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rpl44e rpl44e rps24e rps24e rpl18a rpl18a rpl31e rpl31e rps6e rps6e rpl14e rpl14e rpl34e rpl34e rpl15e rpl15e rpl21e rpl21e infB infB rpl10e rpl10e rpl7ae rpl7ae rps28e rps28e rpl24e rpl24e rps10 rps10 rpl40e rpl40e rps17e rps17e rps19e rps19e rps7 rps7 rps12 rps12 rpl30e rpl30e eIF1A eIF1A rps2 rps2 rps9 rps9 rpl13 rpl13 rpl18e rpl18e rps11 rps11 rps13 rps13 rpl15 rpl15 rpl30 rpl30 rps5 rps5 rpl18 rpl18 rpl19e rpl19e rpl32e rpl32e rpl6 rpl6 rps8 rps8 rps14 rps14 rpl5 rpl5 rps4e rps4e rpl14 rpl14 rps17 rps17 rpl29 rpl29 rps3 rps3 rps19 rps19 rpl2 rpl2 rpl23 rpl23 rpl3 rpl3 rpl35ae rpl35ae rpl1 rpl1 rpl10 rpl10 rpl12 rpl12 rpl37ae rpl37ae rps3ae rps3ae
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpl44eLSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa)
rps24eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps24E). (99 aa)
rpl18aFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rplXA). (77 aa)
rpl31eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl31E). (95 aa)
rps6eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps6E). (125 aa)
rpl14eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl14E). (83 aa)
rpl34eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl34E). (89 aa)
rpl15eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl15E). (194 aa)
rpl21eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl21E). (97 aa)
infBTranslation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity). (984 aa)
rpl10eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification. (181 aa)
rpl7aeLSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. Component of the 70S ribosome. Component of a box C/D small ribonucleoprotein (sRNP) particle that is involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site- specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic d [...] (124 aa)
rps28eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps28E). (71 aa)
rpl24eLSU ribosomal protein L24E; Binds to the 23S rRNA. (66 aa)
rps10SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpl40eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl40E). (51 aa)
rps17eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps17E). (67 aa)
rps19eSSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa)
rps7SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa)
rps12SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa)
rpl30eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl30E). (99 aa)
eIF1ATranslation initiation factor eIF-1a; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (113 aa)
rps2Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps2P). (202 aa)
rps9Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps9P). (135 aa)
rpl13LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (142 aa)
rpl18eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl18E). (120 aa)
rps11SSU ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (137 aa)
rps13SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (148 aa)
rpl15LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (147 aa)
rpl30Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl30P). (155 aa)
rps5SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (236 aa)
rpl18LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (203 aa)
rpl19eLSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa)
rpl32eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl32E). (130 aa)
rpl6LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa)
rps8SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rps14SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
rpl5LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (186 aa)
rps4eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps4E). (243 aa)
rpl14LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa)
rps17SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (113 aa)
rpl29Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl29P). (72 aa)
rps3SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (210 aa)
rps19SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (132 aa)
rpl2LSU ribosomal protein L2P; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (239 aa)
rpl23LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (88 aa)
rpl3LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (365 aa)
rpl35aeFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl35AE). (87 aa)
rpl1LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa)
rpl10LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (339 aa)
rpl12LSU ribosomal protein L12A; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (107 aa)
rpl37aeLSU ribosomal protein L37AE; Binds to the 23S rRNA. (83 aa)
rps3aeFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps3AE). (198 aa)
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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