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THL1_3628 THL1_3628 THL1_3667 THL1_3667 THL1_3687 THL1_3687 THL1_3688 THL1_3688 prmB prmB THL1_3763 THL1_3763 rlmM rlmM THL1_3847 THL1_3847 THL1_3850 THL1_3850 ubiG ubiG THL1_393 THL1_393 THL1_4011 THL1_4011 THL1_4029 THL1_4029 THL1_4037 THL1_4037 THL1_4148 THL1_4148 THL1_4213 THL1_4213 bioC bioC THL1_4351 THL1_4351 THL1_4352 THL1_4352 metE metE THL1_4418 THL1_4418 rlmD rlmD THL1_4522 THL1_4522 pcm pcm THL1_4582 THL1_4582 rsmJ rsmJ THL1_4624 THL1_4624 trmD trmD THL1_4725 THL1_4725 THL1_4752 THL1_4752 THL1_4791 THL1_4791 THL1_4794 THL1_4794 rsmC rsmC prmC prmC THL1_4908 THL1_4908 rlmE-2 rlmE-2 cmoM cmoM prmA prmA rsmA rsmA THL1_5192 THL1_5192 rlmB rlmB rlmJ rlmJ ubiE ubiE THL1_5333 THL1_5333 THL1_5362 THL1_5362 trmL trmL THL1_5533 THL1_5533 THL1_562 THL1_562 rsmG rsmG THL1_590 THL1_590 THL1_637 THL1_637 THL1_660 THL1_660 THL1_737 THL1_737 THL1_738 THL1_738 THL1_741 THL1_741 cbiD cbiD THL1_755 THL1_755 THL1_766 THL1_766 THL1_790 THL1_790 THL1_832 THL1_832 THL1_841 THL1_841 rlmH rlmH THL1_919 THL1_919 rlmG rlmG trmA trmA THL1_1014 THL1_1014 THL1_108 THL1_108 rsmI rsmI rsmH rsmH rlmF rlmF trmJ trmJ rlmN rlmN THL1_1312 THL1_1312 THL1_1315 THL1_1315 mnmC mnmC THL1_1438 THL1_1438 THL1_1470 THL1_1470 THL1_1564 THL1_1564 THL1_1601 THL1_1601 THL1_1656 THL1_1656 THL1_1693 THL1_1693 rlmE rlmE THL1_1811 THL1_1811 THL1_1826 THL1_1826 THL1_19 THL1_19 thyA thyA THL1_2013 THL1_2013 THL1_2059 THL1_2059 rlmL rlmL THL1_217 THL1_217 THL1_2198 THL1_2198 THL1_230 THL1_230 tpm tpm THL1_2379 THL1_2379 THL1_2414 THL1_2414 trmB trmB THL1_2437 THL1_2437 cysG cysG THL1_249 THL1_249 THL1_2542 THL1_2542 THL1_2645 THL1_2645 THL1_2796 THL1_2796 THL1_2949 THL1_2949 THL1_302 THL1_302 THL1_306 THL1_306 THL1_3150 THL1_3150 THL1_3474 THL1_3474 THL1_3493 THL1_3493 THL1_3577 THL1_3577 THL1_3592 THL1_3592 THL1_3595 THL1_3595
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THL1_3628Hypothetical protein. (254 aa)
THL1_3667uroporphyrin-III methyltransferase. (245 aa)
THL1_3687DNA-3-methyladenine glycosidase. (302 aa)
THL1_3688Cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (166 aa)
prmBSAM-dependent methyltransferase; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily. (304 aa)
THL1_3763Type I restriction-modification protein subunit M. (799 aa)
rlmM23S rRNA methyltransferase; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (349 aa)
THL1_3847Methyltransferase. (209 aa)
THL1_38506-O-methylguanine DNA methyltransferase. (385 aa)
ubiG3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (232 aa)
THL1_393Sarcosine oxidase subunit beta. (416 aa)
THL1_4011Chemotaxis protein. (275 aa)
THL1_4029Methyltransferase type 12. (223 aa)
THL1_4037Isoprenylcysteine carboxyl methyltransferase. (218 aa)
THL1_4148Hypothetical protein. (546 aa)
THL1_4213Hypothetical protein. (572 aa)
bioCmalonyl-CoA O-methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (271 aa)
THL1_4351Urea carboxylase. (242 aa)
THL1_4352Hypothetical protein. (211 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (762 aa)
THL1_4418SAM-dependent methyltransferase. (348 aa)
rlmD23S rRNA (uracil-5-)-methyltransferase RumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (450 aa)
THL1_4522tRNA-Thr(GGU) m(6)t(6)A37 methyltransferase TsaA. (230 aa)
pcmprotein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (225 aa)
THL1_4582rRNA methyltransferase. (268 aa)
rsmJSAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA. (257 aa)
THL1_4624Methyltransferase. (416 aa)
trmDtRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (250 aa)
THL1_4725Methyltransferase. (231 aa)
THL1_4752Hypothetical protein. (598 aa)
THL1_4791Hypothetical protein. (624 aa)
THL1_4794Hypothetical protein. (515 aa)
rsmC16S rRNA methyltransferase; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (332 aa)
prmCSAM-dependent methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (276 aa)
THL1_4908SAM-dependent methyltransferase; Belongs to the methyltransferase superfamily. (339 aa)
rlmE-2Hypothetical protein; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (207 aa)
cmoMSAM-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family. (249 aa)
prmARibosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (292 aa)
rsmADimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (268 aa)
THL1_5192Hypothetical protein. (809 aa)
rlmB23S rRNA methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (248 aa)
rlmJLactate dehydrogenase; Specifically methylates the adenine in position 2030 of 23S rRNA. (279 aa)
ubiEUbiquinone biosynthesis methyltransferaseUbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (256 aa)
