STRINGSTRING
rps12 rps12 PF1536 PF1536 PF0007 PF0007 PF0008 PF0008 cdc6 cdc6 radB radB PF0024 PF0024 PF0056 PF0056 PF0057 PF0057 flpA flpA PF0060 PF0060 PF0075 PF0075 kptA kptA PF0084 PF0084 PF0085 PF0085 PF0086 PF0086 PF0089 PF0089 rfcL rfcL rfcS rfcS PF0097 PF0097 priS priS priL priL PF0112 PF0112 engB engB PF0125 PF0125 PF0126 PF0126 PF0142 PF0142 PF0149 PF0149 PF0152 PF0152 aglB1 aglB1 PF0165 PF0165 atpF atpF atpA atpA atpB atpB PF0185 PF0185 pyrK pyrK PF0202 PF0202 gltA gltA PF0205 PF0205 pol pol PF0213 PF0213 rpl44e rpl44e PF0222 PF0222 PF0225 PF0225 PF0226 PF0226 rps24e rps24e PF0258 PF0258 endA endA PF0268 PF0268 PF0275 PF0275 pckG pckG PF0291 PF0291 PF0304 PF0304 PF0313 PF0313 PF0314 PF0314 PF0326 PF0326 PF0354 PF0354 rpl18a rpl18a rpl31e rpl31e PF0380 PF0380 PF0384 PF0384 PF0387 PF0387 PF0405 PF0405 aglB2 aglB2 PF0418 PF0418 PF0435 PF0435 PF0449 PF0449 PF0454 PF0454 PF0463 PF0463 PF0465 PF0465 PF0467 PF0467 rps6e rps6e tfe tfe trmBL2 trmBL2 taw2 taw2 tmcA tmcA PF0512 PF0512 PF0517 PF0517 PF0544 PF0544 PF0557 PF0557 PF0564 PF0564 PF0592 PF0592 PF0596 PF0596 PF0597 PF0597 PF0608 PF0608 PF0620 PF0620 PF0632 PF0632 PF0634 PF0634 PF0635 PF0635 PF0636 PF0636 PF0661 PF0661 hel308 hel308 PF0680 PF0680 PF0689 PF0689 hcp hcp PF0696 PF0696 PF0705 PF0705 PF0711 PF0711 PF0712 PF0712 PF0713 PF0713 PF0724 PF0724 PF0748 PF0748 PF0752 PF0752 PF0759 PF0759 PF0760 PF0760 PF0764 PF0764 PF0804 PF0804 PF0811 PF0811 PF0818 PF0818 rpl14e rpl14e rpl34e rpl34e fni fni PF0863 PF0863 ubiX ubiX rpl15e rpl15e PF0878 PF0878 PF0880 PF0880 hydG hydG PF0915 PF0915 truA truA PF0933 PF0933 leuA leuA PF0941 PF0941 ilvD ilvD PF0972 PF0972 acaC acaC PF0979 PF0979 PF0994 PF0994 PF0998 PF0998 PF1015 PF1015 PF1032 PF1032 rpl21e rpl21e PF1060 PF1060 rps8e rps8e PF1083 PF1083 PF1097 PF1097 PF1107 PF1107 pyrF pyrF PF1115 PF1115 PF1134 PF1134 nop10 nop10 panB panB cobB cobB rbcL rbcL PF1160 PF1160 PF1161 PF1161 PF1164 PF1164 mre11 mre11 rad50 rad50 PF1182 PF1182 PF1186 PF1186 PF1190 PF1190 PF1191 PF1191 PF1192 PF1192 PF1195 PF1195 PF1197 PF1197 PF1199 PF1199 PF1219 PF1219 PF1220 PF1220 PF1221 PF1221 nth nth nep1 nep1 rpl10e rpl10e PF1285 PF1285 PF1286 PF1286 tbp tbp PF1325 PF1325 sudB sudB shyC shyC rnz rnz PF1346 PF1346 rps28e rps28e rpl24e rpl24e PF1373 PF1373 rps10 rps10 fen fen PF1415 PF1415 PF1439 PF1439 PF1456 PF1456 PF1472 PF1472 rpl40e rpl40e PF1477 PF1477 rps17e rps17e PF1495 PF1495 rps19e rps19e PF1500 PF1500 PF1506 PF1506 cetZ cetZ pdxS pdxS PF1532 PF1532 PF1534 PF1534 rps15 rps15 rps3ae rps3ae PF2044 PF2044 PF2025 PF2025 PF2024 PF2024 PF2020 PF2020 PF2010 PF2010 rpl37ae rpl37ae PF1998 PF1998 rpl12 rpl12 rpl10 rpl10 rpl1 rpl1 rpl11 rpl11 PF1986 PF1986 PF1979 PF1979 PF1963 PF1963 PF1942 PF1942 PF1940 PF1940 PF1929 PF1929 PF1928 PF1928 radA radA PF1918 PF1918 PF1912 PF1912 PF1911 PF1911 PF1902 PF1902 PF1899 PF1899 albA albA PF1875 PF1875 rpl35ae rpl35ae rsmA rsmA PF1859 PF1859 PF1853 PF1853 PF1848 PF1848 PF1831 PF1831 PF1829 PF1829 PF1826 PF1826 rpl3 rpl3 rpl23 rpl23 rps19 rps19 rpl22 rpl22 rps3 rps3 rpl29 rpl29 rps17 rps17 rpl14 rpl14 rpl24 rpl24 rps4e rps4e rpl5 rpl5 rps14 rps14 rps8 rps8 rpl6 rpl6 rpl32e rpl32e rpl19e rpl19e rpl18 rpl18 rps5 rps5 PF1791 PF1791 truB truB glyA glyA PF1777 PF1777 ftsY ftsY dnaG dnaG PF1724 PF1724 PF1722 PF1722 taw1 taw1 PF1688 PF1688 lysJ lysJ lysZ lysZ lysY lysY PF1678 PF1678 PF1674 PF1674 PF1669 PF1669 hisD hisD rps13 rps13 rps4 rps4 rpl18e rpl18e rps9 rps9 rps2 rps2 lig lig PF1618 PF1618 rtcB rtcB PF1609 PF1609 PF1603 PF1603 PF1598 PF1598 top6A top6A PF1570 PF1570 rpl30e rpl30e rps7 rps7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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rps12SSU ribosomal protein S12P; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa)
PF1536Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (183 aa)
PF0007Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (495 aa)
PF0008Hit family protein (hit); Function Code: 16 Unknown:. (164 aa)
cdc6Origin recognition protein subunit 1; Involved in regulation of DNA replication. May play essential roles in origin recognition and cell cycle control of replication. Binds specifically to the oriC region, which alters the topological structure of the DNA and introduces localized melting of the DNA duplex. May recruit the MCM helicase onto the oriC region. Shows weak ATPase activity in the absence of DNA. Belongs to the CDC6/cdc18 family. (420 aa)
