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ANJ53747.1 ANJ53747.1 ANJ53981.1 ANJ53981.1 ANJ53985.1 ANJ53985.1 glyA glyA ANJ54609.1 ANJ54609.1 ANJ54684.1 ANJ54684.1 ANJ54731.1 ANJ54731.1 cysB cysB metZ metZ PMA3_09645 PMA3_09645 ANJ55667.1 ANJ55667.1 ANJ55670.1 ANJ55670.1 ANJ56021.1 ANJ56021.1 ANJ59356.1 ANJ59356.1 ANJ59364.1 ANJ59364.1 ANJ56396.1 ANJ56396.1 ANJ56704.1 ANJ56704.1 ANJ56705.1 ANJ56705.1 ANJ56713.1 ANJ56713.1 glyA-2 glyA-2 ANJ56969.1 ANJ56969.1 ANJ59411.1 ANJ59411.1 serS serS selD selD thrH thrH cysH cysH serC serC ANJ57729.1 ANJ57729.1 ANJ57900.1 ANJ57900.1 gcvH gcvH gcvP gcvP gcvT gcvT ANJ58110.1 ANJ58110.1 ANJ58152.1 ANJ58152.1 cysZ cysZ ANJ58490.1 ANJ58490.1 glyA-3 glyA-3 PMA3_28575 PMA3_28575 ANJ58917.1 ANJ58917.1 ANJ58919.1 ANJ58919.1 ilvA ilvA ANJ58943.1 ANJ58943.1 ANJ58944.1 ANJ58944.1 gcvP-2 gcvP-2 gcvH-2 gcvH-2 gcvT-2 gcvT-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANJ53747.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
ANJ53981.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
ANJ53985.1Thiosulfate sulfurtransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
ANJ54609.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
ANJ54684.1Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
ANJ54731.1Cysteine synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa)
cysBLysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa)
PMA3_09645L-asparagine permease; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
ANJ55667.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (780 aa)
ANJ55670.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (376 aa)
ANJ56021.1Hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
ANJ59356.1Selenocysteine-specific translation factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
ANJ59364.1PLP-dependent lyase/thiolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
ANJ56396.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
ANJ56704.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
ANJ56705.1Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
ANJ56713.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
ANJ56969.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
ANJ59411.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
serSserine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa)
selDSelenide,water dikinase SelD; Synthesizes selenophosphate from selenide and ATP. (344 aa)
thrHPhosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Catalyzes the formation of serine from phosphoserine; also has phosphoserine:homoserine phosphotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (246 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
ANJ57729.1Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (324 aa)
ANJ57900.1Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (953 aa)
gcvTGlycine cleavage system protein T; Catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ANJ58110.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
ANJ58152.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (383 aa)
cysZSulfate transporter CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (250 aa)
ANJ58490.1Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
PMA3_28575Hypothetical protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
ANJ58917.1Phosphorylcholine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
ANJ58919.1Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (170 aa)
ilvAPLP-dependent threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)
ANJ58943.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
ANJ58944.1D-3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
gcvP-2Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
gcvH-2Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
gcvT-2Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
Your Current Organism:
Pseudomonas silesiensis
NCBI taxonomy Id: 1853130
Other names: DSM 103370, P. silesiensis, PCM 2856, Pseudomonas silesiensis Kaminski et al. 2018, Pseudomonas sp. A3(2016), strain A3
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