STRINGSTRING
SOS2 SOS2 PTPN11 PTPN11 SOS1 SOS1 INPPL1 INPPL1 PLCG1 PLCG1 GAB1 GAB1 SHC1 SHC1 SHC4 SHC4 SHC3 SHC3 PTK2 PTK2 NTRK1 NTRK1 PDGFRB PDGFRB GRB2 GRB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2 isoform X1. (1318 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11. (532 aa)
SOS1Son of sevenless homolog 1 isoform X2. (441 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2. (1259 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1302 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (700 aa)
SHC1SHC-transforming protein 1 isoform X1. (474 aa)
SHC4SHC-transforming protein 4. (629 aa)
SHC3SHC-transforming protein 3. (107 aa)
PTK2Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
NTRK1High affinity nerve growth factor receptor. (721 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1105 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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