STRINGSTRING
Tb927.2.4550 Tb927.2.4550 Tb927.2.4980 Tb927.2.4980 Tb927.2.3880 Tb927.2.3880 Tb927.6.4350 Tb927.6.4350 Tb927.6.4600 Tb927.6.4600 Tb927.6.4650 Tb927.6.4650 Tb927.2.2950 Tb927.2.2950 Tb927.6.2650 Tb927.6.2650 Tb10.61.1780 Tb10.61.1780 Tb10.61.1920 Tb10.61.1920 Tb10.61.1990 Tb10.61.1990 Tb10.61.2040 Tb10.61.2040 Tb10.61.2370 Tb10.61.2370 Tb10.61.2440 Tb10.61.2440 Tb10.61.2920 Tb10.61.2920 GSK3 GSK3 Tb10.389.0110 Tb10.389.0110 Tb10.389.0120 Tb10.389.0120 Tb10.389.0280 Tb10.389.0280 Tb10.389.1040 Tb10.389.1040 Tb10.389.1290 Tb10.389.1290 Tb10.389.1790 Tb10.389.1790 Tb10.26.0210 Tb10.26.0210 Tb10.329.0040 Tb10.329.0040 Tb10.406.0070 Tb10.406.0070 Tb10.406.0540 Tb10.406.0540 Tb10.6k15.0210 Tb10.6k15.0210 Tb10.6k15.0270 Tb10.6k15.0270 Tb10.6k15.0350 Tb10.6k15.0350 Tb10.6k15.0360 Tb10.6k15.0360 Tb10.6k15.0530 Tb10.6k15.0530 Tb10.6k15.2190 Tb10.6k15.2190 Tb10.6k15.2370 Tb10.6k15.2370 MTR1 MTR1 Tb10.6k15.2760 Tb10.6k15.2760 Tb10.6k15.2890 Tb10.6k15.2890 Tb10.6k15.3160 Tb10.6k15.3160 Tb10.6k15.3210 Tb10.6k15.3210 Tb10.6k15.3220 Tb10.6k15.3220 Tb10.6k15.3240 Tb10.6k15.3240 Tb10.6k15.3470 Tb10.6k15.3470 Tb10.70.0510 Tb10.70.0510 Tb10.70.1410 Tb10.70.1410 Tb10.70.1530 Tb10.70.1530 EIF6 EIF6 Tb10.70.1900 Tb10.70.1900 Tb10.70.2465 Tb10.70.2465 Tb10.70.3950 Tb10.70.3950 Tb10.70.4390 Tb10.70.4390 Tb10.70.4960 Tb10.70.4960 Tb10.70.6220 Tb10.70.6220 Tb10.70.6360 Tb10.70.6360 Tb10.70.6790 Tb10.70.6790 PIF6 PIF6 Tb09.244.2650 Tb09.244.2650 Tb09.244.2790 Tb09.244.2790 Tb09.244.2820 Tb09.244.2820 Tb09.211.4870 Tb09.211.4870 Tb09.211.4290 Tb09.211.4290 Tb09.211.4210 Tb09.211.4210 Tb09.211.4190 Tb09.211.4190 Tb09.211.3670 Tb09.211.3670 Tb09.211.2960 Tb09.211.2960 Tb09.211.2550 Tb09.211.2550 Tb09.211.2300 Tb09.211.2300 Tb09.211.1820 Tb09.211.1820 Tb09.211.1620 Tb09.211.1620 Tb09.211.0180 Tb09.211.0180 Tb09.160.5640 Tb09.160.5640 Tb09.160.5160 Tb09.160.5160 Tb09.160.5070 Tb09.160.5070 Tb09.160.3820 Tb09.160.3820 Tb09.160.3670 Tb09.160.3670 Tb09.160.3540 Tb09.160.3540 Tb09.160.3470 Tb09.160.3470 Tb09.160.1560 Tb09.160.1560 Tb09.160.1020 Tb09.160.1020 Tb09.160.0630 Tb09.160.0630 Tb09.160.0460 Tb09.160.0460 TB927.1.4480 TB927.1.4480 TB927.1.4220 TB927.1.4220 TB927.1.3880 TB927.1.3880 TbEAP1 TbEAP1 TB927.1.1710 TB927.1.1710 TB927.1.1700 TB927.1.1700 TB927.1.1630 TB927.1.1630 TB927.1.1370 TB927.1.1370 TB927.1.1120 TB927.1.1120 TB927.1.560 TB927.1.560 Tb927.8.6540 Tb927.8.6540 Tb927.7.7450 Tb927.7.7450 Tb927.7.270 Tb927.7.270 Tb927.5.3940 Tb927.5.3940 Tb927.5.3830 Tb927.5.3830 Tb927.5.3760 Tb927.5.3760 Tb927.5.3510 Tb927.5.3510 Tb927.8.5040 Tb927.8.5040 Tb927.8.5090 Tb927.8.5090 Tb927.7.4220 Tb927.7.4220 Tb927.7.4340 Tb927.7.4340 Tb927.7.4380 Tb927.7.4380 Tb927.4.470 Tb927.4.470 Tb927.8.4880 Tb927.8.4880 Tb927.3.3220 Tb927.3.3220 Tb927.5.1560 Tb927.5.1560 Tb927.5.1200 Tb927.5.1200 Tb927.7.6300 Tb927.7.6300 Tb927.8.1260 Tb927.8.1260 Tb927.8.1090 Tb927.8.1090 