(46 nodes) Nitrogen metabolism network (Pseudomonas silesiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANJ53635.1	Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (243 aa)
	glnA	Forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
	gltB	Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (1481 aa)
	ANJ53897.1	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
	ANJ54200.1	Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa)
	ANJ54303.1	Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (214 aa)
	ANJ54694.1	Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (447 aa)
	ANJ55322.1	Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (250 aa)
	ANJ55652.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (448 aa)
	ANJ55660.1	Type III glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (444 aa)
	ANJ55973.1	Cytochrome C; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family. (161 aa)
	napA	Nitrate reductase; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite. (834 aa)
	ANJ55985.1	Aliphatic nitrilase; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
	ANJ55990.1	Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (219 aa)
	cynS	Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family. (155 aa)
	ANJ56034.1	Nitrilase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
	ANJ56176.1	Nitric oxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
	ANJ56177.1	Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
	ANJ56206.1	Carbamate kinase; Reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
	ANJ56321.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (452 aa)
	ANJ56407.1	NAD-glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1633 aa)
	ANJ56564.1	2-nitropropane dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
	ANJ56594.1	Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
	narH	With NarGJI catalyzes the reduction of nitrate; the beta subunit is an iron sulfur cluster containing electron transfer subunit; one of 3 nitrate reductases in E. coli and in E. coli is expressed when nitrate levels are high; Derived by automated computational analysis using gene prediction method: Protein Homology. (512 aa)
	narZ	Nitrate reductase subunit alpha; With NarYV catalyzes the reduction of nitrate; the beta subunit is an iron sulfur cluster containing electron transfer subunit; one of 3 nitrate reductases in E. coli; expression of nitrate reductase Z is not dependent on nitrate levels; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1257 aa)
	ANJ56598.1	Nitrate/nitrite transporter NarK; Involved in the transport of nitrate and nitrite; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
	ANJ56599.1	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
	ANJ56615.1	Nitric oxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the heme-copper respiratory oxidase family. (476 aa)
	ANJ56616.1	Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
	ANJ56620.1	Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
	nosZ	TAT-dependent nitrous-oxide reductase; Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide; In the C-terminal section; belongs to the cytochrome c oxidase subunit 2 family. (636 aa)
	ANJ56642.1	Nitrite reductase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
	ANJ56643.1	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (853 aa)
	ANJ56660.1	Gamma-glutamylputrescine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (458 aa)
	ANJ56681.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (457 aa)
	ANJ56712.1	2-nitropropane dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
	ANJ56928.1	Nitrilase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
	ANJ57386.1	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
	ANJ57388.1	Nitrite reductase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (817 aa)
	ANJ57389.1	Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
	ANJ57390.1	Nitrate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (905 aa)
	ANJ57752.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (460 aa)
	ANJ58479.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (454 aa)
	ANJ58679.1	2-nitropropane dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
	ANJ58961.1	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (452 aa)
	ANJ58963.1	Gamma-glutamylputrescine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (458 aa)

Your Current Organism:

Pseudomonas silesiensis

NCBI taxonomy Id: 1853130
Other names: DSM 103370, P. silesiensis, PCM 2856, Pseudomonas silesiensis Kaminski et al. 2018, Pseudomonas sp. A3(2016), strain A3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANJ53635.1	cynS	PMA3_00125	PMA3_12905	Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.	Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family.	0.920
ANJ53897.1	ANJ54200.1	PMA3_01530	PMA3_03100	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.944
ANJ53897.1	ANJ54694.1	PMA3_01530	PMA3_05755	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ55652.1	PMA3_01530	PMA3_11045	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ55660.1	PMA3_01530	PMA3_11085	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Type III glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ55985.1	PMA3_01530	PMA3_12875	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aliphatic nitrilase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
ANJ53897.1	ANJ56034.1	PMA3_01530	PMA3_13130	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nitrilase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
ANJ53897.1	ANJ56321.1	PMA3_01530	PMA3_14705	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ56407.1	PMA3_01530	PMA3_15150	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	NAD-glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.910
ANJ53897.1	ANJ56660.1	PMA3_01530	PMA3_16505	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Gamma-glutamylputrescine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ56681.1	PMA3_01530	PMA3_16610	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ56928.1	PMA3_01530	PMA3_17945	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nitrilase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
ANJ53897.1	ANJ57752.1	PMA3_01530	PMA3_22355	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ58479.1	PMA3_01530	PMA3_26325	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ58961.1	PMA3_01530	PMA3_28870	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	ANJ58963.1	PMA3_01530	PMA3_28880	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Gamma-glutamylputrescine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.694
ANJ53897.1	glnA	PMA3_01530	PMA3_01185	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.694
ANJ53897.1	gltB	PMA3_01530	PMA3_01525	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
ANJ54200.1	ANJ53897.1	PMA3_03100	PMA3_01530	Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.944
ANJ54200.1	ANJ54694.1	PMA3_03100	PMA3_05755	Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.	0.916