THL1_533316S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (235 aa)
THL1_5362Fe-S-oxidoreductase. (131 aa)
trmLrRNA methylase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. (153 aa)
THL1_5533uroporphyrin-III methyltransferase. (377 aa)
THL1_562Hydroxyglutarate oxidase. (416 aa)
rsmGRibosomal RNA small subunit methyltransferase G; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (215 aa)
THL1_590Hypothetical protein. (504 aa)
THL1_637Type III modification methyltransferase; Belongs to the N(4)/N(6)-methyltransferase family. (292 aa)
THL1_660Hypothetical protein. (236 aa)
THL1_737precorrin-3B C17-methyltransferase. (549 aa)
THL1_738Precorrin-2 C20-methyltransferase / precorrin-6A synthase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. (249 aa)
THL1_741precorrin-6Y C5,15-methyltransferase. (408 aa)
cbiDCobalt precorrin-6A synthase; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (365 aa)
THL1_755Precorrin-4 C11-methyltransferase. (256 aa)
THL1_766Methyltransferase. (217 aa)
THL1_790Methyltransferase; Belongs to the methyltransferase superfamily. (312 aa)
THL1_832Phospholipid methyltransferase. (203 aa)
THL1_841Polyketide biosynthesis methyltransferase. (281 aa)
rlmH50S rRNA methyltransferase; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (144 aa)
THL1_919Hypothetical protein. (111 aa)
rlmG50S rRNA methyltransferase; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (374 aa)
trmAtRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (364 aa)
THL1_1014Leader peptidase (Prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. (290 aa)
THL1_108Hypothetical protein. (588 aa)
rsmIMethyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (290 aa)
rsmH16S rRNA methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (315 aa)
rlmF23S rRNA methyltransferase; Specifically methylates the adenine in position 1618 of 23S rRNA. (330 aa)
trmJtRNA:Cm32/Um32 methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA. (257 aa)
rlmN23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (382 aa)
THL1_1312Hypothetical protein. (530 aa)
THL1_1315Thioesterase. (95 aa)
mnmCFAD-dependent cmnm(5)s(2)U34 oxidoreductase; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family. (655 aa)
THL1_1438Chemotaxis protein CheR; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP. (281 aa)
THL1_1470Sarcosine oxidase subunit beta. (413 aa)
THL1_1564Hydroxyglutarate oxidase. (416 aa)
THL1_1601SAM-dependent methyltransferase. (242 aa)
THL1_1656MarR family transcriptional regulator. (131 aa)
THL1_1693rRNA methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (243 aa)
rlmE23S rRNA methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (206 aa)
THL1_1811SAM-dependent methyltransferase. (216 aa)
THL1_1826DNA methyltransferase. (122 aa)
THL1_19Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (437 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
THL1_2013SAM-dependent methyltransferase. (254 aa)
THL1_2059Glycine/betaine transmethylase. (678 aa)
rlmL50S rRNA methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (725 aa)
THL1_217SAM-dependent methyltransferase. (398 aa)
THL1_2198Membrane protein. (257 aa)
THL1_23016S rRNA methyltransferase; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (205 aa)
tpmThiopurine S-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family. (233 aa)
THL1_2379SAM-dependent methyltransferase. (249 aa)
THL1_2414Hypothetical protein. (76 aa)
trmBtRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (238 aa)
THL1_2437Homocysteine methyltransferase. (319 aa)
cysGSirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (464 aa)
THL1_249Methionine biosynthesis protein MetW. (206 aa)
THL1_2542Vanillate O-demethylase reductase component. (320 aa)
THL1_2645Hypothetical protein. (627 aa)
THL1_2796Hypothetical protein. (640 aa)
THL1_2949Isoprenylcysteine carboxyl methyltransferase. (219 aa)
THL1_302Methyltransferase. (295 aa)
THL1_30616S rRNA methyltransferase; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (239 aa)
THL1_3150Hypothetical protein. (617 aa)
THL1_3474Hypothetical protein. (623 aa)
THL1_3493Hypothetical protein. (558 aa)
THL1_3577DNA methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (307 aa)
THL1_3592Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa)
THL1_3595Ribosomal RNA large subunit methyltransferase N; Belongs to the radical SAM superfamily. RlmN family. (346 aa)
Your Current Organism:
Pseudomonas sp. TCUHL1
NCBI taxonomy Id: 1856685
Other names: P. sp. TCU-HL1, Pseudomonas sp. TCU-HL1
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