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| | SFK03311.1 | L-glutamine synthetase. (445 aa) |
| | SFJ57211.1 | NADPH2:quinone reductase. (326 aa) |
| | SFJ57833.1 | Proclavaminate amidinohydrolase; Belongs to the arginase family. (285 aa) |
| | SFJ58807.1 | Sugar lactone lactonase YvrE. (280 aa) |
| | SFJ59749.1 | NADPH2:quinone reductase. (307 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (259 aa) |
| | SFJ63042.1 | CysZ protein. (283 aa) |
| | SFJ66639.1 | UDPglucose 6-dehydrogenase. (457 aa) |
| | pheA | Prephenate dehydratase. (317 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | SFJ67004.1 | Putative NAD(P)H quinone oxidoreductase, PIG3 family. (340 aa) |
| | SFJ68282.1 | Aspartate kinase; Belongs to the aspartokinase family. (421 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa) |
| | SFJ70067.1 | Allantoin racemase. (256 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (424 aa) |
| | SFJ73687.1 | Acetyltransferase (GNAT) family protein. (189 aa) |
| | SFJ73781.1 | MaoC like domain-containing protein. (302 aa) |
| | SFJ76124.1 | Aldo/keto reductase. (259 aa) |
| | SFJ76836.1 | HAD-superfamily subfamily IB hydrolase, TIGR01490. (283 aa) |
| | SFJ77047.1 | Allantoate deiminase. (416 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | SFJ78068.1 | HAD-superfamily subfamily IB hydrolase, TIGR01490. (288 aa) |
| | SFJ79255.1 | Acyl dehydratase; Belongs to the UPF0336 family. (150 aa) |
| | acpS | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (118 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (293 aa) |
| | SFJ93675.1 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (255 aa) |
| | SFJ93720.1 | Phosphoserine phosphatase. (216 aa) |
| | SFJ95150.1 | Adenylyltransferase and sulfurtransferase. (381 aa) |
| | SFJ95522.1 | uroporphyrinogen-III synthase. (369 aa) |
| | SFJ95873.1 | Branched-chain amino acid aminotransferase. (287 aa) |
| | SFJ96703.1 | Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (282 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (405 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (187 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (374 aa) |
| | SFJ97059.1 | Hypothetical protein. (182 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (406 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1119 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (87 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | SFJ98336.1 | Aldo/keto reductase. (278 aa) |
| | SFJ98506.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (451 aa) |
| | SFJ99021.1 | Prephenate dehydrogenase. (369 aa) |
| | SFK00138.1 | Glutamate synthase (NADPH/NADH) small chain. (488 aa) |
| | SFK00158.1 | Glutamate synthase (NADH) large subunit. (1521 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (278 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (438 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (270 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (525 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (156 aa) |
| | hisF | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | SFK00849.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (438 aa) |
| | SFK02291.1 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Belongs to the class-II DAHP synthase family. (450 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (398 aa) |
| | SFK02760.1 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (464 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (337 aa) |
| | SFK03188.1 | L-glutamine synthetase. (474 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (274 aa) |
| | SFK03804.1 | [acyl-carrier-protein] S-malonyltransferase. (340 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase-3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (334 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa) |
| | SFK03872.1 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | SFK04362.1 | NADPH:quinone reductase. (348 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (598 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (434 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (391 aa) |
| | SFK06356.1 | Cystathionine gamma-synthase. (414 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (222 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (487 aa) |
| | SFK12112.1 | 3-oxoacyl-[acyl-carrier-protein] synthase-3. (379 aa) |
| | SFK12129.1 | 3-oxoacyl-[acyl-carrier-protein] synthase-3. (235 aa) |
| | SFK13183.1 | Iron-binding zinc finger CDGSH type. (70 aa) |
