134 items (Trypanosoma brucei) - STRING interaction network

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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	MTR1	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of spliced leader and U1 small nuclear RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped RNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. Recognizes a guanosine cap on RNA independent of its N(7) methylation status. (370 aa)
	Tb09.211.2300	RNA helicase. (795 aa)
	Tb09.211.0180	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (658 aa)
	Tb09.160.5220	RNA pseudouridylate synthase protein, putative. (1279 aa)
	Tb09.160.5160	Exosome complex exonuclease RRP40. (304 aa)
	Tb09.160.3820	Nucleolar RNA binding protein, putative. (501 aa)
	Tb09.160.3670	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
	Tb09.160.2550	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (202 aa)
	Tb09.160.2490	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (202 aa)
	Tb09.160.2000	Pseudouridylate synthase, putative. (406 aa)
	Tb09.160.1560	Uncharacterized protein. (2631 aa)
	Tb09.160.0700	60S ribosomal protein L35, putative. (127 aa)
	TB927.1.3880	Uncharacterized protein. (1737 aa)
	TbEAP1	RNasePH-like protein exosome-associated protein 1 Rrp42 homologue. (397 aa)
	TB927.1.1620	ATP-dependent DEAD/H RNA helicase, putative. (739 aa)
	TB927.1.1370	rRNA biogenesis protein, putative. (679 aa)
	TB927.1.1120	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (369 aa)
	TB927.1.560	Uncharacterized protein. (442 aa)
	Tb927.8.6770	WD_REPEATS_REGION domain-containing protein. (419 aa)
	Tb927.7.270	Ribosome biogenesis protein, putative. (370 aa)
	Tb927.5.3940	Helicase, putative. (671 aa)
	Tb927.8.5040	Uncharacterized protein. (278 aa)
	Tb927.7.4220	Uncharacterized protein. (1110 aa)
	Tb927.7.4340	Uncharacterized protein. (855 aa)
	Tb927.4.470	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (229 aa)
	Tb927.7.1740	60S ribosomal protein L7, putative. (257 aa)
	Tb927.7.1730	60S ribosomal protein L7, putative. (242 aa)
	Tb927.8.1330	60S ribosomal protein L7a, putative. (276 aa)
	Tb11.02.0110	NUC173 domain-containing protein. (1292 aa)
	Tb11.03.0050	RNA processing factor 1, putative. (331 aa)
	Tb11.03.0680	Uncharacterized protein. (948 aa)
	Tb10.61.0490	PINc domain-containing protein. (207 aa)
	Tb10.61.1030	U3 snoRNA-associated protein UTP11, putative. (346 aa)
	Tb10.61.3190	60S ribosomal protein L7, putative. (298 aa)
	Tb10.61.2440	Uncharacterized protein. (1040 aa)
	Tb10.61.2040	Fibrillarin, putative. (228 aa)
	Tb10.61.1990	Ribosome biogenesis protein, putative. (307 aa)
	Tb10.61.1920	Fibrillarin, putative. (304 aa)
	Tb10.6k15.3210	Exosome complex exonuclease RRP41A. (252 aa)
	Tb10.6k15.3220	ATP-dependent DEAD/H RNA helicase, putative. (950 aa)
	Tb10.70.0540	ATP-dependent DEAD/H RNA helicase, putative; Belongs to the DEAD box helicase family. (512 aa)
	Tb10.70.2465	Nucleolar RNA-binding protein, putative. (63 aa)
	Tb10.70.3680	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (467 aa)
	Tb10.70.4960	WD_REPEATS_REGION domain-containing protein. (696 aa)
	Tb09.244.2650	Uncharacterized protein. (897 aa)
	Tb09.244.2790	rRNA processing protein, putative. (251 aa)
	Tb09.211.4190	Uncharacterized protein. (311 aa)
	Tb09.211.3670	CCHC-type domain-containing protein. (390 aa)
	Tb09.211.3170	TP_methylase domain-containing protein. (418 aa)
	Tb09.211.2550	WD_REPEATS_REGION domain-containing protein. (444 aa)
	Tb10.6k15.3160	Fibrillarin. (300 aa)
	Tb10.6k15.2890	40S ribosomal protein S8, putative. (260 aa)
	Tb10.6k15.2760	Uncharacterized protein. (712 aa)
	Tb927.7.5120	SpoU_methylase domain-containing protein. (391 aa)
	Tb927.3.2130	PseudoU_synth_2 domain-containing protein. (828 aa)
	Tb927.5.3260	WD_REPEATS_REGION domain-containing protein. (1399 aa)
	Tb927.5.4270	RNA helicase. (828 aa)
	Tb927.8.6150	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (220 aa)
	Tb927.8.5820	Uncharacterized protein. (378 aa)
	Tb927.4.4170	rRNA methyltransferase, putative. (284 aa)
	Tb927.8.2500	Ribosomal RNA methyltransferase, putative. (255 aa)
	Tb927.8.2600	WD_REPEATS_REGION domain-containing protein. (646 aa)
	Tb927.7.4820	Uncharacterized protein. (127 aa)
	Tb927.7.4670	Ribosomal RNA processing protein 4. (324 aa)
	Tb10.6k15.2320	Uncharacterized protein. (269 aa)
