STRINGSTRING
tatC tatC secE secE ANI78638.1 ANI78638.1 ANI78670.1 ANI78670.1 ANI78727.1 ANI78727.1 ANI78728.1 ANI78728.1 ANI78790.1 ANI78790.1 ANI78821.1 ANI78821.1 ANI78822.1 ANI78822.1 ANI78823.1 ANI78823.1 ANI79120.1 ANI79120.1 ANI78853.1 ANI78853.1 ANI78839.1 ANI78839.1 ANI78831.1 ANI78831.1 ANI78830.1 ANI78830.1 ANI78829.1 ANI78829.1 ANI78828.1 ANI78828.1 ANI78827.1 ANI78827.1 ANI78826.1 ANI78826.1 ANI78825.1 ANI78825.1 ANI78824.1 ANI78824.1 ANI79885.1 ANI79885.1 ANI79563.1 ANI79563.1 ANI79538.1 ANI79538.1 ANI79368.1 ANI79368.1 ANI79204.1 ANI79204.1 ANI79202.1 ANI79202.1 ANI79196.1 ANI79196.1 ANI79158.1 ANI79158.1 ANI79138.1 ANI79138.1 tig tig ANI76564.1 ANI76564.1 ANI76565.1 ANI76565.1 ANI76585.1 ANI76585.1 lolD lolD secA secA ANI77003.1 ANI77003.1 bamD bamD ANI77058.1 ANI77058.1 ANI77095.1 ANI77095.1 bamA bamA ANI77237.1 ANI77237.1 ffh ffh ftsY ftsY ANI77339.1 ANI77339.1 ANI77442.1 ANI77442.1 ANI77500.1 ANI77500.1 secB secB ANI77517.1 ANI77517.1 ANI77600.1 ANI77600.1 ANI77601.1 ANI77601.1 secY secY ANI77664.1 ANI77664.1 secF secF secD secD yajC yajC ANI77696.1 ANI77696.1 ANI77917.1 ANI77917.1 tolB tolB ANI77972.1 ANI77972.1 ANI77973.1 ANI77973.1 ANI77974.1 ANI77974.1 ANI78263.1 ANI78263.1 ANI78264.1 ANI78264.1 ANI78265.1 ANI78265.1 yidC yidC ANI78289.1 ANI78289.1 ANI78402.1 ANI78402.1 flhA flhA fliI fliI ANI78419.1 ANI78419.1 fliP fliP fliQ fliQ ANI78427.1 ANI78427.1 ANI78428.1 ANI78428.1 ANI78492.1 ANI78492.1 ANI78552.1 ANI78552.1 tatA tatA ANI78568.1 ANI78568.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tatCSec-independent protein translocase protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (261 aa)
secEHypothetical protein; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (68 aa)
ANI78638.1Required for bacteriophage N4 adsorption. May be a component of the phage receptor (By similarity). (461 aa)
ANI78670.1Hypothetical protein. (237 aa)
ANI78727.1Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane; Belongs to the TamA family. (682 aa)
ANI78728.1Hypothetical protein. (1392 aa)
ANI78790.1Involved in the secretion of proteases A, B, C and G. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family. (424 aa)
ANI78821.1Hypothetical protein. (274 aa)
ANI78822.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; Belongs to the GSP D family. (725 aa)
ANI78823.1Type II secretion system protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (514 aa)
ANI79120.1Coupling protein TraD; Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Couples the transferosome to a type IV secretion system. Probably forms a pore through which single-stranded plasmid DNA is transferred to the secretion system. The last 37 residues are important for determining plasmid specificity and transfer efficiency, with additional specificity conferred by the TraD-TraM pair; Belongs to the T [...] (684 aa)
ANI78853.1Uncharacterized protein; Involved in the secretion of an unknown compound; Belongs to the GSP D family; Contains 1 BON domain. (497 aa)
ANI78839.1Hypothetical protein. (1073 aa)
ANI78831.1Hypothetical protein; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (161 aa)
ANI78830.1Hypothetical protein. (369 aa)
ANI78829.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; Belongs to the GSP K family. (329 aa)
ANI78828.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane; Belongs to the GSP J family; overlaps another CDS with the same product name. (247 aa)
ANI78827.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane; Belongs to the GSP I family; overlaps another CDS with the same product name. (108 aa)
ANI78826.1Hypothetical protein. (139 aa)
ANI78825.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins; Belongs to the GSP G family. (192 aa)
ANI78824.1Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for the translocation of a variety of enzymes across the outer membrane. Belongs to the GSP F family. (405 aa)
ANI79885.12-iminobutanoate/2-iminopropanoate deaminase; Contains 5 pentapeptide repeat domains; KEGG: csg:Cylst_5108 2-iminobutanoate/2-iminopropanoate deaminase. (226 aa)
ANI79563.1Hypothetical protein. (593 aa)
ANI79538.1Hypothetical protein. (533 aa)
ANI79368.1Hypothetical protein. (92 aa)
ANI79204.1Hypothetical protein. (179 aa)
ANI79202.1Protein TraN. (364 aa)
ANI79196.1Hypothetical protein. (841 aa)
ANI79158.1Hypothetical protein. (392 aa)
ANI79138.1Hypothetical protein. (355 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (535 aa)
ANI76564.1Leukotoxin secretion protein; Involved in the transport of the Leukotoxin. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family. (456 aa)
ANI76565.1Type I secretion system ATP-binding protein PrsD; Mediates secretion of glycanase ExsH; Belongs to the ABC transporter superfamily; Contains 1 ABC transmembrane type-1 domain; Contains 1 ABC transporter domain. (581 aa)
