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| | ODI_03155 | Phosphoglycolate phosphatase. (230 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (375 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (178 aa) |
| | ilvD-2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (619 aa) |
| | ODI_03192 | Isocitrate lyase. (287 aa) |
| | ODI_03194 | Hydroxymethylglutaryl-CoA lyase. (303 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (278 aa) |
| | ribB | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (246 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa) |
| | ODI_03263 | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (349 aa) |
| | ODI_03284 | Phosphoribosyltransferase. (236 aa) |
| | ODI_03308 | Carbon monoxide dehydrogenase large chain parolog without usual motifs. (801 aa) |
| | ODI_00746 | Acetylornithine deacetylase. (391 aa) |
| | ODI_00757 | Hydroxymethylpyrimidine phosphate kinase ThiD. (270 aa) |
| | accD | Acetyl-coenzyme A carboxyl transferase beta chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa) |
| | trpA-2 | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (285 aa) |
| | trpB-2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | queC | Queuosine Biosynthesis QueC ATPase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (241 aa) |
| | argJ | Glutamate N-acetyltransferase / N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | plsX | Phosphate:acyl-ACP acyltransferase PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (345 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (330 aa) |
| | ODI_00829 | Malonyl CoA-acyl carrier protein transacylase. (311 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | ODI_00833 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (409 aa) |
| | ODI_00857 | GTP cyclohydrolase II. (210 aa) |
| | ODI_00959 | Putative inner membrane protein. (145 aa) |
| | ODI_00964 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (383 aa) |
| | ODI_01000 | 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase. (389 aa) |
| | ODI_01004 | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (238 aa) |
| | trpE | Anthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (507 aa) |
| | ODI_01015 | SAM-dependent methyltransferase. (224 aa) |
| | ODI_01017 | Tartrate dehydrogenase @ Tartrate decarboxylase @ D-malic enzyme. (363 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (342 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | ODI_01035 | L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (309 aa) |
| | ODI_01037 | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (348 aa) |
| | ODI_01053 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (286 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (299 aa) |
| | ODI_01086 | ATP:Cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (186 aa) |
| | ODI_01092 | Iron(III) dicitrate transport system, periplasmic iron-binding protein FecB (TC 3.A.1.14.1). (317 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (334 aa) |
| | ODI_01151 | Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa) |
| | ODI_01163 | Glutamine synthetase type I. (470 aa) |
| | ODI_01179 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, FabZ form. (162 aa) |
| | ODI_01180 | Hypothetical protein. (103 aa) |
| | ODI_01194 | Hypothetical protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (310 aa) |
| | ODI_01195 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa) |
| | ODI_01196 | Hypothetical protein. (85 aa) |
| | ODI_01231 | Putative oligoketide cyclase/lipid transport protein, similarity with yeast ubiquinone-binding protein YOL008W. (128 aa) |
| | ODI_01240 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (776 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, FabZ form; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa) |
| | ODI_01253 | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (252 aa) |
| | ODI_01265 | Dihydrofolate synthase @ Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (435 aa) |
| | ODI_01292 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (351 aa) |
| | ODI_01375 | Sulfur carrier protein ThiS. (66 aa) |
| | ODI_01401 | Acetylornithine deacetylase. (436 aa) |
| | ODI_01444 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (564 aa) |
| | ODI_01490 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (172 aa) |
| | coq7 | 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (221 aa) |
| | ODI_01499 | Asparagine synthetase [glutamine-hydrolyzing]. (639 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (524 aa) |
| | ODI_01547 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (254 aa) |
| | ODI_01560 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1271 aa) |
| | ODI_01589 | AroM protein. (227 aa) |
| | ODI_01592 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | ODI_01599 | Riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (318 aa) |
| | dapE | N-succinyl-L,L-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (379 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (273 aa) |
| | ODI_01613 | N-succinyl-L,L-diaminopimelate aminotransferase alternative. (398 aa) |