	Tb927.4.2720	Uncharacterized protein. (739 aa)
	Tb927.2.2180	Ribosomal RNA processing protein 41B. (256 aa)
	Tb11.01.8320	Exosome-associated protein 2. (294 aa)
	Tb11.01.8290	ATP-dependent DEAD/H RNA helicase, putative. (569 aa)
	Tb11.01.6830	Probable ribosome biogenesis protein Tb11.01.6830; Probable pre-rRNA processing protein involved in ribosome biogenesis. (264 aa)
	Tb10.6k15.0530	ATP-dependent DEAD/H RNA helicase, putative. (878 aa)
	Tb10.6k15.0360	Uncharacterized protein. (410 aa)
	Tb10.6k15.0270	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (226 aa)
	Tb10.406.0540	ATP-dependent DEAD/H RNA helicase, putative; Belongs to the DEAD box helicase family. (520 aa)
	Tb10.389.0280	Uncharacterized protein. (1236 aa)
	Tb11.01.5500	U3 small nucleolar ribonucleoprotein protein IMP3, putative. (226 aa)
	Tb11.01.5370	ATP-dependent DEAD/H RNA helicase, putative. (556 aa)
	Tb11.01.3850	Uncharacterized protein. (389 aa)
	Tb11.01.2820	Exosome-associated protein 4. (227 aa)
	Tb11.01.2630	Uncharacterized protein; Belongs to the NOB1 family. (432 aa)
	Tb11.01.2250	Uncharacterized protein. (975 aa)
	Tb11.01.0820	Uncharacterized protein. (1216 aa)
	Tb11.01.0490	Sas10 domain-containing protein. (523 aa)
	Tb11.02.5350	Uncharacterized protein. (599 aa)
	Tb11.02.4620	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (781 aa)
	Tb11.02.4360	40S ribosomal protein S21, putative. (194 aa)
	Tb11.02.4350	40S ribosomal protein S21, putative. (196 aa)
	Tb11.02.3160	Phosphotransferase, putative. (540 aa)
	Tb11.02.2620	ATP-dependent DEAD/H RNA helicase, putative. (601 aa)
	Tb11.02.0380	WD_REPEATS_REGION domain-containing protein. (769 aa)
	Tb11.55.0008	Uncharacterized protein. (214 aa)
	Tb927.2.2950	Uncharacterized protein. (980 aa)
	Tb927.6.4600	Pre-mRNA splicing factor ATP-dependent RNA helicase, putative. (1009 aa)
	Tb927.6.4350	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (325 aa)
	Tb927.2.4980	Uncharacterized protein. (279 aa)
	Tb927.2.4550	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (905 aa)
	Tb927.6.1610	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (344 aa)
	Tb927.6.1900	Bystin, putative. (475 aa)
	Tb927.6.3230	RNA pseudouridylate synthase, putative. (462 aa)
	Tb927.6.2050	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (213 aa)
	Tb927.8.1260	CLP1_P domain-containing protein. (1034 aa)
	Tb927.7.700	Uncharacterized protein. (666 aa)
	Tb927.7.780	PseudoU_synth_2 domain-containing protein. (638 aa)
	Tb927.7.1040	40S ribosomal protein S16, putative. (149 aa)
	Tb927.8.4450	RNA-binding protein, putative. (428 aa)
	Tb927.5.840	Kri1_C domain-containing protein. (994 aa)
	Tb927.5.1080	RRM domain-containing protein. (237 aa)
	Tb927.8.3130	S-adenosyl-methyltransferase mraW-like protein, putative. (474 aa)
	Tb927.8.2970	Uncharacterized protein. (304 aa)
	Tb927.3.3590	U3 small nucleolar ribonucleoprotein protein MPP10, putative. (672 aa)
	Tb927.3.3970	zf-LYAR domain-containing protein. (297 aa)
	Tb927.7.3380	Protein MAK16 homolog; Belongs to the MAK16 family. (276 aa)
	Tb927.3.620	RNA helicase. (808 aa)
	Tb927.8.5490	Uncharacterized protein. (623 aa)
	Tb927.4.2630	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (843 aa)
	Tb927.6.670	Ribosomal RNA processing protein 45. (363 aa)
	Tb927.6.2780	U3 small nuclear ribonucleoprotein (SnRNP), putative. (287 aa)
	Tb927.6.2840	RIO domain-containing protein. (478 aa)
	Tb927.6.2910	PseudoU_synth_2 domain-containing protein. (377 aa)
	Tb927.4.1900	WBS_methylT domain-containing protein. (379 aa)
	Tb927.4.3850	WD_REPEATS_REGION domain-containing protein. (453 aa)
	Tb927.5.2530	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1039 aa)
	Tb927.8.1980	WD_REPEATS_REGION domain-containing protein. (477 aa)
	Tb927.4.1440	Uncharacterized protein. (205 aa)
	Tb927.4.1630	Ribosomal RNA processing protein 6. (736 aa)
	Tb927.3.5130	Exonuclease domain-containing protein. (452 aa)
	Tb927.3.5140	Exonuclease domain-containing protein. (762 aa)
	Tb927.3.5150	Exonuclease, putative. (291 aa)
	Tb927.3.5400	RIO domain-containing protein. (572 aa)
	Tb927.8.1410	Uncharacterized protein. (777 aa)
	Tb927.4.750	50S ribosomal protein L7Ae, putative. (145 aa)
	Tb927.5.1790	Uncharacterized protein. (631 aa)
	Tb927.5.1770	PseudoU_synth_2 domain-containing protein. (700 aa)
	Tb927.3.3100	Peptidyl-prolyl cis-trans isomerase. (122 aa)

