144 items (Trypanosoma brucei) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tb11.01.0280	WD_REPEATS_REGION domain-containing protein. (805 aa)
	Tb11.01.0490	Sas10 domain-containing protein. (523 aa)
	Tb11.02.5790	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (149 aa)
	Tb10.6k15.3160	Fibrillarin. (300 aa)
	Tb11.02.5180	DNA-direcetd RNA polymerase II, subunit 9, putative. (133 aa)
	Tb11.02.4620	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (781 aa)
	Tb11.02.4220	60S ribosomal protein L24, putative. (191 aa)
	Tb11.02.2910	TRM13 domain-containing protein. (510 aa)
	Tb11.02.2620	ATP-dependent DEAD/H RNA helicase, putative. (601 aa)
	Tb11.02.0620	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (655 aa)
	Tb11.02.0570	WD_REPEATS_REGION domain-containing protein. (576 aa)
	Tb11.02.0380	WD_REPEATS_REGION domain-containing protein. (769 aa)
	Tb11.02.0240	GTP-binding protein, putative. (486 aa)
	Tb11.46.0009	Uncharacterized protein. (517 aa)
	Tb11.03.0050	RNA processing factor 1, putative. (331 aa)
	Tb11.03.0450	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1596 aa)
	Tb11.03.0680	Uncharacterized protein. (948 aa)
	Tb11.03.0935	DNA-directed RNA polymerase subunit, putative. (131 aa)
	Tb10.61.0490	PINc domain-containing protein. (207 aa)
	Tb10.61.1030	U3 snoRNA-associated protein UTP11, putative. (346 aa)
	Tb10.61.1040	DNA-directed RNA polymerase, alpha subunit, putative. (337 aa)
	Tb10.61.1360	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	Tb10.61.1780	Uncharacterized protein. (681 aa)
	Tb927.4.1850	Uncharacterized protein. (578 aa)
	Tb927.4.2720	Uncharacterized protein. (739 aa)
	Tb927.2.2180	Ribosomal RNA processing protein 41B. (256 aa)
	RPL18-A	60S ribosomal protein L18. (193 aa)
	Tb11.01.8320	Exosome-associated protein 2. (294 aa)
	Tb11.01.8290	ATP-dependent DEAD/H RNA helicase, putative. (569 aa)
	Tb11.01.5500	U3 small nucleolar ribonucleoprotein protein IMP3, putative. (226 aa)
	Tb11.01.5370	ATP-dependent DEAD/H RNA helicase, putative. (556 aa)
	Tb11.01.3850	Uncharacterized protein. (389 aa)
	Tb11.01.2820	Exosome-associated protein 4. (227 aa)
	Tb10.70.0510	Uncharacterized protein. (613 aa)
	Tb11.01.2250	Uncharacterized protein. (975 aa)
	Tb11.01.1610	WD_REPEATS_REGION domain-containing protein. (391 aa)
	Tb11.01.0950	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (566 aa)
	Tb11.01.0820	Uncharacterized protein. (1216 aa)
	Tb11.01.0625	DNA-dependent RNA polymerases, putative. (134 aa)
	Tb927.2.2950	Uncharacterized protein. (980 aa)
	Tb927.6.4600	Pre-mRNA splicing factor ATP-dependent RNA helicase, putative. (1009 aa)
	Tb927.6.4350	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (325 aa)
	Tb927.2.4980	Uncharacterized protein. (279 aa)
	Tb927.2.4550	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (905 aa)
	Tb927.6.3810	Uncharacterized protein. (511 aa)
	Tb927.6.1900	Bystin, putative. (475 aa)
	Tb927.4.3490	DNA-directed RNA polymerase subunit, putative. (144 aa)
	Tb927.4.3670	CBF domain-containing protein. (457 aa)
	Tb927.6.2050	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (213 aa)
	Tb927.4.4950	Uncharacterized protein. (625 aa)
	Tb927.4.2630	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (843 aa)
	Tb927.4.3140	Uncharacterized protein. (468 aa)
	Tb927.6.2650	MI domain-containing protein. (757 aa)
	Tb927.6.2780	U3 small nuclear ribonucleoprotein (SnRNP), putative. (287 aa)
	Tb927.4.1900	WBS_methylT domain-containing protein. (379 aa)
	Tb927.4.3850	WD_REPEATS_REGION domain-containing protein. (453 aa)
	Tb927.3.2470	Pumilio/PUF RNA binding protein 8, putative. (604 aa)
	Tb927.7.5640	G-patch domain-containing protein. (271 aa)
	Tb927.5.2530	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1039 aa)
