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| | SFK56905.1 | Probable phosphoglycerate mutase. (237 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (386 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...] (597 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | SFK35775.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (333 aa) |
| | SFK36083.1 | L-ascorbate metabolism protein UlaG, beta-lactamase superfamily. (261 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (336 aa) |
| | ldh | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (334 aa) |
| | SFK36616.1 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (399 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | hisC | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (203 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (250 aa) |
| | pheS | phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (356 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (859 aa) |
| | SFK37772.1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (436 aa) |
| | SFK37902.1 | NADPH2:quinone reductase. (332 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (358 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (338 aa) |
| | SFK38041.1 | Acetylornithine aminotransferase apoenzyme. (452 aa) |
| | SFK38066.1 | Ornithine carbamoyltransferase. (310 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (167 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa) |
| | argH | Argininosuccinate lyase. (471 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (425 aa) |
| | SFK41626.1 | Dihydrofolate reductase. (216 aa) |
| | SFK41811.1 | Dihydrofolate reductase. (188 aa) |
| | lysS-2 | lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. (1121 aa) |
| | SFK42089.1 | Hypothetical protein. (193 aa) |
| | SFK42106.1 | 2-Methylisocitrate lyase, PEP mutase family. (284 aa) |
| | SFK42580.1 | Superoxide dismutase, Cu-Zn family. (328 aa) |
| | SFK42600.1 | Superoxide dismutase, Cu-Zn family. (332 aa) |
| | SFK42872.1 | Dihydrofolate reductase. (193 aa) |
| | SFK43589.1 | Deazaflavin-dependent oxidoreductase, nitroreductase family. (159 aa) |
| | SFK43947.1 | Acetyltransferase (GNAT) family protein. (169 aa) |
| | SFK44697.1 | L-2,4-diaminobutyrate decarboxylase. (484 aa) |
| | SFK46312.1 | ATP-grasp domain-containing protein. (274 aa) |
| | SFK46531.1 | Deazaflavin-dependent oxidoreductase, nitroreductase family. (150 aa) |
| | SFK46994.1 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. (372 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (783 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (404 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (994 aa) |
| | SFK47302.1 | ACT domain-containing protein. (164 aa) |
| | SFK47314.1 | Malate dehydrogenase. (371 aa) |
| | SFK47350.1 | N-acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. Belongs to the DapA family. (299 aa) |
| | SFK48014.1 | Isocitrate lyase. (452 aa) |
| | SFK48030.1 | Malate synthase; Belongs to the malate synthase family. (555 aa) |
| | SFK48134.1 | ATP-grasp domain-containing protein. (404 aa) |
| | SFK48157.1 | Glyoxylase, beta-lactamase superfamily II. (231 aa) |
| | SFK48178.1 | Arginase; Belongs to the arginase family. (156 aa) |
| | SFK48768.1 | 6-phosphogluconate dehydrogenase (decarboxylating). (309 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa) |
| | SFK52280.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (363 aa) |
| | SFK52302.1 | Homoserine dehydrogenase. (438 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (460 aa) |
| | argS | arginyl-tRNA synthetase. (582 aa) |
| | SFK52713.1 | Succinyldiaminopimelate aminotransferase apoenzyme. (395 aa) |
| | SFK52831.1 | propionyl-CoA carboxylase carboxyltransferase subunit. (546 aa) |
| | SFK52969.1 | acetyl-CoA/propionyl-CoA carboxylase, biotin carboxylase, biotin carboxyl carrier protein. (604 aa) |
| | SFK53250.1 | Amidohydrolase. (427 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (353 aa) |
| | SFK53624.1 | Succinyldiaminopimelate desuccinylase. (371 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (331 aa) |
| | SFK54730.1 | Threonine dehydrogenase. (401 aa) |
| | SFK55044.1 | Glutamate dehydrogenase (NAD(P)+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (432 aa) |
| | SFJ57211.1 | NADPH2:quinone reductase. (326 aa) |
| | SFJ57401.1 | Long-chain acyl-CoA synthetase. (534 aa) |
| | SFJ57428.1 | acyl-CoA dehydrogenase. (403 aa) |
| | SFJ57544.1 | glutaryl-CoA dehydrogenase. (434 aa) |
| | SFJ57572.1 | acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa) |
| | SFJ57599.1 | Acyl dehydratase. (153 aa) |
