(10 nodes) acetyl-CoA biosynthetic process, and CoA-binding network (Pseudomonas sp. TCUHL1)

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Your Input:
	THL1_2290	acetyl-CoA synthetase. (567 aa)
	THL1_2745	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
	THL1_2865	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa)
	THL1_3999	Hypothetical protein. (705 aa)
	acsA	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
	THL1_4483	Acylphosphatase. (91 aa)
	ackA	Propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (388 aa)
	THL1_4778	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (677 aa)
	acsA-2	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
	THL1_822	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (506 aa)

Your Current Organism:

Pseudomonas sp. TCUHL1

NCBI taxonomy Id: 1856685
Other names: P. sp. TCU-HL1, Pseudomonas sp. TCU-HL1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
THL1_2290	THL1_2745	THL1_2290	THL1_2745	acetyl-CoA synthetase.	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.944
THL1_2290	THL1_2865	THL1_2290	THL1_2865	acetyl-CoA synthetase.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.949
THL1_2290	THL1_3999	THL1_2290	THL1_3999	acetyl-CoA synthetase.	Hypothetical protein.	0.913
THL1_2290	THL1_4483	THL1_2290	THL1_4483	acetyl-CoA synthetase.	Acylphosphatase.	0.903
THL1_2290	THL1_4778	THL1_2290	THL1_4778	acetyl-CoA synthetase.	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.979
THL1_2290	THL1_822	THL1_2290	THL1_822	acetyl-CoA synthetase.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.949
THL1_2290	ackA	THL1_2290	THL1_4777	acetyl-CoA synthetase.	Propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.953
THL1_2290	acsA	THL1_2290	THL1_4296	acetyl-CoA synthetase.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.918
THL1_2290	acsA-2	THL1_2290	THL1_4906	acetyl-CoA synthetase.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.918
THL1_2745	THL1_2290	THL1_2745	THL1_2290	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	acetyl-CoA synthetase.	0.944
THL1_2745	THL1_3999	THL1_2745	THL1_3999	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Hypothetical protein.	0.924
THL1_2745	THL1_4483	THL1_2745	THL1_4483	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Acylphosphatase.	0.905
THL1_2745	THL1_4778	THL1_2745	THL1_4778	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.904
THL1_2745	ackA	THL1_2745	THL1_4777	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.	0.929
THL1_2745	acsA	THL1_2745	THL1_4296	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.944
THL1_2745	acsA-2	THL1_2745	THL1_4906	L-pipecolate dehydrogenase; Belongs to the aldehyde dehydrogenase family.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.944
THL1_2865	THL1_2290	THL1_2865	THL1_2290	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	acetyl-CoA synthetase.	0.949
THL1_2865	THL1_3999	THL1_2865	THL1_3999	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Hypothetical protein.	0.924
THL1_2865	THL1_4483	THL1_2865	THL1_4483	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Acylphosphatase.	0.905
THL1_2865	THL1_4778	THL1_2865	THL1_4778	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.	0.542