| | ODI_01620 | Threonine dehydratase. (405 aa) |
| | ODI_01635 | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase. (342 aa) |
| | ODI_01690 | Methyltransferase, putative. (407 aa) |
| | ubiC | Chorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (190 aa) |
| | argH | Argininosuccinate lyase. (470 aa) |
| | ODI_01730 | B. burgdorferi predicted coding region BB0007. (281 aa) |
| | accA | Acetyl-coenzyme A carboxyl transferase alpha chain; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (321 aa) |
| | ODI_00008 | Putative inner membrane protein. (252 aa) |
| | ODI_00028 | 2-octaprenyl-6-methoxyphenol hydroxylase. (386 aa) |
| | ODI_00039 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. (163 aa) |
| | ODI_00082 | Hypothetical protein. (277 aa) |
| | ODI_00085 | UDP-glucose 4-epimerase. (418 aa) |
| | ODI_00103 | Hydroxymethylglutaryl-CoA lyase. (322 aa) |
| | ODI_00133 | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (217 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (470 aa) |
| | ODI_00151 | Branched-chain amino acid aminotransferase. (367 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (316 aa) |
| | ODI_00164 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (346 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa) |
| | ODI_00198 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa) |
| | ODI_00203 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (311 aa) |
| | ODI_00229 | Pterin-4-alpha-carbinolamine dehydratase. (104 aa) |
| | ODI_00234 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (337 aa) |
| | ODI_00253 | 8-amino-7-oxononanoate synthase. (397 aa) |
| | ODI_00254 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (422 aa) |
| | ODI_00304 | N-succinyl-L,L-diaminopimelate desuccinylase. (419 aa) |
| | ODI_00320 | D-3-phosphoglycerate dehydrogenase. (309 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa) |
| | ODI_00354 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1082 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (356 aa) |
| | ODI_00400 | Threonine dehydratase, catabolic. (322 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (289 aa) |
| | ubiA | 4-hydroxybenzoate polyprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (293 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (295 aa) |
| | ODI_00454 | Putative preQ0 transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (191 aa) |
| | ODI_00456 | FIG139928: Putative protease. (297 aa) |
| | ODI_00457 | Putative lipid carrier protein. (143 aa) |
| | ODI_00474 | Serine acetyltransferase. (315 aa) |
| | ODI_00500 | Hypothetical protein. (148 aa) |
| | ODI_00513 | Anthranilate phosphoribosyltransferase like. (329 aa) |
| | ODI_00519 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (250 aa) |
| | ODI_00521 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa) |
| | fbp | Fructose-1,6-bisphosphatase, type I; Belongs to the FBPase class 1 family. (338 aa) |
| | ODI_00558 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I alpha; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa) |
| | ODI_00581 | Threonine synthase. (471 aa) |
| | ODI_00582 | Homoserine dehydrogenase. (435 aa) |
| | ODI_00583 | Uncharacterized PLP-dependent aminotransferase YfdZ. (395 aa) |
| | ODI_00587 | 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (353 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (629 aa) |
| | ODI_00620 | Sulfite reductase [NADPH] hemoprotein beta-component. (580 aa) |
| | ODI_00638 | Phosphoadenylyl-sulfate reductase [thioredoxin]; Reduction of activated sulfate into sulfite. (256 aa) |
| | ODI_00649 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa) |
| | aroA | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | ODI_00659 | Cyclohexadienyl dehydrogenase. (303 aa) |
| | ODI_00660 | Chorismate mutase I / Prephenate dehydratase. (362 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (380 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (239 aa) |
| | ODI_00674 | PqqC-like protein. (239 aa) |
| | ODI_00688 | Hypothetical protein. (315 aa) |
| | ODI_00690 | Siderophore biosynthesis non-ribosomal peptide synthetase modules. (1092 aa) |
| | kdsA | 2-Keto-3-deoxy-D-manno-octulosonate-8-phosphate synthase; Belongs to the KdsA family. (301 aa) |
| | ODI_00716 | Tartrate dehydrogenase @ Tartrate decarboxylase @ D-malic enzyme. (362 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (379 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | ODI_00727 | Protein GlcG. (135 aa) |
| | aroE | Shikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (289 aa) |
| | ODI_00736 | Quinone oxidoreductase. (334 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (158 aa) |
| | ODI_00739 | D-3-phosphoglycerate dehydrogenase. (322 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (386 aa) |
| | ODI_04365 | Ubiquinone biosynthesis monooxygenase UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. Belongs to the ABC1 family. UbiB subfamily. (517 aa) |
| | ODI_04364 | Protein YigP (COG3165) clustered with ubiquinone biosynthetic genes. (210 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (260 aa) |
