12 items (Carlito syrichta) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	ANXA5	Annexin. (321 aa)
	CCL16	C-C motif chemokine. (118 aa)
	CCND1	G1/S-specific cyclin-D1. (156 aa)
	PGR	Progesterone receptor. (338 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (388 aa)
	AKT1	Non-specific serine/threonine protein kinase. (393 aa)
	EGFR	Receptor protein-tyrosine kinase. (1180 aa)
	LOC103257846	Caspase-3; Belongs to the peptidase C14A family. (277 aa)
	ENSTSYP00000013736	annotation not available (260 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	ENSTSYP00000014268	annotation not available (236 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	ANXA5	ENSTSYP00000030955	ENSTSYP00000021631	Non-specific serine/threonine protein kinase.	Annexin.	0.413
AKT1	CCND1	ENSTSYP00000030955	ENSTSYP00000022614	Non-specific serine/threonine protein kinase.	G1/S-specific cyclin-D1.	0.671
AKT1	EGFR	ENSTSYP00000030955	ENSTSYP00000005737	Non-specific serine/threonine protein kinase.	Receptor protein-tyrosine kinase.	0.689
AKT1	ENSTSYP00000013736	ENSTSYP00000030955	ENSTSYP00000013736	Non-specific serine/threonine protein kinase.	annotation not available	0.413
AKT1	ENSTSYP00000014268	ENSTSYP00000030955	ENSTSYP00000014268	Non-specific serine/threonine protein kinase.	annotation not available	0.773
AKT1	ERBB2	ENSTSYP00000030955	ENSTSYP00000014181	Non-specific serine/threonine protein kinase.	Receptor protein-tyrosine kinase.	0.514
AKT1	ESR1	ENSTSYP00000030955	ENSTSYP00000005747	Non-specific serine/threonine protein kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.659
AKT1	LOC103257846	ENSTSYP00000030955	ENSTSYP00000008395	Non-specific serine/threonine protein kinase.	Caspase-3; Belongs to the peptidase C14A family.	0.773
AKT1	PGR	ENSTSYP00000030955	ENSTSYP00000022764	Non-specific serine/threonine protein kinase.	Progesterone receptor.	0.489
AKT1	TP53	ENSTSYP00000030955	ENSTSYP00000023752	Non-specific serine/threonine protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.935
ANXA5	AKT1	ENSTSYP00000021631	ENSTSYP00000030955	Annexin.	Non-specific serine/threonine protein kinase.	0.413
ANXA5	CCND1	ENSTSYP00000021631	ENSTSYP00000022614	Annexin.	G1/S-specific cyclin-D1.	0.456
ANXA5	EGFR	ENSTSYP00000021631	ENSTSYP00000005737	Annexin.	Receptor protein-tyrosine kinase.	0.447
ANXA5	ERBB2	ENSTSYP00000021631	ENSTSYP00000014181	Annexin.	Receptor protein-tyrosine kinase.	0.433
ANXA5	TP53	ENSTSYP00000021631	ENSTSYP00000023752	Annexin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.590
CCND1	AKT1	ENSTSYP00000022614	ENSTSYP00000030955	G1/S-specific cyclin-D1.	Non-specific serine/threonine protein kinase.	0.671
CCND1	ANXA5	ENSTSYP00000022614	ENSTSYP00000021631	G1/S-specific cyclin-D1.	Annexin.	0.456
CCND1	EGFR	ENSTSYP00000022614	ENSTSYP00000005737	G1/S-specific cyclin-D1.	Receptor protein-tyrosine kinase.	0.596
CCND1	ENSTSYP00000013736	ENSTSYP00000022614	ENSTSYP00000013736	G1/S-specific cyclin-D1.	annotation not available	0.456
CCND1	ENSTSYP00000014268	ENSTSYP00000022614	ENSTSYP00000014268	G1/S-specific cyclin-D1.	annotation not available	0.474