Your Current Organism:

Trypanosoma brucei

NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MTR1	Tb10.6k15.3160	Q38AH0	Q38AL4	Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of spliced leader and U1 small nuclear RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped RNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. Recognizes a guanosine cap on RNA independent of its N(7) methylation status.	Fibrillarin.	0.473
TB927.1.1120	TB927.1.1370	Q4GZA6	Q4GZ82	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	rRNA biogenesis protein, putative.	0.649
TB927.1.1120	TB927.1.1620	Q4GZA6	Q4GZ57	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	ATP-dependent DEAD/H RNA helicase, putative.	0.501
TB927.1.1120	Tb09.211.0180	Q4GZA6	Q38EE3	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.	0.629
TB927.1.1120	Tb09.211.2300	Q4GZA6	Q38DS7	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	RNA helicase.	0.471
TB927.1.1120	Tb09.211.2550	Q4GZA6	Q38DQ1	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	WD_REPEATS_REGION domain-containing protein.	0.566
TB927.1.1120	Tb09.211.3670	Q4GZA6	Q38DE2	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	CCHC-type domain-containing protein.	0.461
TB927.1.1120	Tb09.211.4190	Q4GZA6	Q38D90	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.698
TB927.1.1120	Tb09.244.2650	Q4GZA6	Q38CX5	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.680
TB927.1.1120	Tb09.244.2790	Q4GZA6	Q38CZ4	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	rRNA processing protein, putative.	0.774
TB927.1.1120	Tb10.406.0540	Q4GZA6	Q389T9	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	ATP-dependent DEAD/H RNA helicase, putative; Belongs to the DEAD box helicase family.	0.558
TB927.1.1120	Tb10.61.0490	Q4GZA6	Q387T3	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	PINc domain-containing protein.	0.450
TB927.1.1120	Tb10.61.1030	Q4GZA6	Q387X5	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	U3 snoRNA-associated protein UTP11, putative.	0.749
TB927.1.1120	Tb10.61.1990	Q4GZA6	Q388D6	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Ribosome biogenesis protein, putative.	0.789
TB927.1.1120	Tb10.61.2440	Q4GZA6	Q388G9	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.698
TB927.1.1120	Tb10.61.3190	Q4GZA6	Q388M6	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	60S ribosomal protein L7, putative.	0.438
TB927.1.1120	Tb10.6k15.0270	Q4GZA6	Q389X5	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.712
TB927.1.1120	Tb10.6k15.0360	Q4GZA6	Q389Y4	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.414
TB927.1.1120	Tb10.6k15.0530	Q4GZA6	Q389Z8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	ATP-dependent DEAD/H RNA helicase, putative.	0.640
TB927.1.1120	Tb10.6k15.2320	Q4GZA6	Q38AE4	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.559

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