STRINGSTRING
acoA_2 acoA_2 AQQ72484.1 AQQ72484.1 AQQ72491.1 AQQ72491.1 yitJ_3 yitJ_3 gap gap ped ped yodC yodC AQQ72537.1 AQQ72537.1 AQQ69673.1 AQQ69673.1 AQQ69702.1 AQQ69702.1 AQQ69709.1 AQQ69709.1 AQQ69710.1 AQQ69710.1 hndA_1 hndA_1 AQQ69757.1 AQQ69757.1 hndC_1 hndC_1 AQQ69778.1 AQQ69778.1 acoA_1 acoA_1 bfmBAB bfmBAB AQQ69790.1 AQQ69790.1 AQQ69839.1 AQQ69839.1 AQQ69868.1 AQQ69868.1 AQQ69872.1 AQQ69872.1 proA proA nqrB nqrB nqrC nqrC nqrD nqrD nqrE nqrE nqrF nqrF AQQ69966.1 AQQ69966.1 AQQ69986.1 AQQ69986.1 yitJ_2 yitJ_2 trxA_1 trxA_1 AQQ70011.1 AQQ70011.1 AQQ70012.1 AQQ70012.1 AQQ70015.1 AQQ70015.1 stoA stoA srlD srlD AQQ70069.1 AQQ70069.1 dkgA dkgA tdh tdh serA_1 serA_1 AQQ70134.1 AQQ70134.1 pdxB pdxB AQQ70159.1 AQQ70159.1 yhdN_2 yhdN_2 mtlD mtlD yhdN_3 yhdN_3 fldA fldA nrfA nrfA nrdJ nrdJ guaB guaB zwf zwf dapB dapB AQQ70430.1 AQQ70430.1 rd rd AQQ70450.1 AQQ70450.1 dfx dfx rbr rbr mmgC mmgC etfA_1 etfA_1 etfB_1 etfB_1 rnfB rnfB rnfA rnfA rnfG rnfG rnfD rnfD rnfC rnfC ldhA ldhA ispG ispG AQQ70614.1 AQQ70614.1 ispH ispH ilvC ilvC folD folD leuB leuB nadB nadB AQQ72584.1 AQQ72584.1 AQQ70660.1 AQQ70660.1 pdxA2 pdxA2 bcp bcp gutB gutB AQQ70677.1 AQQ70677.1 etfA_2 etfA_2 etfB_2 etfB_2 tyrA tyrA trxA_2 trxA_2 proC proC queG queG korB korB korA korA AQQ70863.1 AQQ70863.1 AQQ70864.1 AQQ70864.1 queF queF dus dus AQQ70960.1 AQQ70960.1 fabG_1 fabG_1 gltD_1 gltD_1 AQQ71024.1 AQQ71024.1 AQQ71025.1 AQQ71025.1 AQQ71030.1 AQQ71030.1 hisD hisD gdhA_1 gdhA_1 lpd lpd yhdN_4 yhdN_4 hndC_2 hndC_2 hndA_2 hndA_2 murB murB dxr dxr garR garR AQQ71237.1 AQQ71237.1 hemN hemN hndA_3 hndA_3 AQQ71289.1 AQQ71289.1 yqhD yqhD hom hom tuaD tuaD pyrK_1 pyrK_1 gltD_2 gltD_2 AQQ71404.1 AQQ71404.1 hcp hcp fprA fprA AQQ71464.1 AQQ71464.1 argC argC wbpA wbpA AQQ71521.1 AQQ71521.1 msrA msrA AQQ71563.1 AQQ71563.1 AQQ71566.1 AQQ71566.1 AQQ71607.1 AQQ71607.1 hndA_4 hndA_4 ydeM ydeM melA melA gpsA gpsA AQQ71696.1 AQQ71696.1 AQQ71765.1 AQQ71765.1 AQQ71782.1 AQQ71782.1 trxA_3 trxA_3 fabG_2 fabG_2 AQQ71889.1 AQQ71889.1 resA resA AQQ71902.1 AQQ71902.1 bssD bssD AQQ71979.1 AQQ71979.1 pyrK_2 pyrK_2 pyrD pyrD rfbD rfbD ahpC ahpC trxB trxB serA_2 serA_2 AQQ72146.1 AQQ72146.1 katA katA icd icd asd asd AQQ72241.1 AQQ72241.1 gltB_1 gltB_1 gltB_2 gltB_2 AQQ72294.1 AQQ72294.1 gndA gndA AQQ72298.1 AQQ72298.1 maeB maeB AQQ72343.1 AQQ72343.1 nifU nifU gdhA_2 gdhA_2 gpr_2 gpr_2 ribD ribD pflA pflA AQQ72479.1 AQQ72479.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
acoA_2Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (747 aa)
AQQ72484.1Putative FAD-binding dehydrogenase. (604 aa)
AQQ72491.1Hypothetical protein. (968 aa)
yitJ_3Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (611 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (339 aa)
ped(S)-1-Phenylethanol dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
yodCPutative NAD(P)H nitroreductase YodC. (190 aa)
AQQ72537.1Hypothetical protein. (103 aa)
AQQ69673.1Malonic semialdehyde reductase. (193 aa)
AQQ69702.1Intracellular protease, PfpI family. (500 aa)
AQQ69709.1Ribulose-1,5-biphosphate synthetase. (1153 aa)
AQQ69710.1Putative FAD-binding dehydrogenase. (1372 aa)
hndA_1NADP-reducing hydrogenase subunit HndA. (141 aa)
AQQ69757.1Nitronate monooxygenase. (336 aa)
hndC_1NADP-reducing hydrogenase subunit HndC. (782 aa)
AQQ69778.1PPOX class probable F420-dependent enzyme. (145 aa)
acoA_1Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (325 aa)
bfmBAB2-oxoisovalerate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (326 aa)
AQQ69790.1Putative FAD-binding dehydrogenase. (1019 aa)
AQQ69839.1Hypothetical protein. (308 aa)
AQQ69868.1Cytochrome c551/c552. (268 aa)
AQQ69872.1Homospermidine synthase. (395 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (431 aa)
nqrBNa(+)-translocating NADH-quinone reductase subunit B; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. (348 aa)
nqrCNa(+)-translocating NADH-quinone reductase subunit C. (207 aa)
nqrDNa(+)-translocating NADH-quinone reductase subunit D; Belongs to the NqrDE/RnfAE family. (204 aa)
