STRINGSTRING
dnaA dnaA walR walR walK walK vanY_1 vanY_1 saeR saeR saeS saeS ypdA ypdA lytR_1 lytR_1 lrgA lrgA lrgB lrgB narG narG narY narY narX_1 narX_1 narX_2 narX_2 ARQ05920.1 ARQ05920.1 nreB nreB nreC nreC kdpC kdpC kdpB kdpB kdpA kdpA kdpD kdpD kdpE kdpE narT narT des des graR graR graS graS yxdL yxdL bceB bceB ARQ06174.1 ARQ06174.1 uhpT uhpT dltA dltA patA_1 patA_1 dltC dltC ARQ06425.1 ARQ06425.1 kapB kapB ARQ06509.1 ARQ06509.1 kinD kinD wbpA_1 wbpA_1 wbpA_2 wbpA_2 ythA ythA ythB ythB ctaA ctaA phoB phoB glnA glnA mprF mprF arlS arlS arlR_1 arlR_1 srrB srrB srrA srrA spo0A spo0A pstS pstS phoR phoR phoP phoP htrA htrA vraR_2 vraR_2 vraS vraS ARQ07654.1 ARQ07654.1 ywqE ywqE vanY_2 vanY_2 vanYB vanYB agrB agrB ARQ07714.1 ARQ07714.1 agrA agrA mnaA mnaA ptpB ptpB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (445 aa)
walRTranscriptional regulatory protein WalR; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (233 aa)
walKSensor protein kinase WalK; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (612 aa)
vanY_1D-alanyl-D-alanine carboxypeptidase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (235 aa)
saeRResponse regulator SaeR; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (231 aa)
saeSHistidine protein kinase SaeS; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (339 aa)
ypdASensor histidine kinase YpdA; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (583 aa)
lytR_1Sensory transduction protein LytR; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (236 aa)
lrgAAntiholin-like protein LrgA; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (141 aa)
lrgBAntiholin-like protein LrgB; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses; Belongs to the CidB/LrgB family. LrgB subfamily. (235 aa)
narGRespiratory nitrate reductase 1 alpha chain; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1224 aa)
narYRespiratory nitrate reductase 2 beta chain; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (516 aa)
narX_1Nitrate reductase-like protein NarX; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (192 aa)
narX_2Nitrate reductase-like protein NarX; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (224 aa)
ARQ05920.1Hypothetical protein; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (153 aa)
nreBOxygen sensor histidine kinase NreB; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (336 aa)
nreCOxygen regulatory protein NreC; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (216 aa)
kdpCPotassium-transporting ATPase C chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (192 aa)
kdpBPotassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (667 aa)
kdpAPotassium-transporting ATPase A chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (554 aa)
kdpDSensor protein KdpD; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (838 aa)
kdpEKDP operon transcriptional regulatory protein KdpE; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (228 aa)
narTPutative nitrate transporter NarT; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (385 aa)
desFatty acid desaturase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (337 aa)
graRResponse regulator protein GraR; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (227 aa)
graSSensor histidine kinase GraS; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (293 aa)
yxdLABC transporter ATP-binding protein YxdL; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (249 aa)
bceBBacitracin export permease protein BceB; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (656 aa)
ARQ06174.1Putative response regulatory protein; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (243 aa)
uhpTHexose phosphate transport protein; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (461 aa)
dltAD-alanine--poly(phosphoribitol) ligase subunit 1; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (469 aa)
patA_1Peptidoglycan O-acetyltransferase; Could be involved in the transport of activated D-alanine through the membrane. (403 aa)
dltCD-alanine--poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (78 aa)
ARQ06425.1Hypothetical protein; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; DltD C-terminal region. (388 aa)
kapBKinase-associated lipoprotein B precursor; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (125 aa)
ARQ06509.1Serine protease HtrA-like protein; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (501 aa)
kinDSporulation kinase D; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (487 aa)
wbpA_1UDP-N-acetyl-D-glucosamine 6-dehydrogenase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (418 aa)
wbpA_2UDP-N-acetyl-D-glucosamine 6-dehydrogenase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (420 aa)
ythAPutative cytochrome bd menaquinol oxidase subunit I; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (450 aa)
ythBPutative cytochrome bd menaquinol oxidase subunit II; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (339 aa)
ctaAHeme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. (300 aa)
phoBAlkaline phosphatase 3 precursor; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; Belongs to the alkaline phosphatase family. (465 aa)
glnAGlutamine synthetase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; Belongs to the glutamine synthetase family. (445 aa)
mprFPhosphatidylglycerol lysyltransferase; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. (844 aa)
arlSSignal transduction histidine-protein kinase ArlS; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (456 aa)
arlR_1Response regulator ArlR; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (223 aa)
srrBSensor protein SrrB; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (585 aa)
srrATranscriptional regulatory protein SrrA; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (235 aa)
spo0AStage 0 sporulation protein A; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (223 aa)
pstSPhosphate-binding protein PstS precursor; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (320 aa)
phoRAlkaline phosphatase synthesis sensor protein PhoR; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (570 aa)
phoPAlkaline phosphatase synthesis transcriptional regulatory protein PhoP; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (237 aa)
htrASerine protease Do-like HtrA; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (397 aa)
vraR_2Response regulator protein VraR; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (207 aa)
vraSSensor protein VraS; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (339 aa)
ARQ07654.1Hypothetical protein; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (231 aa)
ywqETyrosine-protein phosphatase YwqE; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (267 aa)
vanY_2D-alanyl-D-alanine carboxypeptidase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (216 aa)
vanYBD-alanyl-D-alanine carboxypeptidase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (227 aa)
agrBAccessory gene regulator protein B; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (176 aa)
ARQ07714.1Sensory histidine kinase DcuS; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (436 aa)
agrAAccessory gene regulator protein A; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern. (238 aa)
mnaAUDP-N-acetylglucosamine 2-epimerase; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (380 aa)
ptpBLow molecular weight protein-tyrosine-phosphatase PtpB; Bacteria and source DNA available from Institute of Veterinary Bacteriology, University Bern; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (140 aa)
Your Current Organism:
Macrococcus canis
NCBI taxonomy Id: 1855823
Other names: CCM 8748, CCOS 969, CCOS:969, CCUG 68920, DSM 101690, M. canis, Macrococcus canis Gobeli Brawand et al. 2017, Macrococcus sp. KM45013, strain KM 45013
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