radBRecombinase; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (235 aa)
PF0024Putative glycerate kinase; Function Code: 5.6 Central Intermediary Metabolism: Other. (450 aa)
PF0056Putative carbohydrate binding protein; Function Code: 16.0 Unknown. (122 aa)
PF0057Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (551 aa)
flpAFibrillarin-like pre-rRNA processing protein; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. (227 aa)
PF0060NOP5/NOP56 related protein; Function Code: 12.3 Transcription: RNA processing. (402 aa)
PF0075Alcohol dehydrogenase; Function Code: 6.5 Energy Metabolism: Fermentation. (390 aa)
kptAHypothetical protein; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase. (170 aa)
PF0084Function Code: 16.4 Hypothetical. (40 aa)
PF0085Putative DNA helicase; Function Code: 16.0 Unknown. (1278 aa)
PF0086Partial alanyl-tRNA synthetase matches COOH terminus; Function Code: 13.1 Translation: Amino acyl tRNA synthetases. (214 aa)
PF0089Met-10+ protein; Function Code: 16 Unknown:. (333 aa)
rfcLReplication factor C, large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. (479 aa)
rfcSReplication factor C, small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-dependent ATPase activity which is further stimulated by PCNA. Belongs to the activator 1 small subunits family. RfcS subfamily. (852 aa)
PF0097Bacteriochlorophyll synthase, 43 kDa subunit homolog; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (393 aa)
priSDNA primase, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May [...] (347 aa)
priLHypothetical protein; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (396 aa)
PF0112Hypothetical protein; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA (By similarity). (354 aa)
engBGTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation. (190 aa)
PF0125Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (77 aa)
PF0126DNA repair protein rad25; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. (444 aa)
PF0142Asparaginase; Function Code: 5.6 Central Intermediary Metabolism: Other. (306 aa)
PF0149Putative alcohol dehydrogenase/reductase; Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides. (263 aa)
PF0152Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (219 aa)
aglB1Oligosaccharyl transferase stt3 subunit related protein; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (ManNAcXyl(2)GlcAMan(2)GalNAc in P.furiosus) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. (967 aa)
PF0165Hydrolase related to 2-haloalkanoic acid dehalogenase; Function Code: 16.0 Unknown. (230 aa)
atpFATPase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (103 aa)
atpAATPase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit; Belongs to the ATPase alpha/beta chains family. (1013 aa)
atpBATPase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (462 aa)
PF0185Partial alanyl-tRNA synthetase matches COOH terminus half; Function Code: 13.1 Translation: Amino acyl tRNA synthetases. (404 aa)
pyrKHydrogenase subunit gamma; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (247 aa)
PF0202Isocitrate dehydrogenase; Function Code: 6.10 Energy Metabolism: TCA cycle. (400 aa)
gltACitrate synthase; Function Code: 6.10 Energy Metabolism: TCA cycle. (377 aa)
PF0205Glutamate synthase subunit alpha; Function Code: 1.4 Amino Acid Biosynthesis: Glutamate family; (NADPH); Belongs to the glutamate synthase family. (502 aa)
polDNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity. (775 aa)
PF0213Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (270 aa)
rpl44eLSU ribosomal protein L44E; Binds to the 23S rRNA. (94 aa)
PF0222Hydrolase related to 2-haloalkanoic acid dehalogenase; Function Code: 16.0 Unknown. (219 aa)
PF0225Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (128 aa)
PF0226Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (90 aa)
rps24eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps24E). (99 aa)
PF0258Putative endonuclease IV; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. (281 aa)
endAPutative tRNA-intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (170 aa)
PF0268Na+/H+ antiporter homolog; Function Code: 14.5 Transport and Binding Proteins: Cations. (377 aa)
PF0275Na+/H+ antiporter; Function Code: 14.5 Transport and Binding Proteins: Cations; (napA). (379 aa)
pckGPhosphoenolpyruvate carboxykinase (gtp); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (624 aa)