nqrENa(+)-translocating NADH-quinone reductase subunit E; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (200 aa)
nqrFNa(+)-translocating NADH-quinone reductase subunit F. (367 aa)
AQQ69966.1Alkylhydroperoxidase AhpD family core domain protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (127 aa)
AQQ69986.1Hypothetical protein. (185 aa)
yitJ_2Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (815 aa)
trxA_1Thioredoxin. (159 aa)
AQQ70011.1Thiol:disulfide interchange protein precursor. (232 aa)
AQQ70012.1Putative flavoprotein. (230 aa)
AQQ70015.1Alkylhydroperoxidase AhpD family core domain protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family. (67 aa)
stoAStage IV sporulation protein H. (157 aa)
srlDSorbitol-6-phosphate 2-dehydrogenase. (653 aa)
AQQ70069.1Alcohol dehydrogenase GroES-like domain protein. (546 aa)
dkgA2,5-diketo-D-gluconic acid reductase A. (342 aa)
tdhL-threonine 3-dehydrogenase. (351 aa)
serA_1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (323 aa)
AQQ70134.1Trehalose utilization. (217 aa)
pdxBErythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (379 aa)
AQQ70159.1Flavin reductase like domain protein. (182 aa)
yhdN_2General stress protein 69. (322 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase. (410 aa)
yhdN_3General stress protein 69. (322 aa)
fldAFlavodoxin. (158 aa)
nrfACytochrome c-552 precursor. (468 aa)
nrdJVitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (990 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (492 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (460 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (264 aa)
AQQ70430.1Hypothetical protein. (206 aa)
rdRubredoxin. (52 aa)
AQQ70450.1Hypothetical protein. (161 aa)
dfxDesulfoferrodoxin. (123 aa)
rbrRubrerythrin. (190 aa)
mmgCAcyl-CoA dehydrogenase. (596 aa)
etfA_1Electron transfer flavoprotein large subunit. (342 aa)
etfB_1Electron transfer flavoprotein small subunit. (285 aa)
rnfBNitrogen fixation protein rnfB; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (295 aa)
rnfAElectron transport complex protein RnfA; Belongs to the NqrDE/RnfAE family. (196 aa)
rnfGNitrogen fixation protein RnfG. (208 aa)
rnfDNitrogen fixation protein RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family. (360 aa)
rnfCNitrogen fixation protein RnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily. (448 aa)
ldhAD-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (349 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (341 aa)
AQQ70614.1NADH oxidase. (363 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (276 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
folDBifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
leuB3-isopropylmalate dehydrogenase. (361 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa)
AQQ72584.1Dihydrolipoyl dehydrogenase. (461 aa)
AQQ70660.1Redoxin. (189 aa)
pdxA24-hydroxythreonine-4-phosphate dehydrogenase 2; Belongs to the PdxA family. (346 aa)
bcpPutative peroxiredoxin. (153 aa)
gutBSorbitol dehydrogenase. (344 aa)
AQQ70677.1Putative FAD-linked oxidoreductase. (473 aa)
etfA_2Electron transfer flavoprotein large subunit. (337 aa)
etfB_2Electron transfer flavoprotein small subunit. (262 aa)
tyrAT-protein. (258 aa)
trxA_2Thioredoxin-M; Belongs to the thioredoxin family. (108 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
queGEpoxyqueuosine reductase. (319 aa)
korB2-oxoglutarate oxidoreductase subunit KorB. (480 aa)
korA2-oxoglutarate oxidoreductase subunit KorA. (350 aa)
AQQ70863.13-ketosteroid-delta-1-dehydrogenase. (1164 aa)
AQQ70864.1Putative FAD-binding dehydrogenase. (1168 aa)
queFNADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (116 aa)
dusPutative tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (339 aa)
AQQ70960.1Succinate dehydrogenase flavoprotein subunit. (672 aa)
fabG_13-oxoacyl-[acyl-carrier-protein] reductase FabG. (264 aa)
gltD_1Glutamate synthase [NADPH] small chain. (882 aa)
AQQ71024.1Hypothetical protein. (241 aa)
AQQ71025.1Hypothetical protein. (244 aa)
