STRINGSTRING
coaE coaE THL1_1051 THL1_1051 THL1_1071 THL1_1071 cysC cysC THL1_1143 THL1_1143 ndk ndk THL1_1226 THL1_1226 THL1_1228 THL1_1228 THL1_1327 THL1_1327 THL1_1368 THL1_1368 THL1_1381 THL1_1381 THL1_1389 THL1_1389 THL1_1422 THL1_1422 THL1_1441 THL1_1441 THL1_1445 THL1_1445 THL1_1488 THL1_1488 THL1_1515 THL1_1515 glk glk THL1_1522 THL1_1522 mdcB mdcB THL1_1598 THL1_1598 THL1_1654 THL1_1654 THL1_1669 THL1_1669 THL1_1670 THL1_1670 selD selD THL1_1724 THL1_1724 THL1_1759 THL1_1759 THL1_1792 THL1_1792 THL1_1797 THL1_1797 THL1_1822 THL1_1822 THL1_1824 THL1_1824 aceK aceK THL1_1895 THL1_1895 THL1_1896 THL1_1896 THL1_2009 THL1_2009 nadK nadK THL1_2081 THL1_2081 THL1_2114 THL1_2114 THL1_2116 THL1_2116 lpxK lpxK THL1_2161 THL1_2161 THL1_2179 THL1_2179 THL1_2197 THL1_2197 THL1_2201 THL1_2201 THL1_2251 THL1_2251 THL1_2326 THL1_2326 THL1_2395 THL1_2395 THL1_2431 THL1_2431 THL1_2563 THL1_2563 THL1_2571 THL1_2571 THL1_2592 THL1_2592 THL1_2713 THL1_2713 THL1_2715 THL1_2715 THL1_2775 THL1_2775 THL1_2839 THL1_2839 THL1_2840 THL1_2840 THL1_2853 THL1_2853 THL1_2872 THL1_2872 THL1_290 THL1_290 THL1_303 THL1_303 THL1_3106 THL1_3106 THL1_3117 THL1_3117 THL1_3193 THL1_3193 pgk pgk THL1_325 THL1_325 THL1_3394 THL1_3394 THL1_3398 THL1_3398 THL1_3425 THL1_3425 THL1_3489 THL1_3489 THL1_3515 THL1_3515 THL1_3665 THL1_3665 THL1_367 THL1_367 THL1_3675 THL1_3675 THL1_3676 THL1_3676 THL1_3746 THL1_3746 THL1_3747 THL1_3747 THL1_3768 THL1_3768 THL1_3828 THL1_3828 THL1_3839 THL1_3839 THL1_3853 THL1_3853 cmk cmk THL1_3902 THL1_3902 THL1_3943 THL1_3943 THL1_3969 THL1_3969 THL1_4003 THL1_4003 THL1_4056 THL1_4056 THL1_4057 THL1_4057 THL1_4065 THL1_4065 THL1_4127 THL1_4127 THL1_415 THL1_415 THL1_4262 THL1_4262 srkA srkA phnN phnN THL1_4280 THL1_4280 THL1_43 THL1_43 THL1_4321 THL1_4321 THL1_4360 THL1_4360 glpK glpK THL1_4502 THL1_4502 THL1_4507 THL1_4507 THL1_4512 THL1_4512 THL1_4527 THL1_4527 eno eno pyrH pyrH adk adk THL1_4622 THL1_4622 THL1_4651 THL1_4651 THL1_4675 THL1_4675 THL1_4724 THL1_4724 THL1_4726 THL1_4726 THL1_4749 THL1_4749 ackA ackA THL1_4781 THL1_4781 THL1_4782 THL1_4782 ispE ispE prs prs THL1_4884 THL1_4884 THL1_4898 THL1_4898 THL1_4901 THL1_4901 pgi pgi tpiA tpiA THL1_4949 THL1_4949 THL1_4975 THL1_4975 THL1_4983 THL1_4983 THL1_500 THL1_500 THL1_5012 THL1_5012 THL1_5035 THL1_5035 THL1_5052 THL1_5052 THL1_5064 THL1_5064 THL1_5084 THL1_5084 THL1_509 THL1_509 THL1_5097 THL1_5097 THL1_5140 THL1_5140 THL1_522 THL1_522 hldE hldE THL1_5260 THL1_5260 THL1_5269 THL1_5269 THL1_5270 THL1_5270 THL1_5271 THL1_5271 THL1_5272 THL1_5272 THL1_5278 THL1_5278 THL1_5279 THL1_5279 aroK aroK ubiB ubiB THL1_5377 THL1_5377 gpmI gpmI THL1_5443 THL1_5443 THL1_5449 THL1_5449 THL1_5472 THL1_5472 THL1_5473 THL1_5473 ppk ppk THL1_5537 THL1_5537 THL1_5542 THL1_5542 argB argB gmk gmk THL1_5648 THL1_5648 THL1_568 THL1_568 THL1_5717 THL1_5717 THL1_5719 THL1_5719 THL1_579 THL1_579 THL1_593 THL1_593 THL1_602 THL1_602 THL1_634 THL1_634 anmK anmK coaX coaX thrB thrB thiL thiL THL1_809 THL1_809 THL1_83 THL1_83 THL1_871 THL1_871 THL1_872 THL1_872 proB proB THL1_972 THL1_972 THL1_993 THL1_993
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
THL1_1051Histidine kinase. (418 aa)
THL1_1071PTS fructose transporter subunit IIA. (154 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (633 aa)
THL1_1143Histidine kinase. (672 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
THL1_1226Histidine kinase. (843 aa)
THL1_1228Hypothetical protein. (868 aa)
THL1_1327Histidine kinase. (1159 aa)
THL1_1368Membrane protein. (72 aa)
THL1_1381Histidine kinase. (925 aa)
THL1_1389Polyphosphate kinase. (495 aa)
THL1_1422Toxin/anti-toxin system, HipA-like toxinmodule. (408 aa)
THL1_1441Chemotaxis protein CheA. (612 aa)
THL1_1445Diguanylate cyclase. (824 aa)
THL1_1488Toxin HipA. (438 aa)
THL1_1515Polyphosphate kinase. (274 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (322 aa)
