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leuA leuA aroG aroG rlmN rlmN pdxJ pdxJ queE queE pyrF pyrF pyrDB pyrDB mqnE mqnE preA_1 preA_1 nemA nemA albA_1 albA_1 LuPra_01513 LuPra_01513 lldD_1 lldD_1 LuPra_01824 LuPra_01824 LuPra_01829 LuPra_01829 namA_1 namA_1 lldD_2 lldD_2 pflA pflA LuPra_02439 LuPra_02439 araD_1 araD_1 kdgA kdgA hxlA hxlA dus_1 dus_1 LuPra_03158 LuPra_03158 moaA1 moaA1 deoC2 deoC2 LuPra_03411 LuPra_03411 eutB eutB guaB guaB spsE spsE aroF_1 aroF_1 trpA trpA trpF trpF trpC trpC aroE aroE rpe rpe LuPra_03978 LuPra_03978 preA_2 preA_2 kdsA kdsA thiE thiE tenI tenI yngG yngG araD_2 araD_2 mqnC mqnC hemN_2 hemN_2 nadC nadC LuPra_04583 LuPra_04583 namA_2 namA_2 lipA lipA thiG thiG tal_1 tal_1 dapA_1 dapA_1 LuPra_05045 LuPra_05045 tpiA tpiA LuPra_05108 LuPra_05108 cfiB cfiB albA_2 albA_2 tal_2 tal_2 LuPra_05504 LuPra_05504 gltB_2 gltB_2 dapA_2 dapA_2 LuPra_05792 LuPra_05792 hemB hemB fbaB fbaB ydeM ydeM dapA_3 dapA_3 hisF hisF hisA hisA LuPra_06135 LuPra_06135 LuPra_06150 LuPra_06150 dus_2 dus_2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuA2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (399 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (359 aa)
rlmNProbable dual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (360 aa)
pdxJPyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (247 aa)
queE7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (216 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa)
pyrDBDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (316 aa)
mqnEAminodeoxyfutalosine synthase; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (364 aa)
preA_1NAD-dependent dihydropyrimidine dehydrogenase subunit PreA. (376 aa)
nemAN-ethylmaleimide reductase. (376 aa)
albA_1Antilisterial bacteriocin subtilosin biosynthesis protein AlbA. (382 aa)
LuPra_01513TIM-barrel signal transduction protein. (295 aa)
lldD_1L-lactate dehydrogenase [cytochrome]. (405 aa)
LuPra_01824Uncharacterized protein; Belongs to the DapA family. (347 aa)
LuPra_01829Nitronate monooxygenase. (359 aa)
namA_1NADPH dehydrogenase. (390 aa)
lldD_2L-lactate dehydrogenase [cytochrome]. (388 aa)
pflAPyruvate formate-lyase-activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (281 aa)
LuPra_02439Molybdenum cofactor biosynthesis protein A. (477 aa)
araD_1L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (306 aa)
kdgAKHG/KDPG aldolase. (216 aa)
hxlA3-hexulose-6-phosphate synthase. (246 aa)
dus_1Putative tRNA-dihydrouridine synthase. (369 aa)
LuPra_03158Molybdenum cofactor biosynthesis protein A. (719 aa)
moaA1GTP 3',8-cyclase; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (338 aa)
deoC2Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (294 aa)
LuPra_03411Molybdenum cofactor biosynthesis protein A. (382 aa)
eutBEthanolamine ammonia-lyase heavy chain. (477 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (513 aa)
spsESpore coat polysaccharide biosynthesis protein SpsE. (352 aa)
aroF_1Phospho-2-dehydro-3-deoxyheptonate aldolase. (349 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (266 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (209 aa)
trpCIndole-3-glycerol phosphate synthase; Belongs to the TrpC family. (326 aa)
aroEShikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (493 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
LuPra_03978Uncharacterized protein. (583 aa)
preA_2NAD-dependent dihydropyrimidine dehydrogenase subunit PreA; Catalyzes the conversion of dihydroorotate to orotate. (329 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (273 aa)
thiEThiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (217 aa)
tenIRegulatory protein TenI. (222 aa)
yngGHydroxymethylglutaryl-CoA lyase YngG. (314 aa)
araD_2L-2-keto-3-deoxyarabonate dehydratase; Belongs to the DapA family. (302 aa)
mqnCCyclic dehypoxanthine futalosine synthase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (402 aa)
hemN_2Heme chaperone HemW; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (388 aa)
nadCPutative nicotinate-nucleotide pyrophosphorylase [carboxylating]; Belongs to the NadC/ModD family. (285 aa)
LuPra_04583Pyrroloquinoline quinone biosynthesis protein PqqE. (342 aa)
namA_2NADPH dehydrogenase. (478 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (304 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (261 aa)
tal_1Transaldolase. (430 aa)
dapA_14-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa)
LuPra_05045Putative enoyl-[acyl-carrier-protein] reductase II. (505 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
LuPra_05108Nitronate monooxygenase. (77 aa)
cfiBPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1170 aa)
albA_2Antilisterial bacteriocin subtilosin biosynthesis protein AlbA. (475 aa)
tal_2Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa)
LuPra_05504Molybdenum cofactor biosynthesis protein A. (453 aa)
gltB_2Ferredoxin-dependent glutamate synthase 1. (1541 aa)
dapA_24-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa)
LuPra_05792TIM-barrel signal transduction protein. (287 aa)
hemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (323 aa)
fbaBFructose-bisphosphate aldolase class 1. (357 aa)
ydeMAnaerobic sulfatase-maturating enzyme. (482 aa)
dapA_34-hydroxy-tetrahydrodipicolinate synthase; Belongs to the DapA family. (312 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa)
hisA1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Belongs to the HisA/HisF family. (227 aa)
LuPra_06135NADH oxidase. (437 aa)
LuPra_061505-dehydro-4-deoxyglucarate dehydratase. (311 aa)
dus_2tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (384 aa)
Your Current Organism:
Luteitalea pratensis
NCBI taxonomy Id: 1855912
Other names: Acidobacteria bacterium DSM 100886, Acidobacteria bacterium HEG_-6_39, DSM 100886, KCTC 52215, L. pratensis, Luteitalea pratensis Vieira et al. 2017, strain HEG_-6_39
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