(107 nodes) Mixed, incl. Striated Muscle Contraction, and Myosin II complex network (Carlito syrichta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYLK	Myosin light chain kinase, smooth muscle isoform X1. (1917 aa)
	ANKRD1	Ankyrin repeat domain-containing protein 1. (319 aa)
	MYH1	Myosin-1 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
	MYH8	Myosin-8; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
	LOC103265696	PDZ and LIM domain protein 1. (297 aa)
	MYH15	Myosin-15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1933 aa)
	TNNC2	Troponin C, skeletal muscle. (161 aa)
	MYL5	Myosin light chain 5. (173 aa)
	LOC103268289	Palladin. (577 aa)
	MYOZ1	Myozenin-1. (298 aa)
	TPM2	Tropomyosin beta chain isoform X3; Belongs to the tropomyosin family. (285 aa)
	SMPX	Small muscular protein. (88 aa)
	LOC103277367	Myosin regulatory light chain 12B. (172 aa)
	MYLK3	Myosin light chain kinase 3. (477 aa)
	MYH3	Myosin-3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1951 aa)
	ACTL7B	LOW QUALITY PROTEIN: actin-like protein 7B; Belongs to the actin family. (366 aa)
	TRIM63	E3 ubiquitin-protein ligase TRIM63. (354 aa)
	MYH7B	myosin-7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2006 aa)
	CALD1	Caldesmon 1. (451 aa)
	MYH13	Myosin-13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
	CTNNAL1	Alpha-catulin. (733 aa)
	LOC103259476	LOW QUALITY PROTEIN: myosin-16-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1924 aa)
	CCDC141	Coiled-coil domain-containing protein 141. (952 aa)
	MYLPF	Myosin regulatory light chain 2, skeletal muscle isoform. (172 aa)
	MYH6	Myosin-6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
	MYLK4	Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. (389 aa)
	GAS2L3	GAS2-like protein 3. (683 aa)
	LMOD3	Leiomodin-3. (552 aa)
	MYOZ2	Myozenin-2. (264 aa)
	ACTC1	Actin, alpha cardiac muscle 1 isoform X1. (377 aa)
	MYPN	Myopalladin isoform X1. (1310 aa)
	ACTG2	Actin, gamma-enteric smooth muscle isoform X1. (376 aa)
	KLHL41	Kelch-like protein 41 isoform X1. (606 aa)
	CSRP3	Cysteine and glycine-rich protein 3. (194 aa)
	LMOD1	Leiomodin-1. (600 aa)
	MYL12A	Myosin regulatory light polypeptide 9 isoform X2. (172 aa)
	ENSTSYP00000015705	annotation not available (222 aa)
	TNNT1	Troponin T1, slow skeletal type. (232 aa)
	DYTN	Dystrotelin. (580 aa)
	ENSTSYP00000016056	annotation not available (76 aa)
	TNNI3	Troponin I, cardiac muscle. (211 aa)
	MYL6B	Myosin light chain 6B. (207 aa)
	TTN	Titin isoform X2. (5602 aa)
	SMIM20	Small integral membrane protein 20. (67 aa)
	ENSTSYP00000017157	annotation not available (60 aa)
	LASP1	LIM and SH3 domain protein 1 isoform X1. (255 aa)
	NRAP	Nebulin-related-anchoring protein isoform X1. (1731 aa)
	TPM3	Tropomyosin alpha-3 chain isoform X1; Belongs to the tropomyosin family. (285 aa)
	TPM3-2	Tropomyosin alpha-3 chain isoform X1; Belongs to the tropomyosin family. (99 aa)
	ENSTSYP00000018496	annotation not available (237 aa)
	TNNT3	Troponin T, fast skeletal muscle. (222 aa)
	MYBPC1	Myosin-binding protein C, slow-type. (1174 aa)
	MYL4	Myosin light chain 4. (158 aa)
	LOC103250795	Tropomyosin alpha-3 chain-like isoform X1. (238 aa)
	ENSTSYP00000018893	annotation not available (163 aa)
	ENSTSYP00000018933	annotation not available (272 aa)
	MYL3	Myosin light chain 3. (195 aa)
	LOC103253538	Tropomyosin alpha-1 chain. (62 aa)
	ENSTSYP00000019317	annotation not available (171 aa)
	MYL2	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (136 aa)
	OBSCN	LOW QUALITY PROTEIN: obscurin. (7659 aa)
	LOC103249472	Myosin regulatory light polypeptide 9 isoform X1. (172 aa)
	ACTN3	Alpha-actinin-3 isoform X1. (934 aa)
	MYL10	Myosin regulatory light chain 10. (181 aa)
	LOC103255041	Myosin-11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2012 aa)
	LOC103267800	Tropomyosin alpha-3 chain-like isoform X1; Belongs to the tropomyosin family. (229 aa)
	MYL7	Myosin regulatory light chain 2, atrial isoform isoform X1. (175 aa)
	MYBPC3	Myosin-binding protein C, cardiac-type. (1270 aa)
	LMOD2	Leiomodin-2. (549 aa)
	TNNC1	Troponin C, slow skeletal and cardiac muscles. (182 aa)
	MYH4	Myosin-4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
	LOC103255576	Myosin regulatory light chain 12B-like isoform X2. (161 aa)
	MYH9	Myosin-9 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1952 aa)
	DNAAF3	Dynein assembly factor 3, axonemal. (537 aa)
	ENSTSYP00000025025	annotation not available (362 aa)
	CNN1	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (247 aa)
	ENSTSYP00000025403	annotation not available (567 aa)
	TPM4	Tropomyosin alpha-4 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
	TNNI1	Troponin I, slow skeletal muscle isoform X1. (187 aa)
	ACTN2	Alpha-actinin-2. (894 aa)
	ENSTSYP00000026969	annotation not available (250 aa)
	ENSTSYP00000027244	annotation not available (133 aa)
	MYLK2	Myosin light chain kinase 2, skeletal/cardiac muscle. (559 aa)
	LOC103262462	Tropomyosin alpha-3 chain isoform X5; Belongs to the tropomyosin family. (92 aa)
	ENSTSYP00000028865	annotation not available (429 aa)
	ENSTSYP00000028952	annotation not available (752 aa)
	CALML6	Calmodulin-like protein 6. (164 aa)
	MYH10	Myosin-10 isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
	LOC103252352	Myosin-14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (547 aa)
	ENSTSYP00000029868	annotation not available (246 aa)
	MYL6	LOW QUALITY PROTEIN: myosin light polypeptide 6. (171 aa)
	ENSTSYP00000030021	annotation not available (162 aa)
	ACTN1	Alpha-actinin-1 isoform X1. (888 aa)
	ENSTSYP00000031215	annotation not available (83 aa)
	LOC103252147	Myosin-2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
	ACTA2	Actin, aortic smooth muscle. (377 aa)
	TNNT2	Troponin T, cardiac muscle isoform X3. (301 aa)
	EFCAB11	EF-hand calcium-binding domain-containing protein 11 isoform X1. (162 aa)
	ENSTSYP00000032766	annotation not available (382 aa)
	SPEGNB	CAVP-target protein. (238 aa)
	NEB	Nebulin. (7554 aa)
	ACTN4	Alpha-actinin-4 isoform X2. (880 aa)
	MYL1	Myosin light chain 1/3, skeletal muscle isoform isoform X1. (188 aa)
	TAGLN	Transgelin; Belongs to the calponin family. (201 aa)
	ENSTSYP00000033992	annotation not available (46 aa)
	MYH7	Myosin-7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
	LOC103249841	Myosin light polypeptide 6-like. (152 aa)

