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butA butA accD accD rpiB rpiB accA accA fabZ fabZ ANI77196.1 ANI77196.1 ANI77336.1 ANI77336.1 ANI77337.1 ANI77337.1 ANI77753.1 ANI77753.1 prpS prpS ANI77869.1 ANI77869.1 fabI fabI fabH fabH ANI78311.1 ANI78311.1 fabD fabD ANI78937.1 ANI78937.1 acpP acpP fabF fabF ANI78962.1 ANI78962.1 budC budC ANI79156.1 ANI79156.1 rbsK rbsK ANI79160.1 ANI79160.1 ANI79227.1 ANI79227.1 ANI79232.1 ANI79232.1 ANI79233.1 ANI79233.1 ANI79338.1 ANI79338.1 ANI79365.1 ANI79365.1 ANI79496.1 ANI79496.1 ANI79646.1 ANI79646.1 entA entA ANI79724.1 ANI79724.1 bacC bacC ANI79726.1 ANI79726.1 ANI79727.1 ANI79727.1 ANI79746.1 ANI79746.1 ANI79786.1 ANI79786.1 ANI79789.1 ANI79789.1 ANI79889.1 ANI79889.1 ANI79890.1 ANI79890.1 ANI79891.1 ANI79891.1 ANI79966.1 ANI79966.1 ydfG ydfG ANI80034.1 ANI80034.1 ANI80059.1 ANI80059.1 ANI80060.1 ANI80060.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
butAFatty acyl-CoA reductase; Catalyzes the NADPH-dependent reduction of long chain acyl-CoA (with chain lengths of 14 to 22 carbons) to the corresponding aldehyde; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: bgf:BC1003_2095 meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase; With NAD(+) or NADP(+) as acceptor. (236 aa)
accDAcetyl-CoA carboxylase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (283 aa)
rpiBRibose-5-phosphate isomerase; Belongs to the LacAB/RpiB family; KEGG: serr:Ser39006_3327 ribose 5-phosphate isomerase B. (145 aa)
accAAcetyl-CoA carboxylase; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa)
fabZ3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (160 aa)
ANI77196.1Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: sch:Sphch_1529 3-hydroxybutyrate dehydrogenase. (263 aa)
ANI77336.1Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
ANI77337.1Methylcrotonoyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
ANI77753.1Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate. Belongs to the ribulose-phosphate 3-epimerase family; KEGG: swi:Swit_1941 ribulose-phosphate 3-epimerase. (220 aa)
prpSRibose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
ANI77869.1Hypothetical protein. (270 aa)
fabIEnoyl-[acyl-carrier-protein] reductase (NADH); Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily; KEGG: hhe:HH1313 enoyl-(acyl-carrier protein) reductase I. (269 aa)
fabHBeta-ketoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (322 aa)
ANI78311.1Transcriptional regulatory protein btr; May regulate gene expression in response to changes in oxygen levels or to changes in the redox potential of the bacterial environment. Contains 1 cyclic nucleotide-binding domain; Contains 1 HTH crp-type DNA-binding domain. (244 aa)
fabD[Acyl-carrier-protein] S-malonyltransferase; Belongs to the FabD family; KEGG: rbt:NOVO_02490 (acyl-carrier-protein) S-malonyltransferase. (312 aa)
ANI78937.13-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa)
fabFBeta-ketoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (419 aa)
ANI78962.1Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily; KEGG: tmr:Tmar_0949 3-oxoacyl-(acyl-carrier protein) reductase. (278 aa)
budCAklaviketone reductase DauE; Involved in the biosynthesis of aklavinone which is an important precursor common to the formation of the clinically significant anthracyclines such as carminomycin, daunorubicin (daunomycin), rhodomycin, aclacinomycin T (aklavin) and aclacinomycin A (aclarubicin). These compounds are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the NADPH-specific conversion of aklaviketone to yield aklavinone. It can also convert maggiemycin and 7-oxodaunomycinone to epsilon-rho [...] (248 aa)
ANI79156.13-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the oxidation of D-glucitol (sorbitol) to D- fructose, galactitol to D-tagatose and of L-iditol. Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: serr:Ser39006_0569 3-oxoacyl-(acyl-carrier protein) reductase. (258 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (315 aa)
ANI79160.1Ribose-5-phosphate isomerase; Belongs to the LacAB/RpiB family; KEGG: mca:MCA0043 ribose 5-phosphate isomerase B. (193 aa)
ANI79227.1Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: reh:H16_B0361 3-oxoacyl-(acyl-carrier protein) reductase. (256 aa)
ANI79232.13-hydroxybutyrate dehydrogenase; 7-alpha-dehydroxylation of cholic acid, yielding deoxycholic acid and lithocholic acid, respectively. Highest affinity with taurochenodeoxycholic acid (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: psal:PSLF89_799 3-hydroxybutyrate dehydrogenase. (265 aa)