ANI76585.1Lipoprotein-releasing system transmembrane protein LolC; Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily. (416 aa)
lolDMacrolide export ATP-binding/permease protein MacB; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family. (229 aa)
secAProtein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (910 aa)
ANI77003.1Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily; Contains 1 ABC transporter domain. (605 aa)
bamDOuter membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (261 aa)
ANI77058.1Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (126 aa)
ANI77095.1Hypothetical protein. (220 aa)
bamAOuter membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (880 aa)
ANI77237.1Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane; Belongs to the BamB family. (465 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (482 aa)
ftsYSignal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (313 aa)
ANI77339.1Zinc finger protein ZIC; Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TG [...] (250 aa)
ANI77442.1UPF0056 membrane protein; Belongs to the UPF0056 (MarC) family. (205 aa)
ANI77500.1Hypothetical protein. (218 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (167 aa)
ANI77517.1Biopolymer transport protein exbD1; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates; Belongs to the ExbD/TolR family. (129 aa)
ANI77600.1Hypothetical protein. (700 aa)
ANI77601.1Hypothetical protein. (1403 aa)
secYProtein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (454 aa)
ANI77664.1Hypothetical protein. (431 aa)
secFProtein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (328 aa)
secDProtein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (532 aa)
yajCUPF0092 membrane protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (111 aa)
ANI77696.1Hemolysin secretion protein D, chromosomal; Involved in the transport of hemolysin A. Belongs to the membrane fusion protein (MFP) (TC 8. A. 1) family. (464 aa)
ANI77917.1Hypothetical protein. (168 aa)
tolBProtein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (440 aa)
ANI77972.1Leucine-rich repeat extensin-like protein; Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization; Contains 10 LRR (leucine-rich) repeats. (322 aa)
ANI77973.1Biopolymer transport protein exbD2; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates; Belongs to the ExbD/TolR family. (154 aa)
ANI77974.1Hypothetical protein; Involved in the TonB-independent uptake of proteins; Belongs to the ExbB/TolQ family. (236 aa)
ANI78263.1Protein TolQ; Involved in the TonB-independent uptake of proteins; Belongs to the ExbB/TolQ family. (252 aa)
ANI78264.1Biopolymer transport protein ExbD; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates; Belongs to the ExbD/TolR family. (162 aa)
ANI78265.1Biopolymer transport protein exbD1; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates; Belongs to the ExbD/TolR family. (140 aa)
yidCMembrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (566 aa)
ANI78289.1Putative membrane protein insertion efficiency factor; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (70 aa)
ANI78402.1Chemotaxis protein PomA; PomA and PomB comprise the stator element of the flagellar motor complex. Required for rotation of the flagellar motor. Probable transmembrane proton channel (By similarity); Belongs to the MotA family. (222 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (706 aa)
fliIH(+)-transporting two-sector ATPase; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. Belongs to the ATPase alpha/beta chains family; KEGG: syb:TZ53_02490 flagellum-specific ATP synthase. (442 aa)
ANI78419.1Hypothetical protein. (141 aa)
fliPFlagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (293 aa)
fliQFlagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (90 aa)
ANI78427.1Flagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (260 aa)
ANI78428.1Flagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin (By similarity); Belongs to the type III secretion exporter family. (378 aa)
ANI78492.1Coupling protein TraD; Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Couples the transferosome to a type IV secretion system. Probably forms a pore through which single-stranded plasmid DNA is transferred to the secretion system. The last 37 residues are important for determining plasmid specificity and transfer efficiency, with additional specificity conferred by the TraD-TraM pair; Belongs to the T [...] (656 aa)
ANI78552.1Uncharacterized protein; Involved in the secretion of an unknown compound; Belongs to the GSP D family; Contains 1 BON domain. (506 aa)
tatASec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (79 aa)
ANI78568.1Sec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation; Belongs to the TatB family. (143 aa)
Your Current Organism:
Sphingobium sp. EP60837
NCBI taxonomy Id: 1855519
Other names: S. sp. EP60837
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