(57 nodes) Papain-like cysteine peptidase superfamily network (Trypanosoma brucei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Tb927.5.1070	OTU domain-containing protein. (915 aa)
	Tb10.389.0470	Calpain-like cysteine peptidase, putative; Belongs to the peptidase C2 family. (678 aa)
	Tb11.03.0890	Ubiquitin carboxyl-terminal hydrolase. (236 aa)
	Tb11.57.0008	Calpain-like protein, putative; Belongs to the peptidase C2 family. (5795 aa)
	Tb11.47.0036	Calpain, putative; Belongs to the peptidase C2 family. (1409 aa)
	Tb11.47.0035	Calpain-like cysteine peptidase, putative; Belongs to the peptidase C2 family. (5799 aa)
	Tb11.v4.0001	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (1649 aa)
	Tb11.46.0014	Ubiquitin carboxyl-terminal hydrolase. (554 aa)
	Tb927.4.3790	Ubiquitin carboxyl-terminal hydrolase. (465 aa)
	Tb927.3.4840	Ubiquitin carboxyl-terminal hydrolase. (731 aa)
	Tb927.5.2400	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (986 aa)
	Tb927.5.2700	Ubiquitin thioesterase. (268 aa)
	Tb927.3.1870	Peptidase C51 domain-containing protein. (289 aa)
	Tb927.4.3950	Cytoskeleton-associated protein CAP5.5, putative; Belongs to the peptidase C2 family. (853 aa)
	Tb927.4.3940	Calpain-like cysteine peptidase, putative; Belongs to the peptidase C2 family. (792 aa)
	Tb927.8.2410	Trypanothione synthetase, putative. (237 aa)
	Tb927.8.5620	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (1419 aa)
	Tb927.8.8330	Calpain, putative; Belongs to the peptidase C2 family. (888 aa)
	Tb10.389.0720	Uncharacterized protein. (1013 aa)
	Tb927.5.500	Uncharacterized protein. (1403 aa)
	Tb927.8.5050	OTU domain-containing protein. (746 aa)
	TB927.1.2100	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family. (1146 aa)
	TB927.1.2110	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family. (682 aa)
	Calpain	Calpain, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family. (732 aa)
	Tb09.160.0970	SUMO1/Ulp2, putative. (744 aa)
	Tb09.160.4020	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (1342 aa)
	Tb09.160.5550	Calpain-like cysteine peptidase, putative; Belongs to the peptidase C2 family. (856 aa)
	Tb09.211.0820	Uncharacterized protein. (619 aa)
	Tb09.211.3040	DNA-repair protein, putative. (768 aa)
	Tb927.2.3460	D-alanyl-glycyl endopeptidase-like protein. (280 aa)
	Tb927.2.3440	D-alanyl-glycyl endopeptidase-like protein. (273 aa)
	Tb927.6.560	Cysteine peptidase C (CPC); Belongs to the peptidase C1 family. (340 aa)
	Tb11.01.7970	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (348 aa)
	Tb11.01.7760	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (1184 aa)
	Tb11.01.6080	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (442 aa)
	Tb11.01.5800	Calpain-like cysteine peptidase, putative; Belongs to the peptidase C2 family. (1504 aa)
	Tb11.01.4060	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (790 aa)
	Tb11.12.0016	Glutathionylspermidine synthetase, putative. (274 aa)
	Tb11.02.2940	Ubiquitin carboxyl-terminal hydrolase. (765 aa)
	Tb11.02.2800	Ubiquitin carboxyl-terminal hydrolase. (309 aa)
	Tb11.02.2240	Calpain-like protein, putative; Belongs to the peptidase C2 family. (1051 aa)
	Tb09.211.4270	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (445 aa)
	Tb927.2.4370	Trypanothione synthetase, putative. (627 aa)
	Tb927.6.1690	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (327 aa)
	Tb927.6.1010	Cysteine peptidase; Belongs to the peptidase C1 family. (450 aa)
	Tb927.6.990	Cysteine peptidase; Belongs to the peptidase C1 family. (449 aa)
	Tb927.6.1020	Cysteine peptidase; Belongs to the peptidase C1 family. (450 aa)
	Tb927.6.1030	Cysteine peptidase; Belongs to the peptidase C1 family. (449 aa)
	Tb927.6.1000	Cysteine peptidase; Belongs to the peptidase C1 family. (449 aa)
	Tb927.6.1110	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (1096 aa)
	Tb927.6.3310	Calpain-like cysteine peptidase, putative; Belongs to the peptidase C2 family. (1010 aa)
	Tb927.6.2690	Ubiquitin carboxyl-terminal hydrolase, putative. (639 aa)
	Tb09.211.4910	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family. (1161 aa)
	Tb10.70.5950	Calpain, putative; Belongs to the peptidase C2 family. (1594 aa)
	Tb10.70.5540	Ubiquitin carboxyl-terminal hydrolase. (662 aa)
	Tb10.6k15.3400	Uncharacterized protein. (1155 aa)
	Tb10.6k15.1750	OTU domain-containing protein. (265 aa)

Your Current Organism:

Trypanosoma brucei

NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TB927.1.2100	Tb927.6.1000	Q4GZ11	Q585E2	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.416
TB927.1.2100	Tb927.6.1020	Q4GZ11	Q585E5	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.419
TB927.1.2100	Tb927.6.1030	Q4GZ11	Q585E3	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.416
TB927.1.2100	Tb927.6.990	Q4GZ11	Q585E8	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.419
TB927.1.2110	Tb927.6.1000	Q4GZ10	Q585E2	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.479
TB927.1.2110	Tb927.6.1010	Q4GZ10	Q585F0	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.413
TB927.1.2110	Tb927.6.1020	Q4GZ10	Q585E5	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.479
TB927.1.2110	Tb927.6.1030	Q4GZ10	Q585E3	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.479
TB927.1.2110	Tb927.6.990	Q4GZ10	Q585E8	Calpain-like cysteine peptidase, putative cysteine peptidase, Clan CA, family C2, putative; Belongs to the peptidase C2 family.	Cysteine peptidase; Belongs to the peptidase C1 family.	0.479
Tb09.160.0970	Tb927.2.4370	Q38FU0	Q586P2	SUMO1/Ulp2, putative.	Trypanothione synthetase, putative.	0.458
Tb09.160.4020	Tb927.3.4840	Q38F03	Q582Q1	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase.	0.491
Tb09.211.4270	Tb927.2.4370	Q38D83	Q586P2	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	Trypanothione synthetase, putative.	0.555
Tb09.211.4270	Tb927.5.2700	Q38D83	Q57ZU6	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	Ubiquitin thioesterase.	0.503
Tb09.211.4910	Tb927.3.4840	Q38D19	Q582Q1	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase.	0.491
Tb10.6k15.1750	Tb11.01.6080	Q38A95	Q381Y9	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	0.432
Tb10.6k15.1750	Tb927.3.4840	Q38A95	Q582Q1	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.513
Tb10.6k15.1750	Tb927.4.3790	Q38A95	Q583H3	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.438
Tb10.6k15.1750	Tb927.5.2700	Q38A95	Q57ZU6	OTU domain-containing protein.	Ubiquitin thioesterase.	0.408
Tb11.01.4060	Tb11.01.6080	Q382V7	Q381Y9	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	0.578
Tb11.01.4060	Tb927.4.3790	Q382V7	Q583H3	Ubiquitin carboxyl-terminal hydrolase, putative; Belongs to the peptidase C19 family.	Ubiquitin carboxyl-terminal hydrolase.	0.507

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