(33 nodes) Valine, leucine and isoleucine biosynthesis, and Lysine biosynthesis network (Luteitalea pratensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	leuC	3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (479 aa)
	leuD	3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. (202 aa)
	leuA	2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (399 aa)
	leuB	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (353 aa)
	alaA_1	Glutamate-pyruvate aminotransferase AlaA. (388 aa)
	araC_1	L-arabonate dehydratase; Belongs to the IlvD/Edd family. (575 aa)
	araD_1	L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (306 aa)
	ilvD_1	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (650 aa)
	ilvC	Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (345 aa)
	ilvH	Acetolactate synthase small subunit. (184 aa)
	ilvB	Acetolactate synthase. (569 aa)
	ilvD_2	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (574 aa)
	dapF	Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (263 aa)
	dat_1	D-alanine aminotransferase. (295 aa)
	hom	Homoserine dehydrogenase. (414 aa)
	thrB	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (308 aa)
	thrC_1	Threonine synthase. (418 aa)
	lysC_1	Aspartokinase; Belongs to the aspartokinase family. (447 aa)
	araD_2	L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (302 aa)
	dapA_1	4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa)
	ttuC	Putative tartrate dehydrogenase/decarboxylase TtuC. (352 aa)
	lysA	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa)
	ilvK	Branched-chain-amino-acid aminotransferase 2. (360 aa)
	LuPra_05716	Uncharacterized protein. (78 aa)
	LuPra_05717	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family. (289 aa)
	dapD	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (283 aa)
	dapA_2	4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa)
	dapB	4-hydroxy-tetrahydrodipicolinate reductase; Belongs to the DapB family. (233 aa)
	lysC_2	Aspartokinase; Belongs to the aspartokinase family. (461 aa)
	asd2	Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
	LuPra_06005	FAA_hydrolase domain-containing protein. (275 aa)
	araC_2	L-arabonate dehydratase; Belongs to the IlvD/Edd family. (566 aa)
	alaA_2	Aminotransferase. (406 aa)

Your Current Organism:

Luteitalea pratensis

NCBI taxonomy Id: 1855912
Other names: Acidobacteria bacterium DSM 100886, Acidobacteria bacterium HEG_-6_39, DSM 100886, KCTC 52215, L. pratensis, Luteitalea pratensis Vieira et al. 2017, strain HEG_-6_39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LuPra_05716	LuPra_05717	LuPra_05716	LuPra_05717	Uncharacterized protein.	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family.	0.773
LuPra_05716	asd2	LuPra_05716	LuPra_05723	Uncharacterized protein.	Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family.	0.437
LuPra_05716	dapA_2	LuPra_05716	LuPra_05720	Uncharacterized protein.	4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	0.752
LuPra_05716	dapB	LuPra_05716	LuPra_05721	Uncharacterized protein.	4-hydroxy-tetrahydrodipicolinate reductase; Belongs to the DapB family.	0.438
LuPra_05716	dapD	LuPra_05716	LuPra_05719	Uncharacterized protein.	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family.	0.752
LuPra_05716	lysC_2	LuPra_05716	LuPra_05722	Uncharacterized protein.	Aspartokinase; Belongs to the aspartokinase family.	0.438
LuPra_05717	LuPra_05716	LuPra_05717	LuPra_05716	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family.	Uncharacterized protein.	0.773
LuPra_05717	asd2	LuPra_05717	LuPra_05723	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family.	Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family.	0.437
LuPra_05717	dapA_2	LuPra_05717	LuPra_05720	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family.	4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).	0.752
LuPra_05717	dapB	LuPra_05717	LuPra_05721	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family.	4-hydroxy-tetrahydrodipicolinate reductase; Belongs to the DapB family.	0.449
LuPra_05717	dapD	LuPra_05717	LuPra_05719	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family.	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family.	0.771
LuPra_05717	lysC_2	LuPra_05717	LuPra_05722	Cytokinin riboside 5'-monophosphate phosphoribohydrolase; Belongs to the LOG family.	Aspartokinase; Belongs to the aspartokinase family.	0.441
LuPra_06005	araC_1	LuPra_06005	LuPra_02056	FAA_hydrolase domain-containing protein.	L-arabonate dehydratase; Belongs to the IlvD/Edd family.	0.406
LuPra_06005	araC_2	LuPra_06005	LuPra_06149	FAA_hydrolase domain-containing protein.	L-arabonate dehydratase; Belongs to the IlvD/Edd family.	0.933
LuPra_06005	ilvD_1	LuPra_06005	LuPra_03114	FAA_hydrolase domain-containing protein.	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.	0.932
alaA_1	alaA_2	LuPra_00476	LuPra_06198	Glutamate-pyruvate aminotransferase AlaA.	Aminotransferase.	0.927
alaA_1	dat_1	LuPra_00476	LuPra_03451	Glutamate-pyruvate aminotransferase AlaA.	D-alanine aminotransferase.	0.910
alaA_1	hom	LuPra_00476	LuPra_03863	Glutamate-pyruvate aminotransferase AlaA.	Homoserine dehydrogenase.	0.433
alaA_1	ilvD_2	LuPra_00476	LuPra_03183	Glutamate-pyruvate aminotransferase AlaA.	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.	0.910
alaA_1	ilvK	LuPra_00476	LuPra_05710	Glutamate-pyruvate aminotransferase AlaA.	Branched-chain-amino-acid aminotransferase 2.	0.910

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