| | SFJ57833.1 | Proclavaminate amidinohydrolase; Belongs to the arginase family. (285 aa) |
| | SFJ58644.1 | Glyoxylase, beta-lactamase superfamily II. (268 aa) |
| | SFJ58807.1 | Sugar lactone lactonase YvrE. (280 aa) |
| | SFJ59749.1 | NADPH2:quinone reductase. (307 aa) |
| | SFJ59812.1 | Glutamine amidotransferase. (279 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (377 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (259 aa) |
| | SFJ61461.1 | Pyruvate dehydrogenase E1 component alpha subunit. (387 aa) |
| | SFJ61489.1 | Pyruvate dehydrogenase E1 component beta subunit. (357 aa) |
| | SFJ61516.1 | Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (527 aa) |
| | arcA | Arginine deiminase. (417 aa) |
| | SFJ63042.1 | CysZ protein. (283 aa) |
| | SFJ66639.1 | UDPglucose 6-dehydrogenase. (457 aa) |
| | pheA | Prephenate dehydratase. (317 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | SFJ67004.1 | Putative NAD(P)H quinone oxidoreductase, PIG3 family. (340 aa) |
| | SFJ67970.1 | Imidazolonepropionase. (428 aa) |
| | SFJ68282.1 | Aspartate kinase; Belongs to the aspartokinase family. (421 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (141 aa) |
| | SFJ70067.1 | Allantoin racemase. (256 aa) |
| | SFJ72077.1 | Glucuronate isomerase. (498 aa) |
| | SFJ72197.1 | L-fuconolactonase. (292 aa) |
| | SFJ72597.1 | D-mannonate dehydratase. (411 aa) |
| | SFJ73111.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa) |
| | SFJ73442.1 | Hypothetical protein. (492 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (231 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (424 aa) |
| | SFJ73687.1 | Acetyltransferase (GNAT) family protein. (189 aa) |
| | SFJ73781.1 | MaoC like domain-containing protein. (302 aa) |
| | SFJ73813.1 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (454 aa) |
| | SFJ73852.1 | Acyl-coenzyme A oxidase. (691 aa) |
| | SFJ73956.1 | Glutamate decarboxylase; Belongs to the group II decarboxylase family. (468 aa) |
| | SFJ74029.1 | Glutamate decarboxylase; Belongs to the group II decarboxylase family. (468 aa) |
| | SFJ74111.1 | L-ascorbate metabolism protein UlaG, beta-lactamase superfamily. (219 aa) |
| | SFJ74277.1 | Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa) |
| | SFJ74305.1 | tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (372 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (521 aa) |
| | SFJ76124.1 | Aldo/keto reductase. (259 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (676 aa) |
| | SFJ76784.1 | Malate dehydrogenase (oxaloacetate-decarboxylating). (483 aa) |
| | SFJ76836.1 | HAD-superfamily subfamily IB hydrolase, TIGR01490. (283 aa) |
| | SFJ77047.1 | Allantoate deiminase. (416 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | SFJ78068.1 | HAD-superfamily subfamily IB hydrolase, TIGR01490. (288 aa) |
| | SFJ78365.1 | O-succinylbenzoic acid--CoA ligase. (401 aa) |
| | SFJ79051.1 | ferredoxin--NADP+ reductase. (461 aa) |
| | SFJ79255.1 | Acyl dehydratase; Belongs to the UPF0336 family. (150 aa) |
| | SFJ79280.1 | Acyl dehydratase. (145 aa) |
| | SFJ81030.1 | GMP synthase (glutamine-hydrolysing). (264 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (618 aa) |
| | acpS | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (118 aa) |
| | SFJ81265.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (401 aa) |
| | SFJ81358.1 | Thiosulfate/3-mercaptopyruvate sulfurtransferase. (286 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (526 aa) |
| | SFJ82640.1 | Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (405 aa) |
| | mdh | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | SFJ83511.1 | tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like. (261 aa) |
| | SFJ84261.1 | L-proline dehydrogenase; Belongs to the aldehyde dehydrogenase family. (1151 aa) |
| | SFJ84380.1 | Altronate hydrolase. (521 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (554 aa) |
| | SFJ93675.1 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (255 aa) |
| | SFJ93720.1 | Phosphoserine phosphatase. (216 aa) |
| | SFJ94277.1 | GMP synthase (glutamine-hydrolysing). (236 aa) |
| | SFJ94389.1 | 3-hydroxyacyl-CoA dehydrogenase. (706 aa) |
| | SFJ94406.1 | acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (412 aa) |
| | SFJ94496.1 | 6-phosphogluconate dehydrogenase (decarboxylating); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (484 aa) |
| | SFJ95150.1 | Adenylyltransferase and sulfurtransferase. (381 aa) |
| | SFJ95522.1 | uroporphyrinogen-III synthase. (369 aa) |
| | SFJ95873.1 | Branched-chain amino acid aminotransferase. (287 aa) |
