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| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (479 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. (202 aa) |
| | leuA | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (399 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (353 aa) |
| | metX_1 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (354 aa) |
| | LuPra_00228 | Uncharacterized protein. (260 aa) |
| | xecA1 | 2-hydroxypropyl-CoM lyase. (344 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (359 aa) |
| | pat | Phenylalanine aminotransferase. (375 aa) |
| | msrC | Free methionine-R-sulfoxide reductase. (165 aa) |
| | alaA_1 | Glutamate-pyruvate aminotransferase AlaA. (388 aa) |
| | trpB_1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | hprA | Glycerate dehydrogenase. (401 aa) |
| | LuPra_01908 | Uncharacterized protein. (491 aa) |
| | serC_1 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | serA_1 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (395 aa) |
| | LuPra_01911 | Uncharacterized protein. (61 aa) |
| | araC_1 | L-arabonate dehydratase; Belongs to the IlvD/Edd family. (575 aa) |
| | pucG | Purine catabolism protein PucG. (363 aa) |
| | sdaB_1 | L-serine dehydratase 2. (539 aa) |
| | metE_1 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (381 aa) |
| | araD_1 | L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (306 aa) |
| | mdeA_1 | Methionine gamma-lyase. (437 aa) |
| | metX_2 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (342 aa) |
| | yitJ_1 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (635 aa) |
| | LuPra_03028 | Uncharacterized protein. (248 aa) |
| | ilvD_1 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (650 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (345 aa) |
| | ilvH | Acetolactate synthase small subunit. (184 aa) |
| | ilvB | Acetolactate synthase. (569 aa) |
| | ilvD_2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (574 aa) |
| | pheA_1 | Prephenate dehydratase. (289 aa) |
| | mdeA_2 | Methionine gamma-lyase. (391 aa) |
| | serA_2 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (420 aa) |
| | sdaB_2 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (472 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (168 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (263 aa) |
| | dat_1 | D-alanine aminotransferase. (295 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (501 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1228 aa) |
| | LuPra_03597 | Putative epimerase/dehydratase. (349 aa) |
| | tyrC | Arogenate dehydrogenase. (467 aa) |
| | aroF_1 | Phospho-2-dehydro-3-deoxyheptonate aldolase. (349 aa) |
| | pheA_2 | P-protein. (106 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa) |
| | trpB_2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (209 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (326 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | pabA | Para-aminobenzoate synthase glutamine amidotransferase component II. (189 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa) |
| | aroE | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (493 aa) |
| | aroF_2 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (406 aa) |
| | hom | Homoserine dehydrogenase. (414 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (308 aa) |
| | thrC_1 | Threonine synthase. (418 aa) |
| | lysC_1 | Aspartokinase; Belongs to the aspartokinase family. (447 aa) |
| | metE_2 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (367 aa) |
| | metC | Cystathionine beta-lyase. (386 aa) |
| | cbs | Cystathionine beta-synthase. (455 aa) |
| | araD_2 | L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (302 aa) |
| | ilvA | L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (505 aa) |
| | metK | S-adenosylmethionine synthase; Belongs to the AdoMet synthase family. (369 aa) |
| | thrC_2 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (438 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa) |
| | dapA_1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa) |
| | ttuC | Putative tartrate dehydrogenase/decarboxylase TtuC. (352 aa) |
| | ltaA_1 | L-allo-threonine aldolase. (378 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa) |
| | LuPra_05583 | Uncharacterized protein. (311 aa) |
| | hisC_1 | Histidinol-phosphate aminotransferase. (382 aa) |
| | soxA | Monomeric sarcosine oxidase. (373 aa) |
| | yitJ_2 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (314 aa) |
| | ltaA_2 | L-allo-threonine aldolase. (383 aa) |
| | ilvK | Branched-chain-amino-acid aminotransferase 2. (360 aa) |
| | LuPra_05716 | Uncharacterized protein. (78 aa) |
| | LuPra_05717 | Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family. (289 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (283 aa) |
| | dapA_2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Belongs to the DapB family. (233 aa) |
| | lysC_2 | Aspartokinase; Belongs to the aspartokinase family. (461 aa) |
| | asd2 | Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa) |
| | tdcB_1 | L-threonine dehydratase catabolic TdcB. (317 aa) |
| | LuPra_06005 | FAA_hydrolase domain-containing protein. (275 aa) |
| | tdcB_2 | L-threonine dehydratase catabolic TdcB. (317 aa) |
| | LuPra_06087 | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (103 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (294 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | hisC_2 | Histidinol-phosphate aminotransferase. (414 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (270 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (227 aa) |
| | araC_2 | L-arabonate dehydratase; Belongs to the IlvD/Edd family. (566 aa) |
| | LuPra_06195 | 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase. (393 aa) |
| | alaA_2 | Aminotransferase. (406 aa) |
