98 items (Trypanosoma brucei) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tb09.211.0810	GTP-binding protein, putative. (451 aa)
	Tb927.2.3620	GTP-binding elongation factor Tu family, putative. (805 aa)
	Tb927.2.3780	Translation initiation factor IF-2, putative. (833 aa)
	Tb927.2.4090	SRP54 domain-containing protein. (270 aa)
	Tb927.2.2130	Small GTP-binding protein RAB6, putative. (230 aa)
	Tb927.6.3650	ADP-ribosylation factor, putative; Belongs to the small GTPase superfamily. Arf family. (183 aa)
	Tb927.6.2310	Uncharacterized protein. (142 aa)
	Tb927.6.2290	G domain-containing protein. (924 aa)
	Tb927.4.2380	Sarcoplasmic reticulum glycoprotein, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (624 aa)
	Tb927.4.1820	Selenocysteine-tRNA-specific elongation factor, putative. (655 aa)
	Tb927.3.2170	Translation elongation factor EF-2, putative. (890 aa)
	Tb927.3.4720	Dynamin, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (660 aa)
	Tb927.3.4760	Dynamin, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (660 aa)
	Tb927.3.5550	Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B required for both anterograde and retrograde intraflagellar transport. May be involved in cargo loading of the retrograde transport; Belongs to the small GTPase superfamily. Rab family. (183 aa)
	Tb927.8.1410	Uncharacterized protein. (777 aa)
	Tb927.5.4310	GTP-binding protein, putative. (814 aa)
	Tb927.8.560	EF-hand domain-containing protein. (577 aa)
	Tb927.4.4220	Small GTP-binding rab protein, putative. (563 aa)
	Tb927.7.2410	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (600 aa)
	Tb927.7.2630	EngB-type G domain-containing protein. (900 aa)
	Tb927.3.3450	ADP-ribosylation factor-like protein 3A, putative; Belongs to the small GTPase superfamily. Arf family. (178 aa)
	Tb927.8.2760	G domain-containing protein. (477 aa)
	Tb927.5.4500	ADP-ribosylation factor, putative; Belongs to the small GTPase superfamily. SAR1 family. (194 aa)
	Tb927.3.1150	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (280 aa)
	Tb927.3.1120	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (217 aa)
	Tb927.7.1450	GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (321 aa)
	Tb927.8.8140	Small GTP-binding rab protein, putative. (632 aa)
	Tb927.7.3280	Translation initiation factor IF-2, putative. (787 aa)
	Tb927.7.580	GTP-binding protein, putative. (682 aa)
	Tb927.7.1640	GTP-binding protein, putative. (576 aa)
	Tb927.7.7450	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (601 aa)
	Tb927.8.6880	Translation initiation factor IF-2, putative. (864 aa)
	TB927.1.1150	Zeta tubulin; Belongs to the tubulin family. (480 aa)
	TB927.1.2330	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
	TB927.1.2340	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	Tb10.70.6950	Epsilon tubulin; Belongs to the tubulin family. (487 aa)
	Tb09.160.0600	Uncharacterized protein. (601 aa)
	Tb09.160.0850	Uncharacterized protein. (353 aa)
	Tb09.160.5300	ADP-ribosylation factor-like protein, putative. (193 aa)
	Tb09.211.0720	Developmentally regulated GTP-binding protein, putative. (374 aa)
	Tb09.211.2110	Elongation factor 1-alpha, putative. (618 aa)
	Tb09.211.2330	Small GTPase, putative. (220 aa)
	Tb09.211.3900	G domain-containing protein. (634 aa)
	Tb09.244.2070	Small GTPase, putative. (276 aa)
	Tb10.70.6420	Small GTPase, putative. (269 aa)
	Tb10.70.5680	Elongation factor 1-alpha. (348 aa)
	Tb10.70.5350	Uncharacterized protein. (1057 aa)
	Tb10.70.4880	Eukaryotic translation initiation factor 5, putative. (382 aa)
	Tb10.70.4600	Translation factor GUF1 homolog, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (768 aa)
	Tb10.70.3000	ADP-ribosylation factor 6, putative; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	Tb10.70.2650	Elongation factor 2. (846 aa)
	Tb10.70.2190	Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (746 aa)
	Tb10.70.1880	ADP-ribosylation factor, putative; Belongs to the small GTPase superfamily. Arf family. (270 aa)
	Tb10.70.0590	Small GTPase, putative. (403 aa)
	Tb10.6k15.3970	Developmentally regulated GTP-binding protein, putative. (368 aa)
	Tb10.6k15.3230	GTP-binding protein, putative. (472 aa)
	Tb10.6k15.1990	Small GTPase, putative. (226 aa)
	Tb10.6k15.1970	Uncharacterized protein. (621 aa)
	Tb10.6k15.1960	ADP-ribosylation factor 3, putative; Belongs to the small GTPase superfamily. Arf family. (190 aa)
	Tb10.6k15.1520	Small GTPase, putative. (339 aa)
	Tb10.26.0830	Uncharacterized protein. (486 aa)
	Tb10.389.0550	Ras-related protein rab-5. (230 aa)
	Tb10.389.0070	Elongation factor TU, putative. (470 aa)
	Tb10.61.2200	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (854 aa)
	Tb10.61.1780	Uncharacterized protein. (681 aa)
	Tb10.61.1710	Sarcoplasmic reticulum glycoprotein, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (517 aa)
	Tb11.03.0940	Elongation factor, putative. (653 aa)
	Tb11.03.0660	G domain-containing protein. (382 aa)
	Tb11.02.0240	GTP-binding protein, putative. (486 aa)
	Tb11.02.0620	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (655 aa)
	Tb11.02.1040	GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. (290 aa)
	Tb11.02.1120	Adenylosuccinate synthetase; Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). (602 aa)
	Tb11.02.2160	Small GTPase, putative. (203 aa)
	Tb11.02.3070	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (487 aa)
	Tb11.02.3100	Uncharacterized protein. (330 aa)
	Tb11.02.3850	GTP binding protein. (226 aa)
	Tb11.02.4030	Eukaryotic release factor 3, putative. (698 aa)
	Tb11.01.0710	Elongation factor G2-like protein. (824 aa)
	Tb11.01.0820	Uncharacterized protein. (1216 aa)
	Tb11.01.1650	Signal recognition particle receptor alpha subunit, putative. (582 aa)
	Tb11.01.2695	Delta tubulin; Belongs to the tubulin family. (489 aa)
	Tb11.01.2780	Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (386 aa)
	Tb11.01.3750	Molybdenum cofactor biosynthesis protein, putative. (775 aa)
	Tb11.52.0014	Ras-related GTP-binding protein, putative. (216 aa)
	Tb11.01.4830	Eukaryotic translation initiation factor 2 gamma, putative. (477 aa)
	Tb11.01.5320	Small GTPase, putative. (198 aa)
	Tb11.01.6670	Small GTPase. (199 aa)
	Tb11.01.6890	Small GTPase, putative. (212 aa)
	Tb11.01.7080	U5 small nuclear ribonucleoprotein component, putative. (974 aa)
	IFT22	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family. (219 aa)
	Tb11.01.8760	EngB-type G domain-containing protein. (655 aa)
	Tb10.70.5670	Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (449 aa)
	TEF1	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (449 aa)
	Tb927.8.890	Small GTP-binding protein Rab1, putative. (208 aa)
	Tb927.8.4770	Small GTP-binding protein Rab18. (215 aa)
	Tb927.8.4610	Small GTP-binding protein Rab1. (218 aa)
	Tb927.8.4330	Small GTP-binding protein Rab11. (216 aa)
	Tb927.3.910	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (447 aa)

