STRINGSTRING
DUSP7 DUSP7 NPHS1 NPHS1 MAPK6 MAPK6 PLVAP PLVAP IGF1 IGF1 ARAF ARAF SMAD3 SMAD3 LOC103252205 LOC103252205 MAP3K6 MAP3K6 NLRP12 NLRP12 SBK2 SBK2 BRAP BRAP EPGN EPGN MYC MYC MAP3K7 MAP3K7 DUSP9 DUSP9 TGFB1 TGFB1 TNIK TNIK WNK4 WNK4 MAP4K1 MAP4K1 ENSTSYP00000021212 ENSTSYP00000021212 POU4F2 POU4F2 MEN1 MEN1 MAPK15 MAPK15 ASH1L ASH1L FGF10 FGF10 ITGAV ITGAV KARS KARS SORBS3 SORBS3 FGFR1 FGFR1 MAP3K13 MAP3K13 CAMKK2 CAMKK2 ENSTSYP00000022866 ENSTSYP00000022866 PPP5C PPP5C MAP3K3 MAP3K3 MAP2K6 MAP2K6 MAP3K10 MAP3K10 WNT5A WNT5A TNFSF11 TNFSF11 FGFR3 FGFR3 HESX1 HESX1 MAP3K11 MAP3K11 FGF18 FGF18 MT3 MT3 MAPKAPK5 MAPKAPK5 MAPK8 MAPK8 ENSTSYP00000026316 ENSTSYP00000026316 MAPK11 MAPK11 RAPGEF2 RAPGEF2 MAPK13 MAPK13 ITPKB ITPKB TNF TNF NRG1 NRG1 MAPK3 MAPK3 MAPK8IP2 MAPK8IP2 TF TF MAP3K21 MAP3K21 MAP3K5 MAP3K5 PTPRC PTPRC ANKRD10 ANKRD10 GRB10 GRB10 NOD1 NOD1 MAPK14 MAPK14 FLCN FLCN ABL1 ABL1 NENF NENF LRRK2 LRRK2 IRAK4 IRAK4 RHBDD3 RHBDD3 IL18 IL18 SPRY2 SPRY2 PTK2B PTK2B CRKL CRKL IRAK1 IRAK1 IQGAP3 IQGAP3 CAV3 CAV3 ZFP36L1 ZFP36L1 ARHGEF6 ARHGEF6 MAP4K2 MAP4K2 MAPK7 MAPK7 CAV1 CAV1 MAPK1 MAPK1 MEF2C MEF2C MAPK4 MAPK4 MAPKAPK2 MAPKAPK2 DUSP6 DUSP6 MAPK9 MAPK9 MAPKAPK3 MAPKAPK3 ERCC6 ERCC6 MAP4K5 MAP4K5 ATF2 ATF2 MAP3K4 MAP3K4 CASR CASR IKBKB IKBKB PBK PBK PAK3 PAK3 HRAS HRAS FGF12 FGF12 IGFBP4 IGFBP4 KDR KDR NFKB1 NFKB1 MAP3K9 MAP3K9 MAP2K3 MAP2K3 MAPK10 MAPK10 CTSH CTSH RIPK2 RIPK2 NOX1 NOX1 PABPN1 PABPN1 ENSTSYP00000006680 ENSTSYP00000006680 RET RET CARD9 CARD9 MYD88 MYD88 IL1B IL1B TMEM248 TMEM248 MAP4K3 MAP4K3 C1QL4 C1QL4 NLK NLK MAP3K14 MAP3K14 TLR3 TLR3 YWHAE YWHAE BRAF BRAF EGF EGF CCM2 CCM2 NF1 NF1 SMAD4 SMAD4 AR AR MAP3K1 MAP3K1 IGFBP3 IGFBP3 CTNNB1 CTNNB1 RIPK1 RIPK1 EDN1 EDN1 MAP3K8 MAP3K8 RASGRP3 RASGRP3 ADRA1A ADRA1A IL31RA IL31RA NRK NRK HTR2B HTR2B BTN2A2 BTN2A2 MAP3K20 MAP3K20 TAOK3 TAOK3 GPS2 GPS2 MAP3K2 MAP3K2 STRADB STRADB DUSP10 DUSP10 ENSTSYP00000013911 ENSTSYP00000013911 MAP2K7 MAP2K7 SMAD1 SMAD1 RCE1 RCE1 MAP2K4 MAP2K4 PTPN6 PTPN6 MAP4K4 MAP4K4 AVP AVP TAOK1 TAOK1 MAP3K12 MAP3K12 MAPK8IP1 MAPK8IP1 MINK1 MINK1 SETX SETX DAXX DAXX TBC1D10C TBC1D10C CD36 CD36 MBP MBP MAP2K5 MAP2K5 PTPN7 PTPN7 MAPK12 MAPK12 NOD2 NOD2 PPM1L PPM1L PTPN3 PTPN3 PEA15 PEA15 SH2D3C SH2D3C TAOK2 TAOK2 MAP2K1 MAP2K1 GPS1 GPS1 SHANK3 SHANK3 HSF1 HSF1 NF2 NF2 TLR7 TLR7 RBX1 RBX1 MEF2A MEF2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (385 aa)
NPHS1Nephrin. (1222 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
PLVAPPlasmalemma vesicle-associated protein. (393 aa)
IGF1Insulin-like growth factor I isoform X1. (209 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (611 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LOC103252205Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1262 aa)
NLRP12NACHT, LRR and PYD domains-containing protein 12 isoform X1. (1064 aa)
SBK2LOW QUALITY PROTEIN: serine/threonine-protein kinase SBK2; Belongs to the protein kinase superfamily. (348 aa)
BRAPBRCA1-associated protein. (343 aa)
EPGNEpigen isoform X1. (153 aa)
MYCMyc proto-oncogene protein. (376 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
DUSP9Dual specificity protein phosphatase 9; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (314 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (344 aa)
TNIKTRAF2 and NCK-interacting protein kinase. (1293 aa)
WNK4Serine/threonine-protein kinase WNK4. (1226 aa)
MAP4K1Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (852 aa)
ENSTSYP00000021212annotation not available (41 aa)
POU4F2POU domain protein. (396 aa)
MEN1Menin. (615 aa)
MAPK15Mitogen-activated protein kinase. (277 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X1. (2966 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1041 aa)
KARSLysine--tRNA ligase. (622 aa)
SORBS3Vinexin. (667 aa)
FGFR1Fibroblast growth factor receptor. (832 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13. (540 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (587 aa)