Tb927.7.700 Tb927.7.700 Tb927.8.4450 Tb927.8.4450 Tb927.8.4170 Tb927.8.4170 Tb927.5.840 Tb927.5.840 Tb927.5.1080 Tb927.5.1080 Tb927.3.3590 Tb927.3.3590 Tb927.3.3970 Tb927.3.3970 Tb927.7.3380 Tb927.7.3380 CFAP44 CFAP44 Tb927.7.3700 Tb927.7.3700 Tb927.7.1440 Tb927.7.1440 Tb927.3.620 Tb927.3.620 FEN1 FEN1 Tb927.3.1130 Tb927.3.1130 Tb927.8.5710 Tb927.8.5710 Tb927.7.4460 Tb927.7.4460 Tb927.7.4510 Tb927.7.4510 Tb927.7.4670 Tb927.7.4670 Tb927.7.4920 Tb927.7.4920 Tb927.8.2600 Tb927.8.2600 Tb927.7.2310 Tb927.7.2310 Tb927.7.6900 Tb927.7.6900 Tb927.7.7230 Tb927.7.7230 Tb927.3.1220 Tb927.3.1220 Tb927.3.1250 Tb927.3.1250 Tb927.3.1400 Tb927.3.1400 Tb927.4.4030 Tb927.4.4030 Tb927.4.4170 Tb927.4.4170 Tb927.7.2720 Tb927.7.2720 Tb927.8.5980 Tb927.8.5980 Tb927.8.5990 Tb927.8.5990 Tb927.8.6150 Tb927.8.6150 Tb927.8.7090 Tb927.8.7090 Tb927.5.4270 Tb927.5.4270 Tb927.3.1750 Tb927.3.1750 Tb927.7.5310 Tb927.7.5310 Tb927.5.2080 Tb927.5.2080 Tb927.5.2660 Tb927.5.2660 Tb927.5.3050 Tb927.5.3050 Tb927.4.750 Tb927.4.750 Tb927.8.1410 Tb927.8.1410 Tb927.3.4350 Tb927.3.4350 Tb927.3.4160 Tb927.3.4160 Tb927.4.5320 Tb927.4.5320 Tb927.3.5620 Tb927.3.5620 Tb927.3.5500 Tb927.3.5500 XPB XPB PIF5 PIF5 Tb927.8.3680 Tb927.8.3680 Tb927.8.3750 Tb927.8.3750 Tb927.8.3870 Tb927.8.3870 Tb927.4.1630 Tb927.4.1630 Tb927.4.1330 Tb927.4.1330 Tb927.4.1270 Tb927.4.1270 Tb927.8.2230 Tb927.8.2230 Tb927.8.1980 Tb927.8.1980 Tb927.5.2530 Tb927.5.2530 Tb927.7.5640 Tb927.7.5640 Tb927.3.4810 Tb927.3.4810 Tb927.3.2470 Tb927.3.2470 Tb927.4.4680 Tb927.4.4680 Tb927.4.3840 Tb927.4.3840 Tb927.4.3850 Tb927.4.3850 Tb927.4.2000 Tb927.4.2000 Tb927.4.1900 Tb927.4.1900 Tb927.6.2780 Tb927.6.2780 Tb10.61.1360 Tb10.61.1360 Tb927.6.670 Tb927.6.670 Tb927.4.3140 Tb927.4.3140 Tb927.4.2630 Tb927.4.2630 Tb927.4.4950 Tb927.4.4950 Tb927.6.2050 Tb927.6.2050 Tb927.4.3670 Tb927.4.3670 Tb927.4.3490 Tb927.4.3490 Tb927.6.1900 Tb927.6.1900 Tb927.2.1800 Tb927.2.1800 Tb927.2.5190 Tb927.2.5190 Tb927.6.3810 Tb927.6.3810 Tb10.61.1390 Tb10.61.1390 Tb927.2.5810 Tb927.2.5810 Tb927.2.2190 Tb927.2.2190 Tb927.4.1850 Tb927.4.1850 Tb927.4.2720 Tb927.4.2720 Tb927.5.2900 Tb927.5.2900 Tb927.7.4560 Tb927.7.4560 Tb927.2.2180 Tb927.2.2180 RPL18-A RPL18-A Tb11.01.8320 Tb11.01.8320 Tb11.01.8290 Tb11.01.8290 Tb11.01.8060 Tb11.01.8060 Tb11.01.8050 Tb11.01.8050 XPB-R XPB-R Tb11.01.7240 Tb11.01.7240 Tb11.01.6700 Tb11.01.6700 Tb11.01.6520 Tb11.01.6520 Tb11.01.5600 Tb11.01.5600 Tb11.01.5500 Tb11.01.5500 Tb11.01.5370 Tb11.01.5370 Tb11.01.4270 Tb11.01.4270 Tb11.01.3850 Tb11.01.3850 Tb11.01.3380 Tb11.01.3380 Tb11.01.2820 Tb11.01.2820 Tb11.01.2250 Tb11.01.2250 Tb11.01.2230 Tb11.01.2230 HslV HslV Tb11.01.1990 Tb11.01.1990 Tb11.01.1610 Tb11.01.1610 Tb11.01.0950 Tb11.01.0950 Tb11.01.0820 Tb11.01.0820 Tb11.01.0625 Tb11.01.0625 Tb11.12.0011 Tb11.12.0011 Tb11.01.0280 Tb11.01.0280 Tb11.01.0340 Tb11.01.0340 Tb11.01.0490 Tb11.01.0490 Tb11.02.5790 Tb11.02.5790 