	Tb927.8.1980	WD_REPEATS_REGION domain-containing protein. (477 aa)
	Tb927.8.2230	Uncharacterized protein. (378 aa)
	Tb927.4.1630	Ribosomal RNA processing protein 6. (736 aa)
	Tb927.8.3870	SRP40_C domain-containing protein. (1205 aa)
	Tb927.8.3750	Nucleolar protein, putative. (483 aa)
	PIF5	ATP-dependent DNA helicase PIF5; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Involved in processing of minicircle Okazaki fragments. (928 aa)
	Tb927.8.1410	Uncharacterized protein. (777 aa)
	Tb927.4.750	50S ribosomal protein L7Ae, putative. (145 aa)
	Tb927.5.3050	Poly [ADP-ribose] polymerase. (573 aa)
	Tb927.5.2660	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (860 aa)
	Tb927.5.2080	Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family. (491 aa)
	Tb927.5.4270	RNA helicase. (828 aa)
	Tb10.6k15.3210	Exosome complex exonuclease RRP41A. (252 aa)
	Tb927.8.7470	Uncharacterized protein. (570 aa)
	Tb927.8.6150	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (220 aa)
	Tb927.8.5990	WD_REPEATS_REGION domain-containing protein. (638 aa)
	Tb927.4.4170	rRNA methyltransferase, putative. (284 aa)
	Tb927.4.4030	CHHC U11-48K-type domain-containing protein. (521 aa)
	Tb927.3.1250	DNA-directed RNA polymerase subunit, putative. (84 aa)
	Tb927.7.7230	Nitroreductase, putative. (320 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (248 aa)
	Tb927.8.2600	WD_REPEATS_REGION domain-containing protein. (646 aa)
	Tb927.7.4460	VWFA domain-containing protein. (842 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (393 aa)
	Tb927.3.620	RNA helicase. (808 aa)
	Tb927.7.1440	DNA polymerase sigma-like protein. (488 aa)
	Tb927.7.3700	Uncharacterized protein. (305 aa)
	Tb927.7.3380	Protein MAK16 homolog; Belongs to the MAK16 family. (276 aa)
	Tb927.3.3970	zf-LYAR domain-containing protein. (297 aa)
	Tb927.3.3590	U3 small nucleolar ribonucleoprotein protein MPP10, putative. (672 aa)
	Tb927.5.1080	RRM domain-containing protein. (237 aa)
	Tb927.5.840	Kri1_C domain-containing protein. (994 aa)
	Tb927.8.4170	RNA-binding protein, putative. (857 aa)
	Tb927.8.4450	RNA-binding protein, putative. (428 aa)
	Tb927.7.700	Uncharacterized protein. (666 aa)
	Tb927.8.1090	DNA polymerase sigma, putative. (746 aa)
	Tb927.8.1260	CLP1_P domain-containing protein. (1034 aa)
	Tb927.5.1560	ATP-dependent DEAD/H RNA helicase, putative. (753 aa)
	Tb927.4.470	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (229 aa)
	Tb927.7.4340	Uncharacterized protein. (855 aa)
	Tb927.7.4220	Uncharacterized protein. (1110 aa)
	Tb927.8.5090	DNA-directed RNA polymerase I largest subunit. (1781 aa)
	Tb927.8.5040	Uncharacterized protein. (278 aa)
	Tb927.5.3940	Helicase, putative. (671 aa)
	Tb927.7.270	Ribosome biogenesis protein, putative. (370 aa)
	Tb927.7.7450	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (601 aa)
	TB927.1.1120	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (369 aa)
	TB927.1.1370	rRNA biogenesis protein, putative. (679 aa)
	TB927.1.1700	AATF-Che1 domain-containing protein. (493 aa)
	TbEAP1	RNasePH-like protein exosome-associated protein 1 Rrp42 homologue. (397 aa)
	TB927.1.3880	Uncharacterized protein. (1737 aa)
	Tb09.160.1560	Uncharacterized protein. (2631 aa)
	Tb09.160.3670	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
	Tb09.160.3820	Nucleolar RNA binding protein, putative. (501 aa)
	Tb09.160.5160	Exosome complex exonuclease RRP40. (304 aa)
	Tb09.160.5640	Uncharacterized protein. (1857 aa)
	Tb09.211.0180	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (658 aa)
	Tb09.211.2300	RNA helicase. (795 aa)
	Tb09.211.2550	WD_REPEATS_REGION domain-containing protein. (444 aa)
	Tb09.211.2960	Uncharacterized protein. (200 aa)
	Tb09.211.3670	CCHC-type domain-containing protein. (390 aa)
	Tb09.211.4190	Uncharacterized protein. (311 aa)
