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| | SFJ61461.1 | Pyruvate dehydrogenase E1 component alpha subunit. (387 aa) |
| | SFJ61489.1 | Pyruvate dehydrogenase E1 component beta subunit. (357 aa) |
| | SFJ61516.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (527 aa) |
| | SFJ62765.1 | 2,4-dienoyl-CoA reductase. (642 aa) |
| | SFJ74277.1 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | SFJ75493.1 | 2,4-dienoyl-CoA reductase. (635 aa) |
| | SFJ76784.1 | Malate dehydrogenase (oxaloacetate-decarboxylating). (483 aa) |
| | pxpA | UPF0271 protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (279 aa) |
| | SFJ77320.1 | Sensor histidine kinase inhibitor, KipI family. (667 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | SFJ79553.1 | L-aspartate aminotransferase apoenzyme. (411 aa) |
| | SFJ81852.1 | Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (537 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (406 aa) |
| | SFJ81897.1 | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (704 aa) |
| | SFJ81915.1 | Xylulose-5-phosphate/fructose-6-phosphate phosphoketolase. (851 aa) |
| | sucC | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (425 aa) |
| | sucD | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa) |
| | SFJ82640.1 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa) |
| | mdh | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (302 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | SFJ84261.1 | L-proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. (1151 aa) |
| | SFJ94157.1 | Aconitase. (939 aa) |
| | SFJ94347.1 | Formate C-acetyltransferase. (756 aa) |
| | SFJ94366.1 | Pyruvate formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (294 aa) |
| | SFJ95873.1 | Branched-chain amino acid aminotransferase. (287 aa) |
| | mqo | Malate dehydrogenase (quinone). (495 aa) |
| | SFJ98372.1 | Succinate dehydrogenase subunit B. (249 aa) |
| | SFJ98392.1 | Succinate dehydrogenase subunit A. (686 aa) |
| | SFJ98410.1 | Succinate dehydrogenase / fumarate reductase cytochrome b subunit. (248 aa) |
| | SFK00138.1 | Glutamate synthase (NADPH/NADH) small chain. (488 aa) |
| | SFK00158.1 | Glutamate synthase (NADH) large subunit. (1521 aa) |
| | SFK02958.1 | Dihydrolipoamide dehydrogenase. (460 aa) |
| | SFK02974.1 | 2-oxoglutarate dehydrogenase E2 component. (605 aa) |
| | lipB | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (229 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (337 aa) |
| | SFK03188.1 | L-glutamine synthetase. (474 aa) |
| | SFK03311.1 | L-glutamine synthetase. (445 aa) |
| | SFK03487.1 | 4-hydroxymandelate oxidase. (344 aa) |
| | SFK03739.1 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (914 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (598 aa) |
| | SFK04790.1 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (905 aa) |
| | ppc | Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (900 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (434 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (391 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (222 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (487 aa) |
| | SFK13083.1 | 2,4-dienoyl-CoA reductase. (635 aa) |
| | SFK15930.1 | FAD/FMN-containing dehydrogenase. (982 aa) |
| | SFK17448.1 | L-aspartate aminotransferase apoenzyme. (410 aa) |
| | SFK17871.1 | Urea carboxylase. (1208 aa) |
| | SFK19409.1 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. (600 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa) |
| | fumC | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (478 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (620 aa) |
| | ilvD-2 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (572 aa) |
| | SFK28172.1 | Acetolactate synthase, large subunit. (622 aa) |
| | SFK28193.1 | Acetolactate synthase, small subunit. (174 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (354 aa) |
| | SFK28277.1 | Branched chain amino acid aminotransferase apoenzyme. (368 aa) |
| | SFK28320.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (549 aa) |
| | SFK28354.1 | Lipoate-protein ligase A. (358 aa) |
| | SFK29229.1 | 2-oxoglutarate dehydrogenase E1 component. (1248 aa) |
| | SFK31046.1 | Dihydrolipoamide dehydrogenase. (541 aa) |
| | SFK33394.1 | Acetyl-coenzyme A synthetase. (677 aa) |
| | SFK35734.1 | Succinate semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (278 aa) |
| | SFK35775.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (334 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (404 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (994 aa) |
| | SFK47314.1 | Malate dehydrogenase. (371 aa) |
| | pckG | Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa) |
| | SFK48014.1 | Isocitrate lyase. (452 aa) |
| | SFK48030.1 | Malate synthase; Belongs to the malate synthase family. (555 aa) |
| | SFK48097.1 | RimK-like ATP-grasp domain-containing protein. (281 aa) |
| | SFK48112.1 | phenylacetate-CoA ligase. (324 aa) |
| | SFK48134.1 | ATP-grasp domain-containing protein. (404 aa) |
| | SFK48178.1 | Arginase; Belongs to the arginase family. (156 aa) |
| | SFK53010.1 | Dihydrolipoamide dehydrogenase. (508 aa) |
| | SFK53288.1 | Succinate dehydrogenase subunit C. (132 aa) |
| | SFK53303.1 | Succinate dehydrogenase subunit D. (152 aa) |
| | SFK53321.1 | Succinate dehydrogenase subunit A. (612 aa) |
| | SFK53341.1 | Succinate dehydrogenase subunit B. (261 aa) |
| | SFK53670.1 | Citrate synthase; Belongs to the citrate synthase family. (436 aa) |
| | SFK54631.1 | Protein of unknown function. (636 aa) |
| | SFK55044.1 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (432 aa) |