| | ODI_04353 | D-3-phosphoglycerate dehydrogenase. (399 aa) |
| | ODI_04336 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (567 aa) |
| | ODI_04330 | 3-polyprenyl-4-hydroxybenzoate carboxy-lyase; Belongs to the UbiD family. (477 aa) |
| | ODI_04326 | Carbon monoxide dehydrogenase large chain. (977 aa) |
| | ilvA | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (475 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (188 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (304 aa) |
| | ODI_04278 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (584 aa) |
| | ODI_04270 | Glyoxalase family protein. (157 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa) |
| | bioC | Biotin synthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (303 aa) |
| | ODI_04242 | Hydrolase, haloacid dehalogenase-like family. (217 aa) |
| | ODI_04238 | Hydroxymethylglutaryl-CoA lyase. (302 aa) |
| | ODI_04207 | Tartrate dehydrogenase @ Tartrate decarboxylase @ D-malic enzyme. (348 aa) |
| | ODI_04187 | Hydroxymethylglutaryl-CoA lyase. (323 aa) |
| | ODI_04164 | Prephenate dehydratase. (272 aa) |
| | ODI_04160 | Argininosuccinate lyase. (503 aa) |
| | ODI_04157 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (301 aa) |
| | ODI_04144 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (312 aa) |
| | ODI_04120 | UDP-glucose dehydrogenase. (440 aa) |
| | ODI_04096 | Dihydroxy-acid dehydratase. (586 aa) |
| | ODI_04087 | Glutamate synthase [NADPH] large chain. (1580 aa) |
| | ODI_04083 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I alpha; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (373 aa) |
| | argA | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. (451 aa) |
| | ODI_04069 | Methylcrotonyl-CoA carboxylase carboxyl transferase subunit. (535 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (568 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase. (122 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (134 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (246 aa) |
| | hisH-2 | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (226 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (349 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (227 aa) |
| | acpS-2 | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (135 aa) |
| | ODI_03979 | Hypothetical protein. (79 aa) |
| | ODI_03977 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII. (319 aa) |
| | ODI_03976 | Hypothetical protein. (458 aa) |
| | ODI_03975 | Diaminopimelate decarboxylase. (521 aa) |
| | ODI_03940 | Periplasmic aromatic aldehyde oxidoreductase, molybdenum binding subunit YagR. (741 aa) |
| | ODI_03936 | SAM-dependent methyltransferases. (294 aa) |
| | ODI_03922 | Hypothetical protein. (307 aa) |
| | ODI_03883 | Bifunctional protein: zinc-containing alcohol dehydrogenase; quinone oxidoreductase (NADPH:quinone reductase); Similar to arginate lyase. (324 aa) |
| | ODI_03882 | Ubiquinone biosynthesis monooxygenase UbiB. (549 aa) |
| | ODI_03863 | COGs COG2960. (95 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (221 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (377 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa) |
| | ODI_03826 | Asparagine synthetase [glutamine-hydrolyzing]. (631 aa) |
| | ODI_03790 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (566 aa) |
| | ODI_03742 | 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (257 aa) |
| | ODI_03737 | Malonyl CoA acyl carrier protein transacylase. (309 aa) |
| | ODI_03733 | Malonate decarboxylase beta subunit. (303 aa) |
| | ODI_03732 | Malonate decarboxylase delta subunit. (107 aa) |
| | queE | Queuosine Biosynthesis QueE Radical SAM; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (210 aa) |
| | ODI_03728 | 6-carboxytetrahydropterin synthase @ Queuosine biosynthesis QueD, PTPS-I. (156 aa) |
| | ODI_03724 | Acetylornithine deacetylase. (409 aa) |
| | queH | FIG053235: Diacylglucosamine hydrolase like; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (245 aa) |
| | ODI_03672 | Methylglyoxal synthase. (294 aa) |
| | ODI_03606 | Thiamin-phosphate pyrophosphorylase. (177 aa) |
| | proB | Glutamate 5-kinase / RNA-binding C-terminal domain PUA; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (385 aa) |
| | ODI_03535 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (518 aa) |
| | thiC | Hydroxymethylpyrimidine phosphate synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (637 aa) |
| | ODI_03520 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1278 aa) |
| | thiG | Thiazole biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (275 aa) |
| | ODI_03514 | Hydroxymethylpyrimidine phosphate kinase ThiD. (282 aa) |
| | ODI_03505 | Hypothetical protein. (649 aa) |
| | ODI_03486 | 8-amino-7-oxononanoate synthase. (445 aa) |
| | ODI_03485 | Capsular polysaccharide biosynthesis fatty acid synthase WcbR. (2523 aa) |
| | ODI_03468 | ABC transporter substrate-binding protein. (319 aa) |
| | ribB-2 | 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (395 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (175 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa) |