Your Current Organism:

Carlito syrichta

NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTA2	ACTG2	ENSTSYP00000031723	ENSTSYP00000011225	Actin, aortic smooth muscle.	Actin, gamma-enteric smooth muscle isoform X1.	0.845
ACTA2	ACTN1	ENSTSYP00000031723	ENSTSYP00000030583	Actin, aortic smooth muscle.	Alpha-actinin-1 isoform X1.	0.656
ACTA2	ACTN2	ENSTSYP00000031723	ENSTSYP00000026567	Actin, aortic smooth muscle.	Alpha-actinin-2.	0.695
ACTA2	ACTN3	ENSTSYP00000031723	ENSTSYP00000019894	Actin, aortic smooth muscle.	Alpha-actinin-3 isoform X1.	0.675
ACTA2	ACTN4	ENSTSYP00000031723	ENSTSYP00000033380	Actin, aortic smooth muscle.	Alpha-actinin-4 isoform X2.	0.651
ACTA2	CALD1	ENSTSYP00000031723	ENSTSYP00000007472	Actin, aortic smooth muscle.	Caldesmon 1.	0.492
ACTA2	CCDC141	ENSTSYP00000031723	ENSTSYP00000009207	Actin, aortic smooth muscle.	Coiled-coil domain-containing protein 141.	0.432
ACTA2	CNN1	ENSTSYP00000031723	ENSTSYP00000025130	Actin, aortic smooth muscle.	Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.	0.658
ACTA2	CSRP3	ENSTSYP00000031723	ENSTSYP00000013244	Actin, aortic smooth muscle.	Cysteine and glycine-rich protein 3.	0.445
ACTA2	CTNNAL1	ENSTSYP00000031723	ENSTSYP00000008518	Actin, aortic smooth muscle.	Alpha-catulin.	0.451
ACTA2	DNAAF3	ENSTSYP00000031723	ENSTSYP00000024828	Actin, aortic smooth muscle.	Dynein assembly factor 3, axonemal.	0.448
ACTA2	DYTN	ENSTSYP00000031723	ENSTSYP00000016045	Actin, aortic smooth muscle.	Dystrotelin.	0.478
ACTA2	ENSTSYP00000015705	ENSTSYP00000031723	ENSTSYP00000015705	Actin, aortic smooth muscle.	annotation not available	0.839
ACTA2	ENSTSYP00000016056	ENSTSYP00000031723	ENSTSYP00000016056	Actin, aortic smooth muscle.	annotation not available	0.814
ACTA2	ENSTSYP00000017157	ENSTSYP00000031723	ENSTSYP00000017157	Actin, aortic smooth muscle.	annotation not available	0.588
ACTA2	ENSTSYP00000018496	ENSTSYP00000031723	ENSTSYP00000018496	Actin, aortic smooth muscle.	annotation not available	0.759
ACTA2	ENSTSYP00000018893	ENSTSYP00000031723	ENSTSYP00000018893	Actin, aortic smooth muscle.	annotation not available	0.628
ACTA2	ENSTSYP00000018933	ENSTSYP00000031723	ENSTSYP00000018933	Actin, aortic smooth muscle.	annotation not available	0.473
ACTA2	ENSTSYP00000019317	ENSTSYP00000031723	ENSTSYP00000019317	Actin, aortic smooth muscle.	annotation not available	0.628
ACTA2	ENSTSYP00000025025	ENSTSYP00000031723	ENSTSYP00000025025	Actin, aortic smooth muscle.	annotation not available	0.846