Tb11.02.5330 Tb11.02.5330 Tb11.02.5180 Tb11.02.5180 Tb11.02.5110 Tb11.02.5110 Tb11.02.5060 Tb11.02.5060 PIF2 PIF2 Tb11.02.4620 Tb11.02.4620 Tb11.02.4320 Tb11.02.4320 Tb11.02.4220 Tb11.02.4220 Tb11.02.2930 Tb11.02.2930 Tb11.02.2910 Tb11.02.2910 Tb11.02.2620 Tb11.02.2620 Tb11.02.0620 Tb11.02.0620 Tb11.02.0570 Tb11.02.0570 Tb11.02.0380 Tb11.02.0380 Tb11.02.0310 Tb11.02.0310 Tb11.02.0240 Tb11.02.0240 Tb11.57.0004 Tb11.57.0004 Tb11.46.0009 Tb11.46.0009 Tb11.47.0029 Tb11.47.0029 Tb11.03.0050 Tb11.03.0050 Tb11.03.0450 Tb11.03.0450 Tb11.03.0680 Tb11.03.0680 Tb11.03.0935 Tb11.03.0935 Tb10.61.0490 Tb10.61.0490 Tb10.61.1030 Tb10.61.1030 Tb10.61.1040 Tb10.61.1040 Tb927.8.7470 Tb927.8.7470
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tb927.2.4550Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (905 aa)
Tb927.2.4980Uncharacterized protein. (279 aa)
Tb927.2.3880Heterogeneous nuclear ribonucleoprotein H/F, putative. (487 aa)
Tb927.6.4350KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (325 aa)
Tb927.6.4600Pre-mRNA splicing factor ATP-dependent RNA helicase, putative. (1009 aa)
Tb927.6.4650UV excision repair RAD23 protein, putative. (356 aa)
Tb927.2.2950Uncharacterized protein. (980 aa)
Tb927.6.2650MI domain-containing protein. (757 aa)
Tb10.61.1780Uncharacterized protein. (681 aa)
Tb10.61.1920Fibrillarin, putative. (304 aa)
Tb10.61.1990Ribosome biogenesis protein, putative. (307 aa)
Tb10.61.2040Fibrillarin, putative. (228 aa)
Tb10.61.2370Rtt106 domain-containing protein. (555 aa)
Tb10.61.2440Uncharacterized protein. (1040 aa)
Tb10.61.2920WD_REPEATS_REGION domain-containing protein. (589 aa)
GSK3Glycogen synthase kinase 3. (352 aa)
Tb10.389.0110DNA-directed RNA polymerases II subunit, putative. (219 aa)
Tb10.389.0120DNA-directed RNA polymerase II, putative. (299 aa)
Tb10.389.0280Uncharacterized protein. (1236 aa)
Tb10.389.1040Uncharacterized protein. (1120 aa)
Tb10.389.1290Uncharacterized protein. (649 aa)
Tb10.389.179060S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (215 aa)
Tb10.26.0210Uncharacterized protein. (484 aa)
Tb10.329.0040ATP-binding cassette protein, putative. (684 aa)
Tb10.406.0070Adenosine deaminase-like protein. (618 aa)
Tb10.406.0540ATP-dependent DEAD/H RNA helicase, putative; Belongs to the DEAD box helicase family. (520 aa)
Tb10.6k15.0210WD_REPEATS_REGION domain-containing protein. (555 aa)
Tb10.6k15.0270Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (226 aa)
Tb10.6k15.0350Uncharacterized protein. (590 aa)
Tb10.6k15.0360Uncharacterized protein. (410 aa)
Tb10.6k15.0530ATP-dependent DEAD/H RNA helicase, putative. (878 aa)
Tb10.6k15.2190Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (283 aa)
Tb10.6k15.2370Bromo domain-containing protein. (301 aa)
MTR1Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of spliced leader and U1 small nuclear RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped RNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation. Recognizes a guanosine cap on RNA independent of its N(7) methylation status. (370 aa)
