STRINGSTRING
THL1_3117 THL1_3117 coaE coaE THL1_1051 THL1_1051 THL1_1071 THL1_1071 THL1_1073 THL1_1073 cysD cysD cysC cysC mraY mraY THL1_1134 THL1_1134 THL1_1135 THL1_1135 THL1_1143 THL1_1143 THL1_1145 THL1_1145 THL1_1169 THL1_1169 ndk ndk THL1_1226 THL1_1226 THL1_1228 THL1_1228 THL1_1257 THL1_1257 THL1_1281 THL1_1281 THL1_1327 THL1_1327 THL1_1368 THL1_1368 THL1_1378 THL1_1378 THL1_1381 THL1_1381 THL1_1389 THL1_1389 THL1_143 THL1_143 THL1_1441 THL1_1441 THL1_1445 THL1_1445 mdcG mdcG THL1_1515 THL1_1515 glk glk THL1_1522 THL1_1522 mdcB mdcB THL1_1598 THL1_1598 THL1_1610 THL1_1610 THL1_1669 THL1_1669 THL1_1670 THL1_1670 THL1_1671 THL1_1671 selD selD THL1_1724 THL1_1724 THL1_1759 THL1_1759 THL1_1769 THL1_1769 THL1_1792 THL1_1792 THL1_1793 THL1_1793 THL1_1797 THL1_1797 THL1_1822 THL1_1822 cobS cobS aceK aceK THL1_1889 THL1_1889 THL1_1895 THL1_1895 THL1_1896 THL1_1896 dnaX dnaX THL1_1955 THL1_1955 THL1_1985 THL1_1985 THL1_2 THL1_2 THL1_2009 THL1_2009 nadK nadK THL1_2075 THL1_2075 THL1_2081 THL1_2081 THL1_2093 THL1_2093 THL1_2096 THL1_2096 mobA mobA THL1_2109 THL1_2109 THL1_2114 THL1_2114 THL1_2116 THL1_2116 lpxK lpxK THL1_2161 THL1_2161 kdsB kdsB sucD sucD THL1_2192 THL1_2192 THL1_2197 THL1_2197 THL1_2201 THL1_2201 coaD coaD THL1_2251 THL1_2251 THL1_2326 THL1_2326 THL1_2395 THL1_2395 THL1_2396 THL1_2396 tsaC tsaC THL1_2499 THL1_2499 THL1_2503 THL1_2503 THL1_2563 THL1_2563 THL1_2571 THL1_2571 THL1_2611 THL1_2611 THL1_2692 THL1_2692 THL1_2713 THL1_2713 THL1_2715 THL1_2715 THL1_2718 THL1_2718 THL1_2775 THL1_2775 THL1_2807 THL1_2807 THL1_2840 THL1_2840 THL1_2853 THL1_2853 THL1_2872 THL1_2872 THL1_290 THL1_290 THL1_303 THL1_303 THL1_3106 THL1_3106 THL1_3128 THL1_3128 THL1_3193 THL1_3193 pgk pgk THL1_3312 THL1_3312 THL1_3394 THL1_3394 THL1_3397 THL1_3397 THL1_3398 THL1_3398 THL1_3426 THL1_3426 THL1_3489 THL1_3489 THL1_3611 THL1_3611 dnaQ dnaQ THL1_3665 THL1_3665 THL1_367 THL1_367 THL1_3675 THL1_3675 THL1_3676 THL1_3676 THL1_3745 THL1_3745 THL1_3746 THL1_3746 THL1_3747 THL1_3747 THL1_3768 THL1_3768 THL1_3785 THL1_3785 THL1_3796 THL1_3796 THL1_3828 THL1_3828 THL1_3839 THL1_3839 THL1_3853 THL1_3853 cmk cmk THL1_3890 THL1_3890 THL1_3902 THL1_3902 THL1_3943 THL1_3943 fliA fliA THL1_3959 THL1_3959 THL1_3969 THL1_3969 THL1_4003 THL1_4003 THL1_4056 THL1_4056 THL1_4057 THL1_4057 THL1_4065 THL1_4065 THL1_4082 THL1_4082 THL1_4083 THL1_4083 THL1_4127 THL1_4127 THL1_415 THL1_415 THL1_420 THL1_420 THL1_421 THL1_421 THL1_4262 THL1_4262 THL1_4268 THL1_4268 srkA srkA phnN phnN THL1_4280 THL1_4280 THL1_43 THL1_43 THL1_4321 THL1_4321 THL1_4357 THL1_4357 THL1_4360 THL1_4360 THL1_4372 THL1_4372 glpK glpK THL1_438 THL1_438 dnaE2 dnaE2 THL1_4438 THL1_4438 THL1_444 THL1_444 THL1_4475 THL1_4475 slyX slyX THL1_4494 THL1_4494 THL1_4502 THL1_4502 THL1_4507 THL1_4507 dinB dinB THL1_4512 THL1_4512 THL1_4527 THL1_4527 ispD ispD THL1_4555 THL1_4555 THL1_4565 THL1_4565 pyrH pyrH glnD glnD adk adk THL1_4620 THL1_4620 THL1_4622 THL1_4622 THL1_4648 THL1_4648 THL1_4651 THL1_4651 THL1_4675 THL1_4675 THL1_4678 THL1_4678 THL1_4686 THL1_4686 THL1_4709 THL1_4709 THL1_4724 THL1_4724 THL1_4726 THL1_4726 THL1_4749 THL1_4749 ackA ackA THL1_4781 THL1_4781 THL1_4782 THL1_4782 THL1_4837 THL1_4837 ispE ispE prs prs THL1_4875 THL1_4875 THL1_4884 THL1_4884 THL1_4898 THL1_4898 