94 items (Trypanosoma brucei) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tb927.6.3280	Cyclosome subunit 1, putative. (1837 aa)
	FAZ1	Flagellar attachment zone protein 1; A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth. (1692 aa)
	Tb927.2.5190	TBPIP domain-containing protein. (228 aa)
	Tb927.6.5100	Serine/threonine-protein kinase, putative. (834 aa)
	Tb927.2.3930	DNA helicase; Belongs to the MCM family. (812 aa)
	Tb927.2.3720	Ubiquitin-conjugating enzyme, putative; Belongs to the ubiquitin-conjugating enzyme family. (251 aa)
	Tb927.6.4210	Aldehyde dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. (595 aa)
	Tb927.6.4750	WD_REPEATS_REGION domain-containing protein. (624 aa)
	Tb11.01.0900	ATPase-like protein, putative; Belongs to the AAA ATPase family. (455 aa)
	Tb11.01.0330	Protein kinase, putative; Belongs to the protein kinase superfamily. (309 aa)
	Tb11.01.0340	RAD50 DNA repair-like protein. (1349 aa)
	Tb11.02.5110	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (436 aa)
	Tb11.02.4880	RECA_2 domain-containing protein. (423 aa)
	Tb11.02.4320	Uncharacterized protein. (954 aa)
	Tb11.02.4300	Uncharacterized protein. (441 aa)
	Tb11.02.4280	Uncharacterized protein. (1319 aa)
	Tb11.02.3380	Uncharacterized protein. (371 aa)
	Tb11.02.3010	Protein kinase, putative. (673 aa)
	Tb11.02.2090	Sister chromatid cohesion protein. (1789 aa)
	Tb11.02.0310	Cell division cycle 45 (CDC45), putative. (685 aa)
	Tb11.02.0150	Recombinase Rad51, putative. (507 aa)
	Tb11.47.0006	Uncharacterized protein. (752 aa)
	Tb11.47.0031	Cell-division control protein 2 homolog 6, putative; Belongs to the protein kinase superfamily. (325 aa)
	Tb10.61.2030	Rtf2 domain-containing protein. (220 aa)
	GSK3	Glycogen synthase kinase 3. (352 aa)
	Tb10.70.3870	DNA repair helicase, putative. (1056 aa)
	Tb10.70.6790	Mismatch repair protein, putative. (1165 aa)
	Tb10.70.7040	Cell division protein kinase 2 homolog 1; Belongs to the protein kinase superfamily. (301 aa)
	Tb10.70.7180	TPR_REGION domain-containing protein. (1756 aa)
	Tb10.70.7470	Structural maintenance of chromosomes protein. (1366 aa)
	Tb09.211.2970	Structural maintenance of chromosomes protein. (1275 aa)
	Tb09.211.2660	CULLIN_2 domain-containing protein; Belongs to the cullin family. (770 aa)
	Tb10.70.2210	Cell division related protein kinase 2, putative; Belongs to the protein kinase superfamily. (311 aa)
	Tb10.70.1530	HORMA domain-containing protein. (423 aa)
	Tb10.70.0870	SCD domain-containing protein. (1164 aa)
	Tb10.70.0360	Fe2OG dioxygenase domain-containing protein. (304 aa)
	Tb10.6k15.3980	GCP_N_terminal domain-containing protein. (1727 aa)
	Tb10.6k15.3470	TP6A_N domain-containing protein. (453 aa)
	Tb10.6k15.2920	Uncharacterized protein. (724 aa)
	Tb10.6k15.0540	Spindle pole body component. (784 aa)
	Tb10.406.0610	TPR_REGION domain-containing protein. (557 aa)
	Tb10.406.0600	Structural maintenance of chromosomes protein. (1175 aa)
	Tb09.211.1210	RAD51/dmc1 protein, putative; Belongs to the RecA family. (349 aa)
	Tb09.211.0480	Uncharacterized protein. (1111 aa)
	Tb09.160.4870	Uncharacterized protein. (2550 aa)
	Tb09.160.3540	Uncharacterized protein. (196 aa)
	Tb09.160.3470	Condensin subunit 1, putative. (1258 aa)
	Tb09.160.1740	Uncharacterized protein. (428 aa)
	EB1	End-binding protein 1. (536 aa)
	Tb09.160.0570	Protein kinase, putative. (650 aa)
	Separase	Separase, putative cysteine peptidase, Clan CD, family C50, putative. (1159 aa)
	TB927.1.1660	Acetyltransf_13 domain-containing protein. (295 aa)
	Tb927.8.6740	DNA repair protein, putative. (614 aa)
	Tb927.7.7360	Cell division control protein 2 homolog 2; Belongs to the protein kinase superfamily. (345 aa)
	Tb927.5.3760	Meiotic recombination protein SPO11, putative. (431 aa)
	Tb927.5.3670	DNA repair protein, putative. (1242 aa)
	Tb927.5.3510	Structural maintenance of chromosomes protein. (1199 aa)
	Tb927.8.5390	Cell division control protein 2 homolog 4. (464 aa)
	Tb927.8.4880	DNA polymerase. (1340 aa)
	Tb927.7.2130	Uncharacterized protein. (460 aa)
	Tb927.7.1770	Uncharacterized protein. (609 aa)
	Tb927.7.6310	Serine/threonine-protein kinase PLK. (768 aa)
	Tb927.7.6220	Protein kinase, putative. (545 aa)
	Tb927.8.2890	Uncharacterized protein. (422 aa)
	Tb927.3.3920	Serine/threonine-protein kinase, putative; Belongs to the protein kinase superfamily. (380 aa)
	Tb927.7.1590	Mitotic cyclin; Belongs to the cyclin family. (469 aa)
	Tb927.3.1150	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. (280 aa)
	Tb927.8.5710	Recombination initiation protein NBS1, putative. (918 aa)
	Tb927.7.4920	Uncharacterized protein. (606 aa)
	Tb927.7.6900	Double-strand-break repair protein rad21 homolog, putative. (584 aa)
	Tb11.01.5770	CLASP_N domain-containing protein. (965 aa)
	Tb11.01.4070	DNA helicase; Belongs to the MCM family. (836 aa)
	Tb11.01.8460	Cyclin 6; Belongs to the cyclin family. (426 aa)
	Tb11.01.3730	Uncharacterized protein. (875 aa)
	Tb11.01.3720	Uncharacterized protein. (489 aa)
	Tb11.01.3150	Spindle pole body component. (799 aa)
	Tb11.01.2530	Kinesin-like protein, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (617 aa)
	Tb11.01.2290	Protein kinase, putative. (1260 aa)
	Tb927.3.3110	Cnd3 domain-containing protein. (1061 aa)
	Tb927.5.2720	Zinc-finger protein ZPR1, putative. (471 aa)
	Tb927.5.2950	Uncharacterized protein. (779 aa)
	Tb927.8.1710	Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (404 aa)
	Tb927.3.4280	Mismatch repair protein MSH5, putative. (732 aa)
	Tb927.8.2230	Uncharacterized protein. (378 aa)
	Tb927.3.4670	Cell division control protein, putative. (428 aa)
	Tb927.6.3110	Protein kinase, putative. (439 aa)
	Tb927.6.3090	Uncharacterized protein. (1621 aa)
	Tb927.4.2640	Uncharacterized protein. (1274 aa)
	Tb927.6.2400	Spindle pole body component. (669 aa)
	Tb927.6.2150	Cell division cycle protein 16, putative. (547 aa)
	Tb927.6.1460	Cyclin 3; Belongs to the cyclin family. (414 aa)
	Tb927.3.2020	Kinesin, putative; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (746 aa)
	Tb927.3.1750	Rev7, putative. (201 aa)
	Tb927.7.5090	Uncharacterized protein. (954 aa)