| | ODI_03439 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (306 aa) |
| | ODI_03433 | Hydroxymethylglutaryl-CoA lyase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (312 aa) |
| | ODI_03424 | Hydantoin racemase. (241 aa) |
| | ODI_03407 | PROBABLE TRANSMEMBRANE PROTEIN. (453 aa) |
| | ODI_03370 | UDP-glucose 4-epimerase. (577 aa) |
| | ODI_03362 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (462 aa) |
| | bioD | Biotin synthesis protein BioC / Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (278 aa) |
| | ODI_01760 | Aspartokinase; Belongs to the aspartokinase family. (409 aa) |
| | ODI_01833 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (376 aa) |
| | ODI_01844 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (554 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (446 aa) |
| | ODI_01861 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (313 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (393 aa) |
| | ODI_01914 | Propionyl-CoA carboxylase beta chain. (528 aa) |
| | ODI_01959 | Conserved hypothetical protein potentially related to ribose or hydroxymethylpyrimidine metabolism. (401 aa) |
| | ODI_02009 | Acetolactate synthase large subunit. (624 aa) |
| | ODI_02012 | D-3-phosphoglycerate dehydrogenase. (318 aa) |
| | ODI_02026 | Biotin synthesis protein BioZ. (634 aa) |
| | ODI_02031 | Acetylornithine deacetylase. (446 aa) |
| | argD-2 | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | thrB | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. (322 aa) |
| | ODI_02050 | Periplasmic aromatic aldehyde oxidoreductase, molybdenum binding subunit YagR. (724 aa) |
| | ODI_02066 | Pyrroline-5-carboxylate reductase. (262 aa) |
| | ODI_02071 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (267 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (786 aa) |
| | ODI_02116 | Xanthine-guanine phosphoribosyltransferase. (132 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (349 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (118 aa) |
| | ectC | L-ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (124 aa) |
| | ectA | L-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (177 aa) |
| | ODI_02159 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa) |
| | ODI_02196 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (261 aa) |
| | ODI_02215 | Methylglyoxal reductase, acetol producing / 2,5-diketo-D-gluconic acid reductase B. (267 aa) |
| | ODI_02221 | Pyridoxal kinase; Belongs to the pyridoxine kinase family. (281 aa) |
| | ODI_02256 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (580 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (210 aa) |
| | ODI_02318 | Phosphoserine phosphatase. (285 aa) |
| | ODI_02321 | Hypothetical protein. (310 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | ODI_02428 | Quinone oxidoreductase. (325 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | ODI_02481 | Acetolactate synthase small subunit. (163 aa) |
| | ODI_02482 | Acetolactate synthase large subunit. (572 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (448 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (262 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa) |
| | ODI_02583 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (151 aa) |
| | ODI_02584 | Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | argC-2 | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (353 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | ODI_02620 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (385 aa) |
| | ODI_02621 | Riboflavin synthase eubacterial/eukaryotic. (206 aa) |
| | ODI_02634 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (552 aa) |
| | ODI_02691 | Probable poly(beta-D-mannuronate) O-acetylase; Belongs to the membrane-bound acyltransferase family. (470 aa) |
| | ODI_02692 | Alginate biosynthesis protein AlgJ. (385 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (358 aa) |
| | ODI_02754 | Serine acetyltransferase. (327 aa) |
| | queF | NADPH dependent preQ0 reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (278 aa) |
| | acpS | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (148 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (264 aa) |
| | ODI_02892 | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (204 aa) |
| | ODI_02899 | UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronic acid acetyltransferase. (145 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (412 aa) |
| | prpB | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa) |
| | ODI_02968 | Aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family. (863 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (378 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (360 aa) |
| | cysG | Uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (466 aa) |
| | ubiD | 3-polyprenyl-4-hydroxybenzoate carboxy-lyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (514 aa) |
| | ODI_03083 | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (157 aa) |
| | ODI_03084 | Biotin carboxylase of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (280 aa) |
| | metXS | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (443 aa) |