pcnB pcnB THL1_4901 THL1_4901 pnp pnp THL1_4949 THL1_4949 THL1_4983 THL1_4983 THL1_5012 THL1_5012 THL1_5035 THL1_5035 dnaG dnaG THL1_5052 THL1_5052 THL1_5064 THL1_5064 THL1_509 THL1_509 THL1_5097 THL1_5097 cca cca THL1_5128 THL1_5128 THL1_514 THL1_514 THL1_5140 THL1_5140 THL1_5146 THL1_5146 THL1_5193 THL1_5193 THL1_522 THL1_522 THL1_523 THL1_523 hldE hldE THL1_526 THL1_526 THL1_5260 THL1_5260 THL1_5269 THL1_5269 THL1_5270 THL1_5270 THL1_5271 THL1_5271 THL1_5272 THL1_5272 glnE glnE selO selO aroK aroK ubiB ubiB THL1_5359 THL1_5359 THL1_5364 THL1_5364 thiI thiI THL1_5377 THL1_5377 THL1_5405 THL1_5405 THL1_5406 THL1_5406 THL1_543 THL1_543 THL1_5440 THL1_5440 THL1_5443 THL1_5443 THL1_5449 THL1_5449 THL1_5472 THL1_5472 THL1_5473 THL1_5473 THL1_5503 THL1_5503 THL1_5511 THL1_5511 ppk ppk THL1_552 THL1_552 THL1_5537 THL1_5537 THL1_5542 THL1_5542 argB argB rph rph THL1_5624 THL1_5624 gmk gmk rpoZ rpoZ THL1_5627 THL1_5627 THL1_5648 THL1_5648 THL1_5665 THL1_5665 THL1_568 THL1_568 THL1_569 THL1_569 THL1_5717 THL1_5717 THL1_5719 THL1_5719 THL1_572 THL1_572 THL1_573 THL1_573 glmU glmU THL1_579 THL1_579 THL1_593 THL1_593 THL1_602 THL1_602 THL1_605 THL1_605 THL1_616 THL1_616 THL1_634 THL1_634 anmK anmK coaX coaX rpoB rpoB rpoC rpoC thrB thrB rpoA rpoA polA polA thiL thiL THL1_79 THL1_79 THL1_807 THL1_807 THL1_809 THL1_809 THL1_83 THL1_83 nadD nadD THL1_857 THL1_857 THL1_871 THL1_871 THL1_872 THL1_872 THL1_901 THL1_901 THL1_931 THL1_931 proB proB THL1_972 THL1_972 THL1_993 THL1_993
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THL1_3117Histidine kinase. (689 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
THL1_1051Histidine kinase. (418 aa)
THL1_1071PTS fructose transporter subunit IIA. (154 aa)
THL1_1073RNA polymerase factor sigma-54; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (498 aa)
cysDSulfate adenylyltransferase subunit 2. (305 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (633 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
THL1_1134Retron-type reverse transcriptase. (200 aa)
THL1_1135Retron-type reverse transcriptase. (100 aa)
THL1_1143Histidine kinase. (672 aa)
THL1_1145Transcriptional regulator. (320 aa)
THL1_1169DNA polymerase III subunit chi. (138 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
THL1_1226Histidine kinase. (843 aa)
THL1_1228Hypothetical protein. (868 aa)
THL1_1257Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase AlgA; Belongs to the mannose-6-phosphate isomerase type 2 family. (480 aa)
THL1_1281Cyclic nucleotide-binding protein. (312 aa)
THL1_1327Histidine kinase. (1159 aa)
THL1_1368Membrane protein. (72 aa)
THL1_1378Cardiolipin synthase; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (464 aa)
THL1_1381Histidine kinase. (925 aa)
THL1_1389Polyphosphate kinase. (495 aa)
THL1_143Diguanylate cyclase. (323 aa)
THL1_1441Chemotaxis protein CheA. (612 aa)
THL1_1445Diguanylate cyclase. (824 aa)
mdcGphosphoribosyl-dephospho-CoA transferase; Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme-A to the apo-[acyl-carrier-protein] of the malonate decarboxylase to yield holo-[acyl-carrier-protein]; Belongs to the MdcG family. (205 aa)
THL1_1515Polyphosphate kinase. (274 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (322 aa)
THL1_1522Histidine kinase. (476 aa)