PF0291Prephenate dehydratase; Function Code: 1.2 Amino Acid Biosynthesis: Aromatic amino acid family. (266 aa)
PF0304DEXX-box atpase; Function Code: 16.0 Unknown. (442 aa)
PF0313Signal sequence peptidase I; Function Code: 4.6 Cellular Processes: Protein and peptide secretion; (sec11). (85 aa)
PF0314Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (69 aa)
PF0326Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (331 aa)
PF0354Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (267 aa)
rpl18aFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rplXA). (77 aa)
rpl31eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl31E). (95 aa)
PF0380Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (242 aa)
PF0384Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (330 aa)
PF0387Putative carbohydrate-binding protein; Function Code: 16.0 Unknown. (112 aa)
PF0405Methanol dehydrogenase regulatory protein; Function Code: 10 Regulatory Functions: REGULATORY FUNCTIONS; (moxR). (310 aa)
aglB2Protein-export membrane protein; Oligosaccharyl transferase (OST) that catalyzes the initial transfer of a defined glycan (ManNAcXyl(2)GlcAMan(2)GalNAc in P.furiosus) from the lipid carrier dolichol-monophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. Belongs to the STT3 family. (743 aa)
PF0418Methanol dehydrogenase regulatory protein; Function Code: 10 Regulatory Functions: REGULATORY FUNCTIONS; (moxR). (317 aa)
PF0435DEXX-box atpase; Function Code: 16.0 Unknown. (455 aa)
PF0449Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (287 aa)
PF0454Bacteriochlorophyll synthase, 43 kDa subunit; Function Code: 2.3 Biosynthesis Of Cofactors, Prosthetic Groups And Carriers: Heme and porphyrin; (chlP-2). (370 aa)
PF0463Hydrolase related to 2-haloalkanoic acid dehalogenase; Function Code: 16.0 Unknown. (234 aa)
PF0465Putative glycosyl transferase; Function Code: 3.2 Cell Envelope: Surface polysaccharides, lipopolysaccharides and antigens. (350 aa)
PF0467ATP-dependent protease LA (lon); Function Code: 13.2 Translation: Degradation of proteins, peptides, and glycopeptides; Belongs to the peptidase S16 family. (1028 aa)
rps6eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps6E). (125 aa)
tfeTranscription initiation factor TFIIE; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation co [...] (195 aa)
trmBL2Hypothetical protein; Binds to the maltodextrin transport gene cluster (mdxE operon) promoter and to some other TGM (Thermococcales-Glycolytic- Motif) sequences, but not exclusively; Belongs to the transcriptional regulator TrmB family. (264 aa)
taw2Met-10+ protein; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (278 aa)
tmcADNA helicase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (816 aa)
PF0512Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (174 aa)
PF0517Methanol dehydrogenase regulatory protein; Function Code: 10 Regulatory Functions: REGULATORY FUNCTIONS; (moxR). (314 aa)
PF0544Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (133 aa)
PF05573-oxoacyl-[acyl-carrier protein] reductase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; (fabG). (260 aa)
PF0564ATP-dependent RNA helicase hepa, putative; Function Code: 12.3 Transcription: RNA processing. (940 aa)
PF0592ATP-dependent RNA helicase, putative; Function Code: 12.3 Transcription: RNA processing. (867 aa)
PF0596Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (314 aa)
PF0597Iaa-amino acid hydrolase homolog 1 precursor; Function Code: 13.2 Translation: Degradation of proteins, peptides, and glycopeptides. (440 aa)
PF0608Alcohol dehydrogenase; Function Code: 6.5 Energy Metabolism: Fermentation. (375 aa)
PF0620Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; Belongs to the UPF0251 family. (108 aa)
PF0632Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (253 aa)
PF0634DEXX-box atpase; Function Code: 16.0 Unknown. (458 aa)
PF0635DEXX-box atpase; Function Code: 16.0 Unknown. (449 aa)
PF0636DEXX-box atpase; Function Code: 16.0 Unknown. (456 aa)
PF0661Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (264 aa)
hel308Helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. Unwinds the lagging strand from forked DNA structures in a 3'-5' direction. PCNA, the DNA polymerase sliding clamp subunit, stimulates the helicase activity, and may alter substrate specificity. Unwinds branched DNA (Holliday junctions) in an ATP-dependent fashion; ss- and dsDNA stimulate ATPase to the greatest extent, although it preferentially binds DNA with a single-stranded region. Processes a RecA-mediated recombination intermediate between gapped circular and homolog [...] (720 aa)
