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PF0201 PF0201 PF0202 PF0202 gltA gltA PF0753 PF0753 PF0754 PF0754 PF0935 PF0935 ilvC ilvC leuA leuA leuC1 leuC1 leuD1 leuD1 PF0940 PF0940 PF0941 PF0941 ilvD ilvD porB porB porA porA porD porD vorB vorB vorA vorA vorD vorD porG porG PF1026 PF1026 PF1302 PF1302 PF1497 PF1497 PF1678 PF1678 leuC2 leuC2 leuD2 leuD2 PF1754 PF1754 PF1755 PF1755 PF1767 PF1767 PF1768 PF1768 PF1769 PF1769 PF1770 PF1770 PF1771 PF1771 PF1772 PF1772 PF1773 PF1773
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PF0201Aconitate hydratase (aconitase); Function Code: 6.10 Energy Metabolism: TCA cycle. (831 aa)
PF0202Isocitrate dehydrogenase; Function Code: 6.10 Energy Metabolism: TCA cycle. (400 aa)
gltACitrate synthase; Function Code: 6.10 Energy Metabolism: TCA cycle. (377 aa)
PF07532-keto acid:ferredoxin oxidoreductase subunit beta; Function Code: 6.5 Energy Metabolism: Fermentation. (288 aa)
PF07542-keto acid:ferredoxin oxidoreductase subunit alpha; Function Code: 6.5 Energy Metabolism: Fermentation. (570 aa)
PF0935Acetolactate synthase; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family. (564 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (499 aa)
leuC13-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (424 aa)
leuD1Putative 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
PF09403-isopropylmalate dehydrogenase 2; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family (leuB2); (leuB). (355 aa)
PF0941Leua homolog alpha-isopropylmalate synthase related; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family; Belongs to the alpha-IPM synthase/homocitrate synthase family. (525 aa)
ilvDDihydroxy-acid dehydratase; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family; (ilvD); Belongs to the IlvD/Edd family. (551 aa)
porBPyruvate ferredoxin oxidoreductase subunit beta-2; Function Code: 6.5 Energy Metabolism: Fermentation. (331 aa)
porAPyruvate ferredoxin oxidoreductase subunit alpha-2; Function Code: 6.5 Energy Metabolism: Fermentation. (396 aa)
porDPyruvate ferredoxin oxidoreductase subunit delta; Function Code: 6.5 Energy Metabolism: Fermentation. (105 aa)
vorB2-ketovalerate ferredoxin oxidoreductase subunit beta-2; Function Code: 6.5 Energy Metabolism: Fermentation. (311 aa)
vorA2-ketovalerate ferredoxin oxidoreductase subunit alpha-2; Function Code: 6.5 Energy Metabolism: Fermentation. (394 aa)
vorD2-ketovalerate ferredoxin oxidoreductase subunit delta-2; Function Code: 6.5 Energy Metabolism: Fermentation. (105 aa)
porGPyruvate ferredoxin oxidoreductase/2-ketovalerate ferredoxin oxidoreductase gamma subunit; Function Code: 6.5 Energy Metabolism: Fermentation. (185 aa)
PF1026Malate oxidoreductase (malic enzyme); Function Code: 6.6 Energy Metabolism: Gluconeogenesis. (435 aa)
PF1302Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (147 aa)
PF1497Putative transaminase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family. (398 aa)
PF16782-isopropylmalate synthase; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family; (leuA). (317 aa)
leuC2Putative 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (380 aa)
leuD2Putative 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
PF1754Possible fumarate hydratase (fumarase) beta subunit; Function Code: 6.10 Energy Metabolism: TCA cycle. (166 aa)
PF1755Possible fumarate hydratase (fumarase) alpha subunit; Function Code: 6.10 Energy Metabolism: TCA cycle. (272 aa)
PF17672-keto acid:ferredoxin oxidoreductase subunit delta; Function Code: 6.5 Energy Metabolism: Fermentation. (86 aa)
PF17682-keto acid:ferredoxin oxidoreductase subunit alpha; Function Code: 6.5 Energy Metabolism: Fermentation. (396 aa)
PF17692-keto acid:ferredoxin oxidoreductase subunit beta; Function Code: 6.5 Energy Metabolism: Fermentation. (282 aa)
PF17702-keto acid:ferredoxin oxidoreductase subunit gamma; Function Code: 6.5 Energy Metabolism: Fermentation. (171 aa)
PF17712-keto acid:ferredoxin oxidoreductase subunit alpha; Function Code: 6.5 Energy Metabolism: Fermentation. (387 aa)
PF17722-keto acid:ferredoxin oxidoreductase subunit beta; Function Code: 6.5 Energy Metabolism: Fermentation. (281 aa)
PF17732-keto acid:ferredoxin oxidoreductase subunit gamma; Function Code: 6.5 Energy Metabolism: Fermentation. (180 aa)
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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