(40 nodes) Mixed, incl. Prespliceosome, and mRNA cap binding complex binding network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LUC7L3	Luc7-like protein 3 isoform X1. (473 aa)
	DDX17	Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family. (736 aa)
	RBM25	RNA-binding protein 25. (843 aa)
	TRNAU1AP	tRNA selenocysteine 1-associated protein 1. (287 aa)
	RBM5	LOW QUALITY PROTEIN: RNA-binding protein 5. (693 aa)
	SUGP1	SURP and G-patch domain-containing protein 1 isoform X1. (646 aa)
	SON	Protein SON isoform X2. (2422 aa)
	SRSF11	Serine/arginine-rich splicing factor 11 isoform X3. (481 aa)
	PHAX	Phosphorylated adapter RNA export protein. (395 aa)
	LUC7L	Putative RNA-binding protein Luc7-like 1 isoform X1. (371 aa)
	CCAR1	Cell division cycle and apoptosis regulator protein 1 isoform X2. (1139 aa)
	SNRPC	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (159 aa)
	ZCCHC8	Zinc finger CCHC domain-containing protein 8. (708 aa)
	NCBP1	Nuclear cap-binding protein subunit 1. (423 aa)
	PRPF40A	LOW QUALITY PROTEIN: pre-mRNA-processing factor 40 homolog A. (929 aa)
	PRPF40B	pre-mRNA-processing factor 40 homolog B isoform X2. (894 aa)
	RBM7	RNA-binding protein 7 isoform X1. (267 aa)
	DHX9	ATP-dependent RNA helicase A. (1272 aa)
	PRPF39	pre-mRNA-processing factor 39 isoform X1. (668 aa)
	RBM23	Probable RNA-binding protein 23 isoform X1. (445 aa)
	U2AF2	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa)
	ENSTSYP00000018195	annotation not available (435 aa)
	ZC2HC1C	Zinc finger C2HC domain-containing protein 1C. (432 aa)
	SRRT	Serrate RNA effector molecule homolog isoform X2. (819 aa)
	PRPF4B	Serine/threonine-protein kinase PRP4 homolog. (1008 aa)
	HTATSF1	HIV Tat-specific factor 1. (753 aa)
	ENSTSYP00000025173	annotation not available (199 aa)
	ENSTSYP00000025562	annotation not available (79 aa)
	RBM39	RNA-binding protein 39 isoform X2. (530 aa)
	ENSTSYP00000026531	annotation not available (125 aa)
	RBM10	RNA-binding protein 10 isoform X1. (995 aa)
	PRR3	Proline-rich protein 3 isoform X2. (188 aa)
	SF1	Splicing factor 1. (372 aa)
	DDX5	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (601 aa)
	PNISR	Arginine/serine-rich protein PNISR isoform X1. (803 aa)
	LOC103255522	LOW QUALITY PROTEIN: putative RNA-binding protein Luc7-like 2. (391 aa)
	ZC3H18	Zinc finger CCCH domain-containing protein 18. (970 aa)
	SREK1	Splicing regulatory glutamine/lysine-rich protein 1 isoform X3. (630 aa)
	NCBP2	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
	C6orf52	Trnau1ap domain-containing protein. (141 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C6orf52	DDX17	ENSTSYP00000032677	ENSTSYP00000001207	Trnau1ap domain-containing protein.	Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family.	0.459
C6orf52	DDX5	ENSTSYP00000032677	ENSTSYP00000027519	Trnau1ap domain-containing protein.	Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family.	0.459
C6orf52	ENSTSYP00000018195	ENSTSYP00000032677	ENSTSYP00000018195	Trnau1ap domain-containing protein.	annotation not available	0.454
C6orf52	ENSTSYP00000025173	ENSTSYP00000032677	ENSTSYP00000025173	Trnau1ap domain-containing protein.	annotation not available	0.840
C6orf52	ENSTSYP00000026531	ENSTSYP00000032677	ENSTSYP00000026531	Trnau1ap domain-containing protein.	annotation not available	0.911
C6orf52	LOC103255522	ENSTSYP00000032677	ENSTSYP00000028406	Trnau1ap domain-containing protein.	LOW QUALITY PROTEIN: putative RNA-binding protein Luc7-like 2.	0.891
C6orf52	LUC7L	ENSTSYP00000032677	ENSTSYP00000009791	Trnau1ap domain-containing protein.	Putative RNA-binding protein Luc7-like 1 isoform X1.	0.891
C6orf52	NCBP1	ENSTSYP00000032677	ENSTSYP00000010948	Trnau1ap domain-containing protein.	Nuclear cap-binding protein subunit 1.	0.933
C6orf52	NCBP2	ENSTSYP00000032677	ENSTSYP00000032336	Trnau1ap domain-containing protein.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.911
C6orf52	PRPF39	ENSTSYP00000032677	ENSTSYP00000017492	Trnau1ap domain-containing protein.	pre-mRNA-processing factor 39 isoform X1.	0.959
C6orf52	PRPF40B	ENSTSYP00000032677	ENSTSYP00000012505	Trnau1ap domain-containing protein.	pre-mRNA-processing factor 40 homolog B isoform X2.	0.894
C6orf52	RBM10	ENSTSYP00000032677	ENSTSYP00000026787	Trnau1ap domain-containing protein.	RNA-binding protein 10 isoform X1.	0.405
C6orf52	RBM25	ENSTSYP00000032677	ENSTSYP00000002800	Trnau1ap domain-containing protein.	RNA-binding protein 25.	0.939
C6orf52	RBM5	ENSTSYP00000032677	ENSTSYP00000003817	Trnau1ap domain-containing protein.	LOW QUALITY PROTEIN: RNA-binding protein 5.	0.405
C6orf52	SF1	ENSTSYP00000032677	ENSTSYP00000026929	Trnau1ap domain-containing protein.	Splicing factor 1.	0.915
C6orf52	SNRPC	ENSTSYP00000032677	ENSTSYP00000010285	Trnau1ap domain-containing protein.	U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...]	0.840
C6orf52	SREK1	ENSTSYP00000032677	ENSTSYP00000029741	Trnau1ap domain-containing protein.	Splicing regulatory glutamine/lysine-rich protein 1 isoform X3.	0.454
C6orf52	SRSF11	ENSTSYP00000032677	ENSTSYP00000008015	Trnau1ap domain-containing protein.	Serine/arginine-rich splicing factor 11 isoform X3.	0.454
C6orf52	U2AF2	ENSTSYP00000032677	ENSTSYP00000017949	Trnau1ap domain-containing protein.	U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.	0.935
CCAR1	DDX17	ENSTSYP00000009850	ENSTSYP00000001207	Cell division cycle and apoptosis regulator protein 1 isoform X2.	Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family.	0.556