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SIR2rp3 | NAD-dependent protein deacylase SIR2rp3; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo; Belongs to the sirtuin family. Class III subfamily. (244 aa) | ||||
SIR2rp2 | NAD-dependent protein deacylase SIR2rp2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. (306 aa) | ||||
SIR2rp1 | NAD-dependent protein deacetylase SIR2rp1; NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro. (351 aa) | ||||
DHSp | Deoxyhypusine synthase regulatory subunit; Required for the activation and stability of deoxyhypusine synthase DHSc. Required for cell growth and survival. (342 aa) | ||||
DHSc | Deoxyhypusine synthase; In association with the non-catalytic regulatory subunit DHSp, catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form the intermediate deoxyhypusine residue. Regulates protein levels of its regulatory subunit DHSp. Required for cell growth and survival. (461 aa) | ||||
Tb11.02.5530 | Electron-transfer-flavoprotein, alpha polypeptide, putative. (324 aa) |