Tb10.6k15.2760Uncharacterized protein. (712 aa)
Tb10.6k15.289040S ribosomal protein S8, putative. (260 aa)
Tb10.6k15.3160Fibrillarin. (300 aa)
Tb10.6k15.3210Exosome complex exonuclease RRP41A. (252 aa)
Tb10.6k15.3220ATP-dependent DEAD/H RNA helicase, putative. (950 aa)
Tb10.6k15.3240Bromo domain-containing protein. (224 aa)
Tb10.6k15.3470TP6A_N domain-containing protein. (453 aa)
Tb10.70.0510Uncharacterized protein. (613 aa)
Tb10.70.1410Protein phosphatase 2C, putative. (598 aa)
Tb10.70.1530HORMA domain-containing protein. (423 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (248 aa)
Tb10.70.1900General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (500 aa)
Tb10.70.2465Nucleolar RNA-binding protein, putative. (63 aa)
Tb10.70.3950RNA-binding protein, putative. (878 aa)
Tb10.70.4390DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (577 aa)
Tb10.70.4960WD_REPEATS_REGION domain-containing protein. (696 aa)
Tb10.70.6220Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (388 aa)
Tb10.70.6360Proteasome regulatory non-ATP-ase subunit 5. (482 aa)
Tb10.70.6790Mismatch repair protein, putative. (1165 aa)
PIF6ATP-dependent DNA helicase PIF6; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of genome stability. (796 aa)
Tb09.244.2650Uncharacterized protein. (897 aa)
Tb09.244.2790rRNA processing protein, putative. (251 aa)
Tb09.244.2820DNA polymerase epsilon subunit B, putative. (535 aa)
Tb09.211.4870RNA 3'-terminal phosphate cyclase-like protein. (362 aa)
Tb09.211.4290Spt4 domain-containing protein. (271 aa)
Tb09.211.4210Ubiquitin-protein ligase, putative. (1912 aa)
Tb09.211.4190Uncharacterized protein. (311 aa)
Tb09.211.3670CCHC-type domain-containing protein. (390 aa)
Tb09.211.2960Uncharacterized protein. (200 aa)
Tb09.211.2550WD_REPEATS_REGION domain-containing protein. (444 aa)
Tb09.211.2300RNA helicase. (795 aa)
Tb09.211.1820DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2246 aa)
Tb09.211.1620Uncharacterized protein. (1449 aa)
Tb09.211.0180Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (658 aa)
Tb09.160.5640Uncharacterized protein. (1857 aa)
Tb09.160.5160Exosome complex exonuclease RRP40. (304 aa)
Tb09.160.5070DNA topoisomerase type IB small subunit. (273 aa)
Tb09.160.3820Nucleolar RNA binding protein, putative. (501 aa)
Tb09.160.3670Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
Tb09.160.3540Uncharacterized protein. (196 aa)
Tb09.160.3470Condensin subunit 1, putative. (1258 aa)
Tb09.160.1560Uncharacterized protein. (2631 aa)
Tb09.160.1020Uncharacterized protein. (823 aa)
Tb09.160.0630Mcm10 domain-containing protein. (731 aa)
Tb09.160.0460Uncharacterized protein. (382 aa)
TB927.1.4480Mcl1_mid domain-containing protein. (1484 aa)
TB927.1.4220RNase_H2-Ydr279 domain-containing protein. (428 aa)
