27 items (Trypanosoma brucei) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Your Input:
	IFT22	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family. (219 aa)
	Tb11.01.8240	Dynein light chain roadblock. (98 aa)
	Tb11.01.7825	Tubulin-specific chaperone A; Belongs to the TBCA family. (128 aa)
	Tb11.01.4080	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (620 aa)
	Tb11.01.3150	Spindle pole body component. (799 aa)
	KATNA1	Katanin p60 ATPase-containing subunit A1; Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. (554 aa)
	KATNAL2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (567 aa)
	Tb11.03.0815	Dynein light chain. (90 aa)
	Tb10.61.0770	Dynein light chain. (130 aa)
	Tb10.389.0350	Dynein light chain roadblock. (118 aa)
	Tb10.406.0320	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (111 aa)
	Tb10.6k15.0540	Spindle pole body component. (784 aa)
	Tb10.70.0090	Dynein light chain. (125 aa)
	Tb10.70.2520	Dynein light chain. (112 aa)
	KATNA1-2	Katanin p60 ATPase-containing subunit A1; Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. (680 aa)
	Tb927.2.2900	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (180 aa)
	Tb927.6.2400	Spindle pole body component. (669 aa)
	CFAP43	Cilia- and flagella-associated protein 43; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP43 family. (1460 aa)
	Tb927.5.4440	Dynein light chain. (90 aa)
	CFAP44	Cilia- and flagella-associated protein 44; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP44 family. (1760 aa)
	Tb927.8.4410	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (336 aa)
	TB927.1.2330	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (442 aa)
	TB927.1.2340	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
	Tb11.0845	Dynein light chain. (90 aa)
	Tb09.211.0620	Actin A. (376 aa)
	Tb09.211.3470	Dynein light chain. (155 aa)
	Tb09.211.4920	Dynein light chain roadblock. (98 aa)

Your Current Organism:

Trypanosoma brucei

NCBI taxonomy Id: 185431
Other names: T. brucei brucei TREU927, Trypanosoma brucei TREU927, Trypanosoma brucei brucei TREU927, Trypanosoma brucei brucei strain 927/4 GUTat10.1, Trypanosoma brucei strain TREU927

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CFAP43	CFAP44	Q580P9	Q57WH1	Cilia- and flagella-associated protein 43; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP43 family.	Cilia- and flagella-associated protein 44; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP44 family.	0.844
CFAP44	CFAP43	Q57WH1	Q580P9	Cilia- and flagella-associated protein 44; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP44 family.	Cilia- and flagella-associated protein 43; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP43 family.	0.844
CFAP44	IFT22	Q57WH1	Q381A3	Cilia- and flagella-associated protein 44; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP44 family.	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	0.440
IFT22	CFAP44	Q381A3	Q57WH1	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	Cilia- and flagella-associated protein 44; Flagellar protein involved in flagellum axoneme organization and function; Belongs to the CFAP44 family.	0.440
IFT22	TB927.1.2340	Q381A3	Q4GYY5	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.461
KATNAL2	TB927.1.2330	Q386C7	Q4GYY6	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.546
KATNAL2	TB927.1.2340	Q386C7	Q4GYY5	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.674
TB927.1.2330	KATNAL2	Q4GYY6	Q386C7	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.546
TB927.1.2330	TB927.1.2340	Q4GYY6	Q4GYY5	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.997
TB927.1.2330	Tb09.211.0620	Q4GYY6	Q38E94	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Actin A.	0.604
TB927.1.2330	Tb11.01.7825	Q4GYY6	Q381H1	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin-specific chaperone A; Belongs to the TBCA family.	0.766
TB927.1.2340	IFT22	Q4GYY5	Q381A3	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Intraflagellar transport protein 22; Required for flagellum formation. Belongs to the small GTPase superfamily. Rab family.	0.461
TB927.1.2340	KATNAL2	Q4GYY5	Q386C7	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.674
TB927.1.2340	TB927.1.2330	Q4GYY5	Q4GYY6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.997
TB927.1.2340	Tb09.211.0620	Q4GYY5	Q38E94	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Actin A.	0.762
TB927.1.2340	Tb09.211.4920	Q4GYY5	Q38D18	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein light chain roadblock.	0.423
TB927.1.2340	Tb10.389.0350	Q4GYY5	Q388T6	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein light chain roadblock.	0.423
TB927.1.2340	Tb10.6k15.0540	Q4GYY5	Q389Z9	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Spindle pole body component.	0.455
TB927.1.2340	Tb11.01.7825	Q4GYY5	Q381H1	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin-specific chaperone A; Belongs to the TBCA family.	0.560
TB927.1.2340	Tb11.01.8240	Q4GYY5	Q381D2	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Dynein light chain roadblock.	0.423

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