ANI79233.13-oxoacyl-[acyl-carrier-protein] reductase; Has apparently no steroid dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family; Contains 1 SCP2 domain; KEGG: gpi:GPICK_07935 3-oxoacyl-(acyl-carrier protein) reductase. (269 aa)
ANI79338.1Putative short-chain type dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: mmar:MODMU_1341 meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase; With NAD(+) or NADP(+) as acceptor. (238 aa)
ANI79365.1KEGG: rde:RD1_2925 (acyl-carrier-protein) S-malonyltransferase. (346 aa)
ANI79496.13-oxoacyl-[acyl-carrier-protein] reductase; Involved in the degradation of galactose via the DeLey- Doudoroff pathway. Catalyzes the oxidation of galactose in the presence of NAD(+). Uses NAD(+) as a hydrogen acceptor more efficiently than NADP(+); Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: bgp:BGL_1c20260 3-oxoacyl-(acyl-carrier protein) reductase. (258 aa)
ANI79646.1Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: sml:Smlt3653 3-oxoacyl-(acyl-carrier protein) reductase. (273 aa)
entA2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Catalyzes the NADPH-dependent reduction of beta- ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: bao:BAMF_2996 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase. (268 aa)
ANI79724.1UDP-glucose 4-epimerase; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: bcen:DM39_698 UDP-glucose 4-epimerase. (224 aa)
bacCDihydroanticapsin 7-dehydrogenase; Catalyzes the NADPH-dependent reduction of long chain acyl-CoA (with chain lengths of 14 to 22 carbons) to the corresponding aldehyde; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: strm:M444_35575 dihydroanticapsin dehydrogenase. (284 aa)
ANI79726.1Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: mlo:mll8564 3-oxoacyl-(acyl-carrier protein) reductase. (264 aa)
ANI79727.13-hydroxyacyl-CoA dehydrogenase; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from both straight-chain and 2-methyl- branched-chain fatty acids; Belongs to the short-chain dehydrogenases/reductases (SDR) family; Contains 1 MaoC-like domain; Contains 1 SCP2 domain; KEGG: cin:100187421 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase. (314 aa)
ANI79746.1Glucose 1-dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: lpl:lp_3045 null; Oxidoreductases. (263 aa)
ANI79786.13(or 17)-beta-hydroxysteroid dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: ppuu:PputUW4_01679 3(or 17)beta-hydroxysteroid dehydrogenase. (260 aa)
ANI79789.1Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: pae:PA4389 3-oxoacyl-(acyl-carrier protein) reductase. (262 aa)
ANI79889.1Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: dgo:DGo_PA0311 3-oxoacyl-(acyl-carrier protein) reductase. (247 aa)
ANI79890.1KEGG: cyj:Cyan7822_5881 dTDP-4-dehydrorhamnose reductase; Belongs to the glycosyl hydrolase 1 family. (440 aa)
ANI79891.1Arylsulfatase; Plays an important role in the mineralization of sulfates. Belongs to the sulfatase family; KEGG: fil:BN1229_v1_3960 arylsulfatase. (766 aa)
ANI79966.1Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: npp:PP1Y_AT10488 3-oxoacyl-(acyl-carrier protein) reductase. (255 aa)
ydfG3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: kaf:KAFR_0B03360 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase. (271 aa)
ANI80034.13-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the oxidation of D-glucitol (sorbitol) to D- fructose, galactitol to D-tagatose and of L-iditol. Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: serr:Ser39006_0569 3-oxoacyl-(acyl-carrier protein) reductase. (258 aa)
ANI80059.1KEGG: kpk:A593_26075 gluconate 5-dehydrogenase. (270 aa)
ANI80060.12,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase; Catalyzes the degradation of 2,5-dichloro-2,5- cyclohexadiene-1,4-diol (2,5-DDOL) into 2,5-dichlorohydroquinone (2,5-DCHQ). LinX appears not to be involved in gamma-HCH degradation pathway. Belongs to the short-chain dehydrogenases/reductases (SDR) family; KEGG: swi:Swit_2636 dihydroxycyclohexadiene carboxylate dehydrogenase; 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase. (266 aa)
Your Current Organism:
Sphingobium sp. EP60837
NCBI taxonomy Id: 1855519
Other names: S. sp. EP60837
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