THL1_1522Histidine kinase. (476 aa)
mdcB2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase; Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase; Belongs to the CitG/MdcB family. (283 aa)
THL1_1598Histidine kinase. (479 aa)
THL1_1654Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
THL1_1669PTS fructose transporter subunit IIA; Belongs to the PEP-utilizing enzyme family. (953 aa)
THL1_16701-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (318 aa)
selDSelenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (344 aa)
THL1_1724Diguanylate phosphodiesterase. (733 aa)
THL1_1759Protein kinase. (509 aa)
THL1_1792Histidine kinase. (538 aa)
THL1_1797Histidine kinase. (459 aa)
THL1_1822Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (173 aa)
THL1_1824Phosphoglycerate mutase. (188 aa)
aceKIsocitrate dehydrogenase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (578 aa)
THL1_1895Pyruvate kinase; Belongs to the pyruvate kinase family. (471 aa)
THL1_1896Glycerate 2-kinase. (426 aa)
THL1_2009Sensory hisitidine kinase. (1226 aa)
nadKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)
THL1_2081Hypothetical protein. (1206 aa)
THL1_2114Xylulokinase. (519 aa)
THL1_2116Lipid kinase; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (298 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (334 aa)
THL1_2161Hypothetical protein; Belongs to the UPF0434 family. (61 aa)
THL1_2179Dihydrolipoamide dehydrogenase. (478 aa)
THL1_2197Histidine kinase. (940 aa)
THL1_2201Histidine kinase. (635 aa)
THL1_2251Histidine kinase. (882 aa)
THL1_2326Histidine kinase. (774 aa)
THL1_2395Histidine kinase. (424 aa)
THL1_2431Dihydrolipoamide dehydrogenase. (469 aa)
THL1_2563Hypothetical protein. (862 aa)
THL1_2571ATPase; Member of a two-component regulatory system. (464 aa)
THL1_2592Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
THL1_2713Two-component sensor. (440 aa)
THL1_2715Gluconokinase. (173 aa)
THL1_2775Histidine kinase. (487 aa)
THL1_2839GfdT protein. (388 aa)
THL1_2840ATPase. (856 aa)
THL1_2853Histidine kinase. (420 aa)
THL1_2872Histidine kinase. (445 aa)
THL1_290Phosphoenolpyruvate--protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. (759 aa)
THL1_303Histidine kinase. (2548 aa)
THL1_3106Histidine kinase. (448 aa)
THL1_3117Histidine kinase. (689 aa)
THL1_3193Kinase. (175 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (387 aa)
THL1_325Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
THL1_3394ATPase; Member of a two-component regulatory system. (449 aa)
THL1_3398Histidine kinase. (440 aa)
THL1_3425Hypothetical protein. (151 aa)
THL1_3489Hypothetical protein. (725 aa)
THL1_3515Toxin HipA. (443 aa)
THL1_3665Protein kinase. (556 aa)
THL1_367Chemotaxis protein CheY. (1219 aa)
THL1_3675Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa)
THL1_3676Phosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (272 aa)
THL1_3746Thymidylate kinase. (122 aa)
THL1_3747Putative deoxynucleotide monophosphate kinase. (270 aa)
THL1_3768Thymidylate kinase. (125 aa)
THL1_3828Histidine kinase. (422 aa)
THL1_3839Histidine kinase. (637 aa)
THL1_3853InaA protein-like protein. (231 aa)
cmkCytidylate kinase. (228 aa)
THL1_3902Histidine kinase. (450 aa)
THL1_3943Signal transduction histidine kinase. (735 aa)
THL1_3969Histidine kinase. (401 aa)
THL1_4003Histidine kinase. (748 aa)
THL1_4056Histidine kinase. (458 aa)
THL1_4057Hypothetical protein. (429 aa)
THL1_4065ATPase. (434 aa)
THL1_4127Phospholipase A2 family protein. (632 aa)
THL1_415Histidine kinase. (476 aa)
THL1_4262Phospholipase. (762 aa)
srkASerine/threonine protein kinase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (324 aa)
phnNRibose-phosphate pyrophosphokinase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (194 aa)
THL1_4280Aspartate kinase; Belongs to the aspartokinase family. (411 aa)
THL1_43Haloacid dehalogenase. (214 aa)