Your Current Organism:

Trypanosoma brucei

NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFT22	TB927.1.2340	Q381A3	Q4GYY5	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.461
IFT22	Tb09.160.0850	Q381A3	Q38FV2	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	Uncharacterized protein.	0.430
IFT22	Tb10.70.1880	Q381A3	Q38B80	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	ADP-ribosylation factor, putative; Belongs to the small GTPase superfamily. Arf family.	0.430
IFT22	Tb11.01.6670	Q381A3	Q381T2	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	Small GTPase.	0.499
IFT22	Tb927.3.5550	Q381A3	Q580S0	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B required for both anterograde and retrograde intraflagellar transport. May be involved in cargo loading of the retrograde transport; Belongs to the small GTPase superfamily. Rab family.	0.974
TB927.1.1150	TB927.1.2340	Q4GZA3	Q4GYY5	Zeta tubulin; Belongs to the tubulin family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.964
TB927.1.1150	Tb09.160.0600	Q4GZA3	Q38FX9	Zeta tubulin; Belongs to the tubulin family.	Uncharacterized protein.	0.460
TB927.1.1150	Tb10.70.2650	Q4GZA3	Q38BE4	Zeta tubulin; Belongs to the tubulin family.	Elongation factor 2.	0.409
TB927.1.1150	Tb10.70.3000	Q4GZA3	Q38BH5	Zeta tubulin; Belongs to the tubulin family.	ADP-ribosylation factor 6, putative; Belongs to the small GTPase superfamily. Arf family.	0.463
TB927.1.1150	Tb10.70.5350	Q4GZA3	Q38C06	Zeta tubulin; Belongs to the tubulin family.	Uncharacterized protein.	0.401
TB927.1.1150	Tb11.01.2695	Q4GZA3	Q383I6	Zeta tubulin; Belongs to the tubulin family.	Delta tubulin; Belongs to the tubulin family.	0.590
TB927.1.1150	Tb11.01.6670	Q4GZA3	Q381T2	Zeta tubulin; Belongs to the tubulin family.	Small GTPase.	0.530
TB927.1.1150	Tb927.8.4330	Q4GZA3	D6XLG8	Zeta tubulin; Belongs to the tubulin family.	Small GTP-binding protein Rab11.	0.530
TB927.1.1150	Tb927.8.560	Q4GZA3	Q57YH4	Zeta tubulin; Belongs to the tubulin family.	EF-hand domain-containing protein.	0.401
TB927.1.2330	TB927.1.2340	Q4GYY6	Q4GYY5	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.997
TB927.1.2330	Tb09.160.0600	Q4GYY6	Q38FX9	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.460
TB927.1.2330	Tb09.211.2330	Q4GYY6	Q38DS4	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Small GTPase, putative.	0.905
TB927.1.2330	Tb10.70.2650	Q4GYY6	Q38BE4	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Elongation factor 2.	0.409
TB927.1.2330	Tb10.70.3000	Q4GYY6	Q38BH5	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	ADP-ribosylation factor 6, putative; Belongs to the small GTPase superfamily. Arf family.	0.463
TB927.1.2330	Tb10.70.5350	Q4GYY6	Q38C06	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Uncharacterized protein.	0.401

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