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SIR2rp2 | NAD-dependent protein deacylase SIR2rp2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. (306 aa) | ||||
SIR2rp1 | NAD-dependent protein deacetylase SIR2rp1; NAD-dependent protein deacetylase, which is involved in repression of RNA polymerase I-mediated expression immediately adjacent to telomeres. It is however not involved in antigenic variation and subtelomeric variant surface glycoprotein (VSG) gene silencing. Plays a role in DNA damage response. Also has ADP-ribosylation activity in vitro. (351 aa) | ||||
SIR2rp3 | NAD-dependent protein deacylase SIR2rp3; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo; Belongs to the sirtuin family. Class III subfamily. (244 aa) |