| | thrS | threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (670 aa) |
| | pdxT | Pyridoxal phosphate synthase yaaE subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa) |
| | SFJ96410.1 | Glyoxylase, beta-lactamase superfamily II. (240 aa) |
| | SFJ96429.1 | histidyl-tRNA synthetase. (458 aa) |
| | aspS | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (598 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (897 aa) |
| | SFJ96703.1 | Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (282 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (405 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (374 aa) |
| | pyrB | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (349 aa) |
| | SFJ97059.1 | Hypothetical protein. (182 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (406 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1119 aa) |
| | SFJ97201.1 | Phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (416 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (87 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | SFJ97609.1 | Hypothetical protein. (539 aa) |
| | SFJ98020.1 | L-threonine aldolase. (352 aa) |
| | SFJ98336.1 | Aldo/keto reductase. (278 aa) |
| | SFJ98506.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (451 aa) |
| | SFJ99021.1 | Prephenate dehydrogenase. (369 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (263 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | SFJ99500.1 | Acyl-CoA dehydrogenase. (387 aa) |
| | pfkA-2 | 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | SFK00119.1 | Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) |
| | SFK00138.1 | Glutamate synthase (NADPH/NADH) small chain. (488 aa) |
| | SFK00158.1 | Glutamate synthase (NADH) large subunit. (1521 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (438 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (525 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (156 aa) |
| | hisF | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | SFK00849.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (438 aa) |
| | SFK00883.1 | Alanine dehydrogenase; Belongs to the AlaDH/PNT family. (377 aa) |
| | SFK02291.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Belongs to the class-II DAHP synthase family. (450 aa) |
| | pfp | Pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (406 aa) |
| | SFK02397.1 | Long-chain acyl-CoA synthetase. (600 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (398 aa) |
| | SFK02760.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (464 aa) |
| | SFK02974.1 | 2-oxoglutarate dehydrogenase E2 component. (605 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (337 aa) |
| | SFK03188.1 | L-glutamine synthetase. (474 aa) |
| | SFK03311.1 | L-glutamine synthetase. (445 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (274 aa) |
| | SFK03437.1 | Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II. (487 aa) |
| | SFK03456.1 | Histidine ammonia-lyase/tyrosine ammonia-lyase. (503 aa) |
| | SFK03739.1 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (914 aa) |
| | SFK03804.1 | [acyl-carrier-protein] S-malonyltransferase. (340 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase-3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (334 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa) |
| | SFK03872.1 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | SFK04362.1 | NADPH:quinone reductase. (348 aa) |
| | glyQS | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (462 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (598 aa) |
| | SFK04790.1 | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (905 aa) |
| | leuS | leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (986 aa) |
| | ppc | Phosphoenolpyruvate carboxylase, type 1; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (900 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (434 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (391 aa) |
| | SFK06356.1 | Cystathionine gamma-synthase. (414 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (222 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (487 aa) |
| | SFK11892.1 | Probable phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (237 aa) |
| | SFK12112.1 | 3-oxoacyl-[acyl-carrier-protein] synthase-3. (379 aa) |
| | SFK12129.1 | 3-oxoacyl-[acyl-carrier-protein] synthase-3. (235 aa) |
| | SFK12282.1 | NAD(P)-binding Rossmann-like domain-containing protein. (492 aa) |
| | SFK12765.1 | Thiosulfate/3-mercaptopyruvate sulfurtransferase. (297 aa) |
| | SFK12973.1 | Bile acid-coenzyme A ligase. (478 aa) |