| | SFK14354.1 | Dihydrofolate reductase. (202 aa) |
| | SFK14559.1 | Acetyltransferase (GNAT) domain-containing protein. (131 aa) |
| | SFK15223.1 | Amino-acid N-acetyltransferase. (171 aa) |
| | SFK16040.1 | NADPH:quinone reductase. (336 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (433 aa) |
| | SFK16251.1 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (315 aa) |
| | SFK16270.1 | Dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (545 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (326 aa) |
| | panD | L-aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (156 aa) |
| | SFK16927.1 | NADPH:quinone reductase. (306 aa) |
| | SFK16944.1 | FAD-linked oxidoreductase. (448 aa) |
| | SFK18138.1 | Hippurate hydrolase. (422 aa) |
| | SFK18573.1 | UDPglucose 6-dehydrogenase. (441 aa) |
| | SFK18711.1 | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (380 aa) |
| | SFK18814.1 | Ornithine--oxo-acid transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (408 aa) |
| | SFK19409.1 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. (600 aa) |
| | SFK21512.1 | Cystathionine beta-synthase. (469 aa) |
| | SFK21599.1 | Xylitol oxidase. (422 aa) |
| | SFK21698.1 | Cystathionine gamma-synthase. (411 aa) |
| | SFK21735.1 | Threonine dehydratase. (403 aa) |
| | SFK27399.1 | Hypothetical protein. (339 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (620 aa) |
| | ilvD-2 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (572 aa) |
| | SFK28172.1 | Acetolactate synthase, large subunit. (622 aa) |
| | SFK28193.1 | Acetolactate synthase, small subunit. (174 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (354 aa) |
| | SFK28277.1 | Branched chain amino acid aminotransferase apoenzyme. (368 aa) |
| | SFK28320.1 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (549 aa) |
| | SFK28975.1 | Histidinol-phosphate phosphatase. (259 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (445 aa) |
| | SFK29822.1 | Carbamoyl-phosphate synthase large subunit. (322 aa) |
| | SFK30363.1 | Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (250 aa) |
| | SFK33563.1 | Serine O-acetyltransferase. (194 aa) |
| | SFK33584.1 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | SFK34440.1 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (461 aa) |
| | SFK35170.1 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (458 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (252 aa) |
| | SFK35775.1 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (336 aa) |
| | SFK36616.1 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (399 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | hisC | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (203 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (250 aa) |
| | SFK37772.1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (436 aa) |
| | SFK37902.1 | NADPH2:quinone reductase. (332 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (358 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (338 aa) |
| | SFK38041.1 | Acetylornithine aminotransferase apoenzyme. (452 aa) |
| | SFK38066.1 | Ornithine carbamoyltransferase. (310 aa) |
| | argR | Transcriptional regulator, ArgR family; Regulates arginine biosynthesis genes. (167 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (412 aa) |
| | argH | Argininosuccinate lyase. (471 aa) |
| | SFK41626.1 | Dihydrofolate reductase. (216 aa) |
| | SFK41811.1 | Dihydrofolate reductase. (188 aa) |
| | SFK42580.1 | Superoxide dismutase, Cu-Zn family. (328 aa) |
| | SFK42600.1 | Superoxide dismutase, Cu-Zn family. (332 aa) |
| | SFK42872.1 | Dihydrofolate reductase. (193 aa) |
| | SFK43947.1 | Acetyltransferase (GNAT) family protein. (169 aa) |
| | SFK46312.1 | ATP-grasp domain-containing protein. (274 aa) |
| | SFK46994.1 | Methylenetetrahydrofolate reductase (NADPH); Belongs to the methylenetetrahydrofolate reductase family. (372 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (783 aa) |
| | SFK48134.1 | ATP-grasp domain-containing protein. (404 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa) |
| | SFK52280.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (363 aa) |
| | SFK52302.1 | Homoserine dehydrogenase. (438 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (460 aa) |
| | SFK52831.1 | propionyl-CoA carboxylase carboxyltransferase subunit. (546 aa) |
| | SFK53250.1 | Amidohydrolase. (427 aa) |
| | SFK53624.1 | Succinyldiaminopimelate desuccinylase. (371 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (331 aa) |
