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| | ilvA | L-threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (505 aa) |
| | serS | Serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (479 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Belongs to the LeuD family. (202 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (353 aa) |
| | folA_1 | Dihydrofolate reductase. (179 aa) |
| | metX_1 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (354 aa) |
| | mtnC | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (247 aa) |
| | mtnD | Acireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (188 aa) |
| | LuPra_00096 | Gluconolactonase. (1018 aa) |
| | LuPra_00119 | RibD_C domain-containing protein. (195 aa) |
| | LuPra_00157 | Ribonuclease Z. (340 aa) |
| | folA_2 | Dihydrofolate reductase. (178 aa) |
| | xecA1 | 2-hydroxypropyl-CoM lyase. (344 aa) |
| | aroG | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (359 aa) |
| | pat | Phenylalanine aminotransferase. (375 aa) |
| | LuPra_00439 | RibD_C domain-containing protein. (190 aa) |
| | argH1 | Argininosuccinate lyase 1; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (491 aa) |
| | LuPra_00470 | Gluconolactonase. (450 aa) |
| | LuPra_00561 | Argininosuccinate lyase. (402 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase 3; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (347 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (295 aa) |
| | yxeP_1 | Putative hydrolase YxeP. (429 aa) |
| | argF | Ornithine carbamoyltransferase. (328 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ alpha chain; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (402 aa) |
| | argA_1 | Amino-acid acetyltransferase. (201 aa) |
| | argD | Acetylornithine aminotransferase. (403 aa) |
| | argB | Acetylglutamate kinase. (260 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (322 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (159 aa) |
| | argG_1 | Argininosuccinate synthase. (342 aa) |
| | argH | Argininosuccinate lyase. (458 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH]. (258 aa) |
| | nadA | Quinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (376 aa) |
| | gabT | 4-aminobutyrate aminotransferase GabT; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (444 aa) |
| | LuPra_00921 | Uncharacterized protein. (68 aa) |
| | LuPra_01021 | RibD_C domain-containing protein. (185 aa) |
| | LuPra_01025 | Gluconolactonase. (350 aa) |
| | trpB_1 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | LuPra_01160 | RibD_C domain-containing protein. (176 aa) |
| | LuPra_01161 | Nitrous oxide reductase family maturation protein NosD. (305 aa) |
| | LuPra_01210 | Methylthioribose kinase. (337 aa) |
| | cpg2 | Carboxypeptidase G2. (381 aa) |
| | fabB | 3-oxoacyl-(Acyl carrier protein) synthase. (349 aa) |
| | LuPra_01316 | Uncharacterized protein. (433 aa) |
| | albA_1 | Antilisterial bacteriocin subtilosin biosynthesis protein AlbA. (382 aa) |
| | LuPra_01334 | Gluconolactonase. (335 aa) |
| | LuPra_01586 | Gluconolactonase. (305 aa) |
| | acpH | Acyl carrier protein phosphodiesterase. (205 aa) |
| | gnl | Gluconolactonase. (341 aa) |
| | LuPra_01824 | Uncharacterized protein; Belongs to the DapA family. (347 aa) |
| | LuPra_01885 | Gluconolactonase. (326 aa) |
| | serC_1 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | LuPra_02011 | Nitrous oxide reductase family maturation protein NosD. (403 aa) |
| | araC_1 | L-arabonate dehydratase; Belongs to the IlvD/Edd family. (575 aa) |
| | LuPra_02089 | Gluconolactonase. (345 aa) |
| | cysK1 | O-acetylserine sulfhydrylase. (67 aa) |
| | dapE_1 | Putative succinyl-diaminopimelate desuccinylase. (435 aa) |
| | sir | Sulfite reductase [ferredoxin]; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (561 aa) |
| | LuPra_02258 | Putative hydrolase. (412 aa) |
| | amaB_1 | N-carbamoyl-L-amino acid hydrolase. (404 aa) |
| | LuPra_02266 | F5/8 type C domain protein. (908 aa) |
| | cysM | Cysteine synthase B. (313 aa) |
| | LuPra_02331 | Putative acetyltransferase. (164 aa) |
| | LuPra_02347 | Asparagine synthase (Glutamine-hydrolyzing). (442 aa) |
| | metE_1 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (381 aa) |
| | LuPra_02432 | Succinyl-diaminopimelate desuccinylase. (505 aa) |
| | araD_1 | L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (306 aa) |
| | yxeP_2 | Putative hydrolase YxeP. (209 aa) |
| | LuPra_02935 | Phosphotransferase enzyme family protein. (370 aa) |
| | metX_2 | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (342 aa) |
| | LuPra_02966 | Argininosuccinate lyase. (423 aa) |
| | fabF_1 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (429 aa) |
| | asnB_1 | Asparagine synthetase [glutamine-hydrolyzing] 1. (607 aa) |
| | ilvD_1 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (650 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (345 aa) |
| | ilvH | Acetolactate synthase small subunit. (184 aa) |
| | ilvD_2 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (574 aa) |
| | pheA_1 | Prephenate dehydratase. (289 aa) |
| | abgB_3 | P-aminobenzoyl-glutamate hydrolase subunit B. (556 aa) |
| | LuPra_03266 | Argininosuccinate lyase. (400 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (168 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (440 aa) |
| | asnB_2 | Asparagine synthetase [glutamine-hydrolyzing] 1. (642 aa) |
| | LuPra_03411 | Molybdenum cofactor biosynthesis protein A. (382 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (263 aa) |
| | dat_1 | D-alanine aminotransferase. (295 aa) |
| | LuPra_03455 | HAD phosphoserine phosphatase-like hydrolase, family IB. (274 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa) |
| | qorA_1 | Quinone oxidoreductase 1. (325 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1228 aa) |
| | LuPra_03623 | Carbamoyl phosphate synthase-like protein. (338 aa) |
| | tyrC | Arogenate dehydrogenase. (467 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa) |