PF0680Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (137 aa)
PF0689Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (123 aa)
hcpPrismane protein homolog; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (458 aa)
PF0696Putative carbohydrate-binding protein; Function Code: 16.0 Unknown. (103 aa)
PF0705Cytochrome c-type biogenesis protein; Function Code: 6.4 Energy Metabolism: Electron transport. (433 aa)
PF0711Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (145 aa)
PF0712Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (125 aa)
PF0713Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (60 aa)
PF0724Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (194 aa)
PF0748Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (49 aa)
PF0752Thioredoxin peroxidase; Function Code: 6.5 Energy Metabolism: Fermentation. (149 aa)
PF0759Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (105 aa)
PF0760Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (340 aa)
PF0764DEXX-box atpase; Function Code: 16.0 Unknown. (431 aa)
PF0804Methanol dehydrogenase regulator; Function Code: 10 Regulatory Functions: REGULATORY FUNCTIONS; (moxR). (309 aa)
PF0811Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (146 aa)
PF0818Aminohydrolase; Function Code: 6.1 Energy Metabolism: Amino acids and amines. (335 aa)
rpl14eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl14E). (83 aa)
rpl34eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl34E). (89 aa)
fniHypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (394 aa)
PF0863Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (171 aa)
ubiX3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (177 aa)
rpl15eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl15E). (194 aa)
PF0878Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (62 aa)
PF0880DEXX-box atpase; Function Code: 16.0 Unknown. (467 aa)
hydGSulfhydrogenase gamma subunit; Part of a bifunctional enzyme complex that functions as an NADPH-dependent hydrogen-evolving hydrogenase with sulfur reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity not exhibited with NAD. The beta and gamma subunits form the sulfur reducing component that catalyzes the cytoplasmic production of hydrogen sulfide in the presence of elemental sulfur. Not active in the presence of sodium sulfate, sodium sulfite, sodium thiosulfate or cysteine. (292 aa)
PF0915Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (237 aa)
truAPutative tRNA pseudouridine synthase a; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family. (266 aa)
PF0933DNA repair helicase rad3, putative; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. (631 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate). (499 aa)
PF0941Leua homolog alpha-isopropylmalate synthase related; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family; Belongs to the alpha-IPM synthase/homocitrate synthase family. (525 aa)
ilvDDihydroxy-acid dehydratase; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family; (ilvD); Belongs to the IlvD/Edd family. (551 aa)
PF0972Acyl carrier protein synthase; Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; (acaA); Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa)
acaCHypothetical protein; Function Code: 16.1 Conserved Hypothetical. (136 aa)
PF0979Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (125 aa)
PF0994Type II secretion system protein; Function Code: 4.6 Cellular Processes: Protein and peptide secretion. (1150 aa)
PF0998Hypothetical GTP-binding protein homolog; Function Code: 16 Unknown:. (355 aa)
PF1015Putative transposase b homolog; Function Code: 15.3 Other Categories: Transposon-related functions. (404 aa)
PF1032Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (389 aa)
rpl21eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl21E). (97 aa)
PF1060Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (207 aa)
rps8eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification. (127 aa)
PF1083Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (413 aa)
PF1097Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (354 aa)
PF1107Hit family protein (hit); Function Code: 16 Unknown:. (146 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (211 aa)
