STRINGSTRING
Tb11.03.0700 Tb11.03.0700 Tb11.03.0530 Tb11.03.0530 eIF5A eIF5A Tb11.18.0004 Tb11.18.0004 Tb11.22.0012 Tb11.22.0012 Tb11.02.0230 Tb11.02.0230 Tb11.02.3595 Tb11.02.3595 Tb11.02.4030 Tb11.02.4030 Tb11.02.4570 Tb11.02.4570 Tb11.02.5050 Tb11.02.5050 Tb11.02.5700 Tb11.02.5700 Tb11.01.1370 Tb11.01.1370 Tb11.01.2330 Tb11.01.2330 Tb11.01.2580 Tb11.01.2580 Tb11.01.2750 Tb11.01.2750 Tb11.01.2780 Tb11.01.2780 Tb11.01.3400 Tb11.01.3400 Tb11.01.4830 Tb11.01.4830 Tb11.01.4640 Tb11.01.4640 Tb11.01.3630 Tb11.01.3630 Tb11.01.3570 Tb11.01.3570 TEF1 TEF1 Tb11.01.3420 Tb11.01.3420 Tb10.70.5670 Tb10.70.5670 Tb11.01.8320 Tb11.01.8320 Tb11.01.7070 Tb11.01.7070 Tb11.01.6600 Tb11.01.6600 Tb11.01.5540 Tb11.01.5540 Tb927.2.2910 Tb927.2.2910 Tb927.6.4770 Tb927.6.4770 Tb927.6.4370 Tb927.6.4370 Tb927.2.3620 Tb927.2.3620 Tb927.2.3780 Tb927.2.3780 Tb927.2.5440 Tb927.2.5440 Tb927.6.1870 Tb927.6.1870 Tb927.4.3550 Tb927.4.3550 Tb927.4.3570 Tb927.4.3570 Tb927.4.3590 Tb927.4.3590 Tb927.6.820 Tb927.6.820 Tb927.6.1280 Tb927.6.1280 Tb927.6.3480 Tb927.6.3480 Tb927.6.3420 Tb927.6.3420 Tb927.6.2500 Tb927.6.2500 Tb927.4.2430 Tb927.4.2430 Tb927.4.2500 Tb927.4.2500 Tb927.6.600 Tb927.6.600 Tb927.6.670 Tb927.6.670 Tb927.6.2980 Tb927.6.2980 Tb927.4.1820 Tb927.4.1820 Tb927.4.1930 Tb927.4.1930 Tb927.4.4650 Tb927.4.4650 Tb927.3.2470 Tb927.3.2470 Tb927.7.5380 Tb927.7.5380 Tb927.5.2310 Tb927.5.2310 Tb927.3.5530 Tb927.3.5530 Tb927.3.4340 Tb927.3.4340 Tb927.4.1070 Tb927.4.1070 Tb927.5.2570 Tb927.5.2570 Tb927.3.2900 Tb927.3.2900 Tb927.3.1920 Tb927.3.1920 Tb927.5.3120 Tb927.5.3120 Tb927.8.7260 Tb927.8.7260 Tb927.8.5880 Tb927.8.5880 Tb927.7.2720 Tb927.7.2720 Tb927.7.4730 Tb927.7.4730 Tb927.7.4670 Tb927.7.4670 Tb927.7.3280 Tb927.7.3280 Tb927.3.3630 Tb927.3.3630 Tb927.8.4390 Tb927.8.4390 Tb927.8.4500 Tb927.8.4500 Tb10.70.1380 Tb10.70.1380 Tb927.8.1270 Tb927.8.1270 Tb927.7.6090 Tb927.7.6090 Tb927.5.1490 Tb927.5.1490 Tb927.8.4820 Tb927.8.4820 Tb927.4.410 Tb927.4.410 Tb927.5.3450 Tb927.5.3450 Tb927.8.6880 Tb927.8.6880 TbEAP1 TbEAP1 TB927.1.2600 TB927.1.2600 Tb10.70.2800 Tb10.70.2800 Tb11.1400 Tb11.1400 Tb09.160.0380 Tb09.160.0380 Tb09.160.3270 Tb09.160.3270 Tb09.160.3980 Tb09.160.3980 Tb09.160.5160 Tb09.160.5160 Tb09.211.0930 Tb09.211.0930 Tb09.211.2110 Tb09.211.2110 Tb09.211.2150 Tb09.211.2150 Tb10.100.0190 Tb10.100.0190 Tb10.70.6450 Tb10.70.6450 Tb10.70.5680 Tb10.70.5680 Tb10.70.4880 Tb10.70.4880 Tb10.70.4600 Tb10.70.4600 Tb10.70.3290 Tb10.70.3290 Tb10.70.2650 Tb10.70.2650 Tb10.70.2570 Tb10.70.2570 Tb10.70.2190 Tb10.70.2190 EIF6 EIF6 Tb10.70.1100 Tb10.70.1100 Tb10.6k15.2220 Tb10.6k15.2220 Tb10.329.0040 Tb10.329.0040 Tb10.26.0140 Tb10.26.0140 Tb10.389.0940 Tb10.389.0940 Tb10.389.0150 Tb10.389.0150 Tb10.389.0070 Tb10.389.0070 Tb10.61.0210 Tb10.61.0210 Tb11.03.0940 Tb11.03.0940
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tb11.03.0700SUI1 domain-containing protein. (362 aa)
Tb11.03.0530Uncharacterized protein. (280 aa)
eIF5AEukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping (By similarity). Essential for the translation of poly-(Pro) containing-proteins. Required for cell growth during both bloodstream (BF) and insect procyclic (PF) life cycle stages and for survival of the bloodstream form. (166 aa)
Tb11.18.0004Eukaryotic translation initiation factor 4E, putative; Belongs to the eukaryotic initiation factor 4E family. (233 aa)
Tb11.22.0012Eukaryotic peptide chain release factor subunit 1, putative. (452 aa)
Tb11.02.0230Uncharacterized protein. (657 aa)
Tb11.02.3595Protein translation factor SUI1 homolog, putative. (109 aa)