ENSTSYP00000022866annotation not available (318 aa)
PPP5CSerine/threonine-protein phosphatase. (499 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (528 aa)
MAP2K6LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (352 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase 10. (891 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (250 aa)
FGFR3Fibroblast growth factor receptor. (745 aa)
HESX1Homeobox expressed in ES cells 1. (185 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (745 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (184 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (111 aa)
MAPKAPK5MAP kinase-activated protein kinase 5 isoform X1. (487 aa)
MAPK8Mitogen-activated protein kinase. (384 aa)
ENSTSYP00000026316annotation not available (161 aa)
MAPK11Mitogen-activated protein kinase. (255 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2 isoform X1. (1659 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (819 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (232 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X3. (645 aa)
MAPK3Mitogen-activated protein kinase. (363 aa)
MAPK8IP2C-Jun-amino-terminal kinase-interacting protein 2. (178 aa)
TFLOW QUALITY PROTEIN: serotransferrin-like. (697 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase 21. (760 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1329 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (601 aa)
ANKRD10Ankyrin repeat domain-containing protein 10-like. (350 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (593 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
FLCNFolliculin. (579 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (172 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2. (2527 aa)
IRAK4Interleukin-1 receptor-associated kinase 4. (460 aa)
RHBDD3Rhomboid domain-containing protein 3. (373 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (192 aa)
SPRY2Protein sprouty homolog 2. (338 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CRKLCrk-like protein. (303 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (618 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1632 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ZFP36L1mRNA decay activator protein ZFP36L1. (338 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6 isoform X1. (777 aa)
MAP4K2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (755 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (813 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (363 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
MAPK4Mitogen-activated protein kinase 4. (368 aa)
MAPKAPK2MAP kinase-activated protein kinase 2. (400 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MAPKAPK3MAP kinase-activated protein kinase 3; Belongs to the protein kinase superfamily. (383 aa)
ERCC6DNA excision repair protein ERCC-6. (1481 aa)
MAP4K5Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (810 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (507 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4 isoform X1. (1602 aa)
CASRLOW QUALITY PROTEIN: extracellular calcium-sensing receptor. (1015 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase isoform X1. (325 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (580 aa)
HRASGTPase HRas isoform X6. (189 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (964 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase. (1095 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
MAPK10Mitogen-activated protein kinase. (473 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (335 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2 isoform X1. (539 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
PABPN1Polyadenylate-binding protein 2. (333 aa)