PF1115Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (172 aa)
PF1134Hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (180 aa)
nop10Hypothetical protein; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA; Belongs to the NOP10 family. (60 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (283 aa)
cobBTranscriptional regulatory protein, sir2; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. (297 aa)
rbcLRibulose-1,5-bisphosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (420 aa)
PF1160Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (202 aa)
PF1161Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (211 aa)
PF1164Putative Na+/H+ antiporter; Function Code: 14.5 Transport and Binding Proteins: Cations; (nhe2). (393 aa)
mre11Exonuclease putative; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. (428 aa)
rad50Smc-like protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. The ATP-bound conformation promotes DNA end binding and end tethering, and alters Mre11 nuclease activity. ATP hydrolysis promotes both Mre11 activity as well as HerA/NurA activity. Has also reversible adenylate kina [...] (882 aa)
PF1182Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (126 aa)
PF1186NADH oxidase; Function Code: 4.5 Cellular Processes: Detoxification; (noxA-2). (442 aa)
PF1190Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (174 aa)
PF1191Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (261 aa)
PF1192Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (96 aa)
PF1195Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (163 aa)
PF1197NADH oxidase /nitrite reductase; Function Code: 4.5 Cellular Processes: Detoxification; (noxA-4). (359 aa)
PF1199Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (174 aa)
PF1219Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (125 aa)
PF1220Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (68 aa)
PF1221Dissimilatory sulfate adenylyltransferase; Function Code: 5.5 Central Intermediary Metabolism: Sulfur metabolism. (259 aa)
nthGlycosylase putative; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (225 aa)
nep1Hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (263 aa)
rpl10eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification. (181 aa)
PF1285Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (363 aa)
PF1286Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (475 aa)
tbpTATA-box-binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity). (191 aa)
PF1325Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (362 aa)
sudBHydrogenase subunit gamma; A bifunctional enzyme that catalyzes the reduction of elemental sulfur or polysulfide to hydrogen sulfide with NADPH as electron donor. Also functions as a reduced ferredoxin:NADP oxidoreductase with a very high affinity for reduced ferredoxin. Exhibits a broad specificity for various physiological and non- physiological substrates with varied reduction potentials such as methyl viologen, benzyl viologen, FAD, FMN, methylene blue, 2,6- dichlorophenolindophenol (DCIP), cytochrome C and ferricyanide with highest preference for benzyl viologen. Does not reduce f [...] (278 aa)
shyCH-II gamma (hydrogenase subunit gamma); Part of a bifunctional enzyme complex that functions as a hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity exhibited with NAD in addition to NADPH. The beta and gamma subunits form the sulfur-reducing component that catalyzes the cytoplasmic production of hydrogen sulfide in the presence of elemental sulfur. (288 aa)
rnzArylsulfatase, putative; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Shows also activity toward a broad range of substrates, such as intron containing pre- tRNAs, 5' extended precursors and non-RNA substrates. (307 aa)
PF1346Pheromone shutdown protein; Function Code: 10 Regulatory Functions: REGULATORY FUNCTIONS; (traB). (289 aa)
rps28eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps28E). (71 aa)
rpl24eLSU ribosomal protein L24E; Binds to the 23S rRNA. (66 aa)
PF1373Cation transporter, putative; Function Code: 14.5 Transport and Binding Proteins: Cations. (285 aa)
rps10SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
fenFlap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...] (340 aa)
PF1415Met-10+ protein; Function Code: 16 Unknown:. (333 aa)
PF1439Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (112 aa)