mdcB2-(5''-triphosphoribosyl)-3'-dephospho-CoA synthase; Involved in the formation of 2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A, the prosthetic group of the acyl-carrier protein of the malonate decarboxylase; Belongs to the CitG/MdcB family. (283 aa)
THL1_1598Histidine kinase. (479 aa)
THL1_1610Phosphatidylcholine synthase; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (240 aa)
THL1_1669PTS fructose transporter subunit IIA; Belongs to the PEP-utilizing enzyme family. (953 aa)
THL1_16701-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (318 aa)
THL1_1671PTS fructose transporter subunit IIBC. (581 aa)
selDSelenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (344 aa)
THL1_1724Diguanylate phosphodiesterase. (733 aa)
THL1_1759Protein kinase. (509 aa)
THL1_1769Diguanylate cyclase. (582 aa)
THL1_1792Histidine kinase. (538 aa)
THL1_17934'-phosphopantetheinyl transferase; Belongs to the P-Pant transferase superfamily. (212 aa)
THL1_1797Histidine kinase. (459 aa)
THL1_1822Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (173 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (244 aa)
aceKIsocitrate dehydrogenase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (578 aa)
THL1_1889Diguanylate cyclase. (390 aa)
THL1_1895Pyruvate kinase; Belongs to the pyruvate kinase family. (471 aa)
THL1_1896Glycerate 2-kinase. (426 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (724 aa)
THL1_1955Retron-type reverse transcriptase. (317 aa)
THL1_1985Sugar transferase. (198 aa)
THL1_2DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)
THL1_2009Sensory hisitidine kinase. (1226 aa)
nadKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (295 aa)
THL1_2075Diguanylate cyclase. (925 aa)
THL1_2081Hypothetical protein. (1206 aa)
THL1_2093Hypothetical protein. (316 aa)
THL1_2096Hypothetical protein. (597 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (195 aa)
THL1_2109Molybdopterin biosynthesis protein MoeB; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (179 aa)
THL1_2114Xylulokinase. (519 aa)
THL1_2116Lipid kinase; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (298 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (334 aa)
THL1_2161Hypothetical protein; Belongs to the UPF0434 family. (61 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
THL1_2192DNA polymerase. (275 aa)
THL1_2197Histidine kinase. (940 aa)
THL1_2201Histidine kinase. (635 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
THL1_2251Histidine kinase. (882 aa)
THL1_2326Histidine kinase. (774 aa)
THL1_2395Histidine kinase. (424 aa)
THL1_2396Membrane protein. (547 aa)
tsaCtRNA threonylcarbamoyladenosine biosynthesis protein RimN; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. (184 aa)
THL1_2499CDP-diacylglycerol--glycerol-3-phosphate3- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (186 aa)
THL1_2503UTP--glucose-1-phosphate uridylyltransferase. (279 aa)
THL1_2563Hypothetical protein. (862 aa)
THL1_2571ATPase; Member of a two-component regulatory system. (464 aa)
THL1_2611Diguanylate cyclase. (499 aa)
THL1_2692DNA polymerase II. (787 aa)
THL1_2713Two-component sensor. (440 aa)
THL1_2715Gluconokinase. (173 aa)
THL1_2718Hypothetical protein. (228 aa)
THL1_2775Histidine kinase. (487 aa)
THL1_2807Diguanylate cyclase. (322 aa)