ENSTSYP00000006680annotation not available (255 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1092 aa)
CARD9Caspase recruitment domain-containing protein 9. (541 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (321 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
TMEM248Transmembrane protein 248 isoform X1. (325 aa)
MAP4K3Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (810 aa)
C1QL4Complement C1q-like protein 4. (238 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (529 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (937 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
YWHAE14-3-3 protein epsilon isoform X2; Belongs to the 14-3-3 family. (255 aa)
BRAFSerine/threonine-protein kinase B-raf. (760 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1167 aa)
CCM2Cerebral cavernous malformations 2 protein. (465 aa)
NF1Neurofibromin isoform X2. (2839 aa)
SMAD4Mothers against decapentaplegic homolog. (551 aa)
ARAndrogen receptor. (887 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1346 aa)
IGFBP3Insulin-like growth factor-binding protein 3. (194 aa)
CTNNB1Catenin beta-1 isoform X1. (783 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (671 aa)
EDN1Endothelin-1. (202 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
RASGRP3LOW QUALITY PROTEIN: ras guanyl-releasing protein 3-like. (559 aa)
ADRA1Aalpha-1A adrenergic receptor isoform X1. (466 aa)
IL31RALOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha. (744 aa)
NRKNik-related protein kinase. (1586 aa)
HTR2B5-hydroxytryptamine receptor 2B isoform X1. (480 aa)
BTN2A2Butyrophilin subfamily 2 member A2-like. (519 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (801 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X2. (898 aa)
GPS2G protein pathway suppressor 2 isoform X2. (336 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (531 aa)
STRADBSTE20-related kinase adapter protein beta. (418 aa)
DUSP10Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (486 aa)
ENSTSYP00000013911annotation not available (58 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (414 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
RCE1CAAX prenyl protease 2 isoform X1. (304 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type 6. (402 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4 isoform X1. (1342 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (107 aa)
TAOK1Serine/threonine-protein kinase TAO1 isoform X1. (1001 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (893 aa)
MAPK8IP1C-Jun-amino-terminal kinase-interacting protein 1. (704 aa)
MINK1Misshapen-like kinase 1. (1325 aa)
SETXProbable helicase senataxin. (849 aa)
DAXXDeath domain-associated protein 6 isoform X2. (732 aa)
TBC1D10CCarabin. (261 aa)
CD36Platelet glycoprotein 4; Belongs to the CD36 family. (472 aa)
MBPMyelin basic protein. (304 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily. (448 aa)
PTPN7Tyrosine-protein phosphatase non-receptor type 7 isoform X1. (443 aa)
MAPK12Mitogen-activated protein kinase. (277 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1040 aa)
PPM1LProtein phosphatase 1L. (181 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (908 aa)
PEA15Astrocytic phosphoprotein PEA-15 isoform X1. (150 aa)
SH2D3CSH2 domain-containing protein 3C. (669 aa)
TAOK2Serine/threonine-protein kinase TAO2 isoform X1. (1236 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1. (381 aa)
GPS1COP9 signalosome complex subunit 1 isoform X1. (527 aa)
SHANK3SH3 and multiple ankyrin repeat domains protein 3. (1282 aa)
HSF1Heat shock factor protein 1 isoform X2. (523 aa)
NF2Merlin isoform X1. (598 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (498 aa)
Your Current Organism:
Carlito syrichta
NCBI taxonomy Id: 1868482
Other names: C. syrichta, Philippine tarsier, Tarsius syrichta
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