STRINGSTRING
SIR2rp3 SIR2rp3 SIR2rp2 SIR2rp2 SIR2rp1 SIR2rp1 DHSp DHSp DHSc DHSc Tb11.02.5530 Tb11.02.5530
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
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Your Input:
SIR2rp3NAD-dependent protein deacylase SIR2rp3; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo; Belongs to the sirtuin family. Class III subfamily. (244 aa)
SIR2rp2NAD-dependent protein deacylase SIR2rp2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. (306 aa)
SIR2rp1NAD-dependent protein deacetylase SIR2rp1; NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro. (351 aa)
DHSpDeoxyhypusine synthase regulatory subunit; Required for the activation and stability of deoxyhypusine synthase DHSc. Required for cell growth and survival. (342 aa)
DHScDeoxyhypusine synthase; In association with the non-catalytic regulatory subunit DHSp, catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF5A precursor protein to form the intermediate deoxyhypusine residue. Regulates protein levels of its regulatory subunit DHSp. Required for cell growth and survival. (461 aa)
Tb11.02.5530Electron-transfer-flavoprotein, alpha polypeptide, putative. (324 aa)
Your Current Organism:
Trypanosoma brucei
NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927
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