TB927.1.3880Uncharacterized protein. (1737 aa)
TbEAP1RNasePH-like protein exosome-associated protein 1 Rrp42 homologue. (397 aa)
TB927.1.1710Uncharacterized protein. (1786 aa)
TB927.1.1700AATF-Che1 domain-containing protein. (493 aa)
TB927.1.1630Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (160 aa)
TB927.1.1370rRNA biogenesis protein, putative. (679 aa)
TB927.1.1120Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (369 aa)
TB927.1.560Uncharacterized protein. (442 aa)
Tb927.8.6540DNA repair and transcription factor protein, putative. (351 aa)
Tb927.7.7450Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (601 aa)
Tb927.7.270Ribosome biogenesis protein, putative. (370 aa)
Tb927.5.3940Helicase, putative. (671 aa)
Tb927.5.3830Dihydroorotate dehydrogenase (fumarate); Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. (313 aa)
Tb927.5.3760Meiotic recombination protein SPO11, putative. (431 aa)
Tb927.5.3510Structural maintenance of chromosomes protein. (1199 aa)
Tb927.8.5040Uncharacterized protein. (278 aa)
Tb927.8.5090DNA-directed RNA polymerase I largest subunit. (1781 aa)
Tb927.7.4220Uncharacterized protein. (1110 aa)
Tb927.7.4340Uncharacterized protein. (855 aa)
Tb927.7.4380Bromo domain-containing protein. (630 aa)
Tb927.4.470H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (229 aa)
Tb927.8.4880DNA polymerase. (1340 aa)
Tb927.3.3220Uncharacterized protein. (901 aa)
Tb927.5.1560ATP-dependent DEAD/H RNA helicase, putative. (753 aa)
Tb927.5.1200Exosome component CSL4. (309 aa)
Tb927.7.6300WD_REPEATS_REGION domain-containing protein. (549 aa)
Tb927.8.1260CLP1_P domain-containing protein. (1034 aa)
Tb927.8.1090DNA polymerase sigma, putative. (746 aa)
Tb927.7.700Uncharacterized protein. (666 aa)
Tb927.8.4450RNA-binding protein, putative. (428 aa)
Tb927.8.4170RNA-binding protein, putative. (857 aa)
Tb927.5.840Kri1_C domain-containing protein. (994 aa)
Tb927.5.1080RRM domain-containing protein. (237 aa)
Tb927.3.3590U3 small nucleolar ribonucleoprotein protein MPP10, putative. (672 aa)
Tb927.3.3970zf-LYAR domain-containing protein. (297 aa)
Tb927.7.3380Protein MAK16 homolog; Belongs to the MAK16 family. (276 aa)
CFAP44Cilia- and flagella-associated protein 44; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP44 family. (1760 aa)
Tb927.7.3700Uncharacterized protein. (305 aa)
Tb927.7.1440DNA polymerase sigma-like protein. (488 aa)
Tb927.3.620RNA helicase. (808 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (393 aa)
Tb927.3.1130DNA polymerase delta subunit 2, putative. (566 aa)
Tb927.8.5710Recombination initiation protein NBS1, putative. (918 aa)
Tb927.7.4460VWFA domain-containing protein. (842 aa)
Tb927.7.4510DUF4201 domain-containing protein. (407 aa)
Tb927.7.4670Ribosomal RNA processing protein 4. (324 aa)
Tb927.7.4920Uncharacterized protein. (606 aa)
Tb927.8.2600WD_REPEATS_REGION domain-containing protein. (646 aa)
