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folD folD purU-2 purU-2 THL1_1500 THL1_1500 folD-2 folD-2 purU-3 purU-3 THL1_1504 THL1_1504 THL1_1584 THL1_1584 thyA thyA THL1_2027 THL1_2027 THL1_204 THL1_204 THL1_2370 THL1_2370 THL1_2420 THL1_2420 THL1_2764 THL1_2764 THL1_2765 THL1_2765 THL1_2766 THL1_2766 THL1_2830 THL1_2830 THL1_2831 THL1_2831 gcvP gcvP gcvH gcvH ilvA-2 ilvA-2 THL1_347 THL1_347 folD-3 folD-3 THL1_381 THL1_381 glyA glyA THL1_4282 THL1_4282 gcvH-2 gcvH-2 gcvP-2 gcvP-2 glyA-2 glyA-2 THL1_4390 THL1_4390 THL1_4391 THL1_4391 THL1_4406 THL1_4406 THL1_4504 THL1_4504 THL1_4650 THL1_4650 THL1_4651 THL1_4651 purT purT THL1_4764 THL1_4764 THL1_5226 THL1_5226 gcvP-3 gcvP-3 gcvH-3 gcvH-3 gcvT gcvT THL1_5500 THL1_5500 thrB thrB glyA-3 glyA-3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (307 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
THL1_1500Aminomethyltransferase; Belongs to the GcvT family. (781 aa)
folD-2Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
THL1_1504Aminomethyltransferase; Belongs to the GcvT family. (376 aa)
THL1_1584Threonine synthase. (457 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
THL1_2027Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. (428 aa)
THL1_204Diacylglycerol kinase; Belongs to the dihydrofolate reductase family. (207 aa)
THL1_2370Phosphoserine phosphatase. (205 aa)
THL1_2420Serine acetyltransferase. (313 aa)
THL1_27643-oxoacyl-ACP reductase. (260 aa)
THL1_2765Molybdenum cofactor biosynthesis proteinF. (272 aa)
THL1_2766Oxidoreductase. (258 aa)
THL1_2830Aminomethyltransferase. (372 aa)
THL1_2831Serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
ilvA-2Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)
THL1_347Serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
folD-3Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
THL1_381Serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
THL1_4282Threonine aldolase. (334 aa)
gcvH-2Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvP-2Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
THL1_4390Serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
THL1_4391Aminomethyltransferase. (372 aa)
THL1_4406Alcohol dehydrogenase. (257 aa)
THL1_4504Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
THL1_4650Threonine synthase. (469 aa)
THL1_4651Homoserine dehydrogenase. (434 aa)
purTPhosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
THL1_4764Dihydromonapterin reductase. (236 aa)
THL1_5226Phosphoserine phosphatase. (404 aa)
gcvP-3Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
gcvH-3Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
THL1_55005-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (201 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (316 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
Your Current Organism:
Pseudomonas sp. TCUHL1
NCBI taxonomy Id: 1856685
Other names: P. sp. TCU-HL1, Pseudomonas sp. TCU-HL1
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