THL1_2840ATPase. (856 aa)
THL1_2853Histidine kinase. (420 aa)
THL1_2872Histidine kinase. (445 aa)
THL1_290Phosphoenolpyruvate--protein phosphotransferase; Belongs to the PEP-utilizing enzyme family. (759 aa)
THL1_303Histidine kinase. (2548 aa)
THL1_3106Histidine kinase. (448 aa)
THL1_3128Hypothetical protein. (74 aa)
THL1_3193Kinase. (175 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (387 aa)
THL1_3312Hypothetical protein. (932 aa)
THL1_3394ATPase; Member of a two-component regulatory system. (449 aa)
THL1_3397N-acetylglucosamine-6-sulfatase. (176 aa)
THL1_3398Histidine kinase. (440 aa)
THL1_3426Hypothetical protein. (159 aa)
THL1_3489Hypothetical protein. (725 aa)
THL1_3611Ferrous iron transporter B. (559 aa)
dnaQDNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (253 aa)
THL1_3665Protein kinase. (556 aa)
THL1_367Chemotaxis protein CheY. (1219 aa)
THL1_3675Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (789 aa)
THL1_3676Phosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (272 aa)
THL1_3745DNA polymerase III subunit delta'. (328 aa)
THL1_3746Thymidylate kinase. (122 aa)
THL1_3747Putative deoxynucleotide monophosphate kinase. (270 aa)
THL1_3768Thymidylate kinase. (125 aa)
THL1_3785ATP-NAD kinase. (375 aa)
THL1_3796Mannose-6-phosphate isomerase/mannose-1-phosphate guanylyltransferase AlgA; Belongs to the mannose-6-phosphate isomerase type 2 family. (481 aa)
THL1_3828Histidine kinase. (422 aa)
THL1_3839Histidine kinase. (637 aa)
THL1_3853InaA protein-like protein. (231 aa)
cmkCytidylate kinase. (228 aa)
THL1_3890Diguanylate cyclase. (308 aa)
THL1_3902Histidine kinase. (450 aa)
THL1_3943Signal transduction histidine kinase. (735 aa)
fliAFlagellar biosynthesis sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (248 aa)
THL1_3959Histidine kinase. (117 aa)
THL1_3969Histidine kinase. (401 aa)
THL1_4003Histidine kinase. (748 aa)
THL1_4056Histidine kinase. (458 aa)
THL1_4057Hypothetical protein. (429 aa)
THL1_4065ATPase. (434 aa)
THL1_4082Retron-type reverse transcriptase. (100 aa)
THL1_4083Retron-type reverse transcriptase. (200 aa)
THL1_4127Phospholipase A2 family protein. (632 aa)
THL1_415Histidine kinase. (476 aa)
THL1_420DNA polymerase III subunit epsilon. (234 aa)
THL1_421Cyclic nucleotide-binding protein. (644 aa)
THL1_4262Phospholipase. (762 aa)
THL1_4268Hypothetical protein. (933 aa)
srkASerine/threonine protein kinase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (324 aa)
phnNRibose-phosphate pyrophosphokinase; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (194 aa)
THL1_4280Aspartate kinase; Belongs to the aspartokinase family. (411 aa)
THL1_43Haloacid dehalogenase. (214 aa)
THL1_4321Histidine kinase. (461 aa)
THL1_4357Diguanylate cyclase. (497 aa)
THL1_4360Hypothetical protein. (344 aa)
THL1_4372Hypothetical protein. (507 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (495 aa)
THL1_438Diguanylate cyclase. (430 aa)
dnaE2DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1026 aa)
THL1_4438DNA repair nucleotidyltransferase. (471 aa)
THL1_444Hypothetical protein. (150 aa)
THL1_4475Diguanylate cyclase. (355 aa)
slyXHypothetical protein; Belongs to the SlyX family. (68 aa)
THL1_4494CDP-diacylglycerol--glycerol-3-phosphate3- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (182 aa)