Tb11.02.4030Eukaryotic release factor 3, putative. (698 aa)
Tb11.02.4570Pumilio-repeat, RNA-binding protein, putative. (683 aa)
Tb11.02.5050Protein kinase, putative. (1236 aa)
Tb11.02.5700Endonuclease/exonuclease/phosphatase, putative. (547 aa)
Tb11.01.1370Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (342 aa)
Tb11.01.2330MIF4G domain-containing protein. (697 aa)
Tb11.01.2580Uncharacterized protein. (891 aa)
Tb11.01.2750RWD domain-containing protein. (260 aa)
Tb11.01.2780Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (386 aa)
Tb11.01.3400Uncharacterized protein. (800 aa)
Tb11.01.4830Eukaryotic translation initiation factor 2 gamma, putative. (477 aa)
Tb11.01.4640O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (545 aa)
Tb11.01.3630Eukaryotic translation initiation factor 4E, putative; Belongs to the eukaryotic initiation factor 4E family. (442 aa)
Tb11.01.3570NTP_transferase domain-containing protein. (585 aa)
TEF1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (449 aa)
Tb11.01.3420Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (413 aa)
Tb10.70.5670Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (449 aa)
Tb11.01.8320Exosome-associated protein 2. (294 aa)
Tb11.01.7070CSN8_PSD8_EIF3K domain-containing protein. (205 aa)
Tb11.01.6600PUM-HD domain-containing protein. (704 aa)
Tb11.01.5540Pab1p-dependent poly(A) ribonuclease subunit, putative. (512 aa)
Tb927.2.2910Uncharacterized protein. (405 aa)
Tb927.6.4770Uncharacterized protein. (735 aa)
Tb927.6.4370Eukaryotic translation initiation factor 3 subunit 7-like protein; Belongs to the eIF-3 subunit D family. (506 aa)
Tb927.2.3620GTP-binding elongation factor Tu family, putative. (805 aa)
Tb927.2.3780Translation initiation factor IF-2, putative. (833 aa)
Tb927.2.5440Uncharacterized protein. (962 aa)
Tb927.6.1870Eukaryotic translation initiation factor 4E, putative; Belongs to the eukaryotic initiation factor 4E family. (427 aa)
Tb927.4.355060S ribosomal protein L13a, putative. (222 aa)
Tb927.4.3570Translation elongation factor 1-beta, putative; Belongs to the EF-1-beta/EF-1-delta family. (261 aa)
Tb927.4.3590Translation elongation factor 1-beta, putative; Belongs to the EF-1-beta/EF-1-delta family. (261 aa)
Tb927.6.820Pumilio/PUF RNA binding protein 4, putative. (988 aa)
Tb927.6.1280Translation initiation factor eIF-2B alpha subunit, putative; Belongs to the eIF-2B alpha/beta/delta subunits family. (299 aa)
Tb927.6.3480RNA-binding protein, putative. (347 aa)
Tb927.6.3420Uncharacterized protein. (349 aa)
Tb927.6.2500RF_PROK_I domain-containing protein. (228 aa)
Tb927.4.2430Endo/exonuclease/phosphatase domain-containing protein. (654 aa)
Tb927.4.2500Protein kinase, putative. (1008 aa)
Tb927.6.600CCR4 associated factor, putative. (351 aa)
Tb927.6.670Ribosomal RNA processing protein 45. (363 aa)
Tb927.6.2980Protein kinase, putative. (1038 aa)
Tb927.4.1820Selenocysteine-tRNA-specific elongation factor, putative. (655 aa)
Tb927.4.1930RNA-binding protein, putative. (272 aa)
Tb927.4.4650Diphthine synthase, putative. (269 aa)
Tb927.3.2470Pumilio/PUF RNA binding protein 8, putative. (604 aa)
Tb927.7.5380RNA-binding protein, putative. (599 aa)
Tb927.5.2310PCIF1_WW domain-containing protein. (711 aa)
Tb927.3.5530Tb-292 membrane associated protein; Belongs to the DOCK family. (2463 aa)
Tb927.3.43402-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (357 aa)
Tb927.4.107050S ribosomal protein L13, putative. (202 aa)
Tb927.5.2570Translation initiation factor, putative. (696 aa)
Tb927.3.2900Elongation initiation factor 2 alpha subunit, putative. (418 aa)
