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.	0.728
bhn_I1837	bhn_I2608	bhn_I1837	bhn_I2608	Ribosomal protein S1 RpsA.	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	0.435
bhn_I1837	ispG	bhn_I1837	bhn_I0851	Ribosomal protein S1 RpsA.	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.	0.404
bhn_I1837	ispH	bhn_I1837	bhn_I1838	Ribosomal protein S1 RpsA.	4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.	0.979
bhn_I2290	bhn_I2608	bhn_I2290	bhn_I2608	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	0.605
bhn_I2290	dxr	bhn_I2290	bhn_I0849	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	0.723
bhn_I2290	ispF	bhn_I2290	bhn_I1672	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase IspF; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).	0.908
bhn_I2290	ispG	bhn_I2290	bhn_I0851	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.	0.525
bhn_I2290	ispH	bhn_I2290	bhn_I1838	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.	0.597
bhn_I2550	bhn_I2608	bhn_I2550	bhn_I2608	RNA-binding protein.	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	0.435
bhn_I2550	ispG	bhn_I2550	bhn_I0851	RNA-binding protein.	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase IspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.	0.404
bhn_I2550	ispH	bhn_I2550	bhn_I1838	RNA-binding protein.	4-hydroxy-3-methylbut-2-enyl diphosphate reductase IspH; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.	0.914
bhn_I2608	bhn_I0519	bhn_I2608	bhn_I0519	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	0.757
bhn_I2608	bhn_I1837	bhn_I2608	bhn_I1837	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	Ribosomal protein S1 RpsA.	0.435
bhn_I2608	bhn_I2290	bhn_I2608	bhn_I2290	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD.	0.605
bhn_I2608	bhn_I2550	bhn_I2608	bhn_I2550	4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase IspE.	RNA-binding protein.	0.435