Your Current Organism:

Trypanosoma brucei

NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EB1	Separase	Q38FP4	Q4GYR1	End-binding protein 1.	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	0.508
EB1	Tb09.160.0570	Q38FP4	Q38FY2	End-binding protein 1.	Protein kinase, putative.	0.503
EB1	Tb11.01.0330	Q38FP4	Q384J7	End-binding protein 1.	Protein kinase, putative; Belongs to the protein kinase superfamily.	0.503
EB1	Tb11.01.2290	Q38FP4	Q383M7	End-binding protein 1.	Protein kinase, putative.	0.470
EB1	Tb11.01.5770	Q38FP4	Q382B9	End-binding protein 1.	CLASP_N domain-containing protein.	0.504
EB1	Tb927.3.1750	Q38FP4	Q57ZD6	End-binding protein 1.	Rev7, putative.	0.756
EB1	Tb927.3.3920	Q38FP4	Q57WC8	End-binding protein 1.	Serine/threonine-protein kinase, putative; Belongs to the protein kinase superfamily.	0.503
EB1	Tb927.6.3090	Q38FP4	Q583M5	End-binding protein 1.	Uncharacterized protein.	0.841
EB1	Tb927.6.4750	Q38FP4	Q587E1	End-binding protein 1.	WD_REPEATS_REGION domain-containing protein.	0.722
EB1	Tb927.6.5100	Q38FP4	Q586I2	End-binding protein 1.	Serine/threonine-protein kinase, putative.	0.470
EB1	Tb927.7.6310	Q38FP4	Q57VI0	End-binding protein 1.	Serine/threonine-protein kinase PLK.	0.470
FAZ1	Tb927.7.6310	Q585H6	Q57VI0	Flagellar attachment zone protein 1; A component of FAZ filament that is required for correct FAZ assembly and attachment. Not essential for new flagellum growth.	Serine/threonine-protein kinase PLK.	0.732
Separase	EB1	Q4GYR1	Q38FP4	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	End-binding protein 1.	0.508
Separase	TB927.1.1660	Q4GYR1	Q4GZ53	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	Acetyltransf_13 domain-containing protein.	0.478
Separase	Tb09.160.0570	Q4GYR1	Q38FY2	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	Protein kinase, putative.	0.636
Separase	Tb09.160.3470	Q4GYR1	Q38F58	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	Condensin subunit 1, putative.	0.596
Separase	Tb09.160.4870	Q4GYR1	Q38ES0	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	Uncharacterized protein.	0.718
Separase	Tb09.211.2660	Q4GYR1	Q38DN8	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.640
Separase	Tb09.211.2970	Q4GYR1	Q38DK9	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	Structural maintenance of chromosomes protein.	0.847
Separase	Tb10.406.0600	Q4GYR1	Q389U3	Separase, putative cysteine peptidase, Clan CD, family C50, putative.	Structural maintenance of chromosomes protein.	0.771

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