AQQ71030.1Putative FAD-binding dehydrogenase. (1119 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (438 aa)
gdhA_1NADP-specific glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa)
lpdDihydrolipoyl dehydrogenase. (475 aa)
yhdN_4General stress protein 69. (333 aa)
hndC_2NADP-reducing hydrogenase subunit HndC. (511 aa)
hndA_2NADP-reducing hydrogenase subunit HndA. (165 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (293 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa)
garR2-hydroxy-3-oxopropionate reductase. (289 aa)
AQQ71237.1Putative NTPase (NACHT family). (1267 aa)
hemNOxygen-independent coproporphyrinogen-III oxidase 1; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (363 aa)
hndA_3NADP-reducing hydrogenase subunit HndA. (171 aa)
AQQ71289.1Epimerase family protein. (299 aa)
yqhDAlcohol dehydrogenase YqhD. (379 aa)
homHomoserine dehydrogenase. (443 aa)
tuaDUDP-glucose 6-dehydrogenase TuaD. (435 aa)
pyrK_1Dihydroorotate oxidase B, electron transfer subunit. (284 aa)
gltD_2Glutamate synthase [NADPH] small chain. (490 aa)
AQQ71404.1Putative NTPase (NACHT family). (1082 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (548 aa)
fprANitric oxide reductase. (395 aa)
AQQ71464.1Glucose 1-dehydrogenase. (243 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (335 aa)
wbpAUDP-N-acetyl-D-glucosamine 6-dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (425 aa)
AQQ71521.1Putative FAD-binding dehydrogenase. (459 aa)
msrAPeptide methionine sulfoxide reductase MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (477 aa)
AQQ71563.1Putative lyase. (327 aa)
AQQ71566.1Cytochrome c551/c552. (1100 aa)
AQQ71607.1NADH dehydrogenase subunit E. (87 aa)
hndA_4NADP-reducing hydrogenase subunit HndA. (168 aa)
ydeMAnaerobic sulfatase-maturating enzyme homolog YdeM. (373 aa)
melAAlpha-galactosidase. (435 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (337 aa)
AQQ71696.1Hypothetical protein. (390 aa)
AQQ71765.1Putative FAD-binding dehydrogenase. (438 aa)
AQQ71782.1Peroxiredoxin, subfamily. (144 aa)
trxA_3Thioredoxin; Belongs to the thioredoxin family. (106 aa)
fabG_23-oxoacyl-[acyl-carrier-protein] reductase FabG. (245 aa)
AQQ71889.1Tricarballylate dehydrogenase. (571 aa)
resAThiol-disulfide oxidoreductase ResA. (336 aa)
AQQ71902.1Indolepyruvate oxidoreductase subunit beta. (194 aa)
bssDBenzylsuccinate synthase activating enzyme. (315 aa)
AQQ71979.1FAD dependent oxidoreductase. (762 aa)
pyrK_2Dihydroorotate oxidase B, electron transfer subunit. (308 aa)
pyrDDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (307 aa)
rfbDdTDP-4-dehydrorhamnose reductase. (296 aa)
ahpCAlkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (216 aa)
trxBThioredoxin reductase. (332 aa)
serA_2D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
AQQ72146.1Pyridoxamine 5'-phosphate oxidase. (124 aa)
katACatalase. (478 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the monomeric-type IDH family. (742 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (333 aa)
AQQ72241.1Hypothetical protein. (183 aa)
gltB_1Ferredoxin-dependent glutamate synthase 1. (1520 aa)
gltB_2Glutamate synthase [NADPH] small chain. (475 aa)
AQQ72294.1Putative FAD-binding dehydrogenase. (1135 aa)
gndA6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
AQQ72298.1Putative oxidoreductase. (271 aa)
maeBNADP-dependent malic enzyme. (461 aa)
AQQ72343.1Nitroreductase A. (177 aa)
nifUNifU-like protein; May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins. (281 aa)
gdhA_2Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (422 aa)
gpr_2L-glyceraldehyde 3-phosphate reductase. (331 aa)
ribDRiboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (379 aa)
pflAPyruvate formate-lyase 1-activating enzyme. (338 aa)
AQQ72479.1Hypothetical protein. (954 aa)
Your Current Organism:
Limihaloglobus sulfuriphilus
NCBI taxonomy Id: 1851148
Other names: DSM 100118, JCM 31927, KCTC 15601, L. sulfuriphilus, Limihaloglobus sulfuriphilus Pradel et al., Phycisphaerae bacterium SM-Chi-D1, strain SM-Chi-D1
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