(25 nodes) Tricarboxylic acid cycle enzyme complex, and Tricarboxylic acid metabolic process network (Carlito syrichta)

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	ACO1	Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (894 aa)
	CS	Citrate synthase; Belongs to the citrate synthase family. (453 aa)
	PDHA1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (422 aa)
	BCKDHB	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1. (392 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	DLST	Dihydrolipoamide S-succinyltransferase. (452 aa)
	SUCLA2	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (403 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1150 aa)
	SUCLG1	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (341 aa)
	TXNRD2	Thioredoxin reductase 2, mitochondrial. (460 aa)
	IDH3G	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
	OGDH	2-oxoglutarate dehydrogenase, mitochondrial isoform X1. (869 aa)
	DLAT	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (645 aa)
	PDHB	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
	IDH3A	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (366 aa)
	ACO2	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (783 aa)
	LOC103257676	LOW QUALITY PROTEIN: dihydrolipoyl dehydrogenase, mitochondrial-like. (516 aa)
	IDH3B	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (412 aa)
	OGDHL	2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1. (1010 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	ENSTSYP00000031648	annotation not available (345 aa)
	BCKDHA	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (446 aa)
	DBT	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
	DLD	Dihydrolipoyl dehydrogenase. (516 aa)
	PDHX	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (486 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ACO1	ENSTSYP00000009703	ENSTSYP00000003835	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Cytoplasmic aconitate hydratase; Belongs to the aconitase/IPM isomerase family.	0.930
ACLY	ACO2	ENSTSYP00000009703	ENSTSYP00000022962	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.946
ACLY	BCKDHA	ENSTSYP00000009703	ENSTSYP00000031790	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.760
ACLY	BCKDHB	ENSTSYP00000009703	ENSTSYP00000006000	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial isoform X1.	0.683
ACLY	CS	ENSTSYP00000009703	ENSTSYP00000004057	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Citrate synthase; Belongs to the citrate synthase family.	0.998
ACLY	DBT	ENSTSYP00000009703	ENSTSYP00000033974	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.971
ACLY	DLAT	ENSTSYP00000009703	ENSTSYP00000016524	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.988
ACLY	DLD	ENSTSYP00000009703	ENSTSYP00000033988	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dihydrolipoyl dehydrogenase.	0.844
ACLY	DLST	ENSTSYP00000009703	ENSTSYP00000007263	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dihydrolipoamide S-succinyltransferase.	0.979
ACLY	ENSTSYP00000031648	ENSTSYP00000009703	ENSTSYP00000031648	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	annotation not available	0.683
ACLY	IDH1	ENSTSYP00000009703	ENSTSYP00000006112	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.927
ACLY	IDH2	ENSTSYP00000009703	ENSTSYP00000030456	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.927
ACLY	IDH3A	ENSTSYP00000009703	ENSTSYP00000020055	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.653
ACLY	IDH3B	ENSTSYP00000009703	ENSTSYP00000028786	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.729
ACLY	IDH3G	ENSTSYP00000009703	ENSTSYP00000016023	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.729
ACLY	LOC103257676	ENSTSYP00000009703	ENSTSYP00000023192	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	LOW QUALITY PROTEIN: dihydrolipoyl dehydrogenase, mitochondrial-like.	0.844
ACLY	OGDH	ENSTSYP00000009703	ENSTSYP00000016410	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	2-oxoglutarate dehydrogenase, mitochondrial isoform X1.	0.981
ACLY	OGDHL	ENSTSYP00000009703	ENSTSYP00000029689	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1.	0.981
ACLY	PDHA1	ENSTSYP00000009703	ENSTSYP00000005690	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.728
ACLY	PDHB	ENSTSYP00000009703	ENSTSYP00000019842	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.768