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thrB thrB trpB trpB trpA trpA gpmI gpmI ANJ53981.1 ANJ53981.1 glyA glyA ANJ54292.1 ANJ54292.1 ANJ54346.1 ANJ54346.1 ANJ59270.1 ANJ59270.1 ANJ54457.1 ANJ54457.1 ANJ54684.1 ANJ54684.1 ANJ54686.1 ANJ54686.1 ANJ54976.1 ANJ54976.1 ANJ55149.1 ANJ55149.1 asd asd ANJ55288.1 ANJ55288.1 ANJ59299.1 ANJ59299.1 ANJ55392.1 ANJ55392.1 ANJ59306.1 ANJ59306.1 ANJ55422.1 ANJ55422.1 ANJ55454.1 ANJ55454.1 ANJ55589.1 ANJ55589.1 ANJ55653.1 ANJ55653.1 ANJ55654.1 ANJ55654.1 ANJ55655.1 ANJ55655.1 ANJ55656.1 ANJ55656.1 ANJ55667.1 ANJ55667.1 ANJ55670.1 ANJ55670.1 ANJ55888.1 ANJ55888.1 ANJ55969.1 ANJ55969.1 ANJ56000.1 ANJ56000.1 ANJ56262.1 ANJ56262.1 pssA pssA ANJ56527.1 ANJ56527.1 ANJ56543.1 ANJ56543.1 ANJ56704.1 ANJ56704.1 ANJ56705.1 ANJ56705.1 ANJ56794.1 ANJ56794.1 glyA-2 glyA-2 ANJ56918.1 ANJ56918.1 ANJ56969.1 ANJ56969.1 ANJ57097.1 ANJ57097.1 thrH thrH serC serC ANJ57545.1 ANJ57545.1 ANJ57568.1 ANJ57568.1 gcvH gcvH gcvP gcvP ANJ57903.1 ANJ57903.1 gcvT gcvT ANJ57967.1 ANJ57967.1 ANJ58194.1 ANJ58194.1 ANJ58206.1 ANJ58206.1 ANJ58485.1 ANJ58485.1 ANJ58487.1 ANJ58487.1 ANJ58776.1 ANJ58776.1 ANJ58777.1 ANJ58777.1 ANJ58778.1 ANJ58778.1 ANJ58779.1 ANJ58779.1 glyA-3 glyA-3 ANJ58782.1 ANJ58782.1 ANJ58805.1 ANJ58805.1 betB betB betA betA ANJ58846.1 ANJ58846.1 ilvA ilvA ANJ58944.1 ANJ58944.1 gcvP-2 gcvP-2 gcvH-2 gcvH-2 gcvT-2 gcvT-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thrBHomoserine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudomonas-type ThrB family. (316 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (509 aa)
ANJ53981.1Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
ANJ54292.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (284 aa)
ANJ54346.1Glycerate dehydrogenase; Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
ANJ59270.1Homoserine dehydrogenase; Catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
ANJ54457.1Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
ANJ54684.1Threonine aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
ANJ54686.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (413 aa)
ANJ54976.12,4-diaminobutyrate 4-aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (470 aa)
ANJ55149.1FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa)
ANJ55288.1Aspartate-semialdehyde dehydrogenase; Catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate-semialdehyde dehydrogenase family. (336 aa)
ANJ59299.1Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa)
ANJ55392.1Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
ANJ59306.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
ANJ55422.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
ANJ55454.1Glycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (322 aa)
ANJ55589.1Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
ANJ55653.1Sarcosine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
ANJ55654.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (965 aa)
ANJ55655.1Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (99 aa)
ANJ55656.1Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
ANJ55667.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (780 aa)
ANJ55670.1Aminomethyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (376 aa)
ANJ55888.1Amino acid deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
ANJ55969.1Creatininase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
ANJ56000.1Choline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
ANJ56262.1D-glycerate dehydrogenase; Catalyzes the formation of glycolate from glyoxylate and glycerate from hydroxypyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
pssACatalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
ANJ56527.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ANJ56543.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (380 aa)
ANJ56704.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
ANJ56705.1Cystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
ANJ56794.1Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (562 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
ANJ56918.1FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
ANJ56969.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
ANJ57097.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (498 aa)
thrHPhosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; Catalyzes the formation of serine from phosphoserine; also has phosphoserine:homoserine phosphotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (205 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
ANJ57545.1E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
ANJ57568.1Hydroxypyruvate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (953 aa)
ANJ57903.1L-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
gcvTGlycine cleavage system protein T; Catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ANJ57967.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
ANJ58194.1D-glycerate dehydrogenase; Catalyzes the formation of glycolate from glyoxylate and glycerate from hydroxypyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
ANJ58206.1L-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
ANJ58485.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
ANJ58487.1Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
ANJ58776.1Sarcosine oxidase subunit gamma; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
ANJ58777.1Sarcosine oxidase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family. (1005 aa)
ANJ58778.1Sarcosine oxidase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (109 aa)
ANJ58779.1Sarcosine oxidase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
ANJ58782.1Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa)
ANJ58805.1L-serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
betBBetaine-aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. (490 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (567 aa)
ANJ58846.1Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (586 aa)
ilvAPLP-dependent threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)
ANJ58944.1D-3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa)
gcvP-2Glycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
gcvH-2Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
gcvT-2Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
Your Current Organism:
Pseudomonas silesiensis
NCBI taxonomy Id: 1853130
Other names: DSM 103370, P. silesiensis, PCM 2856, Pseudomonas silesiensis Kaminski et al. 2018, Pseudomonas sp. A3(2016), strain A3
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