PF1456Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (176 aa)
PF1472Aspartate/serine transaminase; Function Code: 1.3 Amino Acid Biosynthesis: Aspartate family. (383 aa)
rpl40eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl40E). (51 aa)
PF1477methylmalonyl-CoA mutase; Function Code: 5.6 Central Intermediary Metabolism: Other. (562 aa)
rps17eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps17E). (67 aa)
PF1495GTP-binding protein, gtp1/obg family; Function Code: 16 Unknown:. (357 aa)
rps19eSSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (150 aa)
PF1500Function Code: 16.4 Hypothetical. (92 aa)
PF1506Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (698 aa)
cetZCell division protein ftsZ homolog; Involved in cell shape control; Belongs to the CetZ family. (366 aa)
pdxSEthylene-inducible protein homolog; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (335 aa)
PF1532NADH oxidase; Function Code: 4.5 Cellular Processes: Detoxification; (noxA-3). (438 aa)
PF1534Stomatin homolog; Function Code: 3.1 Cell Envelope: Membranes, lipoproteins, and porins. (269 aa)
rps15Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps15P). (158 aa)
rps3aeFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps3AE). (198 aa)
PF2044Glycogen synthase; Function Code: 3.2 Cell Envelope: Surface polysaccharides, lipopolysaccharides and antigens; (starch). (451 aa)
PF2025Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (179 aa)
PF2024Transposase; Function Code: 15.3 Other Categories: Transposon-related functions. (417 aa)
PF2020Replication factor A related protein; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. (358 aa)
PF2010Hypothetical protein; Probably involved in the biogenesis of the ribosome. (223 aa)
rpl37aeLSU ribosomal protein L37AE; Binds to the 23S rRNA. (83 aa)
PF1998Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (235 aa)
rpl12LSU ribosomal protein L12A; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (107 aa)
rpl10LSU ribosomal protein L10E; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (339 aa)
rpl1LSU ribosomal protein L1P; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (216 aa)
rpl11LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (164 aa)
PF1986Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (290 aa)
PF1979Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (210 aa)
PF19634-hydroxybenzoate octaprenyltransferase, putative; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (277 aa)
PF1942Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (488 aa)
PF1940Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (166 aa)
PF1929Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (230 aa)
PF1928ATP-binding protein phnp; Function Code: 16 Unknown:; (phnP). (258 aa)
radARecombinase, radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (349 aa)
PF1918Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (358 aa)
PF1912Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (425 aa)
PF1911Putative hydrogenase; Function Code: 6.4 Energy Metabolism: Electron transport. (289 aa)
PF1902DNA repair helicase putative; Function Code: 11.1 Replication: DNA replication, restriction, modification, recombination, and repair. (447 aa)
PF1899Putative 2-deoxy-d-gluconate 3-dehydrogenase; Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides. (263 aa)
albAHypothetical protein; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family. (93 aa)
PF1875Hypothetical protein; Function Code: 16.1 Conserved Hypothetical; (ORF B). (99 aa)
rpl35aeFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl35AE). (87 aa)
rsmADimethyladenosine transferase (s-adenosylmethionine-6-n; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (273 aa)
PF1859Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (183 aa)
PF1853Glucose 1-dehydrogenase; Function Code: 5.1 Central Intermediary Metabolism: Degradation of polysaccharides. (259 aa)
PF18483-hydroxy-3-methylglutaryl-coenzyme a reductase (hmg-CoAreductase); Function Code: 7.1 Fatty Acid and Phospholipid Metabolism: General; Belongs to the HMG-CoA reductase family. (408 aa)
PF1831Archaeal histone a1; Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro). (67 aa)
PF1829Nucleotidyltransferase; Function Code: 16.0 Unknown. (412 aa)
PF1826Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (260 aa)
rpl3LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (365 aa)