	Tb09.244.2790	rRNA processing protein, putative. (251 aa)
	Tb09.244.2650	Uncharacterized protein. (897 aa)
	Tb10.70.4960	WD_REPEATS_REGION domain-containing protein. (696 aa)
	Tb10.70.2465	Nucleolar RNA-binding protein, putative. (63 aa)
	Tb10.61.1920	Fibrillarin, putative. (304 aa)
	Tb10.61.1990	Ribosome biogenesis protein, putative. (307 aa)
	Tb10.61.2040	Fibrillarin, putative. (228 aa)
	Tb10.61.2440	Uncharacterized protein. (1040 aa)
	Tb10.389.0110	DNA-directed RNA polymerases II subunit, putative. (219 aa)
	Tb10.389.0120	DNA-directed RNA polymerase II, putative. (299 aa)
	Tb10.389.0280	Uncharacterized protein. (1236 aa)
	Tb10.389.1040	Uncharacterized protein. (1120 aa)
	Tb10.389.1290	Uncharacterized protein. (649 aa)
	Tb10.389.1790	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (215 aa)
	Tb10.406.0070	Adenosine deaminase-like protein. (618 aa)
	Tb11.12.0011	ATP-dependent DEAD/H RNA helicase, putative; Belongs to the DEAD box helicase family. (401 aa)
	Tb10.406.0540	ATP-dependent DEAD/H RNA helicase, putative; Belongs to the DEAD box helicase family. (520 aa)
	Tb10.6k15.0210	WD_REPEATS_REGION domain-containing protein. (555 aa)
	Tb10.6k15.0270	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (226 aa)
	Tb10.6k15.0360	Uncharacterized protein. (410 aa)
	Tb10.6k15.0530	ATP-dependent DEAD/H RNA helicase, putative. (878 aa)
	Tb10.6k15.2760	Uncharacterized protein. (712 aa)
	Tb10.6k15.2890	40S ribosomal protein S8, putative. (260 aa)

Your Current Organism:

Trypanosoma brucei

NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF6	RPL18-A	Q38B73	P50885	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	60S ribosomal protein L18.	0.998
EIF6	Tb09.160.3670	Q38B73	Q38F38	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.839
EIF6	Tb09.160.3820	Q38B73	Q38F23	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Nucleolar RNA binding protein, putative.	0.518
EIF6	Tb09.211.0180	Q38B73	Q38EE3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.	0.995
EIF6	Tb09.211.2300	Q38B73	Q38DS7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	RNA helicase.	0.763
EIF6	Tb09.211.4190	Q38B73	Q38D90	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.709
EIF6	Tb09.244.2790	Q38B73	Q38CZ4	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	rRNA processing protein, putative.	0.984
EIF6	Tb10.389.1290	Q38B73	Q389A0	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.984
EIF6	Tb10.389.1790	Q38B73	Q389E3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.	0.981
EIF6	Tb10.61.1780	Q38B73	Q388B9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.837
EIF6	Tb10.61.1920	Q38B73	Q388C9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Fibrillarin, putative.	0.599
EIF6	Tb10.61.1990	Q38B73	Q388D6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosome biogenesis protein, putative.	0.958
EIF6	Tb10.61.2040	Q38B73	Q388E0	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Fibrillarin, putative.	0.599
EIF6	Tb10.6k15.0270	Q38B73	Q389X5	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.997
EIF6	Tb10.6k15.2890	Q38B73	Q38AJ3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	40S ribosomal protein S8, putative.	0.997
EIF6	Tb10.6k15.3160	Q38B73	Q38AL4	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Fibrillarin.	0.599
EIF6	Tb10.70.0510	Q38B73	Q38AX4	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.983
EIF6	Tb11.01.0950	Q38B73	Q384A7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.587
EIF6	Tb11.01.1610	Q38B73	Q383U5	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	WD_REPEATS_REGION domain-containing protein.	0.595
EIF6	Tb11.01.3850	Q38B73	Q382X8	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.996

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