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| | THL1_101 | acetyl-CoA hydrolase. (497 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa) |
| | THL1_1293 | Hypothetical protein. (141 aa) |
| | THL1_1294 | Hypothetical protein. (56 aa) |
| | fumC | Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa) |
| | THL1_1409 | Hypothetical protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (407 aa) |
| | THL1_1540 | Esterase. (289 aa) |
| | leuC | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | leuD | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa) |
| | THL1_2172 | Type II citrate synthase; Belongs to the citrate synthase family. (428 aa) |
| | THL1_2173 | Succinate dehydrogenase. (124 aa) |
| | THL1_2174 | Succinate dehydrogenase; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa) |
| | THL1_2175 | Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa) |
| | THL1_2176 | Succinate dehydrogenase. (238 aa) |
| | THL1_2177 | 2-oxoglutarate dehydrogenase. (943 aa) |
| | THL1_2178 | 2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa) |
| | THL1_2179 | Dihydrolipoamide dehydrogenase. (478 aa) |
| | sucC | succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa) |
| | sucD | succinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (321 aa) |
| | THL1_2322 | Aspartate aminotransferase. (403 aa) |
| | THL1_2382 | Lipoate--protein ligase. (236 aa) |
| | mqo | Malate:quinone oxidoreductase. (525 aa) |
| | THL1_2431 | Dihydrolipoamide dehydrogenase. (469 aa) |
| | THL1_2473 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (742 aa) |
| | THL1_2474 | Isocitrate dehydrogenase. (418 aa) |
| | THL1_2739 | Thiamine pyrophosphate-dependent enzyme,possible carboligase or decarboxylase; Belongs to the TPP enzyme family. (560 aa) |
| | THL1_2783 | 2-methylcitrate dehydratase. (494 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (526 aa) |
| | THL1_2811 | Hypothetical protein; Belongs to the TPP enzyme family. (536 aa) |
| | THL1_2922 | Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (329 aa) |
| | THL1_2923 | Pyruvate dehydrogenase. (341 aa) |
| | THL1_2924 | Biotin attachment protein. (77 aa) |
| | THL1_2925 | Acetoin dehydrogenase. (234 aa) |
| | THL1_2926 | Lipoate--protein ligase. (244 aa) |
| | THL1_2942 | 2-methylcitrate dehydratase. (446 aa) |
| | THL1_3205 | Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (288 aa) |
| | THL1_3206 | Fumarate hydrolyase. (202 aa) |
| | THL1_3207 | Tartrate dehydratase subunit alpha. (299 aa) |
| | THL1_3360 | Acetolactate synthase; Belongs to the TPP enzyme family. (547 aa) |
| | THL1_3422 | Malate dehydrogenase; Belongs to the malic enzymes family. (246 aa) |
| | THL1_3425 | Hypothetical protein. (151 aa) |
| | THL1_357 | Formate dehydrogenase. (160 aa) |
| | THL1_358 | Formate dehydrogenase. (519 aa) |
| | THL1_359 | Formate dehydrogenase. (958 aa) |
| | THL1_360 | Formate dehydrogenase. (73 aa) |
| | THL1_3656 | Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (884 aa) |
| | THL1_3677 | 3-methylitaconate isomerase. (395 aa) |
| | THL1_3678 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (876 aa) |
| | THL1_3679 | Methylcitrate synthase; Belongs to the citrate synthase family. (385 aa) |
| | prpB | 2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (294 aa) |
| | THL1_3795 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa) |
| | purU-4 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa) |
| | THL1_3995 | MFS transporter. (378 aa) |
| | THL1_3997 | Aspartate aminotransferase. (396 aa) |
| | THL1_3998 | Decarboxylase; Belongs to the TPP enzyme family. (536 aa) |
| | THL1_4272 | Amino acid dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (350 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa) |
| | THL1_4508 | 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa) |
| | THL1_4602 | 2-methylisocitrate lyase. (275 aa) |
| | ppc | Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (878 aa) |
| | THL1_4675 | Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa) |
| | THL1_4679 | Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (507 aa) |
| | THL1_4745 | Branched-chain alpha-keto acid dehydrogenase subunit E2. (368 aa) |
| | THL1_4746 | 2-oxoisovalerate dehydrogenase. (333 aa) |
| | pdhA | ABC transporter permease; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (363 aa) |
| | THL1_4748 | Amino acid dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (339 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (414 aa) |
| | THL1_479 | Amino acid permease. (471 aa) |
| | mqo-2 | Malate:quinone oxidoreductase. (505 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | THL1_4878 | Acetolactate synthase 3 regulatory subunit. (163 aa) |
| | THL1_4879 | Acetolactate synthase 3 catalytic subunit. (615 aa) |
| | lldD | Lactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. (381 aa) |
| | THL1_5093 | Formate dehydrogenase gamma subunit. (210 aa) |
| | THL1_5094 | Formate dehydrogenase subunit beta; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (308 aa) |
| | THL1_5095 | Formate dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (811 aa) |
| | THL1_5096 | Sulfate ABC transporter substrate-bindingprotein. (272 aa) |
| | THL1_5159 | Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (288 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | THL1_5278 | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (881 aa) |
| | THL1_5279 | Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (648 aa) |
| | THL1_5308 | Malate dehydrogenase. (422 aa) |
| | pckA | Hypothetical protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (514 aa) |
| | THL1_5686 | Pyruvate carboxylase subunit B. (601 aa) |
| | THL1_5687 | Pyruvate carboxylase subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (471 aa) |
| | lipB | Lipoate--protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (208 aa) |
| | lipA-2 | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (350 aa) |