THL1_4321Histidine kinase. (461 aa)
THL1_4360Hypothetical protein. (344 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (495 aa)
THL1_4502(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (748 aa)
THL1_4507Chemotaxis protein CheY. (925 aa)
THL1_4512Phospholipase. (802 aa)
THL1_4527Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (121 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (429 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
THL1_4622Two-component hybrid sensor and regulator. (757 aa)
THL1_4651Homoserine dehydrogenase. (434 aa)
THL1_4675Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa)
THL1_4724InaA protein. (233 aa)
THL1_4726Histidine kinase. (429 aa)
THL1_4749Hypothetical protein. (267 aa)
ackAPropionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (388 aa)
THL1_4781Diguanylate cyclase. (718 aa)
THL1_4782Histidine kinase. (1242 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (283 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa)
THL1_4884Hypothetical protein. (519 aa)
THL1_4898ATPase. (984 aa)
THL1_49012-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (166 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (554 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
THL1_4949Histidine kinase. (972 aa)
THL1_4975Phosphatidylinositol kinase. (400 aa)
THL1_4983Histidine kinase. (485 aa)
THL1_500Toxin HipA. (47 aa)
THL1_5012Histidine kinase. (469 aa)
THL1_5035Hpt domain protein. (729 aa)
THL1_5052Hypothetical protein. (846 aa)
THL1_5064Kinase. (297 aa)
THL1_5084Toxin HipA. (434 aa)
THL1_5092-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (180 aa)
THL1_5097Histidine kinase. (927 aa)
THL1_5140Histidine kinase. (925 aa)
THL1_522Aminoglycoside phosphotransferase. (341 aa)
hldEHeptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
THL1_5260Oligosaccharide repeat unit polymerase Wzy. (228 aa)
THL1_5269Serine/threonine protein kinase. (485 aa)
THL1_5270LPS kinase. (251 aa)
THL1_5271Heptose kinase. (245 aa)
THL1_5272Heptose kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (271 aa)
THL1_5278Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (881 aa)
THL1_5279Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (648 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
ubiBUbiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (530 aa)
THL1_5377Histidine kinase. (361 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
THL1_5443ATPase. (603 aa)
THL1_5449Carbamate kinase; Belongs to the carbamate kinase family. (310 aa)
THL1_5472Diguanylate cyclase. (1261 aa)
THL1_5473ATPase. (437 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (744 aa)
THL1_5537Alginate O-acetyltransferase. (360 aa)
THL1_5542Nucleoside diphosphate kinase regulator. (135 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
THL1_5648Histidine kinase. (434 aa)
THL1_568Diguanylate cyclase. (147 aa)
THL1_5717Hypothetical protein. (136 aa)
THL1_5719Cytochrome C biogenesis protein CcmE. (586 aa)
THL1_579Histidine kinase. (429 aa)
THL1_593Chemotaxis protein CheA. (733 aa)
THL1_602Capsular exopolysaccharide family protein. (746 aa)
THL1_634Histidine kinase. (427 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (363 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (249 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (316 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
THL1_809Tyrosine protein kinase. (746 aa)
THL1_83Histidine kinase. (591 aa)
THL1_871Hydrogenase. (265 aa)
THL1_872Histidine kinase. (799 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa)
THL1_972FMN adenylyltransferase/riboflavin kinase; Belongs to the ribF family. (312 aa)
THL1_993Histidine kinase. (533 aa)
Your Current Organism:
Pseudomonas sp. TCUHL1
NCBI taxonomy Id: 1856685
Other names: P. sp. TCU-HL1, Pseudomonas sp. TCU-HL1
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