Tb927.3.1920Uncharacterized protein. (604 aa)
Tb927.5.3120Translation initiation factor, putative. (313 aa)
Tb927.8.7260Kinetoplast-associated protein, putative. (1028 aa)
Tb927.8.5880Eukaryotic translation initiation factor 1A, putative. (172 aa)
Tb927.7.2720Uncharacterized protein. (663 aa)
Tb927.7.4730Pumilio/PUF RNA binding protein 5, putative. (430 aa)
Tb927.7.4670Ribosomal RNA processing protein 4. (324 aa)
Tb927.7.3280Translation initiation factor IF-2, putative. (787 aa)
Tb927.3.3630Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (274 aa)
Tb927.8.4390Translation initiation factor eIF-2B beta subunit, putative; Belongs to the eIF-2B alpha/beta/delta subunits family. (475 aa)
Tb927.8.4500MIF4G domain-containing protein. (749 aa)
Tb10.70.138040S ribosomal protein S9, putative; Belongs to the universal ribosomal protein uS4 family. (190 aa)
Tb927.8.1270Uncharacterized protein. (562 aa)
Tb927.7.6090Uncharacterized protein. (762 aa)
Tb927.5.1490MIF4G domain-containing protein. (1118 aa)
Tb927.8.4820MIF4G domain-containing protein. (622 aa)
Tb927.4.410Cell differentiation protein, putative. (316 aa)
Tb927.5.3450eIF2A domain-containing protein. (527 aa)
Tb927.8.6880Translation initiation factor IF-2, putative. (864 aa)
TbEAP1RNasePH-like protein exosome-associated protein 1 Rrp42 homologue. (397 aa)
TB927.1.2600Pumillio RNA binding protein, putative. (667 aa)
Tb10.70.2800Pumillo RNA binding protein PUF1. (572 aa)
Tb11.1400Translation initiation factor eIF2B delta subunit, putative; Belongs to the eIF-2B alpha/beta/delta subunits family. (628 aa)
Tb09.160.0380DPH-type MB domain-containing protein. (82 aa)
Tb09.160.3270Probable eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (404 aa)
Tb09.160.3980MIF4G domain-containing protein. (878 aa)
Tb09.160.5160Exosome complex exonuclease RRP40. (304 aa)
Tb09.211.0930Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (566 aa)
Tb09.211.2110Elongation factor 1-alpha, putative. (618 aa)
Tb09.211.2150Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (555 aa)
Tb10.100.0190Pumillio RNA binding protein, putative. (585 aa)
Tb10.70.6450NOT1. (2326 aa)
Tb10.70.5680Elongation factor 1-alpha. (348 aa)
Tb10.70.4880Eukaryotic translation initiation factor 5, putative. (382 aa)
Tb10.70.4600Translation factor GUF1 homolog, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (768 aa)
Tb10.70.3290ATP-dependent DEAD-box RNA helicase, putative; Belongs to the DEAD box helicase family. (406 aa)
Tb10.70.2650Elongation factor 2. (846 aa)
Tb10.70.2570Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (488 aa)
Tb10.70.2190Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (746 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (248 aa)
Tb10.70.1100Translation elongation factor 1-beta, putative; Belongs to the EF-1-beta/EF-1-delta family. (201 aa)
Tb10.6k15.2220Eukaryotic translation initiation factor 3 subunit 8, putative. (740 aa)
Tb10.329.0040ATP-binding cassette protein, putative. (684 aa)
Tb10.26.0140Pumillio RNA binding protein, putative. (843 aa)
Tb10.389.0940Pumillio RNA binding protein, putative. (847 aa)
Tb10.389.0150Uncharacterized protein. (2651 aa)
Tb10.389.0070Elongation factor TU, putative. (470 aa)
Tb10.61.0210Eukaryotic translation initiation factor 4E, putative; Belongs to the eukaryotic initiation factor 4E family. (251 aa)
Tb11.03.0940Elongation factor, putative. (653 aa)
Your Current Organism:
Trypanosoma brucei
NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927
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