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THL1_101 THL1_101 leuA leuA THL1_1409 THL1_1409 leuC leuC leuD leuD leuB leuB ilvD ilvD THL1_2172 THL1_2172 THL1_2173 THL1_2173 THL1_2174 THL1_2174 THL1_2175 THL1_2175 THL1_2176 THL1_2176 THL1_2177 THL1_2177 THL1_2178 THL1_2178 THL1_2179 THL1_2179 sucC sucC sucD sucD THL1_2322 THL1_2322 THL1_2382 THL1_2382 THL1_2431 THL1_2431 THL1_2473 THL1_2473 THL1_2474 THL1_2474 THL1_2739 THL1_2739 THL1_2783 THL1_2783 ilvA ilvA THL1_2811 THL1_2811 THL1_2922 THL1_2922 THL1_2923 THL1_2923 THL1_2924 THL1_2924 THL1_2925 THL1_2925 THL1_2926 THL1_2926 THL1_2942 THL1_2942 THL1_3205 THL1_3205 THL1_3360 THL1_3360 THL1_3425 THL1_3425 THL1_3656 THL1_3656 THL1_3677 THL1_3677 THL1_3678 THL1_3678 THL1_3679 THL1_3679 prpB prpB THL1_3795 THL1_3795 THL1_3995 THL1_3995 THL1_3997 THL1_3997 THL1_3998 THL1_3998 THL1_4272 THL1_4272 lipA lipA THL1_4508 THL1_4508 THL1_4602 THL1_4602 THL1_4675 THL1_4675 THL1_4745 THL1_4745 THL1_4746 THL1_4746 pdhA pdhA THL1_4748 THL1_4748 leuA-2 leuA-2 ilvC ilvC THL1_4878 THL1_4878 THL1_4879 THL1_4879 lldD lldD THL1_5159 THL1_5159 ilvE ilvE THL1_5278 THL1_5278 THL1_5279 THL1_5279 lipB lipB lipA-2 lipA-2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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THL1_101acetyl-CoA hydrolase. (497 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (556 aa)
THL1_1409Hypothetical protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (407 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (214 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (360 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (612 aa)
THL1_2172Type II citrate synthase; Belongs to the citrate synthase family. (428 aa)
THL1_2173Succinate dehydrogenase. (124 aa)
THL1_2174Succinate dehydrogenase; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa)
THL1_2175Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa)
THL1_2176Succinate dehydrogenase. (238 aa)
THL1_21772-oxoglutarate dehydrogenase. (943 aa)
THL1_21782-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (405 aa)
THL1_2179Dihydrolipoamide dehydrogenase. (478 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
THL1_2322Aspartate aminotransferase. (403 aa)
THL1_2382Lipoate--protein ligase. (236 aa)
THL1_2431Dihydrolipoamide dehydrogenase. (469 aa)
THL1_2473Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (742 aa)
THL1_2474Isocitrate dehydrogenase. (418 aa)
THL1_2739Thiamine pyrophosphate-dependent enzyme,possible carboligase or decarboxylase; Belongs to the TPP enzyme family. (560 aa)
THL1_27832-methylcitrate dehydratase. (494 aa)
ilvAThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (526 aa)
THL1_2811Hypothetical protein; Belongs to the TPP enzyme family. (536 aa)
THL1_2922Acetoin:2,6-dichlorophenolindophenol oxidoreductase subunit alpha. (329 aa)
THL1_2923Pyruvate dehydrogenase. (341 aa)
THL1_2924Biotin attachment protein. (77 aa)
THL1_2925Acetoin dehydrogenase. (234 aa)
THL1_2926Lipoate--protein ligase. (244 aa)
THL1_29422-methylcitrate dehydratase. (446 aa)
THL1_3205Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (288 aa)
THL1_3360Acetolactate synthase; Belongs to the TPP enzyme family. (547 aa)
THL1_3425Hypothetical protein. (151 aa)
THL1_3656Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (884 aa)
THL1_36773-methylitaconate isomerase. (395 aa)
THL1_3678Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (876 aa)
THL1_3679Methylcitrate synthase; Belongs to the citrate synthase family. (385 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (294 aa)
THL1_3795Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa)
THL1_3995MFS transporter. (378 aa)
THL1_3997Aspartate aminotransferase. (396 aa)
THL1_3998Decarboxylase; Belongs to the TPP enzyme family. (536 aa)
THL1_4272Amino acid dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (350 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa)
THL1_45082-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
THL1_46022-methylisocitrate lyase. (275 aa)
THL1_4675Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa)
THL1_4745Branched-chain alpha-keto acid dehydrogenase subunit E2. (368 aa)
THL1_47462-oxoisovalerate dehydrogenase. (333 aa)
pdhAABC transporter permease; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (363 aa)
THL1_4748Amino acid dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (339 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (516 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
THL1_4878Acetolactate synthase 3 regulatory subunit. (163 aa)
THL1_4879Acetolactate synthase 3 catalytic subunit. (615 aa)
lldDLactate dehydrogenase; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain. (381 aa)
THL1_5159Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (288 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
THL1_5278Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (881 aa)
THL1_5279Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (648 aa)
lipBLipoate--protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (208 aa)
lipA-2Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (350 aa)
Your Current Organism:
Pseudomonas sp. TCUHL1
NCBI taxonomy Id: 1856685
Other names: P. sp. TCU-HL1, Pseudomonas sp. TCU-HL1
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