Tb927.7.2310DNA primase; Belongs to the eukaryotic-type primase small subunit family. (421 aa)
Tb927.7.6900Double-strand-break repair protein rad21 homolog, putative. (584 aa)
Tb927.7.7230Nitroreductase, putative. (320 aa)
Tb927.3.1220Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (511 aa)
Tb927.3.1250DNA-directed RNA polymerase subunit, putative. (84 aa)
Tb927.3.1400Alpha-tubulin N-acetyltransferase; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynam [...] (334 aa)
Tb927.4.4030CHHC U11-48K-type domain-containing protein. (521 aa)
Tb927.4.4170rRNA methyltransferase, putative. (284 aa)
Tb927.7.2720Uncharacterized protein. (663 aa)
Tb927.8.5980TFIIH basal transcription factor complex helicase subunit, putative. (819 aa)
Tb927.8.5990WD_REPEATS_REGION domain-containing protein. (638 aa)
Tb927.8.615040S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (220 aa)
Tb927.8.7090SMK-1 domain-containing protein. (876 aa)
Tb927.5.4270RNA helicase. (828 aa)
Tb927.3.1750Rev7, putative. (201 aa)
Tb927.7.5310Uncharacterized protein. (662 aa)
Tb927.5.2080Inosine-5'-monophosphate dehydrogenase; Belongs to the IMPDH/GMPR family. (491 aa)
Tb927.5.2660Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (860 aa)
Tb927.5.3050Poly [ADP-ribose] polymerase. (573 aa)
Tb927.4.75050S ribosomal protein L7Ae, putative. (145 aa)
Tb927.8.1410Uncharacterized protein. (777 aa)
Tb927.3.4350BRCT domain-containing protein. (797 aa)
Tb927.3.4160UBA domain-containing protein. (321 aa)
Tb927.4.5320SMK-1 domain-containing protein. (888 aa)
Tb927.3.5620Uncharacterized protein. (1012 aa)
Tb927.3.5500DNA-directed RNA polymerase II subunit 3, putative. (337 aa)
XPBTFIIH basal transcription factor complex helicase XPB subunit; ATP-dependent 3'-5' DNA helicase, component of the general transcription factor IIH (TFIIH) core complex, involved in spliced leader RNA (SL RNA) gene transcription by RNA polymerase II. TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP- dependent helicase activity of XPB is required for promoter opening and promoter escape (By similarity). (938 aa)
PIF5ATP-dependent DNA helicase PIF5; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Involved in processing of minicircle Okazaki fragments. (928 aa)
Tb927.8.3680Uncharacterized protein. (645 aa)
Tb927.8.3750Nucleolar protein, putative. (483 aa)
Tb927.8.3870SRP40_C domain-containing protein. (1205 aa)
Tb927.4.1630Ribosomal RNA processing protein 6. (736 aa)
Tb927.4.1330DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (661 aa)
Tb927.4.1270RuvB-like helicase; Belongs to the RuvB family. (459 aa)
Tb927.8.2230Uncharacterized protein. (378 aa)
Tb927.8.1980WD_REPEATS_REGION domain-containing protein. (477 aa)
Tb927.5.2530RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1039 aa)
Tb927.7.5640G-patch domain-containing protein. (271 aa)