| | SFK13183.1 | Iron-binding zinc finger CDGSH type. (70 aa) |
| | SFK14095.1 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (408 aa) |
| | SFK14354.1 | Dihydrofolate reductase. (202 aa) |
| | SFK14559.1 | Acetyltransferase (GNAT) domain-containing protein. (131 aa) |
| | SFK14971.1 | Probable phosphoglycerate mutase. (218 aa) |
| | SFK15124.1 | Threonine dehydrogenase. (382 aa) |
| | SFK15223.1 | Amino-acid N-acetyltransferase. (171 aa) |
| | SFK15930.1 | FAD/FMN-containing dehydrogenase. (982 aa) |
| | SFK16040.1 | NADPH:quinone reductase. (336 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (433 aa) |
| | SFK16091.1 | O-acetylhomoserine sulfhydrylase. (439 aa) |
| | SFK16251.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (315 aa) |
| | SFK16270.1 | Dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (545 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (326 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (156 aa) |
| | lysS | lysyl-tRNA synthetase, class II; Belongs to the class-II aminoacyl-tRNA synthetase family. (512 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (246 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (247 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (162 aa) |
| | SFK16927.1 | NADPH:quinone reductase. (306 aa) |
| | SFK16944.1 | FAD-linked oxidoreductase. (448 aa) |
| | SFK16981.1 | D-serine deaminase, pyridoxal phosphate-dependent. (416 aa) |
| | cysS | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (479 aa) |
| | SFK17871.1 | Urea carboxylase. (1208 aa) |
| | SFK18008.1 | GMP synthase (glutamine-hydrolysing). (260 aa) |
| | SFK18138.1 | Hippurate hydrolase. (422 aa) |
| | SFK18573.1 | UDPglucose 6-dehydrogenase. (441 aa) |
| | SFK18711.1 | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (380 aa) |
| | SFK18814.1 | Ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa) |
| | SFK18834.1 | N-Dimethylarginine dimethylaminohydrolase. (275 aa) |
| | SFK19409.1 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. (600 aa) |
| | metG | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (595 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (311 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | SFK21512.1 | Cystathionine beta-synthase. (469 aa) |
| | SFK21599.1 | Xylitol oxidase. (422 aa) |
| | SFK21698.1 | Cystathionine gamma-synthase. (411 aa) |
| | SFK21735.1 | Threonine dehydratase. (403 aa) |
| | fumC | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (478 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (351 aa) |
| | SFK27399.1 | Hypothetical protein. (339 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (620 aa) |
| | ilvD-2 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (572 aa) |
| | SFK28172.1 | Acetolactate synthase, large subunit. (622 aa) |
| | SFK28193.1 | Acetolactate synthase, small subunit. (174 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (354 aa) |
| | SFK28277.1 | Branched chain amino acid aminotransferase apoenzyme. (368 aa) |
| | SFK28320.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (549 aa) |
| | SFK28604.1 | Long-chain acyl-CoA synthetase. (570 aa) |
| | SFK28846.1 | 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway). (262 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (503 aa) |
| | SFK28975.1 | Histidinol-phosphate phosphatase. (259 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (445 aa) |
| | SFK29822.1 | Carbamoyl-phosphate synthase large subunit. (322 aa) |
| | SFK30363.1 | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (250 aa) |
| | SFK30412.1 | Broad specificity phosphatase PhoE; Belongs to the phosphoglycerate mutase family. (248 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (560 aa) |
| | nagB | Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily. (260 aa) |
| | SFK33374.1 | O-acetylhomoserine sulfhydrylase. (440 aa) |
| | SFK33394.1 | Acetyl-coenzyme A synthetase. (677 aa) |
| | SFK33563.1 | Serine O-acetyltransferase. (194 aa) |
| | SFK33584.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | SFK33748.1 | Chorismate mutase. (105 aa) |
| | SFK33789.1 | Long-chain acyl-CoA synthetase. (604 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner. (886 aa) |
| | SFK34033.1 | Coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase. (264 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1114 aa) |
| | SFK34440.1 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (461 aa) |
| | SFK34681.1 | Imidazolonepropionase. (362 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa) |
| | SFK35170.1 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa) |
