STRINGSTRING
purU purU THL1_1418 THL1_1418 THL1_1428 THL1_1428 purU-2 purU-2 THL1_1492 THL1_1492 THL1_1500 THL1_1500 purU-3 purU-3 THL1_1504 THL1_1504 THL1_1532 THL1_1532 THL1_1540 THL1_1540 THL1_1616 THL1_1616 THL1_1721 THL1_1721 THL1_186 THL1_186 THL1_188 THL1_188 THL1_1896 THL1_1896 THL1_1897 THL1_1897 THL1_1898 THL1_1898 THL1_1899 THL1_1899 THL1_2004 THL1_2004 THL1_2172 THL1_2172 THL1_2179 THL1_2179 mdh mdh THL1_2275 THL1_2275 THL1_2290 THL1_2290 THL1_2428 THL1_2428 THL1_2431 THL1_2431 THL1_2464 THL1_2464 THL1_2830 THL1_2830 gcvP gcvP gcvH gcvH THL1_2961 THL1_2961 THL1_3167 THL1_3167 THL1_3169 THL1_3169 THL1_3180 THL1_3180 THL1_3206 THL1_3206 THL1_3207 THL1_3207 THL1_3229 THL1_3229 THL1_3486 THL1_3486 THL1_357 THL1_357 THL1_358 THL1_358 THL1_359 THL1_359 THL1_360 THL1_360 THL1_3656 THL1_3656 THL1_3780 THL1_3780 THL1_3795 THL1_3795 glyA glyA purU-4 purU-4 THL1_4019 THL1_4019 THL1_4095 THL1_4095 THL1_4177 THL1_4177 THL1_4220 THL1_4220 glcB glcB THL1_4233 THL1_4233 THL1_4239 THL1_4239 acsA acsA THL1_43 THL1_43 gcvH-2 gcvH-2 gcvP-2 gcvP-2 glyA-2 glyA-2 THL1_4391 THL1_4391 THL1_453 THL1_453 THL1_4793 THL1_4793 THL1_4798 THL1_4798 acsA-2 acsA-2 THL1_5072 THL1_5072 THL1_5093 THL1_5093 THL1_5094 THL1_5094 THL1_5095 THL1_5095 THL1_5096 THL1_5096 THL1_533 THL1_533 THL1_5342 THL1_5342 THL1_5374 THL1_5374 gcvP-3 gcvP-3 gcvH-3 gcvH-3 gcvT gcvT THL1_5710 THL1_5710 THL1_730 THL1_730 glyA-3 glyA-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
THL1_1418acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
THL1_1428acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
THL1_1492Glutamine synthetase. (444 aa)
THL1_1500Aminomethyltransferase; Belongs to the GcvT family. (781 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
THL1_1504Aminomethyltransferase; Belongs to the GcvT family. (376 aa)
THL1_1532Keto-deoxy-phosphogluconate aldolase. (229 aa)
THL1_1540Esterase. (289 aa)
THL1_1616Glutamine synthetase. (454 aa)
THL1_1721Hydroxypyruvate isomerase; Belongs to the hyi family. (261 aa)
THL1_186Gamma-glutamylputrescine synthetase; Belongs to the glutamine synthetase family. (461 aa)
THL1_188Glutamine synthetase. (452 aa)
THL1_1896Glycerate 2-kinase. (426 aa)
THL1_1897Tartronate semialdehyde reductase. (296 aa)
THL1_1898Hydroxypyruvate isomerase; Belongs to the hyi family. (260 aa)
THL1_1899Glyoxylate carboligase; Belongs to the TPP enzyme family. (591 aa)
THL1_20042-dehydro-3-deoxyphosphogluconate aldolase. (216 aa)
THL1_2172Type II citrate synthase; Belongs to the citrate synthase family. (428 aa)
THL1_2179Dihydrolipoamide dehydrogenase. (478 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (321 aa)
THL1_22753-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
THL1_2290acetyl-CoA synthetase. (567 aa)
THL1_2428Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (352 aa)
THL1_2431Dihydrolipoamide dehydrogenase. (469 aa)
THL1_2464Isocitrate lyase. (531 aa)
THL1_2830Aminomethyltransferase. (372 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
THL1_2961D-isomer specific 2-hydroxyacid dehydrogenase. (309 aa)
THL1_3167acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
THL1_3169AMP-binding protein. (539 aa)
THL1_3180Glutamine synthetase. (457 aa)
THL1_3206Fumarate hydrolyase. (202 aa)
THL1_3207Tartrate dehydratase subunit alpha. (299 aa)
THL1_3229acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
THL1_3486Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
THL1_357Formate dehydrogenase. (160 aa)
THL1_358Formate dehydrogenase. (519 aa)
THL1_359Formate dehydrogenase. (958 aa)
THL1_360Formate dehydrogenase. (73 aa)
THL1_3656Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family. (884 aa)
THL1_3780Hydrolase. (230 aa)
THL1_3795Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
purU-4Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (287 aa)
THL1_4019Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (447 aa)
THL1_4095enoyl-CoA hydratase. (156 aa)
THL1_4177Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
THL1_42203-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
THL1_4233acyl-CoA dehydrogenase. (559 aa)
THL1_4239acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (651 aa)
THL1_43Haloacid dehalogenase. (214 aa)
gcvH-2Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa)
gcvP-2Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
THL1_4391Aminomethyltransferase. (372 aa)
THL1_453Glutamine synthetase. (450 aa)
THL1_4793acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
THL1_4798Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa)
acsA-2acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
THL1_5072acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
THL1_5093Formate dehydrogenase gamma subunit. (210 aa)
THL1_5094Formate dehydrogenase subunit beta; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. (308 aa)
THL1_5095Formate dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (811 aa)
THL1_5096Sulfate ABC transporter substrate-bindingprotein. (272 aa)
THL1_533Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (279 aa)
THL1_5342N-formylglutamate amidohydrolase. (267 aa)
THL1_5374Glutamine synthetase. (467 aa)
gcvP-3Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (958 aa)
gcvH-3Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
THL1_5710Glutamine synthetase. (455 aa)
THL1_730Catalase. (481 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
Your Current Organism:
Pseudomonas sp. TCUHL1
NCBI taxonomy Id: 1856685
Other names: P. sp. TCU-HL1, Pseudomonas sp. TCU-HL1
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.