THL1_4502(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (748 aa)
THL1_4507Chemotaxis protein CheY. (925 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (351 aa)
THL1_4512Phospholipase. (802 aa)
THL1_4527Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (121 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (236 aa)
THL1_4555DNA polymerase III subunit alpha. (1174 aa)
THL1_4565Phosphatidate cytidylyltransferase; Belongs to the CDS family. (271 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa)
glnD(protein-PII) uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (900 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
THL1_4620Diguanylate cyclase. (341 aa)
THL1_4622Two-component hybrid sensor and regulator. (757 aa)
THL1_4648Diguanylate cyclase. (384 aa)
THL1_4651Homoserine dehydrogenase. (434 aa)
THL1_4675Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa)
THL1_4678Hypothetical protein. (375 aa)
THL1_4686Phospholipase. (384 aa)
THL1_4709Hypothetical protein. (135 aa)
THL1_4724InaA protein. (233 aa)
THL1_4726Histidine kinase. (429 aa)
THL1_4749Hypothetical protein. (267 aa)
ackAPropionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (388 aa)
THL1_4781Diguanylate cyclase. (718 aa)
THL1_4782Histidine kinase. (1242 aa)
THL1_4837Sulfur carrier protein ThiS adenylyltransferase. (251 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (283 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa)
THL1_4875Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (271 aa)
THL1_4884Hypothetical protein. (519 aa)
THL1_4898ATPase. (984 aa)
pcnBpoly(A) polymerase; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (468 aa)
THL1_49012-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (166 aa)
pnpPolynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (702 aa)
THL1_4949Histidine kinase. (972 aa)
THL1_4983Histidine kinase. (485 aa)
THL1_5012Histidine kinase. (469 aa)
THL1_5035Hpt domain protein. (729 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (661 aa)
THL1_5052Hypothetical protein. (846 aa)
THL1_5064Kinase. (297 aa)
THL1_5092-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (180 aa)
THL1_5097Histidine kinase. (927 aa)
cca2', 3'-cyclic nucleotide 2'-phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. (410 aa)
THL1_5128Diguanylate cyclase. (535 aa)
THL1_514Serine/threonine protein kinase. (640 aa)
THL1_5140Histidine kinase. (925 aa)
THL1_5146Urea ABC transporter substrate-binding protein UrtA. (421 aa)
THL1_5193DeoR family transcriptional regulator. (635 aa)
THL1_522Aminoglycoside phosphotransferase. (341 aa)
THL1_523Nucleotidyltransferase. (223 aa)
hldEHeptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa)
THL1_526Histidine kinase. (796 aa)
THL1_5260Oligosaccharide repeat unit polymerase Wzy. (228 aa)
THL1_5269Serine/threonine protein kinase. (485 aa)
THL1_5270LPS kinase. (251 aa)
THL1_5271Heptose kinase. (245 aa)
THL1_5272Heptose kinase; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core; Belongs to the protein kinase superfamily. KdkA/rfaP family. (271 aa)
glnEBifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (977 aa)
selOHypothetical protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family. (486 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
ubiBUbiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (530 aa)
THL1_5359Diguanylate cyclase. (549 aa)
THL1_5364Hypothetical protein. (590 aa)
thiItRNA s(4)U8 sulfurtransferase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (525 aa)
THL1_5377Histidine kinase. (361 aa)
THL1_5405Topoisomerase. (290 aa)
THL1_5406RNA helicase. (583 aa)
THL1_543DNA polymerase. (315 aa)
THL1_5440Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (290 aa)
THL1_5443ATPase. (603 aa)
THL1_5449Carbamate kinase; Belongs to the carbamate kinase family. (310 aa)
THL1_5472Diguanylate cyclase. (1261 aa)
THL1_5473ATPase. (437 aa)
THL1_5503Diguanylate cyclase. (614 aa)
THL1_5511Exopolyphosphatase; Belongs to the GppA/Ppx family. (500 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (744 aa)
THL1_552Elongation factor GreAB. (271 aa)
THL1_5537Alginate O-acetyltransferase. (360 aa)
THL1_5542Nucleoside diphosphate kinase regulator. (135 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (239 aa)
THL1_5624Hypothetical protein. (287 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa)
rpoZDNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (87 aa)
THL1_5627(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa)
THL1_5648Histidine kinase. (434 aa)
THL1_5665Aldose 1-epimerase; Belongs to the glucose-6-phosphate 1-epimerase family. (302 aa)
THL1_568Diguanylate cyclase. (147 aa)
THL1_569Hypothetical protein. (169 aa)
THL1_5717Hypothetical protein. (136 aa)
THL1_5719Cytochrome C biogenesis protein CcmE. (586 aa)
THL1_572DNA polymerase. (231 aa)
THL1_573DNA polymerase. (267 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (454 aa)
THL1_579Histidine kinase. (429 aa)
THL1_593Chemotaxis protein CheA. (733 aa)
THL1_602Capsular exopolysaccharide family protein. (746 aa)
THL1_605Hypothetical protein. (463 aa)
THL1_616Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (292 aa)
THL1_634Histidine kinase. (427 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (363 aa)
coaXPantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (249 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1357 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1399 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (316 aa)
rpoADNA-directed RNA polymerasesubunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (333 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (916 aa)
thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
THL1_79Diguanylate cyclase. (645 aa)
THL1_807Hypothetical protein. (507 aa)
THL1_809Tyrosine protein kinase. (746 aa)
THL1_83Histidine kinase. (591 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (214 aa)
THL1_857DNA polymerase III subunit delta. (345 aa)
THL1_871Hydrogenase. (265 aa)
THL1_872Histidine kinase. (799 aa)
THL1_901DNA polymerase III subunit epsilon. (203 aa)
THL1_931Molybdopterin-guanine dinucleotide biosynthesis protein MobA. (193 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa)
THL1_972FMN adenylyltransferase/riboflavin kinase; Belongs to the ribF family. (312 aa)
THL1_993Histidine kinase. (533 aa)
Your Current Organism:
Pseudomonas sp. TCUHL1
NCBI taxonomy Id: 1856685
Other names: P. sp. TCU-HL1, Pseudomonas sp. TCU-HL1
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