rpl23LSU ribosomal protein L23P; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (88 aa)
rps19SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (132 aa)
rpl22LSU ribosomal protein L22P; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (155 aa)
rps3SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (210 aa)
rpl29Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl29P). (72 aa)
rps17SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (113 aa)
rpl14LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (141 aa)
rpl24LSU ribosomal protein L24P; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (124 aa)
rps4eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps4E). (243 aa)
rpl5LSU ribosomal protein L5P; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (186 aa)
rps14SSU ribosomal protein S14P; Binds 16S rRNA, required for the assembly of 30S particles. (56 aa)
rps8SSU ribosomal protein S8P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rpl6LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (184 aa)
rpl32eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl32E). (130 aa)
rpl19eLSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa)
rpl18LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (203 aa)
rps5SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (236 aa)
PF1791Small nucleolar rnp gar1-like protein; Function Code: 12.3 Transcription: RNA Processing. (104 aa)
truBCentromere binding protein homolog/pseudouridine synthase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. (340 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
PF1777Hydrolase related to 2-haloalkanoic acid dehalogenase; Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro; Belongs to the HAD-like hydrolase superfamily. (240 aa)
ftsYSignal recognition particle receptor (dpa); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (322 aa)
dnaGHypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (447 aa)
PF1724Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (131 aa)
PF1722Archaeal histone a2; Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro). (67 aa)
taw1Hypothetical protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe). (338 aa)
PF1688Transketolase N-terminal section; Function Code: 6.8 Energy Metabolism: Pentose phosphate pathway. (217 aa)
lysJAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (366 aa)
lysZAcetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (249 aa)
lysYN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (330 aa)
PF16782-isopropylmalate synthase; Function Code: 1.5 Amino Acid Biosynthesis: Pyruvate family; (leuA). (317 aa)
PF1674Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (162 aa)
PF1669Function Code: 16.4 Hypothetical. (576 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (375 aa)
rps13SSU ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (148 aa)
rps4SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (180 aa)
rpl18eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl18E). (120 aa)
rps9Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps9P). (135 aa)
rps2Function Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rps2P). (202 aa)
ligDNA ligase (lig); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (561 aa)
PF1618ATP-binding protein phnp; Function Code: 16 Unknown:; (phnP). (249 aa)
rtcBHypothetical protein; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family. (970 aa)
PF1609Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (364 aa)
PF1603Hypothetical na antiporter; Function Code: 14.5 Transport and Binding Proteins: Cations; (+)/H(+). (427 aa)
PF1598dCMP deaminase; Function Code: 9.5 Purines, Pyrimidines, Nucleosides and Nucleotides: Salvage of nucleosides and nucleotides. (185 aa)
top6AType II DNA topoisomerase subunit a; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (382 aa)
PF1570Hypothetical protein; Function Code: 16.1 Conserved Hypothetical. (236 aa)
rpl30eFunction Code: 13.4 Translation: Ribosomal proteins: synthesis and modification; (rpl30E). (99 aa)
rps7SSU ribosomal protein S7P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (215 aa)
Your Current Organism:
Pyrococcus furiosus
NCBI taxonomy Id: 186497
Other names: P. furiosus DSM 3638, Pyrococcus furiosus DSM 3638, Pyrococcus furiosus str. DSM 3638, Pyrococcus furiosus strain DSM 3638
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