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marS marS phrB phrB yarS yarS cysH cysH asnB asnB iarS iarS ribF ribF coaD coaD varS varS tilS tilS carS carS warS warS guaA-2 guaA-2 mnmA mnmA qarS qarS nadE nadE ANI77796.1 ANI77796.1 larS larS panC panC nadD nadD lysK lysK gluQ gluQ argG argG queC queC rarS rarS ANI78643.1 ANI78643.1 ANI78644.1 ANI78644.1 earS earS ANI79183.1 ANI79183.1 cysD cysD qns1 qns1
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
marSMethionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (520 aa)
phrBDeoxyribodipyrimidine photo-lyase; Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. Belongs to the DNA photolyase class-1 family; Contains 1 photolyase/cryptochrome alpha/beta domain; KEGG: cak:Caul_2919 deoxyribodipyrimidine photo-lyase. (458 aa)
yarSTyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (405 aa)
cysHPhosphoadenylyl-sulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (263 aa)
asnBAsparagine synthase (glutamine-hydrolyzing); Main asparagine synthetase in vegetative cells. Belongs to the asparagine synthetase family; Contains 1 glutamine amidotransferase type-2 domain; KEGG: nhl:Nhal_3235 asparagine synthase (glutamine-hydrolysing). (631 aa)
iarSIsoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (961 aa)
ribFRiboflavin kinase; Belongs to the RibF family; KEGG: syb:TZ53_20235 riboflavin kinase / FMN adenylyltransferase. (313 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa)
varSValine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (899 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (315 aa)
carSCysteine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family; KEGG: sjp:SJA_C1-33290 cysteinyl-tRNA synthetase. (505 aa)
warSTryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (334 aa)
guaA-2GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (519 aa)
mnmAtRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (391 aa)
qarSGlutamine--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (469 aa)
nadENAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (551 aa)
ANI77796.1Hypothetical protein. (176 aa)
larSLeucine--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily; KEGG: sjp:SJA_C1-00420 leucyl-tRNA synthetase. (838 aa)
panCPantoate--beta-alanine ligase (AMP-forming); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (209 aa)
lysKLysine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family; KEGG: sjp:SJA_C1-32460 lysyl-tRNA synthetase, class I. (525 aa)
gluQGlutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family; KEGG: sjp:SJA_C1-07950 glutamyl-Q tRNA(Asp) synthetase; Ligases forming aminoacyl-tRNA and related compounds. (310 aa)
argGBelongs to the argininosuccinate synthase family. Type 1 subfamily; KEGG: lip:LI0656 argininosuccinate synthase. (405 aa)
queC7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (230 aa)
rarSArginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family; KEGG: pgv:SL003B_2346 arginyl-tRNA synthetase. (575 aa)
ANI78643.1The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl- CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Involved in leucine catabolism and in phytol degradation; Belongs to the ETF beta-subunit/FixA family. (249 aa)
ANI78644.1The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity); Belongs to the ETF alpha-subunit/FixB family. (310 aa)
earSGlutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (487 aa)
ANI79183.1KEGG: sphk:SKP52_24275 asparagine synthase (glutamine-hydrolysing). (572 aa)
cysDSulfate adenylyltransferase; Belongs to the PAPS reductase family. CysD subfamily; KEGG: tdn:Suden_0157 sulfate adenylyltransferase subunit 2. (319 aa)
qns1NAD(+) synthase (glutamine-hydrolyzing); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (686 aa)
Your Current Organism:
Sphingobium sp. EP60837
NCBI taxonomy Id: 1855519
Other names: S. sp. EP60837
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