(40 nodes) Mixed, incl. TNFR1-induced NFkappaB signaling pathway, and MyD88-dependent toll-like receptor signaling pathway network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LY96	Lymphocyte antigen 96 isoform X1. (160 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3. (549 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4. (460 aa)
	IRAK2	Interleukin-1 receptor-associated kinase-like 2. (626 aa)
	TLR4	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (840 aa)
	TRAF1	TNF receptor-associated factor. (415 aa)
	ENSTSYP00000006680	annotation not available (255 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B. (462 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
	TAB2	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (937 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (671 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20. (801 aa)
	PLEKHG5	Pleckstrin homology domain-containing family G member 5. (1119 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (512 aa)
	BIRC3	Baculoviral IAP repeat-containing protein 3. (603 aa)
	LOC103255929	Toll-like receptor 9 isoform X2. (1029 aa)
	RNF31	E3 ubiquitin-protein ligase RNF31 isoform X1. (1073 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
	PLEKHG6	Pleckstrin homology domain-containing family G member 6. (673 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	TIRAP	Toll/interleukin-1 receptor domain-containing adapter protein isoform X1. (228 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2. (310 aa)
	SHARPIN	LOW QUALITY PROTEIN: sharpin. (375 aa)
	IKBKG	NF-kappa-B essential modulator. (460 aa)
	RBCK1	ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1. (510 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (718 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (183 aa)
	TAB3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3. (711 aa)
	TMED7	Transmembrane emp24 domain-containing protein 7. (229 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
	IRAK1	Interleukin-1 receptor-associated kinase 1. (618 aa)
	TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2. (504 aa)
	TANK	TRAF family member-associated NF-kappa-B activator. (422 aa)
	LOC103251546	Baculoviral IAP repeat-containing protein 2. (310 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC3	ENSTSYP00000006680	ENSTSYP00000016756	ENSTSYP00000006680	Baculoviral IAP repeat-containing protein 3.	annotation not available	0.873
BIRC3	IKBKE	ENSTSYP00000016756	ENSTSYP00000027047	Baculoviral IAP repeat-containing protein 3.	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	0.736
BIRC3	IKBKG	ENSTSYP00000016756	ENSTSYP00000026410	Baculoviral IAP repeat-containing protein 3.	NF-kappa-B essential modulator.	0.564
BIRC3	IRAK1	ENSTSYP00000016756	ENSTSYP00000030974	Baculoviral IAP repeat-containing protein 3.	Interleukin-1 receptor-associated kinase 1.	0.496
BIRC3	IRAK2	ENSTSYP00000016756	ENSTSYP00000002064	Baculoviral IAP repeat-containing protein 3.	Interleukin-1 receptor-associated kinase-like 2.	0.418
BIRC3	IRAK4	ENSTSYP00000016756	ENSTSYP00000001941	Baculoviral IAP repeat-containing protein 3.	Interleukin-1 receptor-associated kinase 4.	0.401
BIRC3	LOC103251546	ENSTSYP00000016756	ENSTSYP00000034593	Baculoviral IAP repeat-containing protein 3.	Baculoviral IAP repeat-containing protein 2.	0.940
BIRC3	MAP3K14	ENSTSYP00000016756	ENSTSYP00000008184	Baculoviral IAP repeat-containing protein 3.	Mitogen-activated protein kinase kinase kinase 14.	0.757
BIRC3	MAP3K20	ENSTSYP00000016756	ENSTSYP00000012085	Baculoviral IAP repeat-containing protein 3.	Mitogen-activated protein kinase kinase kinase 20.	0.805
BIRC3	MAP3K7	ENSTSYP00000016756	ENSTSYP00000030832	Baculoviral IAP repeat-containing protein 3.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.982
BIRC3	MYD88	ENSTSYP00000016756	ENSTSYP00000007105	Baculoviral IAP repeat-containing protein 3.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.873
BIRC3	PLEKHG5	ENSTSYP00000016756	ENSTSYP00000015454	Baculoviral IAP repeat-containing protein 3.	Pleckstrin homology domain-containing family G member 5.	0.694
BIRC3	PLEKHG6	ENSTSYP00000016756	ENSTSYP00000019922	Baculoviral IAP repeat-containing protein 3.	Pleckstrin homology domain-containing family G member 6.	0.694
BIRC3	RBCK1	ENSTSYP00000016756	ENSTSYP00000026968	Baculoviral IAP repeat-containing protein 3.	ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1.	0.882
BIRC3	RIPK1	ENSTSYP00000016756	ENSTSYP00000010281	Baculoviral IAP repeat-containing protein 3.	Receptor-interacting serine/threonine-protein kinase 1.	0.990
BIRC3	RNF31	ENSTSYP00000016756	ENSTSYP00000017617	Baculoviral IAP repeat-containing protein 3.	E3 ubiquitin-protein ligase RNF31 isoform X1.	0.934
BIRC3	SHARPIN	ENSTSYP00000016756	ENSTSYP00000025127	Baculoviral IAP repeat-containing protein 3.	LOW QUALITY PROTEIN: sharpin.	0.892
BIRC3	TAB1	ENSTSYP00000016756	ENSTSYP00000031761	Baculoviral IAP repeat-containing protein 3.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X2.	0.950
BIRC3	TAB2	ENSTSYP00000016756	ENSTSYP00000007192	Baculoviral IAP repeat-containing protein 3.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.874
BIRC3	TAB3	ENSTSYP00000016756	ENSTSYP00000028034	Baculoviral IAP repeat-containing protein 3.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3.	0.874