| | trpB_2 | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (209 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (326 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (341 aa) |
| | aroE | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (493 aa) |
| | aroF_2 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (406 aa) |
| | tuaD_1 | UDP-glucose 6-dehydrogenase. (444 aa) |
| | dapE_2 | Succinyl-diaminopimelate desuccinylase. (433 aa) |
| | hom | Homoserine dehydrogenase. (414 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (308 aa) |
| | thrC_1 | Threonine synthase. (418 aa) |
| | lysC_1 | Aspartokinase; Belongs to the aspartokinase family. (447 aa) |
| | LuPra_03978 | Uncharacterized protein. (583 aa) |
| | metE_2 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. (367 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (273 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (308 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (158 aa) |
| | accA1_1 | Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (512 aa) |
| | araD_2 | L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (302 aa) |
| | phnP | Phosphoribosyl 1,2-cyclic phosphodiesterase. (260 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1083 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (380 aa) |
| | LuPra_04416 | Uncharacterized protein. (345 aa) |
| | fabF_2 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (413 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (81 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (310 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | mtnP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (287 aa) |
| | LuPra_04583 | Pyrroloquinoline quinone biosynthesis protein PqqE. (342 aa) |
| | thrC_2 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (438 aa) |
| | kynU | Kynureninase. (384 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (304 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (230 aa) |
| | mtnA | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (365 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa) |
| | alr | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (385 aa) |
| | tuaD_2 | UDP-glucose 6-dehydrogenase. (445 aa) |
| | dapA_1 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa) |
| | desA1 | Acyl-[acyl-carrier-protein] desaturase desA1. (318 aa) |
| | LuPra_05229 | Uncharacterized protein. (56 aa) |
| | albA_2 | Antilisterial bacteriocin subtilosin biosynthesis protein AlbA. (475 aa) |
| | LuPra_05324 | Nitrous oxide reductase family maturation protein NosD. (380 aa) |
| | LuPra_05347 | Gluconolactonase. (377 aa) |
| | qorA_2 | Quinone oxidoreductase 1. (370 aa) |
| | ttuC | Putative tartrate dehydrogenase/decarboxylase TtuC. (352 aa) |
| | dapE_3 | Putative succinyl-diaminopimelate desuccinylase. (478 aa) |
| | amaB_2 | N-carbamoyl-L-amino acid hydrolase. (451 aa) |
| | argG_2 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (411 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa) |
| | LuPra_05504 | Molybdenum cofactor biosynthesis protein A. (453 aa) |
| | LuPra_05526 | Gluconolactonase. (332 aa) |
| | gltB_2 | Ferredoxin-dependent glutamate synthase 1. (1541 aa) |
| | fabF_3 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa) |
| | LuPra_05572 | Acyl carrier protein. (85 aa) |
| | fabF_4 | 3-oxoacyl-[acyl-carrier-protein] synthase 2; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (381 aa) |
| | fabZ_1 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ. (143 aa) |
| | icd_2 | Isocitrate dehydrogenase [NADP]. (337 aa) |
| | argE_1 | Acetylornithine deacetylase. (377 aa) |
| | psdht | Phenylserine dehydratase. (320 aa) |
| | hisC_1 | Histidinol-phosphate aminotransferase. (382 aa) |
| | LuPra_05658 | Putative oxidoreductase. (308 aa) |
| | yitJ_2 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase. (314 aa) |
| | LuPra_05683 | Putative acetyltransferase. (205 aa) |
| | ilvK | Branched-chain-amino-acid aminotransferase 2. (360 aa) |
| | argE_2 | Acetylornithine deacetylase. (333 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (283 aa) |
| | dapA_2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Belongs to the DapB family. (233 aa) |
| | lysC_2 | Aspartokinase; Belongs to the aspartokinase family. (461 aa) |
| | asd2 | Aspartate-semialdehyde dehydrogenase 2; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa) |
| | dapE_4 | Putative succinyl-diaminopimelate desuccinylase. (478 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (281 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa) |
| | tdcB_1 | L-threonine dehydratase catabolic TdcB. (317 aa) |
| | LuPra_05981 | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. (190 aa) |
| | dapE_5 | Succinyl-diaminopimelate desuccinylase. (457 aa) |
| | tdcB_2 | L-threonine dehydratase catabolic TdcB. (317 aa) |
| | LuPra_06050 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (321 aa) |
| | dapA_3 | 4-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa) |
| | LuPra_06087 | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (103 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (294 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | hisC_2 | Histidinol-phosphate aminotransferase. (414 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisH1 | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (270 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (227 aa) |
| | araC_2 | L-arabonate dehydratase; Belongs to the IlvD/Edd family. (566 aa) |
| | LuPra_06150 | 5-dehydro-4-deoxyglucarate dehydratase. (311 aa) |
| | glnA_2 | Glutamine synthetase. (470 aa) |
| | LuPra_06195 | 8-amino-7-oxononanoate synthase/2-amino-3-ketobutyrate coenzyme A ligase. (393 aa) |
| | asnO | Asparagine synthetase [glutamine-hydrolyzing] 3. (598 aa) |
| | fabZ_2 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ. (153 aa) |
| | selD | Selenide, water dikinase. (319 aa) |
