(39 nodes) Negative regulation of gene expression network (Trypanosoma brucei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	Tb10.406.0020	Argonaute-like protein. (903 aa)
	Tb927.4.2430	Endo/exonuclease/phosphatase domain-containing protein. (654 aa)
	Tb927.6.600	CCR4 associated factor, putative. (351 aa)
	Tb927.6.670	Ribosomal RNA processing protein 45. (363 aa)
	Tb927.3.4620	CCHC-type domain-containing protein. (1414 aa)
	Tb927.5.2140	Regulator of nonsense transcripts 1, putative. (842 aa)
	Tb927.4.1630	Ribosomal RNA processing protein 6. (736 aa)
	Tb927.4.1070	50S ribosomal protein L13, putative. (202 aa)
	Tb927.3.1920	Uncharacterized protein. (604 aa)
	Tb927.7.2970	Uncharacterized protein. (824 aa)
	Tb927.7.4900	5'-3' exonuclease XRNA, putative. (1418 aa)
	Tb927.7.4670	Ribosomal RNA processing protein 4. (324 aa)
	Tb927.7.1170	RRM domain-containing protein. (159 aa)
	Tb927.8.2810	5'-3' exonuclease XRNC, putative. (868 aa)
	Tb927.7.1710	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (405 aa)
	Tb927.4.410	Cell differentiation protein, putative. (316 aa)
	Tb927.5.3850	XRN_N domain-containing protein. (891 aa)
	TbEAP1	RNasePH-like protein exosome-associated protein 1 Rrp42 homologue. (397 aa)
	Tb09.160.5160	Exosome complex exonuclease RRP40. (304 aa)
	Tb09.211.3670	CCHC-type domain-containing protein. (390 aa)
	Tb10.70.6450	NOT1. (2326 aa)
	Tb10.70.5520	Piwi-like protein 1. (1102 aa)
	Tb10.70.3290	ATP-dependent DEAD-box RNA helicase, putative; Belongs to the DEAD box helicase family. (406 aa)
	Tb10.70.0610	5'-3' exoribonuclease XRND, putative. (801 aa)
	Tb10.6k15.3210	Exosome complex exonuclease RRP41A. (252 aa)
	Tb10.6k15.0270	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (226 aa)
	Tb10.389.1060	Uncharacterized protein. (595 aa)
	Tb927.5.4030	U6 snRNA-associated Sm-like protein LSm7p. (92 aa)
	Tb927.2.2180	Ribosomal RNA processing protein 41B. (256 aa)
	Tb11.01.8320	Exosome-associated protein 2. (294 aa)
	Tb11.01.5540	Pab1p-dependent poly(A) ribonuclease subunit, putative. (512 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (127 aa)
	Tb11.01.2820	Exosome-associated protein 4. (227 aa)
	Tb11.02.5700	Endonuclease/exonuclease/phosphatase, putative. (547 aa)
	Tb11.02.4270	Uncharacterized protein. (1454 aa)
	Tb11.55.0025	XRN_N domain-containing protein. (524 aa)
	Tb927.6.1970	Nuclear cap-binding protein subunit 2. (187 aa)
	Tb927.4.3550	60S ribosomal protein L13a, putative. (222 aa)
	Tb927.6.3420	Uncharacterized protein. (349 aa)

Your Current Organism:

Trypanosoma brucei

NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM4	Tb10.70.3290	Q382E1	Q38BK1	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	ATP-dependent DEAD-box RNA helicase, putative; Belongs to the DEAD box helicase family.	0.934
LSM4	Tb927.5.4030	Q382E1	D6XGY7	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	U6 snRNA-associated Sm-like protein LSm7p.	0.999
LSM4	Tb927.6.1970	Q382E1	Q585L4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	Nuclear cap-binding protein subunit 2.	0.761
LSM4	Tb927.7.4900	Q382E1	Q57XA6	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	5'-3' exonuclease XRNA, putative.	0.838
Tb09.160.5160	Tb09.211.3670	Q38EN5	Q38DE2	Exosome complex exonuclease RRP40.	CCHC-type domain-containing protein.	0.957
Tb09.160.5160	Tb10.6k15.3210	Q38EN5	Q38AL8	Exosome complex exonuclease RRP40.	Exosome complex exonuclease RRP41A.	0.967
Tb09.160.5160	Tb11.01.2820	Q38EN5	Q383H5	Exosome complex exonuclease RRP40.	Exosome-associated protein 4.	0.967
Tb09.160.5160	Tb11.01.8320	Q38EN5	Q381C6	Exosome complex exonuclease RRP40.	Exosome-associated protein 2.	0.999
Tb09.160.5160	Tb927.2.2180	Q38EN5	D7SGF1	Exosome complex exonuclease RRP40.	Ribosomal RNA processing protein 41B.	0.967
Tb09.160.5160	Tb927.4.1630	Q38EN5	Q581R8	Exosome complex exonuclease RRP40.	Ribosomal RNA processing protein 6.	0.979
Tb09.160.5160	Tb927.6.670	Q38EN5	Q583T6	Exosome complex exonuclease RRP40.	Ribosomal RNA processing protein 45.	0.999
Tb09.160.5160	Tb927.7.4670	Q38EN5	Q57X83	Exosome complex exonuclease RRP40.	Ribosomal RNA processing protein 4.	0.999
Tb09.160.5160	Tb927.7.4900	Q38EN5	Q57XA6	Exosome complex exonuclease RRP40.	5'-3' exonuclease XRNA, putative.	0.785
Tb09.160.5160	TbEAP1	Q38EN5	Q4GYW4	Exosome complex exonuclease RRP40.	RNasePH-like protein exosome-associated protein 1 Rrp42 homologue.	0.999
Tb09.211.3670	Tb09.160.5160	Q38DE2	Q38EN5	CCHC-type domain-containing protein.	Exosome complex exonuclease RRP40.	0.957
Tb09.211.3670	Tb10.6k15.0270	Q38DE2	Q389X5	CCHC-type domain-containing protein.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.735
Tb09.211.3670	Tb10.6k15.3210	Q38DE2	Q38AL8	CCHC-type domain-containing protein.	Exosome complex exonuclease RRP41A.	0.843
Tb09.211.3670	Tb11.01.2820	Q38DE2	Q383H5	CCHC-type domain-containing protein.	Exosome-associated protein 4.	0.843
Tb09.211.3670	Tb11.01.8320	Q38DE2	Q381C6	CCHC-type domain-containing protein.	Exosome-associated protein 2.	0.960
Tb09.211.3670	Tb927.2.2180	Q38DE2	D7SGF1	CCHC-type domain-containing protein.	Ribosomal RNA processing protein 41B.	0.843

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