(30 nodes) Cysteine and methionine metabolism, and Glycine, serine and threonine metabolism network (Luteitalea pratensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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protein homology

Your Input:
	metX_1	Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (354 aa)
	LuPra_00228	Uncharacterized protein. (260 aa)
	xecA1	2-hydroxypropyl-CoM lyase. (344 aa)
	msrC	Free methionine-R-sulfoxide reductase. (165 aa)
	trpB_1	Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa)
	pucG	Purine catabolism protein PucG. (363 aa)
	sdaB_1	L-serine dehydratase 2. (539 aa)
	metE_1	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (381 aa)
	mdeA_1	Methionine gamma-lyase. (437 aa)
	metX_2	Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (342 aa)
	yitJ_1	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (635 aa)
	LuPra_03028	Uncharacterized protein. (248 aa)
	mdeA_2	Methionine gamma-lyase. (391 aa)
	sdaB_2	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (472 aa)
	ahcY	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (501 aa)
	metH	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1228 aa)
	LuPra_03597	Putative epimerase/dehydratase. (349 aa)
	metE_2	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (367 aa)
	metC	Cystathionine beta-lyase. (386 aa)
	cbs	Cystathionine beta-synthase. (455 aa)
	ilvA	L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (505 aa)
	metK	S-adenosylmethionine synthase; Belongs to the AdoMet synthase family. (369 aa)
	thrC_2	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (438 aa)
	ltaA_1	L-allo-threonine aldolase. (378 aa)
	soxA	Monomeric sarcosine oxidase. (373 aa)
	yitJ_2	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (314 aa)
	ltaA_2	L-allo-threonine aldolase. (383 aa)
	tdcB_1	L-threonine dehydratase catabolic TdcB. (317 aa)
	tdcB_2	L-threonine dehydratase catabolic TdcB. (317 aa)
	LuPra_06195	8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase. (393 aa)

Your Current Organism:

Luteitalea pratensis

NCBI taxonomy Id: 1855912
Other names: Acidobacteria bacterium DSM 100886, Acidobacteria bacterium HEG_-6_39, DSM 100886, KCTC 52215, L. pratensis, Luteitalea pratensis Vieira et al. 2017, strain HEG_-6_39

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LuPra_00228	LuPra_03028	LuPra_00228	LuPra_03028	Uncharacterized protein.	Uncharacterized protein.	0.924
LuPra_00228	ahcY	LuPra_00228	LuPra_03588	Uncharacterized protein.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.800
LuPra_00228	cbs	LuPra_00228	LuPra_04149	Uncharacterized protein.	Cystathionine beta-synthase.	0.800
LuPra_00228	mdeA_2	LuPra_00228	LuPra_03204	Uncharacterized protein.	Methionine gamma-lyase.	0.800
LuPra_00228	metE_1	LuPra_00228	LuPra_02354	Uncharacterized protein.	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase.	0.824
LuPra_00228	metE_2	LuPra_00228	LuPra_04022	Uncharacterized protein.	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase.	0.800
LuPra_00228	metH	LuPra_00228	LuPra_03590	Uncharacterized protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.803
LuPra_00228	xecA1	LuPra_00228	LuPra_00255	Uncharacterized protein.	2-hydroxypropyl-CoM lyase.	0.823
LuPra_00228	yitJ_1	LuPra_00228	LuPra_03023	Uncharacterized protein.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	0.803
LuPra_00228	yitJ_2	LuPra_00228	LuPra_05682	Uncharacterized protein.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	0.841
LuPra_03028	LuPra_00228	LuPra_03028	LuPra_00228	Uncharacterized protein.	Uncharacterized protein.	0.924
LuPra_03028	ahcY	LuPra_03028	LuPra_03588	Uncharacterized protein.	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.800
LuPra_03028	cbs	LuPra_03028	LuPra_04149	Uncharacterized protein.	Cystathionine beta-synthase.	0.800
LuPra_03028	mdeA_2	LuPra_03028	LuPra_03204	Uncharacterized protein.	Methionine gamma-lyase.	0.800
LuPra_03028	metE_1	LuPra_03028	LuPra_02354	Uncharacterized protein.	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase.	0.800
LuPra_03028	metE_2	LuPra_03028	LuPra_04022	Uncharacterized protein.	5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase.	0.800
LuPra_03028	metH	LuPra_03028	LuPra_03590	Uncharacterized protein.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.803
LuPra_03028	xecA1	LuPra_03028	LuPra_00255	Uncharacterized protein.	2-hydroxypropyl-CoM lyase.	0.800
LuPra_03028	yitJ_1	LuPra_03028	LuPra_03023	Uncharacterized protein.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	0.803
LuPra_03028	yitJ_2	LuPra_03028	LuPra_05682	Uncharacterized protein.	Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase.	0.834

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