Tb927.3.4810DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (283 aa)
Tb927.3.2470Pumilio/PUF RNA binding protein 8, putative. (604 aa)
Tb927.4.4680Sld5 domain-containing protein. (178 aa)
Tb927.4.3840Nucleolar protein, putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (525 aa)
Tb927.4.3850WD_REPEATS_REGION domain-containing protein. (453 aa)
Tb927.4.2000RuvB-like helicase; Belongs to the RuvB family. (474 aa)
Tb927.4.1900WBS_methylT domain-containing protein. (379 aa)
Tb927.6.2780U3 small nuclear ribonucleoprotein (SnRNP), putative. (287 aa)
Tb10.61.1360DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
Tb927.6.670Ribosomal RNA processing protein 45. (363 aa)
Tb927.4.3140Uncharacterized protein. (468 aa)
Tb927.4.2630ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (843 aa)
Tb927.4.4950Uncharacterized protein. (625 aa)
Tb927.6.2050Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (213 aa)
Tb927.4.3670CBF domain-containing protein. (457 aa)
Tb927.4.3490DNA-directed RNA polymerase subunit, putative. (144 aa)
Tb927.6.1900Bystin, putative. (475 aa)
Tb927.2.1800DNA polymerase. (1026 aa)
Tb927.2.5190TBPIP domain-containing protein. (228 aa)
Tb927.6.3810Uncharacterized protein. (511 aa)
Tb10.61.139040S ribosomal protein S13, putative; Belongs to the universal ribosomal protein uS15 family. (151 aa)
Tb927.2.5810Uncharacterized protein. (1543 aa)
Tb927.2.2190Histone deacetylase, putative. (685 aa)
Tb927.4.1850Uncharacterized protein. (578 aa)
Tb927.4.2720Uncharacterized protein. (739 aa)
Tb927.5.2900Histone deacetylase 4. (586 aa)
Tb927.7.4560Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (466 aa)
Tb927.2.2180Ribosomal RNA processing protein 41B. (256 aa)
RPL18-A60S ribosomal protein L18. (193 aa)
Tb11.01.8320Exosome-associated protein 2. (294 aa)
Tb11.01.8290ATP-dependent DEAD/H RNA helicase, putative. (569 aa)
Tb11.01.8060SHQ1 domain-containing protein. (565 aa)
Tb11.01.8050Uncharacterized protein. (351 aa)
XPB-RDNA repair helicase XPB-R; ATP-dependent 3'-5' DNA helicase involved in nucleotide excision repair (NER) of damaged DNA. XPB-R is a paralog of XBP, but is not a component of the TFIIH basal transcription factor and is dispensable for RNA polymerase II transcription. (777 aa)
Tb11.01.7240Histone deacetylase 2. (566 aa)
Tb11.01.6700CBFD_NFYB_HMF domain-containing protein. (132 aa)
Tb11.01.6520DNA_pol_E_B domain-containing protein. (648 aa)
Tb11.01.5600Cyclin 9. (281 aa)
Tb11.01.5500U3 small nucleolar ribonucleoprotein protein IMP3, putative. (226 aa)
Tb11.01.5370ATP-dependent DEAD/H RNA helicase, putative. (556 aa)
Tb11.01.4270Tyrosine phosphatase, putative. (818 aa)
Tb11.01.3850Uncharacterized protein. (389 aa)
Tb11.01.3380Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (604 aa)
Tb11.01.2820Exosome-associated protein 4. (227 aa)
Tb11.01.2250Uncharacterized protein. (975 aa)
Tb11.01.2230Sld5 domain-containing protein. (310 aa)
HslVATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins (By similarity). The HslVU protease complex functions in mitochondrial DNA replication by regulating DNA helicase PIF2 protein levels; Belongs to the peptidase T1B family. HslV subfamily. (209 aa)
Tb11.01.1990CDC73_C domain-containing protein. (391 aa)
Tb11.01.1610WD_REPEATS_REGION domain-containing protein. (391 aa)
Tb11.01.0950SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (566 aa)
Tb11.01.0820Uncharacterized protein. (1216 aa)
Tb11.01.0625DNA-dependent RNA polymerases, putative. (134 aa)
Tb11.12.0011ATP-dependent DEAD/H RNA helicase, putative; Belongs to the DEAD box helicase family. (401 aa)
Tb11.01.0280WD_REPEATS_REGION domain-containing protein. (805 aa)
Tb11.01.0340RAD50 DNA repair-like protein. (1349 aa)
Tb11.01.0490Sas10 domain-containing protein. (523 aa)
Tb11.02.5790DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (149 aa)
Tb11.02.5330Uncharacterized protein; Belongs to the SKP1 family. (136 aa)
Tb11.02.5180DNA-direcetd RNA polymerase II, subunit 9, putative. (133 aa)
Tb11.02.5110Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (436 aa)
Tb11.02.5060SNF2 DNA repair protein, putative. (952 aa)
PIF2ATP-dependent DNA helicase PIF2; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Essential for replication of kinetoplast maxicircles, but not minicircles. Belongs to the helicase family. PIF1 subfamily. (1048 aa)
Tb11.02.4620Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (781 aa)
Tb11.02.4320Uncharacterized protein. (954 aa)
Tb11.02.422060S ribosomal protein L24, putative. (191 aa)
Tb11.02.2930SNF2 DNA repair protein, putative. (968 aa)
Tb11.02.2910TRM13 domain-containing protein. (510 aa)
Tb11.02.2620ATP-dependent DEAD/H RNA helicase, putative. (601 aa)
Tb11.02.0620Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (655 aa)
Tb11.02.0570WD_REPEATS_REGION domain-containing protein. (576 aa)
Tb11.02.0380WD_REPEATS_REGION domain-containing protein. (769 aa)
Tb11.02.0310Cell division cycle 45 (CDC45), putative. (685 aa)
Tb11.02.0240GTP-binding protein, putative. (486 aa)
Tb11.57.0004DNA-directed RNA polymerase II, putative. (132 aa)
Tb11.46.0009Uncharacterized protein. (517 aa)
Tb11.47.0029Uncharacterized protein. (614 aa)
Tb11.03.0050RNA processing factor 1, putative. (331 aa)
Tb11.03.0450DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1596 aa)
Tb11.03.0680Uncharacterized protein. (948 aa)
Tb11.03.0935DNA-directed RNA polymerase subunit, putative. (131 aa)
Tb10.61.0490PINc domain-containing protein. (207 aa)
Tb10.61.1030U3 snoRNA-associated protein UTP11, putative. (346 aa)
Tb10.61.1040DNA-directed RNA polymerase, alpha subunit, putative. (337 aa)
Tb927.8.7470Uncharacterized protein. (570 aa)
Your Current Organism:
Trypanosoma brucei
NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927
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