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mltF_2 mltF_2 ilvD_1 ilvD_1 ilvD_2 ilvD_2 pheA_1 pheA_1 LuPra_03327 LuPra_03327 nnr nnr murQ_2 murQ_2 pdg pdg trpA trpA trpB_2 trpB_2 aroE aroE aroF_2 aroF_2 thrC_1 thrC_1 LuPra_03932 LuPra_03932 leuC leuC leuD leuD cah cah LuPra_00073 LuPra_00073 mutM mutM eno eno nth nth LuPra_00663 LuPra_00663 fpg2 fpg2 LuPra_00777 LuPra_00777 trpB_1 trpB_1 pel pel LuPra_01824 LuPra_01824 murQ_1 murQ_1 LuPra_01929 LuPra_01929 araC_1 araC_1 pknD_1 pknD_1 mltF_1 mltF_1 can can uxuA_1 uxuA_1 uxuA_2 uxuA_2 araD_1 araD_1 LuPra_02952 LuPra_02952 paaF_1 paaF_1 araD_2 araD_2 mqnA mqnA echA8 echA8 LuPra_04459 LuPra_04459 thrC_2 thrC_2 acn acn LuPra_04751 LuPra_04751 aroB aroB rfbB rfbB gmd gmd dapA_1 dapA_1 fumC fumC fabZ_1 fabZ_1 nei1 nei1 dapA_2 dapA_2 LuPra_05788 LuPra_05788 LuPra_05794 LuPra_05794 paaF_2 paaF_2 cysG_4 cysG_4 hemB hemB LuPra_06063 LuPra_06063 dapA_3 dapA_3 hisB hisB araC_2 araC_2 LuPra_06150 LuPra_06150 fabZ_2 fabZ_2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
mltF_2Membrane-bound lytic murein transglycosylase F. (539 aa)
ilvD_1Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (650 aa)
ilvD_2Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (574 aa)
pheA_1Prephenate dehydratase. (289 aa)
LuPra_03327Putative secreted hydrolase. (429 aa)
nnrADP-dependent (S)-NAD(P)H-hydrate dehydratase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to all [...] (528 aa)
murQ_2N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (316 aa)
pdgEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (304 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa)
trpB_2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa)
aroEShikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (493 aa)
aroF_2Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (406 aa)
thrC_1Threonine synthase. (418 aa)
LuPra_03932Putative pterin-4-alpha-carbinolamine dehydratase. (100 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (479 aa)
leuD3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. (202 aa)
cahCarbonic anhydrase. (301 aa)
LuPra_00073Secondary thiamine-phosphate synthase enzyme. (142 aa)
mutMFormamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Belongs to the FPG family. (287 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
nthEndonuclease III. (233 aa)
LuPra_00663Uncharacterized protein. (301 aa)
fpg2Putative formamidopyrimidine-DNA glycosylase-like protein; Belongs to the FPG family. (303 aa)
LuPra_00777Secondary thiamine-phosphate synthase enzyme. (167 aa)
trpB_1Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa)
pelPectate lyase. (452 aa)
LuPra_01824Uncharacterized protein; Belongs to the DapA family. (347 aa)
murQ_1N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (299 aa)
LuPra_01929Secondary thiamine-phosphate synthase enzyme. (169 aa)
araC_1L-arabonate dehydratase; Belongs to the IlvD/Edd family. (575 aa)
pknD_1Serine/threonine-protein kinase PknD. (354 aa)
mltF_1Membrane-bound lytic murein transglycosylase F. (516 aa)
canCarbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family. (223 aa)
uxuA_1Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (359 aa)
uxuA_2Mannonate dehydratase; Catalyzes the dehydration of D-mannonate. (373 aa)
araD_1L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (306 aa)
LuPra_02952Queuosine biosynthesis protein QueD. (145 aa)
paaF_12,3-dehydroadipyl-CoA hydratase. (264 aa)
araD_2L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (302 aa)
mqnAChorismate dehydratase; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (284 aa)
echA8Putative enoyl-CoA hydratase echA8. (260 aa)
LuPra_04459Putative integral membrane protein. (131 aa)
thrC_2Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (438 aa)
acnAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (899 aa)
LuPra_04751Secondary thiamine-phosphate synthase enzyme. (137 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa)
rfbBdTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (353 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (329 aa)
dapA_14-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
fabZ_13-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ. (143 aa)
nei1DNA glycosylase/AP lyase Nei 1. (330 aa)
dapA_24-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa)
LuPra_05788Putative integral membrane protein. (390 aa)
LuPra_05794Pectate lyase. (402 aa)
paaF_22,3-dehydroadipyl-CoA hydratase. (256 aa)
cysG_4Uroporphyrinogen-III C-methyltransferase. (513 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (323 aa)
LuPra_06063Putative pterin-4-alpha-carbinolamine dehydratase. (101 aa)
dapA_34-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa)
hisBImidazoleglycerol-phosphate dehydratase. (195 aa)
araC_2L-arabonate dehydratase; Belongs to the IlvD/Edd family. (566 aa)
LuPra_061505-dehydro-4-deoxyglucarate dehydratase. (311 aa)
fabZ_23-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ. (153 aa)
Your Current Organism:
Luteitalea pratensis
NCBI taxonomy Id: 1855912
Other names: Acidobacteria bacterium DSM 100886, Acidobacteria bacterium HEG_-6_39, DSM 100886, KCTC 52215, L. pratensis, Luteitalea pratensis Vieira et al. 2017, strain HEG_-6_39
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